{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:37:26Z","timestamp":1782373046793,"version":"3.54.5"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Italian Ministry of Health"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.sleep.2013.01.007","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T23:50:19Z","timestamp":1362786619000},"page":"399-406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Effects of long-term use of clonazepam on nonrapid eye movement sleep patterns in rapid eye movement sleep behavior disorder"],"prefix":"10.1016","volume":"14","author":[{"given":"Raffaele","family":"Ferri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Zucconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Marelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos H.","family":"Schenck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferini-Strambi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2013.01.007_b0005","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/sleep\/25.2.120","article-title":"REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP","volume":"25","author":"Schenck","year":"2002","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2013.01.007_b0010","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0002-9343(97)89493-4","article-title":"Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep in 170 adults","volume":"100","author":"Schenck","year":"1996","journal-title":"Am J Med"},{"key":"10.1016\/j.sleep.2013.01.007_b0015","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1212\/01.wnl.0000233926.47469.73","article-title":"Update on the pharmacology of REM sleep behavior disorder","volume":"67","author":"Gagnon","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2013.01.007_b0020","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1345\/aph.1H587","article-title":"Rapid eye movement sleep behavior disorder","volume":"41","author":"Gugger","year":"2007","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.sleep.2013.01.007_b0025","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1111\/j.1556-4029.2009.01163.x","article-title":"Potentially lethal behaviors associated with rapid eye movement sleep behavior disorder: review of the literature and forensic implications","volume":"54","author":"Schenck","year":"2009","journal-title":"J Forensic Sci"},{"key":"10.1016\/j.sleep.2013.01.007_b0265","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.sleep.2012.09.009","article-title":"An observational clinical and video-polysomnographic study of the effects of clonazepam in REM sleep behavior disorder","volume":"14","author":"Ferri","year":"2013","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2013.01.007_b0035","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1212\/WNL.42.7.1371","article-title":"Polysomnographic features of REM sleep behavior disorder: development of a scoring method","volume":"42","author":"Lapierre","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2013.01.007_b0040","first-page":"189","article-title":"Effect of benzodiazepine hypnotics on all-night sleep EEG spectra","volume":"4","author":"Borbely","year":"1985","journal-title":"Hum Neurobiol"},{"key":"10.1016\/j.sleep.2013.01.007_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02246405","article-title":"Polysomnographic effects of hypnotic drugs. A review","volume":"126","author":"Parrino","year":"1996","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.sleep.2013.01.007_b0050","first-page":"1066","article-title":"Increased percentage of slow-wave sleep in REM sleep behavior disorder (RBD): a reanalysis of previously published data from a controlled study of RBD reported in SLEEP","volume":"26","author":"Schenck","year":"2003","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2013.01.007_b0055","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1016\/j.clinph.2005.08.004","article-title":"NREM sleep alterations in narcolepsy\/cataplexy","volume":"116","author":"Ferri","year":"2005","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.sleep.2013.01.007_b0060","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.smrv.2007.08.010","article-title":"Nocturnal aspects of narcolepsy with cataplexy","volume":"12","author":"Plazzi","year":"2008","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleep.2013.01.007_b0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.smrv.2011.02.003","article-title":"Cyclic alternating pattern (CAP): the marker of sleep instability","volume":"16","author":"Parrino","year":"2012","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleep.2013.01.007_b0070","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1365-2869.2011.00981.x","article-title":"A new quantitative automatic method for the measurement of non-rapid eye movement sleep electroencephalographic amplitude variability","volume":"21","author":"Ferri","year":"2012","journal-title":"J Sleep Res"},{"key":"10.1016\/j.sleep.2013.01.007_b0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1365-2869.2008.00631.x","article-title":"A quantitative statistical analysis of the submentalis muscle EMG amplitude during sleep in normal controls and patients with REM sleep behavior disorder","volume":"17","author":"Ferri","year":"2008","journal-title":"J Sleep Res"},{"key":"10.1016\/j.sleep.2013.01.007_b0080","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.sleep.2010.06.003","article-title":"Improved computation of the atonia index in normal controls and patients with REM sleep behavior disorder","volume":"11","author":"Ferri","year":"2010","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2013.01.007_b0085","first-page":"1409","article-title":"Searching for a marker of REM sleep behavior disorder: submentalis muscle EMG amplitude analysis during sleep in patients with narcolepsy\/cataplexy","volume":"31","author":"Ferri","year":"2008","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2013.01.007_b0090","series-title":"Diagnostic and coding manual","article-title":"International classification of sleep disorders","author":"American Academy of Sleep Medicine","year":"2005"},{"key":"10.1016\/j.sleep.2013.01.007_b0095","series-title":"A manual of standardized terminology, techniques, and scoring system for sleep stages of human subjects","author":"Rechtschaffen","year":"1968"},{"key":"10.1016\/j.sleep.2013.01.007_b0100","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/sleep\/30.7.844","article-title":"REM sleep characteristics in narcolepsy and REM sleep behavior disorder","volume":"30","author":"Dauvilliers","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2013.01.007_b0105","doi-asserted-by":"crossref","first-page":"75","DOI":"10.5664\/jcsm.28044","article-title":"Intraindividual variability of REM sleep behavior disorder in Parkinson\u2019s disease: a comparative assessment using a new REM sleep behavior disorder severity scale (RBDSS) for clinical routine","volume":"7","author":"Sixel-Doring","year":"2011","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2013.01.007_b0110","series-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.sleep.2013.01.007_b0115","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5664\/jcsm.26796","article-title":"EEG arousal norms by age","volume":"3","author":"Bonnet","year":"2007","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2013.01.007_b0120","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1093\/sleep\/28.12.1525","article-title":"Sex differences in delta and alpha EEG activities in healthy older adults","volume":"28","author":"Latta","year":"2005","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2013.01.007_b0125","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s100720300004","article-title":"Italian version of the Epworth sleepiness scale: external validity","volume":"23","author":"Vignatelli","year":"2003","journal-title":"Neurol Sci"},{"key":"10.1016\/j.sleep.2013.01.007_b0130","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/sleep\/25.8.28","article-title":"Brainstem proton magnetic resonance spectroscopy in idopathic REM sleep behavior disorder","volume":"25","author":"Iranzo","year":"2002","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2013.01.007_b0135","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.sleep.2005.12.003","article-title":"Cyclic alternating pattern (CAP) alterations in narcolepsy","volume":"7","author":"Terzano","year":"2006","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2013.01.007_b0140","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.clinph.2011.02.028","article-title":"Cyclic alternating pattern in narcolepsy patients and healthy controls after partial and total sleep deprivation","volume":"122","author":"Poryazova","year":"2011","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.sleep.2013.01.007_b0145","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/sleep\/8.2.137","article-title":"The cyclic alternating pattern as a physiologic component of normal NREM sleep","volume":"8","author":"Terzano","year":"1985","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2013.01.007_b0150","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0013-4694(88)90066-1","article-title":"The cyclic alternating pattern sequences in the dynamic organization of sleep","volume":"69","author":"Terzano","year":"1988","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1016\/j.sleep.2013.01.007_b0155","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1389-9457(01)00149-6","article-title":"Atlas, rules, and recording techniques for the scoring of cyclic alternating pattern (CAP) in human sleep","volume":"2","author":"Terzano","year":"2001","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2013.01.007_b0160","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.sleep.2009.10.003","article-title":"Cyclic alternating pattern: a window into pediatric sleep","volume":"11","author":"Bruni","year":"2010","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2013.01.007_b0165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ana.410320103","article-title":"Motor dyscontrol in narcolepsy: rapid-eye-movement (REM) sleep without atonia and REM sleep behavior disorder","volume":"32","author":"Schenck","year":"1992","journal-title":"Ann Neurol"},{"key":"10.1016\/j.sleep.2013.01.007_b0170","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1212\/WNL.48.4.1094","article-title":"REM sleep behavior disorders in multiple system atrophy","volume":"48","author":"Plazzi","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2013.01.007_b0175","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/0891988704267465","article-title":"REM sleep behavior disorder in Parkinson\u2019s disease and dementia with Lewy bodies","volume":"17","author":"Boeve","year":"2004","journal-title":"J Geriatr Psychiatry Neurol"},{"issue":"suppl. 2","key":"10.1016\/j.sleep.2013.01.007_b0180","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1007\/s100720200085","article-title":"Incidence of RBD and hallucination in patients affected by Parkinson\u2019s disease: 8-year follow-up","volume":"23","author":"Onofrj","year":"2002","journal-title":"Neurol Sci"},{"key":"10.1016\/j.sleep.2013.01.007_b0185","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/mds.10269","article-title":"Presumed rapid eye movement behavior disorder in Machado\u2013Joseph disease (spinocerebellar ataxia type 3)","volume":"17","author":"Friedman","year":"2002","journal-title":"Mov Disord"},{"key":"10.1016\/j.sleep.2013.01.007_b0190","first-page":"349","article-title":"REM sleep behavior disorder and REM sleep without atonia in patients with progressive supranuclear palsy","volume":"28","author":"Arnulf","year":"2005","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2013.01.007_b0195","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/sleep\/29.10.1321","article-title":"REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease","volume":"29","author":"Gagnon","year":"2006","journal-title":"Sleep"},{"issue":"Suppl. 1","key":"10.1016\/j.sleep.2013.01.007_b0200","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1007\/s10072-007-0735-y","article-title":"Symptomatic REM sleep behaviour disorder","volume":"28","author":"Thomas","year":"2007","journal-title":"Neurol Sci"},{"key":"10.1016\/j.sleep.2013.01.007_b0205","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1389-9457(02)00042-4","article-title":"Remitting REM sleep behavior disorder as the initial sign of multiple sclerosis","volume":"3","author":"Plazzi","year":"2002","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2013.01.007_b0210","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1212\/01.wnl.0000208518.72660.ff","article-title":"REM sleep behavior disorder initiated by acute brainstem multiple sclerosis","volume":"66","author":"Tippmann-Peikert","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2013.01.007_b0215","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1017\/S031716710000384X","article-title":"REM sleep behaviour disorder in a child with Tourette\u2019s syndrome","volume":"31","author":"Trajanovic","year":"2004","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.sleep.2013.01.007_b0220","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11910-007-0013-7","article-title":"Pathophysiologic mechanisms in REM sleep behavior disorder","volume":"7","author":"Mahowald","year":"2007","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.sleep.2013.01.007_b0225","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.smrv.2010.08.002","article-title":"The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder","volume":"15","author":"Luppi","year":"2011","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleep.2013.01.007_b0230","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/ana.10547","article-title":"Slowing of electroencephalogram in rapid eye movement sleep behavior disorder","volume":"53","author":"Fantini","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.sleep.2013.01.007_b0235","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000085917","article-title":"On the pharmacotherapy of sleep bruxism: placebo-controlled polysomnographic and psychometric studies with clonazepam","volume":"51","author":"Saletu","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.sleep.2013.01.007_b0240","first-page":"619","article-title":"Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder","volume":"34","author":"Fantini","year":"2011","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2013.01.007_b0245","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.neulet.2007.12.025","article-title":"The slow-wave components of the cyclic alternating pattern (CAP) have a role in sleep-related learning processes","volume":"432","author":"Ferri","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.sleep.2013.01.007_b0250","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.sleep.2010.11.009","article-title":"Cyclic alternating pattern in sleep and its relationship to creativity","volume":"12","author":"Drago","year":"2011","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2013.01.007_b0255","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.sleep.2010.01.006","article-title":"The effects of experimental sleep fragmentation on cognitive processing","volume":"11","author":"Ferri","year":"2010","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2013.01.007_b0260","first-page":"649","article-title":"The role of NREM Sleep instability in child cognitive performance","volume":"35","author":"Bruni","year":"2012","journal-title":"Sleep"}],"updated-by":[{"DOI":"10.1016\/j.sleep.2013.10.001","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000}}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138994571300035X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138994571300035X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:09:30Z","timestamp":1761404970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138994571300035X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S138994571300035X"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2013.01.007","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of long-term use of clonazepam on nonrapid eye movement sleep patterns in rapid eye movement sleep behavior disorder","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2013.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}