{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:50:58Z","timestamp":1791337858114,"version":"4.3.1"},"reference-count":116,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T00:00:00Z","timestamp":1413158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/100011096","name":"Jazz Pharmaceuticals, Inc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["sleep-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.sleep.2014.10.002","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T02:15:19Z","timestamp":1413425719000},"page":"9-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"title":["Clinical and practical considerations in the pharmacologic management of narcolepsy"],"prefix":"10.1016","volume":"16","author":[{"given":"Michael J.","family":"Thorpy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Dauvilliers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2014.10.002_bib0010","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jsmc.2010.08.007","article-title":"Therapeutics of narcolepsy","volume":"5","author":"Majid","year":"2010","journal-title":"Sleep Med Clin"},{"key":"10.1016\/j.sleep.2014.10.002_bib0015","series-title":"Narcolepsy and hypersomnia","first-page":"125","article-title":"Epidemiology of narcolepsy","author":"Ohayon","year":"2007"},{"key":"10.1016\/j.sleep.2014.10.002_bib0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jsmc.2012.03.015","article-title":"Neurochemistry and biomarkers of narcolepsy and other primary and secondary hypersomnias","volume":"7","author":"Nishino","year":"2012","journal-title":"Sleep Med Clin"},{"key":"10.1016\/j.sleep.2014.10.002_bib0025","series-title":"Diagnostic and statistical manual of mental disorders, 5th ed. (DSM-5)","first-page":"372","article-title":"Narcolepsy","author":"American Psychiatric Association (APA)","year":"2013"},{"key":"10.1016\/j.sleep.2014.10.002_bib0030","series-title":"International classification of sleep disorders \u2013 3rd ed. (ICSD-3)","author":"American Academy of Sleep Medicine","year":"2014"},{"key":"10.1016\/j.sleep.2014.10.002_bib0035","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaut.2013.02.003","article-title":"Genetic association, seasonal infections and autoimmune basis of narcolepsy","volume":"43","author":"Singh","year":"2013","journal-title":"J Autoimmun"},{"key":"10.1016\/j.sleep.2014.10.002_bib0040","doi-asserted-by":"crossref","first-page":"792687","DOI":"10.1155\/2014\/792687","article-title":"Narcolepsy as an immune-mediated disease","volume":"2014","author":"De la Herran-Arita","year":"2014","journal-title":"Sleep Disord"},{"key":"10.1016\/j.sleep.2014.10.002_bib0045","doi-asserted-by":"crossref","first-page":"845","DOI":"10.5665\/SLEEP.1112","article-title":"Sleep neurobiology from a clinical perspective","volume":"34","author":"Espana","year":"2011","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0050","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature06310","article-title":"Neural substrates of awakening probed with optogenetic control of hypocretin neurons","volume":"450","author":"Adamantidis","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.sleep.2014.10.002_bib0055","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/sleep\/32.8.979","article-title":"Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset","volume":"32","author":"Aran","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0060","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/ana.22587","article-title":"Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China","volume":"70","author":"Han","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.sleep.2014.10.002_bib0065","doi-asserted-by":"crossref","first-page":"e33723","DOI":"10.1371\/journal.pone.0033723","article-title":"Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland","volume":"7","author":"Partinen","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.sleep.2014.10.002_bib0070","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.sleep.2013.03.020","article-title":"Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A","volume":"14","author":"Heier","year":"2013","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0075","doi-asserted-by":"crossref","first-page":"f794","DOI":"10.1136\/bmj.f794","article-title":"Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A\/H1N1 2009 influenza vaccine: retrospective analysis","volume":"346","author":"Miller","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.sleep.2014.10.002_bib0080","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1212\/WNL.0b013e31828ab26f","article-title":"Increased childhood incidence of narcolepsy in western Sweden after H1N1 influenza vaccination","volume":"80","author":"Szakacs","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2014.10.002_bib0085","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/ana.1130","article-title":"Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy","volume":"50","author":"Nishino","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.sleep.2014.10.002_bib0090","doi-asserted-by":"crossref","first-page":"e1003270","DOI":"10.1371\/journal.pgen.1003270","article-title":"ImmunoChip study implicates antigen presentation to T cells in narcolepsy","volume":"9","author":"Faraco","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.sleep.2014.10.002_bib0095","series-title":"Narcolepsy fact sheet","author":"National Institute of Neurological Disorders and Stroke","year":"2014"},{"key":"10.1016\/j.sleep.2014.10.002_bib0100","doi-asserted-by":"crossref","first-page":"955","DOI":"10.5664\/jcsm.3004","article-title":"Disrupted nighttime sleep in narcolepsy","volume":"9","author":"Roth","year":"2013","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0105","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.sleep.2011.03.006","article-title":"Hallucinations in narcolepsy with and without cataplexy: contrasts with Parkinson's disease","volume":"12","author":"Leu-Semenescu","year":"2011","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0110","doi-asserted-by":"crossref","first-page":"419","DOI":"10.5665\/sleep.3428","article-title":"Delusional confusion of dreaming and reality in narcolepsy","volume":"37","author":"Wamsley","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0115","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.sleep.2014.03.006","article-title":"Nightmares in narcolepsy: underinvestigated symptom?","volume":"15","author":"Pisko","year":"2014","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0120","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.sleep.2004.11.007","article-title":"The association between narcolepsy and REM behavior disorder (RBD)","volume":"6","author":"Nightingale","year":"2005","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0125","doi-asserted-by":"crossref","first-page":"805","DOI":"10.5664\/jcsm.2926","article-title":"Delayed diagnosis, range of severity and multiple sleep comorbidities: a clinical and polysomnographic analysis of 100 patients of the Innsbruck narcolepsy cohort","volume":"9","author":"Frauscher","year":"2013","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0130","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1212\/WNL.57.11.2029","article-title":"Age at onset of narcolepsy in two large populations of patients in France and Quebec","volume":"57","author":"Dauvilliers","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2014.10.002_bib0135","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/sleep\/25.1.27","article-title":"Clinical aspects of narcolepsy-cataplexy across ethnic groups","volume":"25","author":"Okun","year":"2002","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0140","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.sleep.2014.01.015","article-title":"Delayed diagnosis of narcolepsy: characterization and impact","volume":"15","author":"Thorpy","year":"2014","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0145","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3810\/pgm.2014.01.2727","article-title":"The AWAKEN survey: knowledge of narcolepsy among physicians and the general population","volume":"126","author":"Rosenberg","year":"2014","journal-title":"Postgrad Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0150","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.sleep.2013.03.002","article-title":"Narcolepsy is complicated by high medical and psychiatric comorbidities: a comparison with the general population","volume":"14","author":"Ohayon","year":"2013","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0155","doi-asserted-by":"crossref","first-page":"835","DOI":"10.5665\/sleep.2706","article-title":"Comorbidity and mortality of narcolepsy: a controlled retro- and prospective national study","volume":"36","author":"Jennum","year":"2013","journal-title":"Sleep"},{"issue":"Suppl.","key":"10.1016\/j.sleep.2014.10.002_bib0160","first-page":"A249","article-title":"High rates of medical comorbidity in narcolepsy: findings from the burden of narcolepsy disease (BOND) study of 9,312 patients in the United States [abstract]","volume":"36","author":"Black","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0165","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3810\/pgm.2014.05.2769","article-title":"Patients\u2019 journey to a narcolepsy diagnosis: a physician survey and retrospective chart review","volume":"126","author":"Carter","year":"2014","journal-title":"Postgrad Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0170","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/sleep\/25.1.36","article-title":"Diagnoses received by narcolepsy patients in the year prior to diagnosis by a sleep specialist","volume":"25","author":"Kryger","year":"2002","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0175","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1093\/brain\/awt277","article-title":"Clinical and polysomnographic course of childhood narcolepsy with cataplexy","volume":"136","author":"Pizza","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.sleep.2014.10.002_bib0180","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.sleep.2014.02.001","article-title":"The burden of narcolepsy disease (BOND) study: healthcare utilization and cost findings","volume":"15","author":"Black","year":"2014","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0185","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.sleep.2006.10.010","article-title":"Health-related quality of life in patients with narcolepsy","volume":"8","author":"Dodel","year":"2007","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0190","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.sleep.2012.06.006","article-title":"Health, social, and economic consequences of narcolepsy: a controlled national study evaluating the societal effect on patients and their partners","volume":"13","author":"Jennum","year":"2012","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0195","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.sleep.2012.08.002","article-title":"The burden of narcolepsy with cataplexy: how disease history and clinical features influence socio-economic outcomes","volume":"13","author":"Ingravallo","year":"2012","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0200","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.sleep.2010.07.010","article-title":"Sleep disorders and accidental risk in a large group of regular registered highway drivers","volume":"11","author":"Philip","year":"2010","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0205","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.aap.2009.12.004","article-title":"Sleep disorders, medical conditions, and road accident risk","volume":"43","author":"Smolensky","year":"2011","journal-title":"Accid Anal Prev"},{"key":"10.1016\/j.sleep.2014.10.002_bib0210","doi-asserted-by":"crossref","first-page":"439","DOI":"10.5665\/sleep.3470","article-title":"Increased mortality in narcolepsy","volume":"37","author":"Ohayon","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0215","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1468-1331.2006.01473.x","article-title":"EFNS guidelines on management of narcolepsy","volume":"13","author":"Billiard","year":"2006","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.sleep.2014.10.002_bib0220","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1093\/sleep\/30.12.1705","article-title":"Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin","volume":"30","author":"Morgenthaler","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0225","series-title":"Xyrem (sodium oxybate) oral solution [prescribing information]","year":"2014"},{"key":"10.1016\/j.sleep.2014.10.002_bib0230","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.sleep.2012.07.008","article-title":"Mazindol in narcolepsy and idiopathic and symptomatic hypersomnia refractory to stimulants: a long-term chart review","volume":"14","author":"Nittur","year":"2013","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0235","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s13311-012-0150-9","article-title":"A practical guide to the therapy of narcolepsy and hypersomnia syndromes","volume":"9","author":"Mignot","year":"2012","journal-title":"Neurother"},{"key":"10.1016\/j.sleep.2014.10.002_bib0240","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1517\/14656566.2013.783021","article-title":"Pharmacotherapy options for cataplexy","volume":"14","author":"Lopez","year":"2013","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.sleep.2014.10.002_bib0245","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/S1474-4422(13)70225-4","article-title":"Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial","volume":"12","author":"Dauvilliers","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.sleep.2014.10.002_bib0250","unstructured":"Black J., Swick T., Feldman N., Doekel R. Jr, Khayrallah M., Bream G., et\u00a0al. Efficacy and safety of oral ADX-N05 for the treatment of excessive daytime sleepiness in adults with narcolepsy: results of a randomized, double-blind, placebo-controlled trial [abstract]. Presented at: 28th Annual Meeting of the Associated Professional Sleep Societies (SLEEP); May 31\u2013June 4, 2014; Minneapolis, MN. Abstract LBA4; 2014."},{"issue":"Suppl.","key":"10.1016\/j.sleep.2014.10.002_bib0255","first-page":"A257","article-title":"A double-blind placebo-controlled randomized crossover study of the efficacy and safety of ADX-N05 for the treatment of excessive daytime sleepiness in adult subjects with narcolepsy [abstract]","volume":"36","author":"Bogan","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0260","doi-asserted-by":"crossref","first-page":"e95342","DOI":"10.1371\/journal.pone.0095342","article-title":"Effects of hypocretin\/orexin cell transplantation on narcoleptic-like sleep behavior in rats","volume":"9","author":"Arias-Carrion","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.sleep.2014.10.002_bib0265","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbr.2013.12.045","article-title":"The effect of intranasal orexin-A (hypocretin-1) on sleep, wakefulness and attention in narcolepsy with cataplexy","volume":"262","author":"Weinhold","year":"2014","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.sleep.2014.10.002_bib0270","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jsmc.2012.03.013","article-title":"Narcolepsy","volume":"7","author":"Overeem","year":"2012","journal-title":"Sleep Med Clin"},{"key":"10.1016\/j.sleep.2014.10.002_bib0275","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.chc.2007.11.010","article-title":"Understanding the risk of using medications for attention deficit hyperactivity disorder with respect to physical growth and cardiovascular function","volume":"17","author":"Vitiello","year":"2008","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"key":"10.1016\/j.sleep.2014.10.002_bib0280","series-title":"Provigil (modafinil) tablets [prescribing information]","year":"2010"},{"key":"10.1016\/j.sleep.2014.10.002_bib0285","series-title":"Nuvigil (armodafinil) tablets [prescribing information]","year":"2010"},{"key":"10.1016\/j.sleep.2014.10.002_bib0290","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.pediatrneurol.2007.12.010","article-title":"Narcolepsy in children: a single-center clinical experience","volume":"38","author":"Vendrame","year":"2008","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.sleep.2014.10.002_bib0295","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/sleep\/33.11.1457","article-title":"Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children","volume":"33","author":"Aran","year":"2010","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0300","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2869.2011.00991.x","article-title":"Clinical experience suggests that modafinil is an effective and safe treatment for paediatric narcolepsy","volume":"21","author":"Lecendreux","year":"2012","journal-title":"J Sleep Res"},{"key":"10.1016\/j.sleep.2014.10.002_bib0305","doi-asserted-by":"crossref","first-page":"e38977","DOI":"10.1371\/journal.pone.0038977","article-title":"Non-dipping blood pressure profile in narcolepsy with cataplexy","volume":"7","author":"Dauvilliers","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.sleep.2014.10.002_bib0310","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1212\/WNL.0000000000000045","article-title":"Orexin\/hypocretin system and autonomic control: new insights and clinical correlations","volume":"82","author":"Grimaldi","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2014.10.002_bib0315","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1532-5415.2012.03923.x","article-title":"American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults","volume":"60","author":"American Geriatrics Society 2012 Beers Criteria Update Expert Panel","year":"2012","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.sleep.2014.10.002_bib0320","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00002826-200403000-00005","article-title":"Effects of modafinil on wakefulness and executive function in patients with narcolepsy experiencing late-day sleepiness","volume":"27","author":"Schwartz","year":"2004","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.sleep.2014.10.002_bib0325","first-page":"113","article-title":"Status cataplecticus induced by abrupt withdrawal of clomipramine [Article in Spanish]","volume":"17","author":"Martinez-Rodriguez","year":"2002","journal-title":"Neurologia"},{"key":"10.1016\/j.sleep.2014.10.002_bib0330","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s00213-002-1343-4","article-title":"Initiating treatment with modafinil for control of excessive daytime sleepiness in patients switching from methylphenidate: an open-label safety study assessing three strategies","volume":"167","author":"Thorpy","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.sleep.2014.10.002_bib0335","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/sleep\/28.6.667","article-title":"Risks of high-dose stimulants in the treatment of disorders of excessive somnolence: a case-control study","volume":"28","author":"Auger","year":"2005","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0340","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.5665\/sleep.2958","article-title":"Effect of psychostimulants on impulsivity and risk taking in narcolepsy with cataplexy","volume":"36","author":"Bayard","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0345","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fnbeh.2013.00050","article-title":"Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy","volume":"7","author":"Bayard","year":"2013","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.sleep.2014.10.002_bib0350","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnbeh.2013.00028","article-title":"Role of orexin in modulating arousal, feeding, and motivation","volume":"7","author":"Tsujino","year":"2013","journal-title":"Front Behav Neurosci"},{"issue":"1","key":"10.1016\/j.sleep.2014.10.002_bib0355","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003724.pub3","article-title":"Antidepressant drugs for narcolepsy","author":"Vignatelli","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.sleep.2014.10.002_bib0360","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1212\/WNL.44.4.707","article-title":"Fluoxetine suppresses human cataplexy: a pilot study","volume":"44","author":"Frey","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2014.10.002_bib0365","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.sleep.2007.11.014","article-title":"Effective treatment of narcolepsy-cataplexy with duloxetine: a report of three cases [letter]","volume":"10","author":"Izzi","year":"2009","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0370","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1089\/cap.2008.036","article-title":"Treatment with venlafaxine in six cases of children with narcolepsy and with cataplexy and hypnagogic hallucinations","volume":"19","author":"Moller","year":"2009","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"10.1016\/j.sleep.2014.10.002_bib0375","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.sleep.2010.07.022","article-title":"Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants","volume":"12","author":"Ju","year":"2011","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0380","first-page":"164","article-title":"Drug-induced restless legs syndrome","volume":"19","year":"2010","journal-title":"Prescrire Int"},{"key":"10.1016\/j.sleep.2014.10.002_bib0385","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/sleep\/29.7.939","article-title":"Sodium oxybate improves excessive daytime sleepiness in narcolepsy","volume":"29","author":"Black","year":"2006","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0390","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ajem.2009.11.008","article-title":"Case series of 226 gamma-hydroxybutyrate-associated deaths: lethal toxicity and trauma","volume":"29","author":"Zvosec","year":"2011","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0395","doi-asserted-by":"crossref","first-page":"365","DOI":"10.5664\/jcsm.27549","article-title":"Safety overview of postmarketing and clinical experience of sodium oxybate (Xyrem): abuse, misuse, dependence, and diversion","volume":"5","author":"Wang","year":"2009","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0400","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000324549","article-title":"Sodium oxybate in narcolepsy with cataplexy: Zurich sleep center experience","volume":"65","author":"Poryazova","year":"2011","journal-title":"Eur Neurol"},{"key":"10.1016\/j.sleep.2014.10.002_bib0405","first-page":"187","article-title":"Focusing on vigilance instead of sleepiness in the assessment of narcolepsy: high sensitivity of the sustained attention to response task (SART)","volume":"29","author":"Fronczek","year":"2006","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0410","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0415","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3109\/07853890109002089","article-title":"The RAND-36 measure of health-related quality of life","volume":"33","author":"Hays","year":"2001","journal-title":"Ann Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0420","first-page":"835","article-title":"An instrument to measure functional status outcomes for disorders of excessive sleepiness","volume":"20","author":"Weaver","year":"1997","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0425","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1389-9457(00)00065-4","article-title":"Validation of the Insomnia Severity Index as an outcome measure for insomnia research","volume":"2","author":"Bastien","year":"2001","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0430","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med Care"},{"key":"10.1016\/j.sleep.2014.10.002_bib0435","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","article-title":"A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity","volume":"34","author":"Ware","year":"1996","journal-title":"Med Care"},{"key":"10.1016\/j.sleep.2014.10.002_bib0440","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0168-8510(90)90421-9","article-title":"EuroQol\u2013a new facility for the measurement of health-related quality of life","volume":"16","year":"1990","journal-title":"Health Policy (New York)"},{"key":"10.1016\/j.sleep.2014.10.002_bib0445","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0450","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.sleep.2014.10.002_bib0455","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1741-7015-11-78","article-title":"Hypersomnia and depressive symptoms: methodological and clinical aspects","volume":"11","author":"Dauvilliers","year":"2013","journal-title":"BMC Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0460","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/01.yco.0000218600.40593.18","article-title":"Sleep and youth suicidal behavior: a neglected field","volume":"19","author":"Liu","year":"2006","journal-title":"Curr Opin Psychiatry"},{"key":"10.1016\/j.sleep.2014.10.002_bib0465","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1037\/0022-006X.76.1.84","article-title":"Sleep disturbance preceding completed suicide in adolescents","volume":"76","author":"Goldstein","year":"2008","journal-title":"J Consult Clin Psychol"},{"issue":"Suppl. S16","key":"10.1016\/j.sleep.2014.10.002_bib0470","first-page":"52","article-title":"A longitudinal study of 322 individuals with narcolepsy [abstract]","volume":"72","author":"Ohayon","year":"2012","journal-title":"Ann Neurol"},{"key":"10.1016\/j.sleep.2014.10.002_bib0475","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1176\/appi.ajp.2011.10111704","article-title":"The Columbia-Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults","volume":"168","author":"Posner","year":"2011","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.sleep.2014.10.002_bib0480","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2147\/NDT.S18455","article-title":"Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?","volume":"7","author":"Engel","year":"2011","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.sleep.2014.10.002_bib0485","doi-asserted-by":"crossref","first-page":"231","DOI":"10.5665\/sleep.1628","article-title":"Glucose tolerance in patients with narcolepsy","volume":"35","author":"Beitinger","year":"2012","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0490","doi-asserted-by":"crossref","first-page":"795","DOI":"10.5665\/sleep.3592","article-title":"Glucose and fat metabolism in narcolepsy and the effect of sodium oxybate: a hyperinsulinemic-euglycemic clamp study","volume":"37","author":"Donjacour","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0495","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.sleep.2006.06.003","article-title":"Restless legs syndrome in narcolepsy: a side effect of sodium oxybate?","volume":"8","author":"Abril","year":"2007","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0500","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2869.2011.00942.x","article-title":"Periodic leg movements during sleep in narcoleptic patients with or without restless legs syndrome","volume":"21","author":"Plazzi","year":"2012","journal-title":"J Sleep Res"},{"key":"10.1016\/j.sleep.2014.10.002_bib0505","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000348719","article-title":"Sleep-disordered breathing and periodic limb movements in narcolepsy with cataplexy: a systematic analysis of 35 consecutive patients","volume":"70","author":"Pizza","year":"2013","journal-title":"Eur Neurol"},{"key":"10.1016\/j.sleep.2014.10.002_bib0510","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-2869.2007.00601.x","article-title":"Periodic leg movements during sleep and wakefulness in narcolepsy","volume":"16","author":"Dauvilliers","year":"2007","journal-title":"J Sleep Res"},{"key":"10.1016\/j.sleep.2014.10.002_bib0515","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1600-0404.2006.00754.x","article-title":"Periodic leg movements in narcolepsy patients: impact on sleep architecture","volume":"115","author":"Bahammam","year":"2007","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.sleep.2014.10.002_bib0520","doi-asserted-by":"crossref","first-page":"597","DOI":"10.5664\/jcsm.1458","article-title":"Periodic limb movements during sleep in children with narcolepsy","volume":"7","author":"Jambhekar","year":"2011","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0525","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00002826-198902000-00004","article-title":"Nocturnal gamma-hydroxybutyrate. Effect on periodic leg movements and sleep organization of narcoleptic patients","volume":"12","author":"Bedard","year":"1989","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.sleep.2014.10.002_bib0530","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2174\/187152709788921690","article-title":"REM sleep behavior disorder and narcolepsy","volume":"8","author":"Billiard","year":"2009","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.sleep.2014.10.002_bib0535","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s004060170057","article-title":"Increased prevalence of obesity in narcoleptic patients and relatives","volume":"251","author":"Dahmen","year":"2001","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.sleep.2014.10.002_bib0540","doi-asserted-by":"crossref","first-page":"175","DOI":"10.5665\/sleep.2366","article-title":"High prevalence of precocious puberty and obesity in childhood narcolepsy with cataplexy","volume":"36","author":"Poli","year":"2013","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2014.10.002_bib0545","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.sleep.2003.10.006","article-title":"A putative link between childhood narcolepsy and obesity","volume":"5","author":"Kotagal","year":"2004","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0550","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.sleep.2009.02.009","article-title":"Obstructive sleep apnea in narcolepsy","volume":"11","author":"Sansa","year":"2010","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0555","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11325-009-0283-1","article-title":"Clinical perspective: monitoring sodium oxybate-treated narcolepsy patients for the development of sleep-disordered breathing","volume":"14","author":"Feldman","year":"2010","journal-title":"Sleep Breath"},{"key":"10.1016\/j.sleep.2014.10.002_bib0560","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.sleep.2008.05.012","article-title":"Weight loss in narcolepsy patients treated with sodium oxybate","volume":"10","author":"Husain","year":"2009","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0565","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.sleep.2012.11.021","article-title":"Management of narcolepsy during pregnancy","volume":"14","author":"Thorpy","year":"2013","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0570","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/jsr.12047","article-title":"Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies","volume":"22","author":"Maurovich-Horvat","year":"2013","journal-title":"J Sleep Res"},{"key":"10.1016\/j.sleep.2014.10.002_bib0575","doi-asserted-by":"crossref","first-page":"390","DOI":"10.5664\/jcsm.27554","article-title":"Narcoleptic patients\u2019 perceptions of nicotine [letter]","volume":"5","author":"Krahn","year":"2009","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0580","doi-asserted-by":"crossref","first-page":"195","DOI":"10.5664\/jcsm.1780","article-title":"Narcolepsy with cataplexy masked by the use of nicotine","volume":"8","author":"Ebben","year":"2012","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2014.10.002_bib0585","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00213-009-1588-2","article-title":"Hypocretin mechanisms in nicotine addiction: evidence and speculation","volume":"206","author":"Corrigall","year":"2009","journal-title":"Psychopharmacology (Berl)"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945714004195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945714004195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T21:22:04Z","timestamp":1598390524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945714004195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":116,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S1389945714004195"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2014.10.002","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and practical considerations in the pharmacologic management of narcolepsy","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2014.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}