{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:25:36Z","timestamp":1770449136814,"version":"3.49.0"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011096","name":"Jazz Pharmaceuticals, Inc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Aerial BioPharma, LLC"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","sleep-journal.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.sleep.2017.07.006","type":"journal-article","created":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T22:16:04Z","timestamp":1500761764000},"page":"108-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Identifying clinically important difference on the Epworth Sleepiness Scale: results from a narcolepsy clinical trial of JZP-110"],"prefix":"10.1016","volume":"38","author":[{"given":"Lawrence","family":"Scrima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene A.","family":"Emsellem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip M.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Ruoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Lankford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Bream","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moise","family":"Khayrallah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jed","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2017.07.006_bib1","series-title":"The international classification of sleep disorders \u2013 third edition (ICSD-3)","author":"American Academy of Sleep Medicine","year":"2014"},{"key":"10.1016\/j.sleep.2017.07.006_bib2","series-title":"Narcolepsy. Diagnostic and statistical manual of mental disorders fifth edition (DSM-5)","first-page":"372","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.sleep.2017.07.006_bib3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.sleep.2010.07.010","article-title":"Sleep disorders and accidental risk in a large group of regular registered highway drivers","volume":"11","author":"Philip","year":"2010","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2017.07.006_bib4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.aap.2009.12.004","article-title":"Sleep disorders, medical conditions, and road accident risk","volume":"43","author":"Smolensky","year":"2011","journal-title":"Accid Anal Prev"},{"key":"10.1016\/j.sleep.2017.07.006_bib5","series-title":"Poster presented at: winter conference on brain research; January 23\u201328, 2016; Breckenridge, Colorado, Poster #Su23","article-title":"JZP-110: a dopamine\u2013norepinephrine reuptake inhibitor (DNRI) with robust wake-promoting effects and low abuse potential","author":"Carter","year":"2016"},{"key":"10.1016\/j.sleep.2017.07.006_bib6","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A\u00a0new method for measuring daytime sleepiness: the Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2017.07.006_bib7","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.sleep.2015.05.013","article-title":"Effect of oral JZP-110 (ADX-N05) treatment on wakefulness and sleepiness in adults with narcolepsy","volume":"16","author":"Bogan","year":"2015","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2017.07.006_bib8","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.5665\/sleep.5968","article-title":"Effect of oral JZP-110 (ADX-N05) on wakefulness and sleepiness in adults with narcolepsy: a phase 2b study","volume":"39","author":"Ruoff","year":"2016","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2017.07.006_bib9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0197-2456(89)90005-6","article-title":"Measurement of health status. Ascertaining the minimal clinically important difference","volume":"10","author":"Jaeschke","year":"1989","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.sleep.2017.07.006_bib10","series-title":"Psychophysics: the fundamentals","first-page":"1","article-title":"Psychophysical measurement of thresholds: differential sensitivity","author":"Gescheider","year":"1997"},{"key":"10.1016\/j.sleep.2017.07.006_bib11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(01)00349-9","article-title":"Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale","volume":"94","author":"Farrar","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.sleep.2017.07.006_bib12","author":"Food and Drug Administration"},{"issue":"Suppl","key":"10.1016\/j.sleep.2017.07.006_bib13","first-page":"A361","article-title":"Development of a definition of response to narcolepsy treatment [abstract]","volume":"37","author":"Steffen","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2017.07.006_bib14","series-title":"ECDEU assessment manual for psychopharmacology, revised","author":"Guy","year":"1976"},{"key":"10.1016\/j.sleep.2017.07.006_bib15","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/acr.20132","article-title":"Patient\u2013physician discordance in assessments of global disease severity in rheumatoid arthritis","volume":"62","author":"Barton","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.sleep.2017.07.006_bib16","first-page":"401","article-title":"Association of patient-rated severity with other outcomes in patients with painful diabetic peripheral neuropathy","volume":"4","author":"Taylor-Stokes","year":"2011","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.sleep.2017.07.006_bib17","first-page":"381","article-title":"Relationship between patient-reported disease severity and other clinical outcomes in osteoarthritis: a European perspective","volume":"14","author":"Bushmakin","year":"2011","journal-title":"J\u00a0Med Econ"},{"key":"10.1016\/j.sleep.2017.07.006_bib18","first-page":"1048","article-title":"Do patients and physicians agree in their assessment of the severity of psoriasis? Insights from tofacitinib phase 3 clinical trials","volume":"3","author":"Paul","year":"2015","journal-title":"J\u00a0Dermatol Clin Res"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945717302940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945717302940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T15:30:21Z","timestamp":1538667021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945717302940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":18,"alternative-id":["S1389945717302940"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2017.07.006","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identifying clinically important difference on the Epworth Sleepiness Scale: results from a narcolepsy clinical trial of JZP-110","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2017.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}