{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:51:55Z","timestamp":1787169115009,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"TEVA Pharmaceuticals, Inc.","award":["1S10RR028898"],"award-info":[{"award-number":["1S10RR028898"]}]},{"name":"TEVA Pharmaceuticals, Inc.","award":["1R01EB026716"],"award-info":[{"award-number":["1R01EB026716"]}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.sleep.2018.09.011","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T23:43:18Z","timestamp":1538178198000},"page":"51-59","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["White matter structural differences in OSA patients experiencing residual daytime sleepiness with high CPAP use: a non-Gaussian diffusion MRI study"],"prefix":"10.1016","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2439-7607","authenticated-orcid":false,"given":"Jiaxuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri E.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn A.","family":"Nisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly R.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana D.","family":"Steffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Muge","family":"Karaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-4925","authenticated-orcid":false,"given":"Xiaohong Joe","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2018.09.011_bib1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1513\/pats.200709-155MG","article-title":"The epidemiology of adult obstructive sleep apnea","volume":"5","author":"Punjabi","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.sleep.2018.09.011_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.smrv.2016.07.002","article-title":"Prevalence of obstructive sleep apnea in the general population: a systematic review","volume":"34","author":"Senaratna","year":"2017","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleep.2018.09.011_bib3","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1053\/j.ajkd.2012.08.033","article-title":"Association of sleep-disordered breathing with cognitive dysfunction in CKD stages 4-5","volume":"60","author":"Kang","year":"2012","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.sleep.2018.09.011_bib4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(08)61622-0","article-title":"Obstructive sleep apnoea and its cardiovascular consequences","volume":"373","author":"Bradley","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.sleep.2018.09.011_bib5","first-page":"967","article-title":"Brain structural changes in obstructive sleep apnea","volume":"31","author":"Macey","year":"2008","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.smrv.2009.02.004","article-title":"A\u00a0systematic review of continuous positive airway pressure for obstructive sleep apnoea-hypopnoea syndrome","volume":"13","author":"McDaid","year":"2009","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleep.2018.09.011_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/sleep\/34.1.111","article-title":"The effect of CPAP in normalizing daytime sleepiness, quality of life, and neurocognitive function in patients with moderate to severe OSA","volume":"34","author":"Antic","year":"2011","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib8","first-page":"1323","article-title":"New developments in the use of positive airway pressure for obstructive sleep apnea","volume":"7","author":"Donovan","year":"2015","journal-title":"J\u00a0Thorac Dis"},{"key":"10.1016\/j.sleep.2018.09.011_bib9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.5664\/jcsm.4556","article-title":"Quality measures for the care of adult patients with obstructive sleep apnea","volume":"11","author":"Aurora","year":"2015","journal-title":"J\u00a0Clin Sleep Med"},{"key":"10.1016\/j.sleep.2018.09.011_bib10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/sleep\/30.6.711","article-title":"Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning","volume":"30","author":"Weaver","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/jsr.12039","article-title":"Residual sleepiness in sleep apnea patients treated by continuous positive airway pressure","volume":"22","author":"Gasa","year":"2013","journal-title":"J\u00a0Sleep Res"},{"key":"10.1016\/j.sleep.2018.09.011_bib12","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1183\/09031936.04.00127603","article-title":"Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study","volume":"24","author":"Alchanatis","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.sleep.2018.09.011_bib13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1183\/09031936.00040410","article-title":"Residual sleepiness in obstructive sleep apnoea: phenotype and related symptoms","volume":"38","author":"Vernet","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.sleep.2018.09.011_bib14","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/sleep\/27.2.194","article-title":"Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions","volume":"27","author":"Veasey","year":"2004","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib15","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5664\/jcsm.26665","article-title":"A\u00a0review of neuroimaging in obstructive sleep apnea","volume":"2","author":"Zimmemnan","year":"2006","journal-title":"J\u00a0Clin Sleep Med"},{"key":"10.1016\/j.sleep.2018.09.011_bib16","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1164\/rccm.200201-050OC","article-title":"Brain morphology associated with obstructive sleep apnea","volume":"166","author":"Macey","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2018.09.011_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.12659\/PJR.889923","article-title":"Proton magnetic resonance spectroscopy of periventricular white matter and hippocampus in obstructive sleep apnea patients","volume":"78","author":"K\u0131z\u0131lg\u00f6z","year":"2013","journal-title":"Pol J Radiol"},{"key":"10.1016\/j.sleep.2018.09.011_bib18","doi-asserted-by":"crossref","first-page":"723","DOI":"10.5665\/sleep.3578","article-title":"Abnormal myelin and axonal integrity in recently diagnosed patients with obstructive sleep apnea","volume":"37","author":"Kumar","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.5665\/sleep.4490","article-title":"White matter damage and systemic inflammation in obstructive sleep apnea","volume":"38","author":"Chen","year":"2015","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib20","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.5665\/sleep.3994","article-title":"White matter integrity in obstructive sleep apnea before and after treatment","volume":"37","author":"Castronovo","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib21","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/jmri.25463","article-title":"Brain white matter changes in CPAP-treated obstructive sleep apnea patients with residual sleepiness","volume":"45","author":"Xiong","year":"2017","journal-title":"J\u00a0Magn Reson Imag"},{"key":"10.1016\/j.sleep.2018.09.011_bib22","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/mrm.1910360607","article-title":"Biexponential diffusion attenuation in various states of brain tissue: implications for diffusion-weighted imaging","volume":"36","author":"Niendorf","year":"1996","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.sleep.2018.09.011_bib23","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/mrm.10581","article-title":"Characterization of continuously distributed cortical water diffusion rates with a stretched-exponential model","volume":"50","author":"Bennett","year":"2003","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.sleep.2018.09.011_bib24","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1002\/mrm.20508","article-title":"Diffusional kurtosis imaging: the quantification of non-Gaussian water diffusion by means of magnetic resonance imaging","volume":"53","author":"Jensen","year":"2005","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.sleep.2018.09.011_bib25","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1148\/radiol.2015142156","article-title":"Differentiation of low- and high-grade pediatric brain tumors with high b-value diffusion-weighted MR imaging and a fractional order calculus model","volume":"277","author":"Sui","year":"2015","journal-title":"Radiology"},{"key":"10.1016\/j.sleep.2018.09.011_bib26","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.nicl.2016.10.003","article-title":"A\u00a0fractional motion diffusion model for grading pediatric brain tumors","volume":"12","author":"Karaman","year":"2016","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.sleep.2018.09.011_bib27","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuroimage.2012.03.072","article-title":"NODDI: practical in\u00a0vivo neurite orientation dispersion and density imaging of the human brain","volume":"61","author":"Zhang","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.sleep.2018.09.011_bib28","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/mrm.24706","article-title":"On random walks and entropy in diffusion-weighted magnetic resonance imaging studies of neural tissue","volume":"71","author":"Ingo","year":"2014","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.sleep.2018.09.011_bib29","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/mrm.26012","article-title":"Differentiating low- and high-grade pediatric brain tumors using a continuous-time random-walk diffusion model at high b-values","volume":"76","author":"Karaman","year":"2015","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.sleep.2018.09.011_bib30","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.sleep.2018.09.011_bib31","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/sleep\/32.2.150","article-title":"The new AASM criteria for scoring hypopneas: impact on the apnea hypopnea index","volume":"32","author":"Ruehland","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib32","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/sleep\/34.5.581","article-title":"Maximizing sensitivity of the psychomotor vigilance test (PVT) to sleep loss","volume":"34","author":"Basner","year":"2011","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2147\/NSS.S53721","article-title":"Obstructive sleep apnea and psychomotor vigilance task performance","volume":"6","author":"Batool-Anwar","year":"2014","journal-title":"Nat Sci Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib34","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A\u00a0new method for measuring daytime sleepiness: the Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib35","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","volume":"62","author":"Jenkinson","year":"2012","journal-title":"FSL. Neuroimage"},{"key":"10.1016\/j.sleep.2018.09.011_bib36","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.neuroimage.2007.12.035","article-title":"Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template","volume":"40","author":"Mori","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.sleep.2018.09.011_bib37","series-title":"Applied logistic regression analysis","first-page":"1","author":"Menard","year":"2002"},{"key":"10.1016\/j.sleep.2018.09.011_bib38","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/sleep\/33.2.211","article-title":"Age-related reduction in daytime sleep propensity and nocturnal slow wave sleep","volume":"33","author":"Dijk","year":"2010","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/sleep\/26.2.117","article-title":"The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation","volume":"26","author":"Van Dongen","year":"2003","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib40","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.3174\/ajnr.A4836","article-title":"Differentiation of low- and high-grade gliomas using high b-value diffusion imaging with a non-Gaussian diffusion model","volume":"37","author":"Xiong","year":"2016","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.sleep.2018.09.011_bib41","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1161\/CIRCULATIONAHA.107.741512","article-title":"Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea","volume":"117","author":"Jelic","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.sleep.2018.09.011_bib42","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0166-2236(99)01401-0","article-title":"Pathobiology of ischaemic stroke: an integrated view","volume":"22","author":"Dirnagl","year":"1999","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.sleep.2018.09.011_bib43","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-2990.2010.01139.x","article-title":"Review: cerebral microvascular pathology in ageing and neurodegeneration","volume":"37","author":"Brown","year":"2011","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.sleep.2018.09.011_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cns.12263","article-title":"Oligodendrocyte pathophysiology and treatment strategies in cerebral ischemia","volume":"20","author":"Mifsud","year":"2014","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.sleep.2018.09.011_bib45","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/nbm.1441","article-title":"Intravoxel water diffusion heterogeneity imaging of human high-grade gliomas","volume":"23","author":"Kwee","year":"2010","journal-title":"NMR Biomed"},{"key":"10.1016\/j.sleep.2018.09.011_bib46","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/mrm.26798","article-title":"Non-Gaussian diffusion imaging with a fractional order calculus model to predict response of gastrointestinal stromal tumor to second-line sunitinib therapy","volume":"79","author":"Tang","year":"2018","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.sleep.2018.09.011_bib47","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/mrm.22285","article-title":"Studies of anomalous diffusion in the human brain using fractional order calculus","volume":"63","author":"Zhou","year":"2010","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.sleep.2018.09.011_bib48","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1002\/jnr.23083","article-title":"Altered global and regional brain mean diffusivity in patients with obstructive sleep apnea","volume":"90","author":"Kumar","year":"2012","journal-title":"J\u00a0Neurosci Res"},{"key":"10.1016\/j.sleep.2018.09.011_bib49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neulet.2013.09.033","article-title":"Regional cerebral blood flow alterations in obstructive sleep apnea","volume":"555","author":"Yadav","year":"2013","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.sleep.2018.09.011_bib50","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/RCT.0000000000000537","article-title":"Non-Gaussian diffusion imaging shows brain myelin and axonal changes in obstructive sleep apnea","volume":"41","author":"Tummala","year":"2017","journal-title":"J\u00a0Comput Assist Tomogr"},{"key":"10.1016\/j.sleep.2018.09.011_bib51","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.neurobiolaging.2004.09.017","article-title":"Age-related alterations in white matter microstructure measured by diffusion tensor imaging","volume":"26","author":"Salat","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.sleep.2018.09.011_bib52","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5665\/sleep.5316","article-title":"Global and regional brain non-Gaussian diffusion changes in newly diagnosed patients with obstructive sleep apnea","volume":"39","author":"Tummala","year":"2016","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2018.09.011_bib53","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuroimage.2015.10.006","article-title":"Specific white matter tissue microstructure changes associated with obesity","volume":"125","author":"Kullmann","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.sleep.2018.09.011_bib54","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.bbr.2014.10.010","article-title":"Brain structure and cognitive correlates of body mass index in healthy older adults","volume":"278","author":"Bolzenius","year":"2015","journal-title":"Behav Brain Res"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945718307512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945718307512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T17:56:28Z","timestamp":1720634188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945718307512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":54,"alternative-id":["S1389945718307512"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2018.09.011","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"White matter structural differences in OSA patients experiencing residual daytime sleepiness with high CPAP use: a non-Gaussian diffusion MRI study","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2018.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}