{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T05:40:57Z","timestamp":1774762857345,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","content-domain":{"domain":["sleep-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.sleep.2014.02.005","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T03:38:22Z","timestamp":1396323502000},"page":"614-618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Increased cerebrospinal fluid levels of nerve cell biomarkers in narcolepsy with cataplexy"],"prefix":"10.1016","volume":"15","author":[{"given":"M.S.","family":"Heier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Skinningsrud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Paus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.M.","family":"Gautvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2014.02.005_b0005","series-title":"The international classification of sleep disorders","author":"American Academy of Sleep Medicine","year":"2005"},{"key":"10.1016\/j.sleep.2014.02.005_b0010","doi-asserted-by":"crossref","first-page":"8733","DOI":"10.1073\/pnas.93.16.8733","article-title":"Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional PCR subtraction","volume":"93","author":"Gautvik","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.sleep.2014.02.005_b0015","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"De Lecea","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.sleep.2014.02.005_b0020","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0896-6273(00)00058-1","article-title":"Reduced number of hypocretin neurons in human narcolepsy","volume":"27","author":"Thannickal","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.sleep.2014.02.005_b0025","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/sleep\/30.8.969","article-title":"CSF hypocretin-1 levels and clinical profiles in narcolepsy and idiopathic CNS hypersomnia in Norway","volume":"30","author":"Heier","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.02.005_b0030","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.sleep.2011.04.002","article-title":"Melanin concentrating hormone in central hypersomnia","volume":"12","author":"Peyron","year":"2011","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.02.005_b0035","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0140-6736(99)05582-8","article-title":"CSF hypocretin\/orexin deficiency in human narcolepsy","volume":"355","author":"Nishino","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.sleep.2014.02.005_b0040","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1212\/WNL.57.12.2253","article-title":"CSF hypocretin\/orexin levels in narcolepsy and other neurological conditions","volume":"57","author":"Ripley","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2014.02.005_b0045","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1001\/archneur.59.10.1553","article-title":"The role of cerebrospinal fluid hypocretin measurements in the diagnosis of narcolepsy and other hypersomnias","volume":"59","author":"Mignot","year":"2002","journal-title":"Arch Neurol"},{"key":"10.1016\/j.sleep.2014.02.005_b0050","first-page":"1012","article-title":"HLADQB1*0602 is associated with cataplexy in 509 narcoleptic patients","volume":"20","author":"Mignot","year":"1997","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.02.005_b0055","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/sleep\/25.1.27","article-title":"Clinical aspects of narcolepsy\u2013cataplexy across ethnic groups","volume":"25","author":"Okun","year":"2002","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.02.005_b0060","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ng.372","article-title":"Narcolepsy is strongly associated with the T-cell receptor alpha locus","volume":"41","author":"Hallmayer","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.sleep.2014.02.005_b0065","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1172\/JCI41366","article-title":"Elevated Tribbles homolog 2-specific antibody levels in narcolepsy","volume":"120","author":"Cvetkovic-Lopes","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.sleep.2014.02.005_b0070","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/ana.22587","article-title":"Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China","volume":"70","author":"Han","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.sleep.2014.02.005_b0075","doi-asserted-by":"crossref","first-page":"e33723","DOI":"10.1371\/journal.pone.0033723","article-title":"Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland","volume":"7","author":"Partinen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.sleep.2014.02.005_b0080","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.sleep.2013.03.020","article-title":"Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1Nl influenza A","volume":"14","author":"Heier","year":"2013","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.02.005_b0085","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/sleep\/33.11.1457","article-title":"Clinical and therapeutic aspects of childhood narcolepsy\u2013cataplexy: a retrospective study of 51 children","volume":"33","author":"Aran","year":"2010","journal-title":"Sleep"},{"issue":"Pt. 12","key":"10.1016\/j.sleep.2014.02.005_b0090","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1093\/brain\/awt277","article-title":"Clinical and polysomnographic course of childhood narcolepsy with cataplexy","volume":"136","author":"Pizza","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.sleep.2014.02.005_b0095","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1093\/clinchem\/47.10.1776","article-title":"Tau and Abeta42 in cerebrospinal fluid from healthy adults 21\u201393years of age: establishment of reference values","volume":"47","author":"Sj\u00f6gren","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.sleep.2014.02.005_b0100","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1515\/CCLM.2006.258","article-title":"Analytical performance and clinical utility of the INNOTEST PHOSPHOTAU181P assay for discrimination between Alzheimer\u2019s disease and a dementia with Lewy bodies","volume":"44","author":"Vanderstichele","year":"2006","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.sleep.2014.02.005_b0105","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1093\/clinchem\/35.10.2034","article-title":"Immunoradiometric assay for \u03b1\u03b3- and \u03b3\u03b3-enolase (neuron-specific enolase), with use of monoclonal antibodies and magnetizable polymer particles","volume":"35","author":"Paus","year":"1989","journal-title":"Clin Chem"},{"key":"10.1016\/j.sleep.2014.02.005_b0110","first-page":"93","article-title":"Cerebrospinal fluid neuron-specific enolase: a further marker of Alzheimer\u2019s disease?","volume":"23","author":"Palumbo","year":"2008","journal-title":"Funct Neurol"},{"key":"10.1016\/j.sleep.2014.02.005_b0115","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11011-005-2479-9","article-title":"Cerebrospinal fluid neurone-specific enolase in mitochondrial encephalomyopathies","volume":"20","author":"Finsterer","year":"2005","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.sleep.2014.02.005_b0120","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00702-010-0433-4","article-title":"The role of microglia in amyloid clearance from the AD brain","volume":"117","author":"Lee","year":"2010","journal-title":"J Neural Transm"},{"key":"10.1016\/j.sleep.2014.02.005_b0125","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuropharm.2010.02.011","article-title":"The functional physiology of the amyloid precursor protein (APP) processing pathway","volume":"59","author":"Randall","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.sleep.2014.02.005_b0130","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1038\/emboj.2011.119","article-title":"APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP","volume":"30","author":"Weyer","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.sleep.2014.02.005_b0135","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3233\/JAD-2009-1202","article-title":"Amyloid-beta, tau protein, and oxidative changes as a physiological compensatory mechanism to maintain CNS plasticity under Alzheimer\u2019s disease and other neurodegenerative conditions","volume":"18","author":"Koudinov","year":"2009","journal-title":"J Alzheimer\u2019s Dis"},{"key":"10.1016\/j.sleep.2014.02.005_b0140","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1093\/brain\/awl269","article-title":"CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer\u2019s disease","volume":"129","author":"Buerger","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.sleep.2014.02.005_b0145","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1212\/01.wnl.0000234030.77831.5a","article-title":"Associations between white matter lesions, cerebrovascular risk factors, and low CSF Abeta42","volume":"67","author":"Stenset","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2014.02.005_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12031-011-9665-5","article-title":"CSF biomarkers for amyloid and tau pathology in Alzheimer\u2019s disease","volume":"47","author":"Rosenmann","year":"2011","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.sleep.2014.02.005_b0155","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.sleep.2014.02.005_b0160","first-page":"1537","article-title":"Self-reported sleep and \u03b2-amyloid deposition in community-dwelling older adults","volume":"70","author":"Spira","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.sleep.2014.02.005_b0165","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1001\/jamaneurol.2013.4215","article-title":"Modification of the relationship of the apolipoprotein E\u03b54 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep","volume":"70","author":"Lim","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.sleep.2014.02.005_b0170","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.neurobiolaging.2010.12.008","article-title":"Coexistence of narcolepsy and Alzheimer\u2019s disease","volume":"33","author":"Scammell","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.sleep.2014.02.005_b0175","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/neu.2006.23.295","article-title":"New insights into neuronal regeneration: the role of axonal protein synthesis in pathfinding and axonal extension","volume":"23","author":"Twiss","year":"2006","journal-title":"J Neurotrauma"},{"issue":"Suppl.","key":"10.1016\/j.sleep.2014.02.005_b0180","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/16501960310010098","article-title":"Neurogenesis and its implications for regeneration in the adult brain","volume":"41","author":"Eriksson","year":"2003","journal-title":"J Rehab Med"},{"key":"10.1016\/j.sleep.2014.02.005_b0185","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1440-1681.2007.04609.x","article-title":"Progenitor cells and adult neurogenesis in degenerative diseases and injuries of the basal ganglia","volume":"34","author":"Curtis","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.sleep.2014.02.005_b0190","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1042\/BST0371412","article-title":"Cortical excitability and post stroke recovery","volume":"37","author":"Clarkson","year":"2009","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.sleep.2014.02.005_b0195","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pneurobio.2009.02.001","article-title":"Cell migration in the normal and pathological postnatal mammalian brain","volume":"88","author":"Cayre","year":"2009","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.sleep.2014.02.005_b0200","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1152\/physrev.00032.2010","article-title":"Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of normal stem cells","volume":"91","author":"Martino","year":"2011","journal-title":"Physiol Rev"},{"key":"10.1016\/j.sleep.2014.02.005_b0205","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/ana.23968","article-title":"Greatly increased numbers of histamine cells in human narcolepsy with cataplexy","volume":"74","author":"John","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1016\/j.sleep.2014.02.005_b0210","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/ana.24019","article-title":"Increase of histaminergic tuberomammillary neurons in narcolepsy","volume":"74","author":"Valco","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1016\/j.sleep.2014.02.005_b0215","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neulet.2013.03.031","article-title":"Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy","volume":"544","author":"Klein","year":"2013","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.sleep.2014.02.005_b0220","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/S0014-4886(03)00388-1","article-title":"Relationship between CSF hypocretin levels and hypocretin neurone loss","volume":"184","author":"Gerashenko","year":"2003","journal-title":"Exp Neurol"},{"key":"10.1016\/j.sleep.2014.02.005_b0225","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ntt.2012.01.007","article-title":"A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague\u2013Dawley rats during the waking (lights off) cycle","volume":"34","author":"Levi","year":"2012","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.sleep.2014.02.005_b0230","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.neuroimage.2011.05.041","article-title":"In vivo imaging of mitochondrial function in methamphetamine treated rats","volume":"57","author":"Shiba","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.sleep.2014.02.005_b0235","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ncl.2011.05.004","article-title":"Neurologic manifestations of chronic methamphetamine abuse","volume":"29","author":"Rusyniak","year":"2011","journal-title":"Neurol Clin"},{"key":"10.1016\/j.sleep.2014.02.005_b0240","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/1874473711003040239","article-title":"Brain injury associated with widely abused amphetamines: neuroinflammation, neurogenesis and blood\u2013brain barrier","volume":"3","author":"Silva","year":"2010","journal-title":"Curr Drug Abuse Rev"},{"key":"10.1016\/j.sleep.2014.02.005_b0245","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s00406-008-0838-3","article-title":"Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau\/Abeta 1\u201342 ratios in CSF in patients with mild Altzheimer\u2019s disease dementia","volume":"259","author":"Laske","year":"2009","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.sleep.2014.02.005_b0250","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1210\/jc.2002-020638","article-title":"Dynamics of the pituitary\u2013adrenal ensemble in hypocretin-deficient narcoleptic humans: blunted basal adrenocorticotropin release and evidence for normal time-keeping by the master pacemaker","volume":"87","author":"Kok","year":"2002","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945714001166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945714001166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T02:21:19Z","timestamp":1597630879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945714001166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S1389945714001166"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2014.02.005","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased cerebrospinal fluid levels of nerve cell biomarkers in narcolepsy with cataplexy","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2014.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}