{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:25:16Z","timestamp":1773282316531,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.sleep.2020.02.023","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T20:27:44Z","timestamp":1583526464000},"page":"201-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)"],"prefix":"10.1016","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4746-529X","authenticated-orcid":false,"given":"Canan","family":"Gunduz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozen K.","family":"Basoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Arthur","family":"Kvamme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Verbraecken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4273-1173","authenticated-orcid":false,"given":"Ulla","family":"Anttalainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6819-7928","authenticated-orcid":false,"given":"Oreste","family":"Marrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paschalis","family":"Steiropoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Roisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavol","family":"Joppa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Hein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Trakada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Hedner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludger","family":"Grote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Steiropoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Verbraecken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Petiet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Trakada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Montserrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Fietze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Penzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ondrej","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Rodenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.F.","family":"Masa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Bouloukaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Schiza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.T.","family":"McNicholas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.L.","family":"Riha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Kvamme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Grote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hedner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.","family":"P\u00e9pin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bailly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lavie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lavie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.K.","family":"Basoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Tasbakan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Varoneckas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Joppa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Tkacova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Staats","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Barb\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Parati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Drummond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"van Zeller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.R.","family":"Bonsignore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Marrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Petitjean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Roisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pretl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vitols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Dogas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Galic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pataka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Anttalainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Saaresranta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Plywaczewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sliwinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bielicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2020.02.023_bib1","first-page":"1311","article-title":"Obstructive sleep apnea is a common disorder in the population \u2013 a review on the epidemiology of sleep apnea","volume":"7","author":"Franklin","year":"2015","journal-title":"J\u00a0Thorac Dis"},{"key":"10.1016\/j.sleep.2020.02.023_bib2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1378\/chest.07-0040","article-title":"Adult obstructive sleep apnea","volume":"132","author":"Patil","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.sleep.2020.02.023_bib3","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1183\/09031936.00027406","article-title":"Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities","volume":"29","author":"McNicholas","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.sleep.2020.02.023_bib4","doi-asserted-by":"crossref","first-page":"15015","DOI":"10.1038\/nrdp.2015.15","article-title":"Obstructive sleep apnoea syndrome","volume":"1","author":"L\u00e9vy","year":"2015","journal-title":"Nat Rev Dis Prim"},{"key":"10.1016\/j.sleep.2020.02.023_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/13813450802307337","article-title":"Intermittent hypoxia and activation of inflammatory molecular pathways in OSAS","volume":"114","author":"Ryan","year":"2008","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.sleep.2020.02.023_bib6","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/resp.13372","article-title":"Obstructive sleep apnoea independently predicts lipid levels: data from the European Sleep Apnea Database","volume":"23","author":"G\u00fcnd\u00fcz","year":"2018","journal-title":"Respirology"},{"key":"10.1016\/j.sleep.2020.02.023_bib7","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/joim.12952","article-title":"Hyperlipidemia prevalence and cholesterol control in obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)","volume":"286","author":"Gunduz","year":"2019","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.sleep.2020.02.023_bib8","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.5664\/jcsm.4282","article-title":"Effect of CPAP treatment for obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis","volume":"10","author":"Nadeem","year":"2014","journal-title":"J\u00a0Clin Sleep Med"},{"key":"10.1016\/j.sleep.2020.02.023_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.smrv.2014.07.004","article-title":"Impact of obstructive sleep apnea treatment by continuous positive airway pressure on cardiometabolic biomarkers: a systematic review from sham CPAP randomized controlled trials","volume":"21","author":"Jullian-Desayes","year":"2015","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleep.2020.02.023_bib10","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1183\/09031936.00046710","article-title":"The European sleep apnoea database (ESADA): report from 22 European sleep laboratories","volume":"38","author":"Hedner","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.sleep.2020.02.023_bib11","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A\u00a0new method for measuring daytime sleepiness: the Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2020.02.023_bib12","series-title":"The AASM manual for the scoring of sleep and associated events: rules, terminology, and technical specification","author":"Iber","year":"2007"},{"key":"10.1016\/j.sleep.2020.02.023_bib13","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/jsr.12318","article-title":"The diagnostic method has a strong influence on classification of obstructive sleep apnea","volume":"24","author":"Escourrou","year":"2015","journal-title":"J\u00a0Sleep Res"},{"key":"10.1016\/j.sleep.2020.02.023_bib14","first-page":"40","article-title":"Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults","volume":"285","year":"2001","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.sleep.2020.02.023_bib15","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"Wilson","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.sleep.2020.02.023_bib16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"10.1016\/j.sleep.2020.02.023_bib17","article-title":"JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice","volume":"91","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.sleep.2020.02.023_bib18","doi-asserted-by":"crossref","first-page":"S4201","DOI":"10.21037\/jtd.2018.08.56","article-title":"Mechanisms of cardiovascular disease in obstructive sleep apnoea","volume":"10","author":"Ryan","year":"2018","journal-title":"J\u00a0Thorac Dis"},{"key":"10.1016\/j.sleep.2020.02.023_bib19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3390\/cells8030214","article-title":"Hypoxia-inducible factors and the regulation of lipid metabolism","volume":"8","author":"Mylonis","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.sleep.2020.02.023_bib20","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1194\/jlr.M083436","article-title":"Obstructive sleep apnea and effects of CPAP on triglyceride-rich lipoprotein metabolism","volume":"59","author":"Drager","year":"2018","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.sleep.2020.02.023_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.sleep.2007.10.011","article-title":"Nasal continuous positive airway pressure treatment reduces systemic oxidative stress in patients with severe obstructive sleep apnea syndrome","volume":"10","author":"Christou","year":"2009","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2020.02.023_bib22","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1183\/09031936.06.00067605","article-title":"Antioxidant status in patients with sleep apnoea and impact of continuous positive airway pressure treatment","volume":"27","author":"Barcel\u00f3","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.sleep.2020.02.023_bib23","first-page":"e12874","article-title":"Effect of 5-year continuous positive airway pressure treatment on the lipid profile of patients with obstructive sleep apnea: a pilot study","author":"Simon","year":"2019","journal-title":"J\u00a0Sleep Res"},{"key":"10.1016\/j.sleep.2020.02.023_bib24","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1001\/archinte.159.15.1793","article-title":"Clinical outcomes in statin treatment trials: a meta-analysis","volume":"159","author":"Ross","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.sleep.2020.02.023_bib25","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1016\/S0140-6736(16)31357-5","article-title":"Interpretation of the evidence for the efficacy and safety of statin therapy","volume":"388","author":"Collins","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.sleep.2020.02.023_bib26","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0025-7125(16)30182-1","article-title":"The effects of lowering serum cholesterol on coronary heart disease risk","volume":"78","author":"Rossouw","year":"1994","journal-title":"Med Clin N Am"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945720301039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945720301039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:22:42Z","timestamp":1761405762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945720301039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":26,"alternative-id":["S1389945720301039"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2020.02.023","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2020.02.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}