{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:18:35Z","timestamp":1791454715893,"version":"4.3.3"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","sleep-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.sleep.2016.08.001","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T04:01:47Z","timestamp":1470974507000},"page":"87-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea"],"prefix":"10.1016","volume":"25","author":[{"given":"Behrouz","family":"Jafari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Mohsenin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2016.08.001_bib0010","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1056\/NEJM199304293281704","article-title":"The occurrence of sleep-disordered breathing among middle-aged adults","volume":"328","author":"Young","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.sleep.2016.08.001_bib0015","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1056\/NEJM200005113421901","article-title":"Prospective study of the association between sleep-disordered breathing and hypertension","volume":"342","author":"Peppard","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.sleep.2016.08.001_bib0020","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1164\/rccm.200503-340OC","article-title":"Early signs of atherosclerosis in obstructive sleep apnea","volume":"172","author":"Drager","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2016.08.001_bib0025","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11325-009-0298-7","article-title":"Obstructive sleep apnea as a risk factor for coronary events or cardiovascular death","volume":"14","author":"Shah","year":"2010","journal-title":"Sleep Breath"},{"key":"10.1016\/j.sleep.2016.08.001_bib0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1164\/ajrccm.163.1.2001008","article-title":"Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health study","volume":"163","author":"Shahar","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2016.08.001_bib0035","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1056\/NEJMoa043104","article-title":"Obstructive sleep apnea as a risk factor for stroke and death","volume":"353","author":"Yaggi","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.sleep.2016.08.001_bib0040","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.pcad.2008.08.002","article-title":"Endothelial function in obstructive sleep apnea","volume":"51","author":"Atkeson","year":"2009","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.sleep.2016.08.001_bib0045","doi-asserted-by":"crossref","DOI":"10.1161\/01.CIR.0000131515.03336.f8","article-title":"Role of endothelial dysfunction in atherosclerosis","volume":"109","author":"Davignon","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.sleep.2016.08.001_bib0050","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"352","author":"Hansson","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.sleep.2016.08.001_bib0055","doi-asserted-by":"crossref","first-page":"13076","DOI":"10.1074\/jbc.270.22.13076","article-title":"Identification of a 38-kDa heparin-binding glycoprotein (gp38k) in differentiating vascular smooth muscle cells as a member of a group of proteins associated with tissue remodeling","volume":"270","author":"Shackelton","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.sleep.2016.08.001_bib0060","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1475-2840-8-61","article-title":"YKL-40 \u2013 an emerging biomarker in cardiovascular disease and diabetes","volume":"8","author":"Rathcke","year":"2009","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.sleep.2016.08.001_bib0065","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF00285287","article-title":"Albuminuria reflects widespread vascular damage. The Steno hypothesis","volume":"32","author":"Deckert","year":"1989","journal-title":"Diabetologia"},{"key":"10.1016\/j.sleep.2016.08.001_bib0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2261-12-35","article-title":"Association between human cartilage glycoprotein 39 (YKL-40) and arterial stiffness in essential hypertension","volume":"12","author":"Ma","year":"2012","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.sleep.2016.08.001_bib0075","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1475-2840-10-54","article-title":"YKL-40 levels are independently associated with albuminuria in type 2 diabetes","volume":"10","author":"Rondbjerg","year":"2011","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.sleep.2016.08.001_bib0080","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/ana.22220","article-title":"Elevated plasma YKL-40 levels and ischemic stroke in the general population","volume":"68","author":"Kjaergaard","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.sleep.2016.08.001_bib0085","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijcard.2009.01.043","article-title":"Low grade inflammation as measured by levels of YKL-40: association with an increased overall and cardiovascular mortality rate in an elderly population","volume":"143","author":"Rathcke","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.sleep.2016.08.001_bib0090","doi-asserted-by":"crossref","first-page":"e000897","DOI":"10.1161\/JAHA.114.000897","article-title":"Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40, variation in the chitinase 3-like 1 gene (CHI3L1), and incident cardiovascular events","volume":"3","author":"Ridker","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.sleep.2016.08.001_bib0095","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.imbio.2012.10.015","article-title":"Serum YKL-40 predicts long-term mortality in patients with stable coronary disease: a prognostic study within the CLARICOR trial","volume":"218","author":"Harutyunyan","year":"2013","journal-title":"Immunobiology"},{"key":"10.1016\/j.sleep.2016.08.001_bib0100","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/eurheartj\/ehp049","article-title":"High serum YKL-40 concentration is associated with cardiovascular and all-cause mortality in patients with stable coronary artery disease","volume":"30","author":"Kastrup","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.sleep.2016.08.001_bib0105","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.imbio.2011.11.003","article-title":"The inflammatory biomarker YKL-40 as a new prognostic marker for all-cause mortality in patients with heart failure","volume":"217","author":"Harutyunyan","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.sleep.2016.08.001_bib0110","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/01.ATV.19.3.687","article-title":"Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages","volume":"19","author":"Boot","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.sleep.2016.08.001_bib0115","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.atherosclerosis.2010.02.035","article-title":"Increased YKL-40 expression in patients with carotid atherosclerosis","volume":"211","author":"Michelsen","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.sleep.2016.08.001_bib0120","doi-asserted-by":"crossref","first-page":"e98629","DOI":"10.1371\/journal.pone.0098629","article-title":"Increased plasma YKL-40\/chitinase-3-like-protein-1 is associated with endothelial dysfunction in obstructive sleep apnea","volume":"9","author":"Jafari","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.sleep.2016.08.001_bib0125","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","article-title":"The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report","volume":"289","author":"Chobanian","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.sleep.2016.08.001_bib0130","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.rmed.2011.01.001","article-title":"Circulating antiangiogenic proteins in obstructive sleep apnea and hypertension","volume":"105","author":"Mohsenin","year":"2011","journal-title":"Respir Med"},{"key":"10.1016\/j.sleep.2016.08.001_bib0135","doi-asserted-by":"crossref","first-page":"587","DOI":"10.5665\/sleep.4576","article-title":"A systematic assessment of the association of polysomnographic indices with blood pressure: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"38","author":"Dean","year":"2015","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2016.08.001_bib0140","first-page":"469","article-title":"Hypopnea in sleep-disordered breathing in adults","volume":"24","author":"Meoli","year":"2001","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2016.08.001_bib0145","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/00365540110080233","article-title":"Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease","volume":"34","author":"Kronborg","year":"2002","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.sleep.2016.08.001_bib0150","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1006\/excr.1999.4511","article-title":"Gp38k, a protein synthesized by vascular smooth muscle cells, stimulates directional migration of human umbilical vein endothelial cells","volume":"250","author":"Malinda","year":"1999","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.sleep.2016.08.001_bib0155","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0014-4827(03)00069-7","article-title":"gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells","volume":"287","author":"Nishikawa","year":"2003","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.sleep.2016.08.001_bib0160","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/rheumatology\/kei216","article-title":"Serum cartilage oligomeric matrix protein and other biomarker profiles in tibiofemoral and patellofemoral osteoarthritis of the knee","volume":"45","author":"Sharif","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.sleep.2016.08.001_bib0165","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/rheumatology\/35.6.553","article-title":"40 levels in healthy children and adults. Comparison with serum and synovial fluid levels of YKL-40 in patients with osteoarthritis or trauma of the knee joint","volume":"35","author":"Johansen","year":"1996","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.sleep.2016.08.001_bib0170","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1056\/NEJMoa073600","article-title":"A chitinase-like protein in the lung and circulation of patients with severe asthma","volume":"357","author":"Chupp","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.sleep.2016.08.001_bib0175","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.4049\/jimmunol.181.7.5167","article-title":"YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages","volume":"181","author":"Letuve","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.sleep.2016.08.001_bib0180","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1002\/ijc.23313","article-title":"Experimental anti-angiogenesis causes upregulation of genes associated with poor survival in glioblastoma","volume":"122","author":"Saidi","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.sleep.2016.08.001_bib0185","doi-asserted-by":"crossref","first-page":"15332","DOI":"10.1074\/jbc.M110.212514","article-title":"Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma","volume":"286","author":"Francescone","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.sleep.2016.08.001_bib0190","doi-asserted-by":"crossref","DOI":"10.1152\/ajpregu.00069.2012","article-title":"Control of soluble fms-like tyrosine-1 (sFlt-1) production response to placental ischemia\/hypoxia: role of tumor necrosis factor-alpha","volume":"304","author":"Murphy","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.sleep.2016.08.001_bib0195","doi-asserted-by":"crossref","DOI":"10.1152\/ajpregu.00794.2005","article-title":"Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1","volume":"291","author":"Nevo","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.sleep.2016.08.001_bib0200","doi-asserted-by":"crossref","first-page":"486053","DOI":"10.1155\/2012\/486053","article-title":"Heme oxygenase-1 attenuates hypoxia-induced sFlt-1 and oxidative stress in placental villi through its metabolic products CO and bilirubin","volume":"2012","author":"George","year":"2012","journal-title":"Int J Hypertens"},{"key":"10.1016\/j.sleep.2016.08.001_bib0205","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.2353\/ajpath.2010.090800","article-title":"Effects of hypoxia-inducible factor-1alpha overexpression in pregnant mice: possible implications for preeclampsia and intrauterine growth restriction","volume":"177","author":"Tal","year":"2010","journal-title":"Am J Pathol"},{"issue":"396","key":"10.1016\/j.sleep.2016.08.001_bib0210","first-page":"e391","article-title":"The effect of over-expression of sFlt-1 on blood pressure and the occurrence of other manifestations of preeclampsia in unrestrained conscious pregnant mice","volume":"196","author":"Lu","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.sleep.2016.08.001_bib0215","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.sleep.2016.08.001_bib0220","first-page":"393","article-title":"In vivo rat model of preeclampsia","volume":"122","author":"Karumanchi","year":"2006","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.sleep.2016.08.001_bib0225","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/j.1582-4934.2009.00820.x","article-title":"Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model","volume":"14","author":"Bergmann","year":"2009","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.sleep.2016.08.001_bib0230","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.jacc.2004.07.027","article-title":"Flow-mediated vasodilation and the risk of developing hypertension in healthy postmenopausal women","volume":"44","author":"Rossi","year":"2004","journal-title":"J Am Coll Cardiol"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945716301010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945716301010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T03:56:05Z","timestamp":1536465365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945716301010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":45,"alternative-id":["S1389945716301010"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2016.08.001","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2016.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}