{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T19:10:43Z","timestamp":1792350643378,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.sleep.2012.10.009","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T01:18:53Z","timestamp":1358817533000},"page":"744-748","source":"Crossref","is-referenced-by-count":768,"title":["Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series"],"prefix":"10.1016","volume":"14","author":[{"given":"Carlos H.","family":"Schenck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F.","family":"Boeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Mahowald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2012.10.009_b0005","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1212\/WNL.46.2.388","article-title":"Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder","volume":"46","author":"Schenck","year":"1996","journal-title":"Neurology"},{"issue":"Suppl.","key":"10.1016\/j.sleep.2012.10.009_b0010","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ana.410320721","article-title":"Criteria for diagnosing Parkinson\u2019s disease","volume":"32","author":"Calne","year":"1992","journal-title":"Ann Neurol"},{"key":"10.1016\/j.sleep.2012.10.009_b0015","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF02309628","article-title":"Consensus statement on the diagnosis of multiple system atrophy. Amercian Autonomic Society and American Academy of Neurology","volume":"8","author":"Gilman","year":"1998","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.sleep.2012.10.009_b0020","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2012.10.009_b0025","series-title":"Paradox lost: midnight in the battleground of sleep and dreams","author":"Schenck","year":"2005"},{"key":"10.1016\/j.sleep.2012.10.009_b0030","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0006-3223(96)00070-4","article-title":"A case of REM sleep behavior disorder with autopsy-confirmed Alzheimer\u2019s disease: postmortem brain stem histochemical analyses","volume":"40","author":"Schenck","year":"1996","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.sleep.2012.10.009_b0035","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0006-3223(97)00228-X","article-title":"Lewy body variant of Alzheimer\u2019s disease (AD) identified by postmortem ubiquitin staining in a previously reported case of AD associated with REM sleep behavior disorder","volume":"42","author":"Schenck","year":"1997","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.sleep.2012.10.009_b0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/jnnp.62.1.16","article-title":"Hallucinations and signs of parkinsonism help distinguish patients with dementia and cortical Lewy bodies from patients with Alzheimer\u2019s disease at presentation: a clinicopathological study","volume":"6","author":"Ala","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.sleep.2012.10.009_b0045","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00005072-199710000-00002","article-title":"Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease","volume":"56","author":"Hyman","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.sleep.2012.10.009_b0050","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/NEN.0b013e31817d7a1d","article-title":"Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases","volume":"67","author":"Fujishiro","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.sleep.2012.10.009_b0055","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-Mental State: a practical method for grading the cognitive state of patients for clinicians","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.sleep.2012.10.009_b0060","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1212\/WNL.0b013e3181ec7fac","article-title":"REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century","volume":"75","author":"Claassen","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2012.10.009_b0065","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1212\/WNL.45.4.709","article-title":"Incidental Lewy body disease in a patient with REM sleep behavior disorder","volume":"45","author":"Uchiyama","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2012.10.009_b0070","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.sleep.2006.08.017","article-title":"Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease","volume":"8","author":"Boeve","year":"2007","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2012.10.009_b0075","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/brain\/awh376","article-title":"Involvement of medullary regions controlling sympathetic output in Lewy body disease","volume":"128","author":"Benarroch","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.sleep.2012.10.009_b0080","first-page":"299","article-title":"Lewy body disease with and without dementia: a clinicopathological study of 35 cases","volume":"7","author":"Kosaka","year":"1988","journal-title":"Clin Neuropathol"},{"key":"10.1016\/j.sleep.2012.10.009_b0085","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/jnnp.57.5.594","article-title":"Diffuse neurofibrillary tangles with calcification: a new presenile dementia","volume":"57","author":"Kosaka","year":"1994","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.sleep.2012.10.009_b0090","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.sleep.2012.10.009_b0095","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1001\/archneurol.2009.170","article-title":"Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease","volume":"66","author":"Frigerio","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.sleep.2012.10.009_b0100","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1016\/j.clinph.2011.03.033","article-title":"Incidental Lewy body disease: electrophysiological findings suggesting pre-clinical Lewy body disorders","volume":"122","author":"Caviness","year":"2011","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.sleep.2012.10.009_b0105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1440-1789.2011.01211.x","article-title":"Lewy body-related alpha-synucleinopathy in the spinal cord of cases with incidental Lewy body disease","volume":"32","author":"Tamura","year":"2012","journal-title":"Neuropathology"},{"key":"10.1016\/j.sleep.2012.10.009_b0110","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/mds.24954","article-title":"Premotor Parkinson\u2019s disease: concepts and definitions","volume":"27","author":"Siderowf","year":"2012","journal-title":"Mov Disord"},{"key":"10.1016\/j.sleep.2012.10.009_b0115","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/mds.24921","article-title":"Lewy pathology and neurodegeneration in premotor Parkinson\u2019s disease","volume":"27","author":"Del Tredici","year":"2012","journal-title":"Mov Disord"},{"key":"10.1016\/j.sleep.2012.10.009_b0120","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.sleep.2012.10.009_b0125","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ana.22628","article-title":"An operational approach to National Institute on Aging-Alzheimer\u2019s Association criteria for preclinical Alzheimer disease","volume":"71","author":"Jack","year":"2012","journal-title":"Ann Neurol"},{"key":"10.1016\/j.sleep.2012.10.009_b0130","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1212\/WNL.52.5.951","article-title":"REM sleep behavior disorder and dementia: cognitive differences when compared with AD","volume":"52","author":"Ferman","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2012.10.009_b0135","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1212\/01.WNL.0000073619.94467.B0","article-title":"Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism","volume":"61","author":"Boeve","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2012.10.009_b0140","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S1474-4422(06)70476-8","article-title":"Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study","volume":"5","author":"Iranzo","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.sleep.2012.10.009_b0145","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1212\/01.wnl.0000340980.19702.6e","article-title":"Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder","volume":"72","author":"Postuma","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2012.10.009_b0150","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/S1474-4422(10)70216-7","article-title":"Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]","volume":"9","author":"Iranzo","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.sleep.2012.10.009_b0155","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/ana.22282","article-title":"Olfaction and color vision identify impending neurodegeneration in idiopathic REM sleep behavior disorder","volume":"69","author":"Postuma","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.sleep.2012.10.009_b0160","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S1474-4422(11)70152-1","article-title":"Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study","volume":"10","author":"Iranzo","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.sleep.2012.10.009_b0165","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.smrv.2008.11.003","article-title":"The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases","volume":"13","author":"Iranzo","year":"2009","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleep.2012.10.009_b0170","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1749-6632.2009.05115.x","article-title":"REM sleep behavior disorder: Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions","volume":"1184","author":"Boeve","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.sleep.2012.10.009_b0175","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.nbd.2011.10.003","article-title":"REM sleep behavior disorder: from dreams to neurodegeneration","volume":"46","author":"Postuma","year":"2011","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.sleep.2012.10.009_b0180","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1136\/jnnp.2009.174748","article-title":"Clinical prediction of Parkinson\u2019s disease: planning for the age of neuroprotection","volume":"81","author":"Postuma","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.sleep.2012.10.009_b0185","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/S1474-4422(10)70221-0","article-title":"Predicting the future in idiopathic rapid-eye-movement sleep behaviour disorder","volume":"9","author":"Boeve","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.sleep.2012.10.009_b0190","doi-asserted-by":"crossref","unstructured":"Schenck CH, Montplaisir J, Frauscher B, et al. REM sleep behavior disorder (RBD): devising controlled active treatment studies for symptomatic and neuroprotective therapy\u2014a consensus statement by the International RBD Study Group. Sleep Med 2013;14:795\u2013806.","DOI":"10.1016\/j.sleep.2013.02.016"},{"key":"10.1016\/j.sleep.2012.10.009_b0195","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s11910-012-0253-z","article-title":"REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease","volume":"12","author":"McCarter","year":"2012","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"Pt 11","key":"10.1016\/j.sleep.2012.10.009_b0200","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1093\/brain\/awm056","article-title":"Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease","volume":"130","author":"Boeve","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.sleep.2012.10.009_b0205","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1212\/WNL.0b013e31822e560e","article-title":"Associated factors for REM sleep behavior disorder in Parkinson disease","volume":"77","author":"TE Sixel-D\u00f6ring","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2012.10.009_b0210","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1212\/WNL.0b013e31822e14d7","article-title":"The strong presence of REM sleep behavior disorder in PD: clinical and research implications [editorial]","volume":"77","author":"Schenck","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2012.10.009_b0215","series-title":"Therapy in sleep medicine","first-page":"549","article-title":"REM sleep parasomnias in adults: REM sleep behavior disorder, isolated sleep paralysis, and nightmare disorders","author":"Schenck","year":"2011"},{"key":"10.1016\/j.sleep.2012.10.009_b0220","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1111\/j.1556-4029.2009.01163.x","article-title":"Potentially lethal behaviors associated with rapid eye movement sleep behavior disorder: review of the literature and forensic implications","volume":"54","author":"Schenck","year":"2009","journal-title":"J Forensic Sci"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945712003814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945712003814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T06:53:02Z","timestamp":1539931982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945712003814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S1389945712003814"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2012.10.009","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]}}}