{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:01:23Z","timestamp":1786996883636,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.sleep.2019.03.016","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T10:40:43Z","timestamp":1554547243000},"page":"6-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Eszopiclone for the treatment of primary insomnia: a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials"],"prefix":"10.1016","volume":"62","author":[{"given":"Liang","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2019.03.016_bib1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1053\/smrv.2002.0186","article-title":"Epidemiology of insomnia: what we know and what we still need to learn","volume":"6","author":"Ohayon","year":"2002","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleep.2019.03.016_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.7326\/M15-1781","article-title":"Pharmacologic treatment of insomnia disorder: an evidence report for a clinical practice guideline by the American college of physicians","volume":"165","author":"Wilt","year":"2016","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.sleep.2019.03.016_bib3","first-page":"487","article-title":"Clinical guideline for the evaluation and management of chronic insomnia in adults","volume":"4","author":"Schutte-Rodin","year":"2008","journal-title":"J\u00a0Clin Sleep Med JCSM Offic Publ Am Acad Sleep Med"},{"key":"10.1016\/j.sleep.2019.03.016_bib4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1176\/appi.ps.56.3.332","article-title":"Diagnosis and treatment of chronic insomnia: a review","volume":"56","author":"Benca","year":"2005","journal-title":"Psychiatr Serv"},{"key":"10.1016\/j.sleep.2019.03.016_bib5","first-page":"313","article-title":"Eszopiclone for late-life insomnia","volume":"2","author":"McCrae","year":"2007","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.sleep.2019.03.016_bib6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1358\/dot.2011.47.4.1590792","article-title":"Eszopiclone: an update on its use in insomnia","volume":"47","author":"Owen","year":"2011","journal-title":"Drugs Today"},{"key":"10.1016\/j.sleep.2019.03.016_bib7","doi-asserted-by":"crossref","first-page":"e8343","DOI":"10.1136\/bmj.e8343","article-title":"Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration","volume":"345","author":"Huedo-Medina","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.sleep.2019.03.016_bib8","first-page":"2359","article-title":"Eszopiclone (Lunesta) for treatment of transient and chronic insomnia","volume":"71","author":"Wessell","year":"2005","journal-title":"Am Fam Phys"},{"key":"10.1016\/j.sleep.2019.03.016_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.sleep.2004.09.001","article-title":"An assessment of the efficacy and safety of eszopiclone in the treatment of transient insomnia in healthy adults","volume":"6","author":"Rosenberg","year":"2005","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2019.03.016_bib10","doi-asserted-by":"crossref","first-page":"W65","DOI":"10.7326\/0003-4819-151-4-200908180-00136","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"151","author":"Liberati","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.sleep.2019.03.016_bib11","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.sleep.2012.08.015","article-title":"A\u00a0randomized placebo-controlled polysomnographic study of eszopiclone in Japanese patients with primary insomnia","volume":"13","author":"Uchimura","year":"2012","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2019.03.016_bib12","doi-asserted-by":"crossref","first-page":"g7647","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"350","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.sleep.2019.03.016_bib13","first-page":"489","article-title":"DSM-III: the 3d edition of the diagnostic and statistical manual of mental disorders from the American psychiatric association","volume":"142","author":"Pichot","year":"1986","journal-title":"Revue neurologique"},{"key":"10.1016\/j.sleep.2019.03.016_bib14","first-page":"607","article-title":"DSM-III (diagnostic and statistical manual of mental disorders, the 3d edition), a new diagnostic criteria in the United States","volume":"83","author":"Kasahara","year":"1981","journal-title":"Seishin shinkeigaku zasshi Psychiatria et neurologia Japonica"},{"key":"10.1016\/j.sleep.2019.03.016_bib15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.7326\/0003-4819-88-3-424","article-title":"The international classification of Diseases: ninth revision (ICD-9)","volume":"88","author":"Slee","year":"1978","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.sleep.2019.03.016_bib16","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/sleep\/17.7.630","article-title":"Clinical diagnoses in 216 insomnia patients using the international classification of sleep disorders (ICSD), DSM-IV and ICD-10 categories: a report from the APA\/NIMH DSM-IV field trial","volume":"17","author":"Buysse","year":"1994","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2019.03.016_bib17","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/jcsm.12312","article-title":"From meta-analysis to Cochrane reviews","volume":"9","author":"Ebner","year":"2018","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.sleep.2019.03.016_bib18","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/sim.5726","article-title":"Meta-analysis of randomised trials with a continuous outcome according to baseline imbalance and availability of individual participant data","volume":"32","author":"Riley","year":"2013","journal-title":"Stat Med"},{"key":"10.1016\/j.sleep.2019.03.016_bib19","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/sleep\/26.7.793","article-title":"Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia","volume":"26","author":"Krystal","year":"2003","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2019.03.016_bib20","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1185\/030079906X112741","article-title":"A\u00a0polysomnography study of eszopiclone in elderly patients with insomnia","volume":"22","author":"McCall","year":"2006","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.sleep.2019.03.016_bib21","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1185\/174234304X15174","article-title":"Efficacy and safety of eszopiclone across 6-weeks of treatment for primary insomnia","volume":"20","author":"Zammit","year":"2004","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.sleep.2019.03.016_bib22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/sleep\/33.2.225","article-title":"A\u00a012-week, randomized, double-blind, placebo-controlled study evaluating the effect of eszopiclone 2 mg on sleep\/wake function in older adults with primary and comorbid insomnia","volume":"33","author":"Ancoli-Israel","year":"2010","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2019.03.016_bib23","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/sleep\/30.8.959","article-title":"Nightly treatment of primary insomnia with eszopiclone for six months: effect on sleep, quality of life, and work limitations","volume":"30","author":"Walsh","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2019.03.016_bib24","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/sleep\/28.6.720","article-title":"A\u00a02-week efficacy and safety study of eszopiclone in elderly patients with primary insomnia","volume":"28","author":"Scharf","year":"2005","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2019.03.016_bib25","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1525-1497.2005.0243.x","article-title":"The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis","volume":"20","author":"Buscemi","year":"2005","journal-title":"J\u00a0Gen Intern Med"},{"key":"10.1016\/j.sleep.2019.03.016_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063773","article-title":"Meta-analysis: melatonin for the treatment of primary sleep disorders","volume":"8","author":"Ferracioli-Oda","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.sleep.2019.03.016_bib27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1358\/dot.2011.47.4.1590792","article-title":"Eszopiclone: an update on its use in insomnia","volume":"47","author":"Owen","year":"2011","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.sleep.2019.03.016_bib28","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0140-6736(98)04087-2","article-title":"Association of road-traffic accidents with benzodiazepine use","volume":"352","author":"Barbone","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.sleep.2019.03.016_bib29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2174\/157488606775252674","article-title":"Hypnotics and driving safety: meta-analyses of randomized controlled trials applying the on-the-road driving test","volume":"1","author":"Verster","year":"2006","journal-title":"Curr Drug Saf"},{"key":"10.1016\/j.sleep.2019.03.016_bib30","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.sleep.2015.05.021","article-title":"Residual effects of zolpidem, triazolam, rilmazafone and placebo in healthy elderly subjects: a randomized double-blind study","volume":"16","author":"Uemura","year":"2015","journal-title":"Sleep Med"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945718306518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945718306518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:14:34Z","timestamp":1761405274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945718306518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":30,"alternative-id":["S1389945718306518"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2019.03.016","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eszopiclone for the treatment of primary insomnia: a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2019.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}