{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:41:32Z","timestamp":1793418092437,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007108","name":"George Washington University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.sleep.2020.05.034","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T11:32:03Z","timestamp":1591356723000},"page":"242-247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Intranasal oxytocin increases respiratory rate and reduces obstructive event duration and oxygen desaturation in obstructive sleep apnea patients: a randomized double blinded placebo controlled study"],"prefix":"10.1016","volume":"74","author":[{"given":"Vivek","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Kimbro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Kowalik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Milojevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Maritza Dowling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Lloyd","family":"Hunley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Del Rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mendelowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2020.05.034_bib1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1513\/pats.200709-155MG","article-title":"The epidemiology of adult obstructive sleep apnea","volume":"5","author":"Punjabi","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.sleep.2020.05.034_bib2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1161\/HYPERTENSIONAHA.106.085175","article-title":"Effect of nocturnal nasal continuous positive airway pressure on blood pressure in obstructive sleep apnea","volume":"50","author":"Bazzano","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.sleep.2020.05.034_bib3","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(05)71141-7","article-title":"Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study","volume":"365","author":"Marin","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.sleep.2020.05.034_bib4","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1253\/circj.CJ-09-0364","article-title":"Obstructive sleep apnea and cardiovascular disease","volume":"73","author":"Kato","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.sleep.2020.05.034_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000132","article-title":"Sleep-disordered breathing and mortality: a prospective cohort study","volume":"6","author":"Punjabi","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.sleep.2020.05.034_bib6","first-page":"1071","article-title":"Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort","volume":"31","author":"Young","year":"2008","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2020.05.034_bib7","first-page":"1079","article-title":"Sleep apnea as an independent risk factor for all-cause mortality: the Busselton Health Study","volume":"31","author":"Marshall","year":"2008","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2020.05.034_bib8","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1056\/NEJM199903183401104","article-title":"The association between sleep apnea and the risk of traffic accidents","volume":"340","author":"Ter\u00e1n-Santos","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.sleep.2020.05.034_bib9","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1164\/rccm.201304-0726ST","article-title":"An official American Thoracic Society Clinical Practice Guideline: sleep apnea, sleepiness, and driving risk in noncommercial drivers. An update of a 1994 Statement","volume":"187","author":"Strohl","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2020.05.034_bib10","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMoa1606599","article-title":"CPAP for prevention of cardiovascular events in obstructive sleep apnea","volume":"375","author":"McEvoy","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.sleep.2020.05.034_bib11","doi-asserted-by":"crossref","first-page":"H1549","DOI":"10.1152\/ajpheart.00808.2015","article-title":"Oxytocin neuron activation prevents hypertension that occurs with chronic intermittent hypoxia\/hypercapnia in rats","volume":"310","author":"Jameson","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.sleep.2020.05.034_bib12","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1152\/japplphysiol.00839.2001","article-title":"Paraventricular oxytocin neurons are involved in neural modulation of breathing","volume":"92","author":"Mack","year":"2002","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.sleep.2020.05.034_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.resp.2010.08.001","article-title":"Modulation of cardiorespiratory function mediated by the paraventricular nucleus","volume":"174","author":"Kc","year":"2010","journal-title":"Respir Physiol Neurobiol"},{"issue":"80","key":"10.1016\/j.sleep.2020.05.034_bib14","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1126\/science.7201163","article-title":"Oxytocin, vasopressin, and estrogen-stimulated neurophysin: daily patterns of concentration in cerebrospinal fluid","volume":"216","author":"Perlow","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.sleep.2020.05.034_bib15","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1038\/srep03440","article-title":"Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans","volume":"3","author":"Striepens","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.sleep.2020.05.034_bib16","doi-asserted-by":"crossref","first-page":"L825","DOI":"10.1152\/ajplung.00206.2017","article-title":"Benefits of oxytocin administration in obstructive sleep apnea","volume":"313","author":"Jain","year":"2017","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.sleep.2020.05.034_bib17","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s11325-019-01798-3","article-title":"The reduction of apnea\u2013hypopnea duration ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in a rat model of obstructive sleep apnea","volume":"23","author":"Wu","year":"2019","journal-title":"Sleep Breath"},{"key":"10.1016\/j.sleep.2020.05.034_bib18","series-title":"2014 36th annu. Int. Conf. IEEE eng. Med. Biol. Soc. EMBC 2014","first-page":"270","article-title":"Effect of apnea duration on apnea induced variations in cerebral blood flow velocity and arterial blood pressure","volume":"vol. 2014","author":"Alex","year":"2014"},{"key":"10.1016\/j.sleep.2020.05.034_bib19","first-page":"e5493","article-title":"Mean apnea-hypopnea duration (but not apnea-hypopnea index) is associated with worse hypertension in patients with obstructive sleep apnea","volume":"95","author":"Wu","year":"2016","journal-title":"Med (United States)"},{"key":"10.1016\/j.sleep.2020.05.034_bib20","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/jsr.12070","article-title":"The severity of individual obstruction events is related to increased mortality rate in severe obstructive sleep apnea","volume":"22","author":"Muraja-Murro","year":"2013","journal-title":"J\u00a0Sleep Res"},{"key":"10.1016\/j.sleep.2020.05.034_bib21","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s11517-013-1039-4","article-title":"Novel parameters indicate significant differences in severity of obstructive sleep apnea with patients having similar apnea-hypopnea index","volume":"51","author":"Kulkas","year":"2013","journal-title":"Med Biol Eng Comput"},{"key":"10.1016\/j.sleep.2020.05.034_bib22","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3389\/fneur.2018.00962","article-title":"Silencing of hypoglossal motoneurons leads to sleep disordered breathing in lean mice","volume":"9","author":"Fleury Curado","year":"2018","journal-title":"Front Neurol"},{"key":"10.1016\/j.sleep.2020.05.034_bib23","doi-asserted-by":"crossref","first-page":"44392","DOI":"10.1038\/srep44392","article-title":"Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency","volume":"7","author":"Fleury Curado","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.sleep.2020.05.034_bib24","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1152\/jappl.1996.81.6.2618","article-title":"Effect of topical upper airway anesthesia on apnea duration through the night in obstructive sleep apnea","volume":"81","author":"Cala","year":"1996","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.sleep.2020.05.034_bib25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0006-8993(94)90213-5","article-title":"Action of vasopressin on hypoglossal motoneurons of the rat: presynaptic and postsynaptic effects","volume":"650","author":"Palouzier-Paulignan","year":"1994","journal-title":"Brain Res"},{"key":"10.1016\/j.sleep.2020.05.034_bib26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/japplphysiol.00522.2006","article-title":"Stimulation of the hypothalamic paraventricular nucleus modulates cardiorespiratory responses via oxytocinergic innervation of neurons in pre-B\u00f6tzinger complex","volume":"102","author":"Mack","year":"2007","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.sleep.2020.05.034_bib27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/pcn.12627","article-title":"Systematic review and meta-analysis of reported adverse events of long-term intranasal oxytocin treatment for autism spectrum disorder","volume":"72","author":"Cai","year":"2018","journal-title":"Psychiatr Clin Neurosci"},{"key":"10.1016\/j.sleep.2020.05.034_bib28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jpsychires.2017.12.014","article-title":"Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: a randomized, placebo-controlled pilot trial","volume":"98","author":"Flanagan","year":"2018","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.sleep.2020.05.034_bib29","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3109\/16066359.2016.1173682","article-title":"A\u00a0two-week pilot study of intranasal oxytocin for cocaine-dependent individuals receiving methadone maintenance treatment for opioid use disorder","volume":"24","author":"Stauffer","year":"2016","journal-title":"Addiction Res Theor"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945720302446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945720302446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:23:04Z","timestamp":1761405784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945720302446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":29,"alternative-id":["S1389945720302446"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2020.05.034","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intranasal oxytocin increases respiratory rate and reduces obstructive event duration and oxygen desaturation in obstructive sleep apnea patients: a randomized double blinded placebo controlled study","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2020.05.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}