{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:01:53Z","timestamp":1771455713668,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.sleep.2021.12.004","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T12:38:20Z","timestamp":1639658300000},"page":"122-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["REM sleep without atonia and vestibular-evoked myogenic potentials: clinical brainstem dysfunction in early-stage Parkinson's disease and isolated REM sleep behavior disorder"],"prefix":"10.1016","volume":"89","author":[{"given":"Wei-ye","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2812-2929","authenticated-orcid":false,"given":"Ya-li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-xing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-hui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-jie","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-ping","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.sleep.2021.12.004_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/bpa.12168","article-title":"The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies","volume":"25","author":"Seidel","year":"2015","journal-title":"Brain Pathol"},{"key":"10.1016\/j.sleep.2021.12.004_bib2","doi-asserted-by":"crossref","first-page":"117309","DOI":"10.1016\/j.jns.2021.117309","article-title":"Single-dose L-dopa increases upper brainstem GABA in Parkinson's disease: a preliminary study","volume":"422","author":"Song","year":"2021","journal-title":"J\u00a0Neurol Sci"},{"issue":"1","key":"10.1016\/j.sleep.2021.12.004_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41572-018-0016-5","article-title":"REM sleep behaviour disorder","volume":"4","author":"Dauvilliers","year":"2018","journal-title":"Nat Rev Dis Prim"},{"issue":"5","key":"10.1016\/j.sleep.2021.12.004_bib4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/mds.27018","article-title":"REM sleep behavior disorder in Parkinson's disease and other synucleinopathies","volume":"32","author":"St Louis","year":"2017","journal-title":"Mov Disord"},{"issue":"5","key":"10.1016\/j.sleep.2021.12.004_bib5","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/mds.27003","article-title":"Degeneration of rapid eye movement sleep circuitry underlies rapid eye movement sleep behavior disorder","volume":"32","author":"McKenna","year":"2017","journal-title":"Mov Disord"},{"issue":"5","key":"10.1016\/j.sleep.2021.12.004_bib6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1474-4422(13)70056-5","article-title":"Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study","volume":"12","author":"Iranzo","year":"2013","journal-title":"Lancet Neurol"},{"issue":"11","key":"10.1016\/j.sleep.2021.12.004_bib7","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1212\/WNL.0b013e31822e560e","article-title":"Associated factors for REM sleep behavior disorder in Parkinson disease","volume":"77","author":"Sixel-Doring","year":"2011","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.sleep.2021.12.004_bib8","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/jamaneurol.2015.0703","article-title":"New clinical subtypes of Parkinson disease and their longitudinal progression: a prospective cohort comparison with other phenotypes","volume":"72","author":"Fereshtehnejad","year":"2015","journal-title":"JAMA Neurol"},{"issue":"6","key":"10.1016\/j.sleep.2021.12.004_bib9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.sleep.2013.12.021","article-title":"Clinical manifestations of Parkinson disease and the onset of rapid eye movement sleep behavior disorder","volume":"15","author":"Gong","year":"2014","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2021.12.004_bib10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.parkreldis.2017.09.003","article-title":"Two polysomnographic features of REM sleep behavior disorder: clinical variations insight for Parkinson's disease","volume":"44","author":"Shen","year":"2017","journal-title":"Park Relat Disord"},{"issue":"6","key":"10.1016\/j.sleep.2021.12.004_bib11","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.clinph.2014.09.014","article-title":"Clinical correlates of rapid eye movement sleep without atonia in Parkinson's disease","volume":"126","author":"Shen","year":"2015","journal-title":"Clin Neurophysiol"},{"issue":"4","key":"10.1016\/j.sleep.2021.12.004_bib12","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.clinph.2012.09.026","article-title":"Ocular vestibular evoked myogenic potentials induced by air-conducted sound in patients with acute brainstem lesions","volume":"124","author":"Oh","year":"2013","journal-title":"Clin Neurophysiol"},{"issue":"2","key":"10.1016\/j.sleep.2021.12.004_bib13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/jnnp.57.2.190","article-title":"Myogenic potentials generated by a click-evoked vestibulocollic reflex","volume":"57","author":"Colebatch","year":"1994","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"13","key":"10.1016\/j.sleep.2021.12.004_bib14","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1113\/jphysiol.2011.226225","article-title":"Single motor unit activity in human extraocular muscles during the vestibulo-ocular reflex","volume":"590","author":"Weber","year":"2012","journal-title":"J\u00a0Physiol"},{"issue":"Pt 1","key":"10.1016\/j.sleep.2021.12.004_bib15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1113\/jphysiol.2003.047274","article-title":"A\u00a0short latency vestibulomasseteric reflex evoked by electrical stimulation over the mastoid in healthy humans","volume":"553","author":"Deriu","year":"2003","journal-title":"J\u00a0Physiol"},{"issue":"Pt 1","key":"10.1016\/j.sleep.2021.12.004_bib16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1113\/jphysiol.2006.123240","article-title":"Origin of sound-evoked EMG responses in human masseter muscles","volume":"580","author":"Deriu","year":"2007","journal-title":"J\u00a0Physiol"},{"issue":"6","key":"10.1016\/j.sleep.2021.12.004_bib17","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s10072-014-2054-4","article-title":"Abnormalities of vestibular-evoked myogenic potentials in idiopathic Parkinson's disease are associated with clinical evidence of brainstem involvement","volume":"36","author":"de Natale","year":"2015","journal-title":"Neurol Sci"},{"issue":"10","key":"10.1016\/j.sleep.2021.12.004_bib18","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.clinph.2014.12.017","article-title":"Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson's Disease","volume":"126","author":"de Natale","year":"2015","journal-title":"Clin Neurophysiol"},{"issue":"9","key":"10.1016\/j.sleep.2021.12.004_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsz128","article-title":"REM Sleep without atonia correlates with abnormal vestibular-evoked myogenic potentials in isolated REM sleep behavior disorder","volume":"42","author":"Puligheddu","year":"2019","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.sleep.2021.12.004_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsw060","article-title":"Comparison between automatic and visual scorings of REM sleep without atonia for the diagnosis of REM sleep behavior disorder in Parkinson disease","volume":"40","author":"Figorilli","year":"2017","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.sleep.2021.12.004_bib21","first-page":"428","article-title":"Chinese Society of Parkinson\u2019s Disease and Movement Disorders. Chinese guidelines for treatment of Parkinson's disease (the third edition)","volume":"47","year":"2014","journal-title":"Chin J Neurol"},{"issue":"5","key":"10.1016\/j.sleep.2021.12.004_bib22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.5664\/jcsm.6576","article-title":"AASM scoring manual updates for 2017 (version 2.4)","volume":"13","author":"Berry","year":"2017","journal-title":"J\u00a0Clin Sleep Med"},{"issue":"12","key":"10.1016\/j.sleep.2021.12.004_bib23","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov Disord"},{"issue":"15","key":"10.1016\/j.sleep.2021.12.004_bib24","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/mds.23429","article-title":"Systematic review of levodopa dose equivalency reporting in Parkinson's disease","volume":"25","author":"Tomlinson","year":"2010","journal-title":"Mov Disord"},{"issue":"7","key":"10.1016\/j.sleep.2021.12.004_bib25","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.sleep.2011.01.015","article-title":"Utility of the REM sleep behavior disorder screening questionnaire (RBDSQ) in Parkinson's disease patients","volume":"12","author":"Nomura","year":"2011","journal-title":"Sleep Med"},{"issue":"16","key":"10.1016\/j.sleep.2021.12.004_bib26","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1002\/mds.21740","article-title":"The REM sleep behavior disorder screening questionnaire--a new diagnostic instrument","volume":"22","author":"Stiasny-Kolster","year":"2007","journal-title":"Mov Disord"},{"issue":"2","key":"10.1016\/j.sleep.2021.12.004_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/sleep\/28.2.203","article-title":"Severe obstructive sleep apnea\/hypopnea mimicking REM sleep behavior disorder","volume":"28","author":"Iranzo","year":"2005","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2021.12.004_bib28","series-title":"The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications","author":"Berry","year":"2017"},{"issue":"13","key":"10.1016\/j.sleep.2021.12.004_bib29","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1002\/mds.23257","article-title":"Polysomnographic diagnosis of idiopathic REM sleep behavior disorder","volume":"25","author":"Montplaisir","year":"2010","journal-title":"Mov Disord"},{"issue":"7","key":"10.1016\/j.sleep.2021.12.004_bib30","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1212\/WNL.42.7.1371","article-title":"Polysomnographic features of REM sleep behavior disorder: development of a scoring method","volume":"42","author":"Lapierre","year":"1992","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.sleep.2021.12.004_bib31","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/j.clinph.2014.12.027","article-title":"Effects of muscle contraction on cervical vestibular evoked myogenic potentials in normal subjects","volume":"126","author":"Rosengren","year":"2015","journal-title":"Clin Neurophysiol"},{"issue":"2","key":"10.1016\/j.sleep.2021.12.004_bib32","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.clinph.2008.10.157","article-title":"Ocular vestibular-evoked myogenic potentials elicited from monaural versus binaural acoustic stimulations","volume":"120","author":"Wang","year":"2009","journal-title":"Clin Neurophysiol"},{"issue":"4","key":"10.1016\/j.sleep.2021.12.004_bib33","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.clinph.2013.11.042","article-title":"International guidelines for the clinical application of cervical vestibular evoked myogenic potentials: an expert consensus report","volume":"125","author":"Papathanasiou","year":"2014","journal-title":"Clin Neurophysiol"},{"issue":"11","key":"10.1016\/j.sleep.2021.12.004_bib34","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1016\/j.clinph.2011.04.001","article-title":"Ocular and cervical vestibular evoked myogenic potentials produced by air- and bone-conducted stimuli: comparative properties and effects of age","volume":"122","author":"Rosengren","year":"2011","journal-title":"Clin Neurophysiol"},{"issue":"2","key":"10.1016\/j.sleep.2021.12.004_bib35","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/ene.12557","article-title":"The vestibular evoked myogenic potentials (VEMP) score: a promising tool for evaluation of brainstem involvement in multiple sclerosis","volume":"22","author":"Gabelic","year":"2015","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.sleep.2021.12.004_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fneur.2017.00055","article-title":"Auditory- and vestibular-evoked potentials correlate with motor and non-motor features of Parkinson's disease","volume":"8","author":"Shalash","year":"2017","journal-title":"Front Neurol"},{"issue":"4","key":"10.1016\/j.sleep.2021.12.004_bib37","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/mds.26114","article-title":"Selective changes of ocular vestibular myogenic potentials in Parkinson's disease","volume":"30","author":"Potter-Nerger","year":"2015","journal-title":"Mov Disord"},{"issue":"10","key":"10.1016\/j.sleep.2021.12.004_bib38","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/mds.25061","article-title":"Differential effect of dopa and subthalamic stimulation on vestibular activity in Parkinson's disease","volume":"27","author":"Potter-Nerger","year":"2012","journal-title":"Mov Disord"},{"issue":"7","key":"10.1016\/j.sleep.2021.12.004_bib39","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat Rev Neurosci"},{"issue":"Pt 4","key":"10.1016\/j.sleep.2021.12.004_bib40","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/brain\/aww006","article-title":"The coeruleus\/subcoeruleus complex in idiopathic rapid eye movement sleep behaviour disorder","volume":"139","author":"Ehrminger","year":"2016","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.sleep.2021.12.004_bib41","doi-asserted-by":"crossref","first-page":"315","DOI":"10.14336\/AD.2019.0324","article-title":"Rapid eye movement sleep behavior disorder and neurodegenerative diseases: an update","volume":"11","author":"Zhang","year":"2020","journal-title":"Aging Dis"},{"issue":"1","key":"10.1016\/j.sleep.2021.12.004_bib42","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-018-2852-8","article-title":"The REM sleep circuit and how its impairment leads to REM sleep behavior disorder","volume":"373","author":"Iranzo","year":"2018","journal-title":"Cell Tissue Res"},{"issue":"2","key":"10.1016\/j.sleep.2021.12.004_bib43","first-page":"210","article-title":"Vestibular-evoked myogenic potentials in central vestibular disorders","volume":"263","author":"Oh","year":"2016","journal-title":"J\u00a0Neurol"},{"issue":"9","key":"10.1016\/j.sleep.2021.12.004_bib44","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsz132","article-title":"Simultaneous tonic and phasic REM sleep without atonia best predicts early phenoconversion to neurodegenerative disease in idiopathic REM sleep behavior disorder","volume":"42","author":"Nepozitek","year":"2019","journal-title":"Sleep"},{"issue":"9","key":"10.1016\/j.sleep.2021.12.004_bib45","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/S1474-4422(06)70549-X","article-title":"The mystery of motor asymmetry in Parkinson's disease","volume":"5","author":"Djaldetti","year":"2006","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.sleep.2021.12.004_bib46","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00441-018-2832-z","article-title":"Lateralisation in Parkinson disease","volume":"373","author":"Riederer","year":"2018","journal-title":"Cell Tissue Res"},{"issue":"6","key":"10.1016\/j.sleep.2021.12.004_bib47","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1097\/AUD.0b013e31828fc9f2","article-title":"Effects of age on the tuning of the cVEMP and oVEMP","volume":"34","author":"Piker","year":"2013","journal-title":"Ear Hear"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945721005827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945721005827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:35:52Z","timestamp":1761406552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945721005827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":47,"alternative-id":["S1389945721005827"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2021.12.004","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"REM sleep without atonia and vestibular-evoked myogenic potentials: clinical brainstem dysfunction in early-stage Parkinson's disease and isolated REM sleep behavior disorder","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2021.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}