{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:21:10Z","timestamp":1790036470124,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20240241"],"award-info":[{"award-number":["Y20240241"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["slas-technology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Technology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.slast.2026.100433","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T14:54:46Z","timestamp":1779029686000},"page":"100433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Machine learning-based study on Xin-Pi simultaneous treatment formula via drug nanodelivery systems regulating macrophage polarization and TEAD2\/PKM2 synergistic repair strategy in myocarditis"],"prefix":"10.1016","volume":"40","author":[{"given":"Yunrui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songsong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.slast.2026.100433_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103865","article-title":"Dissecting the cellular landscape and transcriptome network in viral myocarditis by single-cell RNA sequencing","volume":"25","author":"Lasrado","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.slast.2026.100433_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103016","article-title":"M2 macrophage exosome-derived lncRNA AK083884 protects mice from CVB3-induced viral myocarditis through regulating PKM2\/HIF-1\u03b1 axis","volume":"69","author":"Zhang","year":"2024","journal-title":"Redox Biol"},{"issue":"1","key":"10.1016\/j.slast.2026.100433_bib0003","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00011-024-01979-1","article-title":"Mediation of macrophage M1 polarization dynamics change by ubiquitin-autophagy-pathway regulated NLRP3 inflammasomes in PD-1 inhibitor-related myocardial inflammatory injury","volume":"74","author":"Chen","year":"2025","journal-title":"Inflamm Res"},{"key":"10.1016\/j.slast.2026.100433_bib0004","article-title":"Nanoparticles coated with immune cell hybrid membranes for targeted delivery of janus kinase inhibitors and synergistic treatment of autoimmune myocarditis","author":"Zhou","year":"2025","journal-title":"Acta Biomater"},{"key":"10.1016\/j.slast.2026.100433_bib0005","article-title":"Drp1 Promotes macrophage M1 polarization and inflammatory response in autoimmune myocarditis by driving mitochondrial fission","author":"Li","year":"2024","journal-title":"Clin Immunol"},{"key":"10.1016\/j.slast.2026.100433_bib0006","article-title":"Exosomal PKM2: a noninvasive diagnostic marker linking macrophage metabolic reprogramming to gastric cancer pathogenesis","author":"Liu","year":"2025","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.slast.2026.100433_bib0007","article-title":"Effects of metabolism on macrophage polarization under different disease backgrounds","volume":"13","author":"Xu","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.slast.2026.100433_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156374","article-title":"mTOR\/HIF-1\u03b1 pathway-mediated glucose reprogramming and macrophage polarization by Sini decoction plus ginseng soup in ALF","volume":"137","author":"Zhang","year":"2025","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.slast.2026.100433_bib0009","article-title":"PKM2 promotes proinflammatory macrophage activation in ankylosing spondylitis","volume":"123","author":"Chen","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.slast.2026.100433_bib0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13072-025-00575-9","article-title":"Crosstalk between metabolism and epigenetics during macrophage polarization","volume":"18","author":"Zhang","year":"2025","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.slast.2026.100433_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.810232","article-title":"Applications of single-cell RNA sequencing in cardiovascular research","volume":"9","author":"Fan","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.slast.2026.100433_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.905151","article-title":"Advances in application of single-cell RNA sequencing in cardiovascular research","volume":"9","author":"Hu","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"43","key":"10.1016\/j.slast.2026.100433_bib0013","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1093\/eurheartj\/ehac095","article-title":"Single-cell technologies to decipher cardiovascular diseases","volume":"43","author":"Abplanalp","year":"2022","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.slast.2026.100433_bib0014","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41569-022-00805-7","article-title":"Single-cell transcriptomics for the assessment of cardiac disease","volume":"20","author":"Miranda","year":"2023","journal-title":"Nat Rev Cardiol"},{"issue":"3","key":"10.1016\/j.slast.2026.100433_bib0015","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3390\/ijms26030995","article-title":"Spatial transcriptomics in Human cardiac tissue","volume":"26","author":"Nguyen","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.slast.2026.100433_bib0016","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41586-022-05060-x","article-title":"Spatial multi-omic map of human myocardial infarction","volume":"608","author":"Kuppe","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.slast.2026.100433_bib0017","first-page":"70","article-title":"Single-cell and spatial transcriptomics: advances in heart development and disease applications","volume":"13","author":"Liu","year":"2023","journal-title":"Cell Biosci"},{"issue":"8","key":"10.1016\/j.slast.2026.100433_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101157","article-title":"The integration of machine learning into traditional Chinese medicine","volume":"15","author":"Hong","year":"2025","journal-title":"J Pharm Anal"},{"issue":"9","key":"10.1016\/j.slast.2026.100433_bib0019","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202500214","article-title":"Machine learning-enhanced network pharmacology in traditional Chinese medicine","volume":"22","author":"Yang","year":"2025","journal-title":"Chem Biodivers"},{"key":"10.1016\/j.slast.2026.100433_bib0020","article-title":"Artificial intelligence in traditional Chinese medicine","volume":"16","author":"Li","year":"2025","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.slast.2026.100433_bib0021","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1142\/S0192415X22500045","article-title":"Machine learning approaches in traditional Chinese medicine: a systematic review","volume":"50","author":"Chen","year":"2022","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.slast.2026.100433_bib0022","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/bs.ctdb.2022.02.010","article-title":"Hippo signaling in cardiac fibroblasts during development, tissue repair, and fibrosis","volume":"149","author":"Meng","year":"2022","journal-title":"Curr Top Dev Biol"},{"issue":"3","key":"10.1016\/j.slast.2026.100433_bib0023","first-page":"502","article-title":"Targeting the Hippo pathway for cardiac regeneration","volume":"40","author":"Tsai","year":"2025","journal-title":"Physiology"},{"issue":"18","key":"10.1016\/j.slast.2026.100433_bib0024","article-title":"Multi-omic analyses and network biology in cardiovascular disease","volume":"23","author":"Reitz","year":"2023","journal-title":"Proteomics"},{"key":"10.1016\/j.slast.2026.100433_bib0025","first-page":"425","article-title":"Machine learning and multi-omics integration in cardiovascular research","volume":"23","author":"Liu","year":"2025","journal-title":"J Transl Med"},{"issue":"5","key":"10.1016\/j.slast.2026.100433_bib0026","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41569-020-00477-1","article-title":"Systems biology in cardiovascular disease: a multiomics approach","volume":"18","author":"Guo","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.slast.2026.100433_bib0027","article-title":"From multi-omics approaches to personalized medicine in myocardial infarction","volume":"10","author":"Li","year":"2023","journal-title":"Front Cardiovasc Med"}],"container-title":["SLAS Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472630326000464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472630326000464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T23:46:42Z","timestamp":1786060002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472630326000464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"alternative-id":["S2472630326000464"],"URL":"https:\/\/doi.org\/10.1016\/j.slast.2026.100433","relation":{},"ISSN":["2472-6303"],"issn-type":[{"value":"2472-6303","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Machine learning-based study on Xin-Pi simultaneous treatment formula via drug nanodelivery systems regulating macrophage polarization and TEAD2\/PKM2 synergistic repair strategy in myocarditis","name":"articletitle","label":"Article Title"},{"value":"SLAS Technology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.slast.2026.100433","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Society for Laboratory Automation and Screening.","name":"copyright","label":"Copyright"}],"article-number":"100433"}}