{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:49:25Z","timestamp":1771663765819,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.sleep.2021.08.002","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T23:55:23Z","timestamp":1628726123000},"page":"48-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The impact of obstructive sleep apnea on endothelial function during weight loss in an obese pediatric population"],"prefix":"10.1016","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-9600","authenticated-orcid":false,"given":"Sofie","family":"Jacobs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8460-1054","authenticated-orcid":false,"given":"Emilie","family":"Mylemans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijke","family":"Ysebaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eline","family":"Vermeiren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"De Guchtenaere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde","family":"Heuten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-9925","authenticated-orcid":false,"given":"Luc","family":"Bruyndonckx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0327-6304","authenticated-orcid":false,"given":"Benedicte Y.","family":"De Winter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Van Hoorenbeeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stijn L.","family":"Verhulst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4722-969X","authenticated-orcid":false,"given":"Annelies","family":"Van Eyck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2021.08.002_bib1","series-title":"Obesity and overweight","author":"World Health Organization","year":"2016"},{"key":"10.1016\/j.sleep.2021.08.002_bib2","series-title":"Brussel","article-title":"Gezondheidsenqu\u00eate 2018: voedinsstatus","author":"Drieskens","year":"2018"},{"key":"10.1016\/j.sleep.2021.08.002_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0026-0495(96)90060-8","article-title":"Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study","volume":"45","author":"Srinivasan","year":"1996","journal-title":"Metabolism"},{"key":"10.1016\/j.sleep.2021.08.002_bib4","first-page":"124","article-title":"Cardiovascular consequences of childhood obesity","volume":"31","author":"McCrindle","year":"2015","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.sleep.2021.08.002_bib5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1164\/ajrccm.164.1.2008171","article-title":"Sleep-disordered breathing in children","volume":"164","author":"Marcus","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2021.08.002_bib6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.smrv.2007.11.002","article-title":"The prevalence, anatomical correlates and treatment of sleep-disordered breathing in obese children and adolescents","volume":"12","author":"Verhulst","year":"2008","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleep.2021.08.002_bib7","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.chest.2019.02.011","article-title":"OSA and cardiovascular risk in pediatrics","volume":"156","author":"Smith","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.sleep.2021.08.002_bib8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1164\/rccm.200703-375OC","article-title":"Association between metabolic syndrome and sleep-disordered breathing in adolescents","volume":"176","author":"Redline","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2021.08.002_bib9","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.sleep.2007.04.013","article-title":"Systemic inflammation in non-obese children with obstructive sleep apnea","volume":"9","author":"Gozal","year":"2008","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2021.08.002_bib10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1183\/23120541.00038-2016","article-title":"Sleep disordered breathing and autonomic function in overweight and obese children and adolescents","volume":"2","author":"Van Eyck","year":"2016","journal-title":"ERJ Open Research"},{"key":"10.1016\/j.sleep.2021.08.002_bib11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/oby.2011.282","article-title":"Weight loss and sleep-disordered breathing in childhood obesity: effects on inflammation and uric acid","volume":"20","author":"Van Hoorenbeeck","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.sleep.2021.08.002_bib12","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1161\/CIRCULATIONAHA.107.696823","article-title":"Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy","volume":"116","author":"Gozal","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.sleep.2021.08.002_bib13","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1378\/chest.11-1777","article-title":"Endothelial dysfunction in children without hypertension: potential contributions of obesity and obstructive sleep apnea","volume":"141","author":"Bhattacharjee","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.sleep.2021.08.002_bib14","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1542\/peds.2014-1577","article-title":"Diet, exercise, and endothelial function in obese adolescents","volume":"135","author":"Bruyndonckx","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.sleep.2021.08.002_bib15","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/oby.2008.673","article-title":"The effect of weight loss on sleep-disordered breathing in obese teenagers","volume":"17","author":"Verhulst","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.sleep.2021.08.002_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jpeds.2017.12.056","article-title":"Clinical predictors of residual sleep apnea after weight loss therapy in obese adolescents","volume":"196","author":"Van Eyck","year":"2018","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.sleep.2021.08.002_bib17","first-page":"244","article-title":"Inpatient treatment of children and adolescents with severe obesity","volume":"22","author":"Tanghe","year":"2020","journal-title":"Belgian Journal of Paediatrics"},{"key":"10.1016\/j.sleep.2021.08.002_bib18","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3109\/03014460903049074","article-title":"References for growth and pubertal development from birth to 21 years in Flanders (Belgium)","volume":"36","author":"Roelants","year":"2009","journal-title":"Ann Hum Biol"},{"key":"10.1016\/j.sleep.2021.08.002_bib19","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1136\/bmj.320.7244.1240","article-title":"Establishing a standard definition for child overweight and obesity worldwide: international survey","volume":"320","author":"Cole","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.sleep.2021.08.002_bib20","first-page":"140","article-title":"Clinical practice guideline for screening and management of high blood pressure in children and adolescents","author":"Flynn","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.sleep.2021.08.002_bib21","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1016\/j.ijcard.2013.07.236","article-title":"Methodological considerations and practical recommendations for the application of peripheral arterial tonometry in children and adolescents","volume":"168","author":"Bruyndonckx","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.sleep.2021.08.002_bib22","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12872-019-1167-3","article-title":"Establishing the interchangeability of arterial stiffness but not endothelial function parameters in healthy individuals","volume":"19","author":"Perrault","year":"2019","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.sleep.2021.08.002_bib23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/thx.2010.152801","article-title":"A\u00a0simplified model of screening questionnaire and home monitoring for obstructive sleep apnoea in primary care","volume":"66","author":"Chai-Coetzer","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.sleep.2021.08.002_bib24","article-title":"Validation of the ApneaLink\u2122 for the screening of sleep apnea: a novel and simple single-channel recording device","volume":"3","author":"Erman","year":"2007","journal-title":"J\u00a0Clin Sleep Med"},{"key":"10.1016\/j.sleep.2021.08.002_bib25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1183\/13993003.00385-2015","article-title":"Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management","volume":"47","author":"Kaditis","year":"2016","journal-title":"Eur Respir J"},{"key":"10.1016\/j.sleep.2021.08.002_bib26","doi-asserted-by":"crossref","first-page":"665","DOI":"10.5664\/jcsm.6576","article-title":"AASM scoring manual updates for 2017 (version 2.4)","volume":"13","author":"Berry","year":"2017","journal-title":"J\u00a0Clin Sleep Med"},{"key":"10.1016\/j.sleep.2021.08.002_bib27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.sleep.2015.11.014","article-title":"Sleep-disordered breathing, systemic adipokine secretion and metabolic dysregulation in overweight and obese children and adolescents","volume":"30","author":"Van Eyck","year":"2017","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2021.08.002_bib28","doi-asserted-by":"crossref","first-page":"268","DOI":"10.5664\/JCSM.1068","article-title":"Relationship between sleep apnea, fat distribution, and insulin resistance in obese children","volume":"7","author":"Canapari","year":"2011","journal-title":"J\u00a0Clin Sleep Med"},{"key":"10.1016\/j.sleep.2021.08.002_bib29","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1164\/rccm.201008-1249OC","article-title":"Upper airway structure and body fat composition in obese children with obstructive sleep apnea syndrome","volume":"183","author":"Arens","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2021.08.002_bib30","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/S0140-6736(01)06525-4","article-title":"Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study","volume":"358","author":"Tounian","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.sleep.2021.08.002_bib31","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jpeds.2009.04.060","article-title":"Impaired vascular function in obese adolescents with insulin resistance","volume":"155","author":"Mahmud","year":"2009","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.sleep.2021.08.002_bib32","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1467-789X.2011.00956.x","article-title":"Endothelial dysfunction, inflammation, and oxidative stress in obese children and adolescents: markers and effect of lifestyle intervention","volume":"13","author":"Montero","year":"2012","journal-title":"Obes Rev"},{"key":"10.1016\/j.sleep.2021.08.002_bib33","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s11906-020-01100-x","article-title":"Effect of sleep disorders on blood pressure and hypertension in children","volume":"22","author":"DelRosso","year":"2020","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.sleep.2021.08.002_bib34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.sleep.2018.07.023","article-title":"Polysomnographic correlates of endothelial function in children with obstructive sleep apnea","volume":"52","author":"Zhang","year":"2018","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2021.08.002_bib35","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.sleep.2013.02.010","article-title":"Obstructive sleep apnea in children is associated with severity-dependent deterioration in overnight endothelial function","volume":"14","author":"Kheirandish-Gozal","year":"2013","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2021.08.002_bib36","doi-asserted-by":"crossref","first-page":"e1161","DOI":"10.1542\/peds.2010-0688","article-title":"Neurocognitive and endothelial dysfunction in children with obstructive sleep apnea","volume":"126","author":"Gozal","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.sleep.2021.08.002_bib37","first-page":"217","article-title":"The cardiovascular risk in paediatrics: the paradigm of the obstructive sleep apnoea syndrome","volume":"18","author":"Zaffanello","year":"2020","journal-title":"Blood Transfus"},{"key":"10.1016\/j.sleep.2021.08.002_bib38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijporl.2019.04.031","article-title":"Impact of weight-loss management on children and adolescents with obesity and obstructive sleep apnea","volume":"123","author":"Andersen","year":"2019","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.1016\/j.sleep.2021.08.002_bib39","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1183\/09031936.00013815","article-title":"Treatment outcomes of obstructive sleep apnoea in obese community-dwelling children: the NANOS study","volume":"46","author":"Alonso-Alvarez","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.sleep.2021.08.002_bib40","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1136\/hrt.2005.061317","article-title":"Childhood origins of endothelial dysfunction","volume":"91","author":"Halcox","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.sleep.2021.08.002_bib41","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/j.jacc.2011.06.063","article-title":"Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events","volume":"58","author":"Mozaffarian","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.sleep.2021.08.002_bib42","first-page":"119","article-title":"Effect of long-term Vitamin C intake on vascular endothelial function in diabetic children and adolescents: a pilot study","volume":"21","author":"Sabri","year":"2016","journal-title":"J\u00a0Res Med Sci"},{"key":"10.1016\/j.sleep.2021.08.002_bib43","doi-asserted-by":"crossref","first-page":"118398","DOI":"10.1016\/j.lfs.2020.118398","article-title":"Nobiletin ameliorates high-fat diet-induced vascular and renal changes by reducing inflammation with modulating AdipoR1 and TGF-beta1 expression in rats","volume":"260","author":"Bunbupha","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.sleep.2021.08.002_bib44","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/sleep\/30.6.703","article-title":"Two year reduction in sleep apnea symptoms and associated diabetes incidence after weight loss in severe obesity","volume":"30","author":"Grunstein","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2021.08.002_bib45","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/sj.ijo.0803363","article-title":"The effect of sibutramine-assisted weight loss in men with obstructive sleep apnoea","volume":"31","author":"Yee","year":"2007","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.sleep.2021.08.002_bib46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5664\/jcsm.1912","article-title":"The utility of a portable recording device for screening of obstructive sleep apnea in obese adolescents","volume":"8","author":"Lesser","year":"2012","journal-title":"J\u00a0Clin Sleep Med"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945721004342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945721004342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:33:38Z","timestamp":1761406418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945721004342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":46,"alternative-id":["S1389945721004342"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2021.08.002","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of obstructive sleep apnea on endothelial function during weight loss in an obese pediatric population","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2021.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}