{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:39:33Z","timestamp":1783543173282,"version":"3.55.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007753","name":"University of Eastern Finland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007753","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006706","name":"Tampere Tuberculosis Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004756","name":"Emil Aaltonen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012691","name":"Olvi Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008413","name":"Instrumentarium Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008413","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008309","name":"Research Foundation of the Pulmonary Diseases","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008309","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sein\u00e4joki Central Hospital","award":["6020"],"award-info":[{"award-number":["6020"]}]},{"name":"Competitive State Research Financing of Expert Responsibility Area of Tampere University Hospital","award":["VTR3114"],"award-info":[{"award-number":["VTR3114"]}]},{"name":"Competitive State Research Financing of Expert Responsibility Area of Tampere University Hospital","award":["VTR3221"],"award-info":[{"award-number":["VTR3221"]}]},{"name":"Competitive State Research Financing of Expert Responsibility Area of Tampere University Hospital","award":["EVO2089"],"award-info":[{"award-number":["EVO2089"]}]},{"name":"National Program of Sustainability II","award":["LQ1605"],"award-info":[{"award-number":["LQ1605"]}]},{"name":"FNUSA-ICRC","award":["CZ.1.05\/1.1.00\/02.0123"],"award-info":[{"award-number":["CZ.1.05\/1.1.00\/02.0123"]}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.sleep.2017.06.004","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T11:46:11Z","timestamp":1498304771000},"page":"32-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Severity of individual obstruction events increases with age in patients with obstructive sleep apnea"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4017-821X","authenticated-orcid":false,"given":"Timo","family":"Lepp\u00e4nen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"T\u00f6yr\u00e4s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esa","family":"Mervaala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Penzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Kulkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2017.06.004_bib1","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/aje\/kws342","article-title":"Increased prevalence of sleep-disordered breathing in adults","volume":"177","author":"Peppard","year":"2013","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.sleep.2017.06.004_bib2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1513\/pats.200709-155MG","article-title":"The epidemiology of adult obstructive sleep apnea","volume":"5","author":"Punjabi","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.sleep.2017.06.004_bib3","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1001\/jama.284.23.3015","article-title":"Longitudinal study of moderate weight change and sleep-disordered breathing","volume":"284","author":"Peppard","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.sleep.2017.06.004_bib4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/sleep\/26.6.703","article-title":"Predictors of longitudinal change in sleep-disordered breathing in a nonclinic population","volume":"26","author":"Redline","year":"2003","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2017.06.004_bib5","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1097\/MLG.0b013e3180514d08","article-title":"Evolution of mild obstructive sleep apnea after different treatments","volume":"117","author":"Sahlman","year":"2007","journal-title":"Laryngoscope"},{"key":"10.1016\/j.sleep.2017.06.004_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1164\/ajrccm.157.1.9706079","article-title":"Effects of age on sleep apnea in men: I. Prevalence and severity","volume":"157","author":"Bixler","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2017.06.004_bib7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/sleep\/20.3.192","article-title":"Longitudinal changes in diary-and laboratory-based sleep measures in healthy \u201cold old\u201d and \u201cyoung old\u201d subjects: a three-year follow-up","volume":"20","author":"Hoch","year":"1997","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2017.06.004_bib8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S1389-9457(00)00096-4","article-title":"Long-term follow-up of sleep disordered breathing in older adults","volume":"2","author":"Ancoli-Israel","year":"2001","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2017.06.004_bib9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/sleep\/22.5.667","article-title":"Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research","volume":"22","author":"American Academy of Sleep Medicine (AASM)","year":"1999","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2017.06.004_bib10","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s11517-015-1290-y","article-title":"Amount of weight loss or gain influences the severity of respiratory events in sleep apnea","volume":"53","author":"Kulkas","year":"2015","journal-title":"Med Biol Eng Comput"},{"key":"10.1016\/j.sleep.2017.06.004_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9645347","article-title":"Length of individual apnea events is increased by supine position and modulated by severity of obstructive sleep apnea","volume":"2016","author":"Lepp\u00e4nen","year":"2016","journal-title":"Sleep Disord"},{"key":"10.1016\/j.sleep.2017.06.004_bib12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s11325-016-1430-0","article-title":"Severity of individual obstruction events is gender dependent in sleep apnea","volume":"21","author":"Lepp\u00e4nen","year":"2017","journal-title":"Sleep Breath"},{"key":"10.1016\/j.sleep.2017.06.004_bib13","first-page":"119","article-title":"RemLogic plug-in enables clinical application of apnea-hypopnea index adjusted for severity of individual obstruction events","volume":"40","author":"Lepp\u00e4nen","year":"2016","journal-title":"J\u00a0Med Eng Technol"},{"key":"10.1016\/j.sleep.2017.06.004_bib14","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s11325-013-0927-z","article-title":"Adjustment of apnea-hypopnea index with severity of obstruction events enhances detection of sleep apnea patients with the highest risk of severe health consequences","volume":"18","author":"Muraja-Murro","year":"2014","journal-title":"Sleep Breath"},{"key":"10.1016\/j.sleep.2017.06.004_bib15","first-page":"135","article-title":"Novel parameters for evaluating severity of sleep disordered breathing and for supporting diagnosis of sleep apnea-hypopnea syndrome","volume":"37","author":"Kulkas","year":"2013","journal-title":"J\u00a0Med Eng Technol"},{"key":"10.1016\/j.sleep.2017.06.004_bib16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s11325-012-0798-8","article-title":"Mortality in middle-aged men with obstructive sleep apnea in Finland","volume":"17","author":"Muraja-Murro","year":"2013","journal-title":"Sleep Breath"},{"key":"10.1016\/j.sleep.2017.06.004_bib17","series-title":"The AASM manual for the scoring of sleep and associated events: rules, terminology, and technical specifications","first-page":"17","author":"Iber","year":"2007"},{"key":"10.1016\/j.sleep.2017.06.004_bib18","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s11517-013-1039-4","article-title":"Novel parameters indicate significant differences in severity of obstructive sleep apnea with patients having similar apnea\u2013hypopnea index","volume":"51","author":"Kulkas","year":"2013","journal-title":"Med Biol Eng Comput"},{"key":"10.1016\/j.sleep.2017.06.004_bib19","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.5665\/sleep.3844","article-title":"Obstructive sleep apnea in older adults is a distinctly different physiological phenotype","volume":"37","author":"Edwards","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2017.06.004_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00043.2008","article-title":"Pathophysiology of sleep apnea","volume":"90","author":"Dempsey","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1016\/j.sleep.2017.06.004_bib21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/jsr.12070","article-title":"The severity of individual obstruction events is related to increased mortality rate in severe obstructive sleep apnea","volume":"22","author":"Muraja-Murro","year":"2013","journal-title":"J\u00a0Sleep Res"},{"key":"10.1016\/j.sleep.2017.06.004_bib22","doi-asserted-by":"crossref","first-page":"e104572","DOI":"10.1371\/journal.pone.0104572","article-title":"Effects of aging on genioglossus motor units in humans","volume":"9","author":"Saboisky","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.sleep.2017.06.004_bib23","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1172\/JCI107363","article-title":"Attenuation of the ventilatory and heart rate responses to hypoxia and hypercapnia with aging in normal men","volume":"52","author":"Kronenberg","year":"1973","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.sleep.2017.06.004_bib24","doi-asserted-by":"crossref","first-page":"737","DOI":"10.5664\/jcsm.27032","article-title":"Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients","volume":"3","author":"Collop","year":"2007","journal-title":"J\u00a0Clin Sleep Med"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138994571730254X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138994571730254X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T21:46:15Z","timestamp":1657575975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138994571730254X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":24,"alternative-id":["S138994571730254X"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2017.06.004","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Severity of individual obstruction events increases with age in patients with obstructive sleep apnea","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2017.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}