{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:42:40Z","timestamp":1791243760638,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["sleep-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.sleep.2013.08.786","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T20:49:28Z","timestamp":1381783768000},"page":"1260-1265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["The effect of continuous positive airway pressure therapy on arterial stiffness and endothelial function in obstructive sleep apnea: a randomized controlled trial in patients without cardiovascular disease"],"prefix":"10.1016","volume":"14","author":[{"given":"Anne","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Vennelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Connell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"McKillop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Newby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata L.","family":"Riha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2013.08.786_b0005","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1056\/NEJM199304293281704","article-title":"The occurrence of sleep-disordered breathing among middle-aged adults","volume":"328","author":"Young","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.sleep.2013.08.786_b0010","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(05)74229-X","article-title":"Long-term cardiovascular outcomes in men with obstructive sleep apnoea\u2013hypopnoea with or without treatment with continuous positive airway pressure: an observational study","volume":"365","author":"Marin","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.sleep.2013.08.786_b0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1164\/ajrccm.163.1.2001008","article-title":"Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study","volume":"163","author":"Shahar","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"Suppl. 2","key":"10.1016\/j.sleep.2013.08.786_b0195","first-page":"ii45","article-title":"Sleep apnoea and hypertension: proof at last?","volume":"56","author":"Stradling","year":"2001","journal-title":"Thorax"},{"key":"10.1016\/j.sleep.2013.08.786_b0025","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1152\/jappl.1993.74.3.1123","article-title":"Arterial blood pressure responses to graded transient arousal from sleep in normal humans","volume":"74","author":"Davies","year":"1993","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.sleep.2013.08.786_b0030","first-page":"850","article-title":"Arterial stiffness increases during obstructive sleep apneas","volume":"25","author":"Jelic","year":"2002","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2013.08.786_b0035","doi-asserted-by":"crossref","first-page":"S529","DOI":"10.1097\/00004872-198812040-00166","article-title":"Is high and fluctuating muscle nerve sympathetic activity in the sleep apnoea syndrome of pathogenetic importance for the development of hypertension?","volume":"6","author":"Hedner","year":"1988","journal-title":"J Hypertens Suppl"},{"key":"10.1016\/j.sleep.2013.08.786_b0040","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1136\/thx.2008.105577","article-title":"Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?","volume":"85","author":"Ryan","year":"2009","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.sleep.2013.08.786_b0045","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.sleep.2013.01.001","article-title":"Arterial stiffness and endothelial function in obstructive sleep apnoea\/hypopnoea syndrome","volume":"14","author":"Jones","year":"2013","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2013.08.786_b0050","doi-asserted-by":"crossref","first-page":"115","DOI":"10.7326\/0003-4819-156-2-201201170-00006","article-title":"Cardiovascular mortality in women with obstructive sleep apnea with or without continuous positive airway pressure treatment: a cohort study","volume":"156","author":"Campos-Rodriguez","year":"2012","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.sleep.2013.08.786_b0055","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1001\/jama.2012.3418","article-title":"Association between treated and untreated obstructive sleep apnea and risk of hypertension","volume":"307","author":"Marin","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.sleep.2013.08.786_b0060","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1164\/ajrccm.163.2.2005037","article-title":"Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apnea\u2013hypopnea syndrome","volume":"163","author":"Faccenda","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2013.08.786_b0065","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0140-6736(02)07445-7","article-title":"Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial","volume":"359","author":"Pepperell","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.sleep.2013.08.786_b0070","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1164\/rccm.200306-767OC","article-title":"Endothelial function in obstructive sleep apnea and response to treatment","volume":"169","author":"Ip","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2013.08.786_b0075","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1136\/thx.2007.081877","article-title":"Continuous positive airway pressure improves vascular function in obstructive sleep apnoea\/hypopnoea syndrome: a randomised controlled trial","volume":"63","author":"Cross","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.sleep.2013.08.786_b0200","series-title":"A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects","author":"Rechtschaffen","year":"1968"},{"key":"10.1016\/j.sleep.2013.08.786_b0085","series-title":"The American academy of sleep medicine manual for the scoring of sleep and associated events: rules, terminology and technical specifications","author":"Iber","year":"2007"},{"key":"10.1016\/j.sleep.2013.08.786_b0090","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/eurheartj\/ehl254","article-title":"Expert consensus document on arterial stiffness: methodological issues and clinical applications","volume":"27","author":"Laurent","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.sleep.2013.08.786_b0095","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/hq0102.101770","article-title":"Pulse-wave analysis: clinical evaluation of a noninvasive, widely applicable method for assessing endothelial function","volume":"22","author":"Wilkinson","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.sleep.2013.08.786_b0100","unstructured":"AtCor Medical. Instructions for PWV measurements. http:\/\/atcormedical.com [Accessed September 23, 2013]."},{"key":"10.1016\/j.sleep.2013.08.786_b0105","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1161\/HYPERTENSIONAHA.106.085175","article-title":"Effect of nocturnal nasal continuous positive airway pressure on blood pressure in obstructive sleep apnea","volume":"50","author":"Bazzano","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.sleep.2013.08.786_b0110","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/eurheartj\/ehq024","article-title":"Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis","volume":"31","author":"Vlachopoulos","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.sleep.2013.08.786_b0115","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1183\/09031936.00026608","article-title":"CPAP and measures of cardiovascular risk in males with OSAS","volume":"32","author":"Kohler","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.sleep.2013.08.786_b0120","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11325-010-0465-x","article-title":"Treatment of obstructive sleep apnea reduces arterial stiffness","volume":"16","author":"Buchner","year":"2012","journal-title":"Sleep Breath"},{"key":"10.1016\/j.sleep.2013.08.786_b0125","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/CIRCULATIONAHA.105.579342","article-title":"Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population","volume":"113","author":"Willum-Hansen","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.sleep.2013.08.786_b0130","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1164\/rccm.200703-500OC","article-title":"Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea","volume":"176","author":"Drager","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2013.08.786_b0135","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/hr.2010.200","article-title":"Increased arterial stiffness in obstructive sleep apnea: a systematic review","volume":"34","author":"Doonan","year":"2011","journal-title":"Hypertens Res"},{"key":"10.1016\/j.sleep.2013.08.786_b0140","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/j.1540-8175.2009.00957.x","article-title":"Effect of continuous positive airway pressure therapy on aortic stiffness in patients with obstructive sleep apnea syndrome","volume":"26","author":"Keles","year":"2009","journal-title":"Echocardiography"},{"key":"10.1016\/j.sleep.2013.08.786_b0145","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.atherosclerosis.2012.03.036","article-title":"Atherosclerosis and arterial stiffness in obstructive sleep apnea \u2013 a cardiovascular magnetic resonance study","volume":"222","author":"Kylintireas","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.sleep.2013.08.786_b0150","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1164\/ajrccm.165.7.2102003","article-title":"Impaired vasodilator responses in obstructive sleep apnea are improved with continuous positive airway pressure therapy","volume":"165","author":"Imadojemu","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2013.08.786_b0155","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/thx.2004.039164","article-title":"Treatment of obstructive sleep apnoea leads to improved microvascular endothelial function in the systemic circulation","volume":"61","author":"Lattimore","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.sleep.2013.08.786_b0160","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/sleep\/32.10.1257","article-title":"Endothelial function in normotensive men with obstructive sleep apnea before and 6 months after CPAP treatment","volume":"32","author":"Bayram","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2013.08.786_b0165","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1183\/09031936.06.00062805","article-title":"Continuous positive airway pressure does not reduce blood pressure in nonsleepy hypertensive OSA patients","volume":"27","author":"Robinson","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.sleep.2013.08.786_b0170","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1001\/jama.2012.4366","article-title":"Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial","volume":"307","author":"Barb\u00e9","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.sleep.2013.08.786_b0175","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1183\/09031936.00111208","article-title":"Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation","volume":"33","author":"Garvey","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.sleep.2013.08.786_b0180","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(94)91522-9","article-title":"Effect of continuous positive airway pressure treatment on daytime function in sleep apnoea\/hypopnoea syndrome","volume":"343","author":"Engleman","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.sleep.2013.08.786_b0185","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5664\/jcsm.28049","article-title":"Ethical issues in the conduct of clinical trials in obstructive sleep apnea","volume":"7","author":"Brown","year":"2011","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2013.08.786_b0190","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1023\/A:1007711617112","article-title":"Effect of antihypertensive therapy on aortic distensibility in patients with essential hypertension: comparison with trichlormethiazide, nicardipine and alacepril","volume":"13","author":"Honda","year":"1999","journal-title":"Cardiovasc Drugs Ther"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945713011507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945713011507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T23:53:14Z","timestamp":1596671594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945713011507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1389945713011507"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2013.08.786","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of continuous positive airway pressure therapy on arterial stiffness and endothelial function in obstructive sleep apnea: a randomized controlled trial in patients without cardiovascular disease","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2013.08.786","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}