{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:23:33Z","timestamp":1787909013592,"version":"build-2784847793"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011096","name":"Jazz Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.sleep.2021.06.010","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T11:00:46Z","timestamp":1624100446000},"page":"380-388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Assessing the impact of sodium oxybate treatment on functioning, productivity, and health-related quality of life in patients with narcolepsy: findings from the Nexus Narcolepsy Registry (waves 1\u20134)"],"prefix":"10.1016","volume":"84","author":[{"given":"Michael J.","family":"Thorpy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice M.","family":"Ohayon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginger","family":"Carls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jed","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2637-9293","authenticated-orcid":false,"given":"David J.","family":"Pasta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5669-7121","authenticated-orcid":false,"given":"Danielle L.","family":"Hyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen F.","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.sleep.2021.06.010_bib1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.sleep.2014.02.001","article-title":"The Burden of Narcolepsy Disease (BOND) study: health-care utilization and cost findings","volume":"15","author":"Black","year":"2014","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2021.06.010_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.sleep.2016.04.004","article-title":"Medical comorbidity in narcolepsy: findings from the Burden of Narcolepsy Disease (BOND) study","volume":"33","author":"Black","year":"2017","journal-title":"Sleep Med"},{"issue":"4","key":"10.1016\/j.sleep.2021.06.010_bib3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.sleep.2007.03.008","article-title":"Clinical and neurobiological aspects of narcolepsy","volume":"8","author":"Nishino","year":"2007","journal-title":"Sleep Med"},{"issue":"1","key":"10.1016\/j.sleep.2021.06.010_bib4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jsmc.2016.10.001","article-title":"Reducing the clinical and socioeconomic burden of narcolepsy by earlier diagnosis and effective treatment","volume":"12","author":"Thorpy","year":"2017","journal-title":"Sleep Med Clin"},{"key":"10.1016\/j.sleep.2021.06.010_bib5","series-title":"International classification of sleep disorders","author":"American Academy of Sleep Medicine","year":"2014"},{"issue":"12","key":"10.1016\/j.sleep.2021.06.010_bib6","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1212\/WNL.58.12.1826","article-title":"Prevalence of narcolepsy symptomatology and diagnosis in the European general population","volume":"58","author":"Ohayon","year":"2002","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.sleep.2021.06.010_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/sleep\/25.2.197","article-title":"The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study","volume":"25","author":"Silber","year":"2002","journal-title":"Sleep"},{"issue":"1","key":"10.1016\/j.sleep.2021.06.010_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/sleep\/30.1.13","article-title":"The epidemiology of narcolepsy","volume":"30","author":"Longstreth","year":"2007","journal-title":"Sleep"},{"issue":"4","key":"10.1016\/j.sleep.2021.06.010_bib9","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.sleep.2008.05.009","article-title":"Prevalence of narcolepsy in King County, Washington, USA","volume":"10","author":"Longstreth","year":"2009","journal-title":"Sleep Med"},{"issue":"3","key":"10.1016\/j.sleep.2021.06.010_bib10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.5664\/jcsm.6494","article-title":"Listening to the patient voice in narcolepsy: diagnostic delay, disease burden, and treatment efficacy","volume":"13","author":"Maski","year":"2017","journal-title":"J\u00a0Clin Sleep Med"},{"issue":"6","key":"10.1016\/j.sleep.2021.06.010_bib11","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/jsr.12420","article-title":"Diagnostic delay in narcolepsy type 1: combining the patients' and the doctors' perspectives","volume":"25","author":"Taddei","year":"2016","journal-title":"J\u00a0Sleep Res"},{"issue":"10","key":"10.1016\/j.sleep.2021.06.010_bib12","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1468-1331.2006.01473.x","article-title":"EFNS guidelines on management of narcolepsy","volume":"13","author":"Billiard","year":"2006","journal-title":"Eur J Neurol"},{"issue":"12","key":"10.1016\/j.sleep.2021.06.010_bib13","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1093\/sleep\/30.12.1705","article-title":"Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin","volume":"30","author":"Morgenthaler","year":"2007","journal-title":"Sleep"},{"issue":"1","key":"10.1016\/j.sleep.2021.06.010_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.sleep.2014.10.002","article-title":"Clinical and practical considerations in the pharmacologic management of narcolepsy","volume":"16","author":"Thorpy","year":"2015","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2021.06.010_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.smrv.2018.09.006","article-title":"Neurobiological and immunogenetic aspects of narcolepsy: implications for pharmacotherapy","volume":"43","author":"Szabo","year":"2019","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleep.2021.06.010_bib16","series-title":"Xyrem [summary of product characteristics]","year":"2021"},{"key":"10.1016\/j.sleep.2021.06.010_bib17","series-title":"Xyrem [product monograph including patient medication information]","year":"2018"},{"key":"10.1016\/j.sleep.2021.06.010_bib18","series-title":"Xyrem (sodium oxybate) oral solution Prescribing Information","year":"2020"},{"issue":"7","key":"10.1016\/j.sleep.2021.06.010_bib19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/sleep\/29.7.939","article-title":"Sodium oxybate improves excessive daytime sleepiness in narcolepsy","volume":"29","author":"Black","year":"2006","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.sleep.2021.06.010_bib20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.sleep.2003.11.002","article-title":"Sodium oxybate demonstrates long-term efficacy for the treatment of cataplexy in patients with narcolepsy","volume":"5","year":"2004","journal-title":"Sleep Med"},{"issue":"1","key":"10.1016\/j.sleep.2021.06.010_bib21","first-page":"42","article-title":"A\u00a0randomized, double blind, placebo-controlled multicenter trial comparing the effects of three doses of orally administered sodium oxybate with placebo for the treatment of narcolepsy","volume":"25","year":"2002","journal-title":"Sleep"},{"issue":"4","key":"10.1016\/j.sleep.2021.06.010_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.5664\/jcsm.26368","article-title":"A\u00a0double-blind, placebo-controlled study demonstrates sodium oxybate is effective for the treatment of excessive daytime sleepiness in narcolepsy","volume":"1","year":"2005","journal-title":"J\u00a0Clin Sleep Med"},{"issue":"7","key":"10.1016\/j.sleep.2021.06.010_bib23","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S2352-4642(18)30133-0","article-title":"Treatment of paediatric narcolepsy with sodium oxybate: a double-blind, placebo-controlled, randomised-withdrawal multicentre study and open-label investigation","volume":"2","author":"Plazzi","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"issue":"4","key":"10.1016\/j.sleep.2021.06.010_bib24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/jsr.12468","article-title":"Effect of sodium oxybate on disrupted nighttime sleep in patients with narcolepsy","volume":"26","author":"Roth","year":"2017","journal-title":"J\u00a0Sleep Res"},{"issue":"8","key":"10.1016\/j.sleep.2021.06.010_bib25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.sleep.2009.05.004","article-title":"The nightly administration of sodium oxybate results in significant reduction in the nocturnal sleep disruption of patients with narcolepsy","volume":"10","author":"Black","year":"2009","journal-title":"Sleep Med"},{"issue":"6","key":"10.1016\/j.sleep.2021.06.010_bib26","doi-asserted-by":"crossref","first-page":"596","DOI":"10.5664\/jcsm.27994","article-title":"The nightly use of sodium oxybate is associated with a reduction in nocturnal sleep disruption: a double-blind, placebo-controlled study in patients with narcolepsy","volume":"6","author":"Black","year":"2010","journal-title":"J\u00a0Clin Sleep Med"},{"key":"10.1016\/j.sleep.2021.06.010_bib27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.sleep.2017.07.030","article-title":"Effect of sodium oxybate, modafinil, and their combination on disrupted nighttime sleep in narcolepsy","volume":"40","author":"Dauvilliers","year":"2017","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2021.06.010_bib28","first-page":"CD003724","article-title":"Antidepressant drugs for narcolepsy","volume":"1","author":"Vignatelli","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"10.1016\/j.sleep.2021.06.010_bib29","doi-asserted-by":"crossref","first-page":"715","DOI":"10.5664\/jcsm.2848","article-title":"Status cataplecticus precipitated by abrupt withdrawal of venlafaxine","volume":"9","author":"Wang","year":"2013","journal-title":"J\u00a0Clin Sleep Med"},{"issue":"4","key":"10.1016\/j.sleep.2021.06.010_bib30","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.sleep.2008.04.004","article-title":"Exacerbation of cataplexy following gradual withdrawal of antidepressants: manifestation of probable protracted rebound cataplexy","volume":"10","author":"Ristanovic","year":"2009","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2021.06.010_bib31","series-title":"Wakix [package insert]","year":"2020"},{"key":"10.1016\/j.sleep.2021.06.010_bib32","series-title":"Wakix [summary of product characteristics]","year":"2019"},{"issue":"3","key":"10.1016\/j.sleep.2021.06.010_bib33","doi-asserted-by":"crossref","first-page":"401","DOI":"10.5664\/jcsm.5594","article-title":"The humanistic and economic burden of narcolepsy","volume":"12","author":"Flores","year":"2016","journal-title":"J\u00a0Clin Sleep Med"},{"issue":"27","key":"10.1016\/j.sleep.2021.06.010_bib34","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1056\/NEJMra1500587","article-title":"Narcolepsy","volume":"373","author":"Scammell","year":"2015","journal-title":"N\u00a0Engl J Med"},{"issue":"10","key":"10.1016\/j.sleep.2021.06.010_bib35","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.sleep.2010.07.010","article-title":"Sleep disorders and accidental risk in a large group of regular registered highway drivers","volume":"11","author":"Philip","year":"2010","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2021.06.010_bib36","article-title":"Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims","author":"US Food and Drug Administration","year":"2009","journal-title":"Health Qual Life Outcome"},{"issue":"2","key":"10.1016\/j.sleep.2021.06.010_bib37","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s40120-017-0076-6","article-title":"Correlation of changes in patient-reported quality of life with physician-rated global impression of change in patients with narcolepsy participating in a clinical trial of sodium oxybate: a post hoc analysis","volume":"6","author":"Bogan","year":"2017","journal-title":"Neurol Ther"},{"issue":"suppl 1","key":"10.1016\/j.sleep.2021.06.010_bib38","first-page":"1086","article-title":"Demographics and diagnosis experience of people with narcolepsy: first wave results from the Nexus Narcolepsy Registry [abstract]","volume":"39","author":"Thorpy","year":"2016","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.sleep.2021.06.010_bib39","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A\u00a0new method for measuring daytime sleepiness: the Epworth Sleepiness Scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"issue":"7","key":"10.1016\/j.sleep.2021.06.010_bib40","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/sleep\/32.7.915","article-title":"Development of the FOSQ-10: a short version of the functional outcomes of sleep questionnaire","volume":"32","author":"Chasens","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2021.06.010_bib41","series-title":"SF-36 health survey manual and interpretation guide","author":"Ware","year":"1993"},{"issue":"5","key":"10.1016\/j.sleep.2021.06.010_bib42","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2165\/00019053-199304050-00006","article-title":"The validity and reproducibility of a work productivity and activity impairment instrument","volume":"4","author":"Reilly","year":"1993","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.sleep.2021.06.010_bib43","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.sleep.2019.11.1250","article-title":"Measures of functional outcomes, work productivity, and quality of life from a randomized, phase 3 study of solriamfetol in participants with narcolepsy","volume":"67","author":"Emsellem","year":"2020","journal-title":"Sleep Med"},{"issue":"8","key":"10.1016\/j.sleep.2021.06.010_bib44","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1513\/AnnalsATS.202002-136OC","article-title":"Effects of solriamfetol on quality of life measures from a 12-week phase 3 randomized trial","volume":"17","author":"Weaver","year":"2020","journal-title":"Ann Am Thorac Soc"},{"issue":"9","key":"10.1016\/j.sleep.2021.06.010_bib45","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/sleep\/29.9.1189","article-title":"A\u00a0randomized trial evaluating the effectiveness of sodium oxybate therapy on quality of life in narcolepsy","volume":"29","author":"Weaver","year":"2006","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.sleep.2021.06.010_bib46","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s40120-016-0053-5","article-title":"Evaluation of quality of life in patients with narcolepsy treated with sodium oxybate: use of the 36-Item Short-Form Health Survey in a clinical trial","volume":"5","author":"Bogan","year":"2016","journal-title":"Neurol Ther"},{"key":"10.1016\/j.sleep.2021.06.010_bib47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.sleep.2016.07.010","article-title":"Impact of sodium oxybate, modafinil, and combination treatment on excessive daytime sleepiness in patients who have narcolepsy with or without cataplexy","volume":"24","author":"Black","year":"2016","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2021.06.010_bib48","author":"United States Census Bureau"},{"key":"10.1016\/j.sleep.2021.06.010_bib49","series-title":"Current population reports, P60-260, health insurance coverage in the United States: 2016","author":"Barnett","year":"2017"},{"issue":"4","key":"10.1016\/j.sleep.2021.06.010_bib50","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1086\/318638","article-title":"The effects of response rate changes on the index of consumer sentiment","volume":"64","author":"Curtin","year":"2000","journal-title":"Publ Opin Q"},{"issue":"2","key":"10.1016\/j.sleep.2021.06.010_bib51","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1086\/317761","article-title":"Experiments with incentives in telephone surveys","volume":"64","author":"Singer","year":"2000","journal-title":"Publ Opin Q"},{"issue":"3","key":"10.1016\/j.sleep.2021.06.010_bib52","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1086\/317990","article-title":"Leverage-saliency theory of survey participation: description and an illustration","volume":"64","author":"Groves","year":"2000","journal-title":"Publ Opin Q"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945721003452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945721003452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:31:10Z","timestamp":1761406270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945721003452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":52,"alternative-id":["S1389945721003452"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2021.06.010","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing the impact of sodium oxybate treatment on functioning, productivity, and health-related quality of life in patients with narcolepsy: findings from the Nexus Narcolepsy Registry (waves 1\u20134)","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2021.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}