{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:19:53Z","timestamp":1778858393705,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.sleep.2021.10.035","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T22:47:53Z","timestamp":1636670873000},"page":"84-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The association of saccadic abnormalities with rem sleep in patients with Huntington's disease"],"prefix":"10.1016","volume":"93","author":[{"given":"Jagadish","family":"Annapureddy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0072-7838","authenticated-orcid":false,"given":"Somdattaa","family":"Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4085-2377","authenticated-orcid":false,"given":"Nitish","family":"Kamble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulshan","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3000-7268","authenticated-orcid":false,"given":"Pramod Kumar","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seshagiri","family":"DV","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9508-351X","authenticated-orcid":false,"given":"Sanjeev","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindu","family":"Kutty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8016-9089","authenticated-orcid":false,"given":"Ravi","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.sleep.2021.10.035_bib1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1192\/bjp.171.4.393c","article-title":"Sleep disturbance and Huntingdon's disease","volume":"171","author":"Taylor","year":"1997","journal-title":"Br J Psychiatr"},{"issue":"6","key":"10.1016\/j.sleep.2021.10.035_bib2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1159\/000480701","article-title":"Subjective assessment of sleep in Huntington disease: reliability of sleep questionnaires compared to polysomnography","volume":"17","author":"Piano","year":"2017","journal-title":"Neurodegener Dis"},{"issue":"4","key":"10.1016\/j.sleep.2021.10.035_bib3","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/ana.24495","article-title":"Sleep deficits but no metabolic deficits in premanifest Huntington's disease","volume":"78","author":"Lazar","year":"2015","journal-title":"Ann Neurol"},{"issue":"9","key":"10.1016\/j.sleep.2021.10.035_bib4","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.5665\/sleep.4996","article-title":"Polysomnographic findings and clinical correlates in Huntington disease: a cross-sectional cohort study","volume":"38","author":"Piano","year":"2015","journal-title":"Sleep"},{"issue":"9","key":"10.1016\/j.sleep.2021.10.035_bib5","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1002\/mds.21002","article-title":"Excessive daytime sleepiness in patients with Parkinson's disease: a polysomnography study","volume":"21","author":"Shpirer","year":"2006","journal-title":"Mov Disord: official journal of the Movement Disorder Society"},{"issue":"1","key":"10.1016\/j.sleep.2021.10.035_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s41782-021-00144-6","article-title":"Patients with primary cervical dystonia have significant sleep impairment and polysomnographic abnormalities","volume":"5","author":"Ray","year":"2021","journal-title":"Sleep and Vigilance"},{"key":"10.1016\/j.sleep.2021.10.035_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.sleep.2017.09.030","article-title":"Challenges in sleep stage R scoring in patients with autosomal dominant spinocerebellar ataxias (SCA1, SCA2 and SCA3) and oculomotor abnormalities: a whole night polysomnographic evaluation","volume":"42","author":"Seshagiri","year":"2018","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2021.10.035_bib8","series-title":"DeJong's the neurologic examination","first-page":"818","author":"Jellinger","year":"2013"},{"issue":"13","key":"10.1016\/j.sleep.2021.10.035_bib9","doi-asserted-by":"crossref","first-page":"e1255","DOI":"10.1212\/WNL.0000000000006250","article-title":"Optokinetic nystagmus in patients with SCA: a bedside test for oculomotor dysfunction grading","volume":"91","author":"Seshagiri","year":"2018","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.sleep.2021.10.035_bib10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified huntington's disease rating scale: reliability and consistency. Huntington study group","volume":"11","year":"1996","journal-title":"Mov Disord"},{"issue":"4","key":"10.1016\/j.sleep.2021.10.035_bib11","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1001\/archneur.65.4.482","article-title":"Rapid eye movement sleep disturbances in Huntington disease","volume":"65","author":"Arnulf","year":"2008","journal-title":"Arch Neurol"},{"issue":"2","key":"10.1016\/j.sleep.2021.10.035_bib12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.psychres.2010.04.030","article-title":"Earliest functional declines in Huntington disease","volume":"178","author":"Beglinger","year":"2010","journal-title":"Psychiatr Res"},{"issue":"5","key":"10.1016\/j.sleep.2021.10.035_bib13","doi-asserted-by":"crossref","first-page":"475","DOI":"10.5664\/jcsm.2670","article-title":"Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in a community-based sample","volume":"9","author":"Boeve","year":"2013","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"10.1016\/j.sleep.2021.10.035_bib14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1389-9457(02)00258-7","article-title":"Validation of the international restless legs syndrome study group rating scale for restless legs syndrome","volume":"4","author":"Walters","year":"2003","journal-title":"Sleep Med"},{"issue":"6","key":"10.1016\/j.sleep.2021.10.035_bib15","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A\u00a0new method for measuring daytime sleepiness: the Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.sleep.2021.10.035_bib16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res"},{"issue":"4","key":"10.1016\/j.sleep.2021.10.035_bib17","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","article-title":"Development of a rating scale for primary depressive illness","volume":"6","author":"Hamilton","year":"1967","journal-title":"Br J Soc Clin Psychol"},{"key":"10.1016\/j.sleep.2021.10.035_bib18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br J Med Psychol"},{"key":"10.1016\/j.sleep.2021.10.035_bib19","series-title":"The AASM manual for the scoring of sleep and associated events","author":"Berry","year":"2017"},{"issue":"4","key":"10.1016\/j.sleep.2021.10.035_bib20","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1176\/jnp.17.4.496","article-title":"Depression and stages of Huntington's disease","volume":"17","author":"Paulsen","year":"2005","journal-title":"J\u00a0Neuropsychiatry"},{"issue":"4","key":"10.1016\/j.sleep.2021.10.035_bib21","first-page":"203","article-title":"Nocturnal sleep in Huntington's disease","volume":"238","author":"Wiegand","year":"1991","journal-title":"J\u00a0Neurol"},{"issue":"6","key":"10.1016\/j.sleep.2021.10.035_bib22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.parkreldis.2008.10.002","article-title":"Daytime somnolence and nocturnal sleep disturbances in Huntington disease","volume":"15","author":"Videnovic","year":"2009","journal-title":"Park Relat Disord"},{"key":"10.1016\/j.sleep.2021.10.035_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/currents.RRN1189","article-title":"Identifying sleep disturbances in Huntington's disease using a simple disease-focused questionnaire","volume":"2","author":"Goodman","year":"2010","journal-title":"PLoS currents"},{"issue":"11","key":"10.1016\/j.sleep.2021.10.035_bib24","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1212\/01.wnl.0000247054.90322.14","article-title":"Stages of sleep pathology in spinocerebellar ataxia type 2 (SCA2)","volume":"67","author":"Tuin","year":"2006","journal-title":"Neurology"},{"issue":"24","key":"10.1016\/j.sleep.2021.10.035_bib25","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1016\/S0042-6989(96)00169-1","article-title":"Ocular motor abnormalities in Huntington's disease","volume":"37","author":"Lasker","year":"1997","journal-title":"Vis Res"},{"issue":"5","key":"10.1016\/j.sleep.2021.10.035_bib26","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S1389-9457(02)00041-2","article-title":"Eye movements in REM sleep could be controlled by the same conjugate system while awake","volume":"3","author":"Kimura","year":"2002","journal-title":"Sleep Med"},{"issue":"1","key":"10.1016\/j.sleep.2021.10.035_bib27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0013-4694(78)90337-1","article-title":"Sleep disturbances in progressive supranuclear palsy","volume":"45","author":"Gross","year":"1978","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"8","key":"10.1016\/j.sleep.2021.10.035_bib28","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1212\/WNL.26.8.769","article-title":"Sleep abnormalities in patients with brain stem lesions","volume":"26","author":"Markand","year":"1976","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.sleep.2021.10.035_bib29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1212\/WNL.34.1.118","article-title":"Localized pontine lesion: nearly absence of REM sleep","volume":"34","author":"Lavie","year":"1984","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.sleep.2021.10.035_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/155005948301400106","article-title":"Disturbances of the sleep-waking cycle in patients with vascular brain stem lesions","volume":"14","author":"Tamura","year":"1983","journal-title":"Clin Electroencephalogr"},{"issue":"4","key":"10.1016\/j.sleep.2021.10.035_bib31","doi-asserted-by":"crossref","first-page":"M131","DOI":"10.1093\/geronj\/45.4.M131","article-title":"Sleep disturbances in patients with mild-stage Alzheimer's disease","volume":"45","author":"Vitiello","year":"1990","journal-title":"J\u00a0Gerontol"},{"issue":"4","key":"10.1016\/j.sleep.2021.10.035_bib32","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/WCO.0b013e328305044d","article-title":"Abnormal sleep and sleepiness in Parkinson's disease","volume":"21","author":"Arnulf","year":"2008","journal-title":"Curr Opin Neurol"},{"issue":"1","key":"10.1016\/j.sleep.2021.10.035_bib33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0013-4694(68)90083-7","article-title":"Disturbances of rapid eye movements during sleep in patients with lesions of the nervous system","volume":"25","author":"Appenzeller","year":"1968","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"2","key":"10.1016\/j.sleep.2021.10.035_bib34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1001\/archneur.1971.00490020069008","article-title":"Eye movements during sleep: I. The pattern in the normal human","volume":"25","author":"Jacobs","year":"1971","journal-title":"Arch Neurol"},{"issue":"2","key":"10.1016\/j.sleep.2021.10.035_bib35","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1001\/archneur.1992.00530260052019","article-title":"Locus coeruleus involvement in Huntington's disease","volume":"49","author":"Zweig","year":"1992","journal-title":"Arch Neurol"},{"issue":"1","key":"10.1016\/j.sleep.2021.10.035_bib36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1523\/JNEUROSCI.3842-04.2005","article-title":"Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease","volume":"25","author":"Morton","year":"2005","journal-title":"J\u00a0Neurosci"},{"issue":"11","key":"10.1016\/j.sleep.2021.10.035_bib37","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1523\/JNEUROSCI.20-11-04300.2000","article-title":"Circadian and homeostatic control of rapid eye movement (REM) sleep: promotion of REM tendency by the suprachiasmatic nucleus","volume":"20","author":"Wurts","year":"2000","journal-title":"J\u00a0Neurosci"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945721005487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945721005487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:36:06Z","timestamp":1761406566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945721005487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":37,"alternative-id":["S1389945721005487"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2021.10.035","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association of saccadic abnormalities with rem sleep in patients with Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2021.10.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}