{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:25:15Z","timestamp":1779186315300,"version":"3.51.4"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011096","name":"Jazz Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.sleep.2023.12.015","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T19:50:13Z","timestamp":1703361013000},"page":"255-265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Effects of oxybate dose and regimen on disrupted nighttime sleep and sleep architecture"],"prefix":"10.1016","volume":"114","author":[{"given":"Thomas","family":"Roth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Dauvilliers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard K.","family":"Bogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jed","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.sleep.2023.12.015_bib1","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.5664\/jcsm.8482","article-title":"Prevalence of narcolepsy, other sleep disorders, and diagnostic tests from 2013\u20132016: insured patients actively seeking care","volume":"16","author":"Acquavella","year":"2020","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2023.12.015_bib2","series-title":"Text revision (ICSD-3-TR)","article-title":"International classification of sleep disorders","author":"American Academy of Sleep Medicine","year":"2023"},{"issue":"6","key":"10.1016\/j.sleep.2023.12.015_bib3","doi-asserted-by":"crossref","first-page":"zsaa009","DOI":"10.1093\/sleep\/zsaa009","article-title":"Narcolepsy Severity Scale: a reliable tool assessing symptom severity and consequences","volume":"43","author":"Dauvilliers","year":"2020","journal-title":"Sleep"},{"issue":"9","key":"10.1016\/j.sleep.2023.12.015_bib4","doi-asserted-by":"crossref","first-page":"955","DOI":"10.5664\/jcsm.3004","article-title":"Disrupted nighttime sleep in narcolepsy","volume":"9","author":"Roth","year":"2013","journal-title":"J Clin Sleep Med"},{"issue":"1","key":"10.1016\/j.sleep.2023.12.015_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.5664\/jcsm.9638","article-title":"Disrupted nighttime sleep and sleep instability in narcolepsy","volume":"18","author":"Maski","year":"2022","journal-title":"J Clin Sleep Med"},{"issue":"21","key":"10.1016\/j.sleep.2023.12.015_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.025252","article-title":"Redefining cardiovascular health to include sleep: prospective associations with cardiovascular disease in the MESA sleep study","volume":"11","author":"Makarem","year":"2022","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"10.1016\/j.sleep.2023.12.015_bib7","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1161\/CIR.0000000000001078","article-title":"Life's Essential 8: updating and enhancing the American Heart Association's construct of cardiovascular health: a presidential advisory from the American Heart Association","volume":"146","author":"Lloyd-Jones","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.sleep.2023.12.015_bib8","doi-asserted-by":"crossref","first-page":"zsad161","DOI":"10.1093\/sleep\/zsad161","article-title":"Cardiovascular Burden of Narcolepsy Disease (CV-BOND): a real-world evidence study [published online ahead of print June 12, 2023]","author":"Ben-Joseph","year":"2023","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.sleep.2023.12.015_bib9","doi-asserted-by":"crossref","first-page":"e479","DOI":"10.1212\/WNL.0000000000004911","article-title":"Effect of psychostimulants on blood pressure profile and endothelial function in narcolepsy","volume":"90","author":"Bosco","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.sleep.2023.12.015_bib10","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.sleep.2021.02.040","article-title":"Metabolic profile in patients with narcolepsy: a systematic review and meta-analysis","volume":"81","author":"Mohammadi","year":"2021","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2023.12.015_bib11","series-title":"Xyrem\u00ae (sodium oxybate) oral solution, CIII [prescribing information]","year":"2023"},{"key":"10.1016\/j.sleep.2023.12.015_bib12","series-title":"Xyrem [summary of product characteristics]","year":"2022"},{"key":"10.1016\/j.sleep.2023.12.015_bib13","series-title":"Xywav\u00ae (calcium, magnesium, potassium, and sodium oxybates) oral solution, CIII [prescribing information]","year":"2023"},{"issue":"3","key":"10.1016\/j.sleep.2023.12.015_bib14","doi-asserted-by":"crossref","first-page":"zsaa206","DOI":"10.1093\/sleep\/zsaa206","article-title":"Efficacy and safety of calcium, magnesium, potassium, and sodium oxybates (lower-sodium oxybate [LXB]; JZP-258) in a placebo-controlled, double-blind, randomized withdrawal study in adults with narcolepsy with cataplexy","volume":"44","author":"Bogan","year":"2021","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2023.12.015_bib15","series-title":"For extended-release oral solution, CIII [prescribing information]","year":"2023"},{"key":"10.1016\/j.sleep.2023.12.015_bib16","series-title":"Principles and practice of sleep medicine","first-page":"16","article-title":"Normal human sleep: an overview","author":"Carskadon","year":"2011"},{"issue":"4","key":"10.1016\/j.sleep.2023.12.015_bib17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s40675-020-00197-5","article-title":"Clinician-focused overview and developments in polysomnography","volume":"6","author":"Markun","year":"2020","journal-title":"Curr Sleep Med Rep"},{"issue":"7","key":"10.1016\/j.sleep.2023.12.015_bib18","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/sleep\/27.7.1255","article-title":"Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan","volume":"27","author":"Ohayon","year":"2004","journal-title":"Sleep"},{"issue":"4","key":"10.1016\/j.sleep.2023.12.015_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s40263-022-00904-6","article-title":"Effect of FT218, a once-nightly sodium oxybate formulation, on disrupted nighttime sleep in patients with narcolepsy: results from the randomized phase III REST-ON trial","volume":"36","author":"Roth","year":"2022","journal-title":"CNS Drugs"},{"issue":"3","key":"10.1016\/j.sleep.2023.12.015_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5664\/jcsm.26796","article-title":"EEG arousal norms by age","volume":"3","author":"Bonnet","year":"2007","journal-title":"J Clin Sleep Med"},{"issue":"4","key":"10.1016\/j.sleep.2023.12.015_bib21","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1590\/S0004-282X2009000600006","article-title":"Correlations between subjective and objective features of nocturnal sleep and excessive diurnal sleepiness in patients with narcolepsy","volume":"67","author":"Jimenez-Correa","year":"2009","journal-title":"Arq Neuropsiquiatr"},{"issue":"2","key":"10.1016\/j.sleep.2023.12.015_bib22","first-page":"173","article-title":"EEG arousals: scoring rules and examples. A preliminary report from the sleep disorders atlas task force of the American sleep disorders association","volume":"15","author":"Bonnet","year":"1992","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2023.12.015_bib23","series-title":"The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications","author":"Berry","year":"2020"},{"key":"10.1016\/j.sleep.2023.12.015_bib24","series-title":"A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects","author":"Rechtschaffen","year":"1968"},{"issue":"6","key":"10.1016\/j.sleep.2023.12.015_bib25","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S2213-2600(19)30057-8","article-title":"Normal polysomnography parameters in healthy adults: a systematic review and meta-analysis","volume":"7","author":"Boulos","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"1","key":"10.1016\/j.sleep.2023.12.015_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1365-2869.2003.00331.x","article-title":"Spectral analysis of all-night human sleep EEG in narcoleptic patients and normal subjects","volume":"12","author":"Mukai","year":"2003","journal-title":"J Sleep Res"},{"issue":"5","key":"10.1016\/j.sleep.2023.12.015_bib27","first-page":"649","article-title":"The role of NREM sleep instability in child cognitive performance","volume":"35","author":"Bruni","year":"2012","journal-title":"Sleep"},{"issue":"12","key":"10.1016\/j.sleep.2023.12.015_bib28","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1093\/sleep\/31.12.1737","article-title":"Polysomnographic values in children undergoing puberty: pediatric vs. adult respiratory rules in adolescents","volume":"31","author":"Tapia","year":"2008","journal-title":"Sleep"},{"issue":"8","key":"10.1016\/j.sleep.2023.12.015_bib29","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/sleep\/30.8.980","article-title":"Insufficient non-REM sleep intensity in narcolepsy-cataplexy","volume":"30","author":"Khatami","year":"2007","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.sleep.2023.12.015_bib30","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/sleep\/31.6.859","article-title":"Challenging sleep homeostasis in narcolepsy-cataplexy: implications for non-REM and REM sleep regulation","volume":"31","author":"Khatami","year":"2008","journal-title":"Sleep"},{"issue":"3","key":"10.1016\/j.sleep.2023.12.015_bib31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1046\/j.1365-2869.2000.00217.x","article-title":"Night-time sleep and daytime sleepiness in narcolepsy","volume":"9","author":"Harsh","year":"2000","journal-title":"J Sleep Res"},{"issue":"8","key":"10.1016\/j.sleep.2023.12.015_bib32","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.5665\/sleep.4908","article-title":"Nocturnal sleep dynamics identify narcolepsy type 1","volume":"38","author":"Pizza","year":"2015","journal-title":"Sleep"},{"issue":"12","key":"10.1016\/j.sleep.2023.12.015_bib33","doi-asserted-by":"crossref","first-page":"zsz169","DOI":"10.1093\/sleep\/zsz169","article-title":"Cardiovascular autonomic dysfunction, altered sleep architecture, and muscle overactivity during nocturnal sleep in pediatric patients with narcolepsy type 1","volume":"42","author":"Vandi","year":"2019","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.sleep.2023.12.015_bib34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.21307\/ane-2017-047","article-title":"Narcolepsy type 1 and hypersomnia associated with a psychiatric disorder show different slow wave activity dynamics","volume":"77","author":"Walacik-Ufnal","year":"2017","journal-title":"Acta Neurobiol Exp"},{"issue":"3","key":"10.1016\/j.sleep.2023.12.015_bib35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0163-8343(90)90078-Q","article-title":"Subjective and polysomnographic characteristics of patients diagnosed with narcolepsy","volume":"12","author":"Rosenthal","year":"1990","journal-title":"Gen Hosp Psychiatr"},{"issue":"5","key":"10.1016\/j.sleep.2023.12.015_bib36","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1136\/jnnp.60.5.576","article-title":"A comparison of idiopathic hypersomnia and narcolepsy-cataplexy using self report measures and sleep diary data","volume":"60","author":"Bruck","year":"1996","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"10.1016\/j.sleep.2023.12.015_bib37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1365-2869.1998.00093.x","article-title":"The clinical diagnosis of the narcoleptic syndrome","volume":"7","author":"Parkes","year":"1998","journal-title":"J Sleep Res"},{"issue":"4","key":"10.1016\/j.sleep.2023.12.015_bib38","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1365-2869.2011.00906.x","article-title":"Motor disturbances during non-REM and REM sleep in narcolepsy-cataplexy: a video-polysomnographic analysis","volume":"20","author":"Frauscher","year":"2011","journal-title":"J Sleep Res"},{"issue":"10","key":"10.1016\/j.sleep.2023.12.015_bib39","doi-asserted-by":"crossref","first-page":"zsaa066","DOI":"10.1093\/sleep\/zsaa066","article-title":"Defining disrupted nighttime sleep and assessing its diagnostic utility for pediatric narcolepsy type 1","volume":"43","author":"Maski","year":"2020","journal-title":"Sleep"},{"issue":"21","key":"10.1016\/j.sleep.2023.12.015_bib40","doi-asserted-by":"crossref","first-page":"e2900","DOI":"10.1212\/WNL.0000000000010743","article-title":"Association of CSF orexin-A levels and nocturnal sleep stability in patients with hypersomnolence","volume":"95","author":"Barateau","year":"2020","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.sleep.2023.12.015_bib41","doi-asserted-by":"crossref","first-page":"zsac054","DOI":"10.1093\/sleep\/zsac054","article-title":"Linking clinical complaints and objective measures of disrupted nighttime sleep in narcolepsy type 1","volume":"45","author":"Barateau","year":"2022","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.sleep.2023.12.015_bib42","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/sleep\/13.6.479","article-title":"The effects of gamma-hydroxybutyrate on the sleep of narcolepsy patients: a double-blind study","volume":"13","author":"Scrima","year":"1990","journal-title":"Sleep"},{"issue":"3","key":"10.1016\/j.sleep.2023.12.015_bib43","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/sleep\/16.3.216","article-title":"Gammahydroxybutyrate and narcolepsy: a double-blind placebo-controlled study","volume":"16","author":"Lammers","year":"1993","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.sleep.2023.12.015_bib44","first-page":"222","article-title":"The effects and effectiveness of gamma-hydroxybutyrate in patients with narcolepsy","volume":"46","author":"Scharf","year":"1985","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"10.1016\/j.sleep.2023.12.015_bib45","first-page":"23","article-title":"Effects of nocturnal gamma-hydroxybutyrate on sleep\/waking patterns in narcolepsy-cataplexy","volume":"7","author":"Broughton","year":"1980","journal-title":"Can J Neurol Sci"},{"issue":"1","key":"10.1016\/j.sleep.2023.12.015_bib46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00002826-198902000-00004","article-title":"Nocturnal gamma-hydroxybutyrate. Effect on periodic leg movements and sleep organization of narcoleptic patients","volume":"12","author":"B\u00e9dard","year":"1989","journal-title":"Clin Neuropharmacol"},{"issue":"4","key":"10.1016\/j.sleep.2023.12.015_bib47","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0006-3223(89)90048-6","article-title":"Efficacy of gamma-hydroxybutyrate versus placebo in treating narcolepsy-cataplexy: double-blind subjective measures","volume":"26","author":"Scrima","year":"1989","journal-title":"Biol Psychiatr"},{"issue":"6","key":"10.1016\/j.sleep.2023.12.015_bib48","doi-asserted-by":"crossref","first-page":"596","DOI":"10.5664\/jcsm.27994","article-title":"The nightly use of sodium oxybate is associated with a reduction in nocturnal sleep disruption: a double-blind, placebo-controlled study in patients with narcolepsy","volume":"6","author":"Black","year":"2010","journal-title":"J Clin Sleep Med"},{"issue":"4","key":"10.1016\/j.sleep.2023.12.015_bib49","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/jsr.12468","article-title":"Effect of sodium oxybate on disrupted nighttime sleep in patients with narcolepsy","volume":"26","author":"Roth","year":"2017","journal-title":"J Sleep Res"},{"issue":"8","key":"10.1016\/j.sleep.2023.12.015_bib50","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.sleep.2009.05.004","article-title":"The nightly administration of sodium oxybate results in significant reduction in the nocturnal sleep disruption of patients with narcolepsy","volume":"10","author":"Black","year":"2009","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2023.12.015_bib51","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.sleep.2017.07.030","article-title":"Effect of sodium oxybate, modafinil, and their combination on disrupted nighttime sleep in narcolepsy","volume":"40","author":"Dauvilliers","year":"2017","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2023.12.015_bib52","doi-asserted-by":"crossref","first-page":"zsad152","DOI":"10.1093\/sleep\/zsad152","article-title":"Efficacy of once-nightly sodium oxybate (FT218) in narcolepsy type 1 and type 2: post hoc analysis from the phase 3 REST-ON trial","author":"Dauvilliers","year":"2023","journal-title":"Sleep"},{"issue":"7","key":"10.1016\/j.sleep.2023.12.015_bib53","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/sleep\/27.7.1327","article-title":"A pilot study on the effects of sodium oxybate on sleep architecture and daytime alertness in narcolepsy","volume":"27","author":"Mamelak","year":"2004","journal-title":"Sleep"},{"issue":"suppl 1","key":"10.1016\/j.sleep.2023.12.015_bib54","first-page":"S256","article-title":"Effects of sodium oxybate treatment on sleep architecture in paediatric patients with narcolepsy [abstract]","volume":"64","author":"Mignot","year":"2019","journal-title":"Sleep Med"},{"issue":"4","key":"10.1016\/j.sleep.2023.12.015_bib55","doi-asserted-by":"crossref","first-page":"391","DOI":"10.5664\/jcsm.26368","article-title":"A double-blind, placebo-controlled study demonstrates sodium oxybate is effective for the treatment of excessive daytime sleepiness in narcolepsy","volume":"1","year":"2005","journal-title":"J Clin Sleep Med"},{"issue":"7","key":"10.1016\/j.sleep.2023.12.015_bib56","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/sleep\/29.7.939","article-title":"Sodium oxybate improves excessive daytime sleepiness in narcolepsy","volume":"29","author":"Black","year":"2006","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.sleep.2023.12.015_bib57","doi-asserted-by":"crossref","first-page":"zsab200","DOI":"10.1093\/sleep\/zsab200","article-title":"Once-nightly sodium oxybate (FT218) demonstrated improvement of symptoms in a phase 3 randomized clinical trial in patients with narcolepsy","volume":"45","author":"Kushida","year":"2022","journal-title":"Sleep"},{"issue":"7","key":"10.1016\/j.sleep.2023.12.015_bib58","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S2352-4642(18)30133-0","article-title":"Treatment of paediatric narcolepsy with sodium oxybate: a double-blind, placebo-controlled, randomised-withdrawal multicentre study and open-label investigation","volume":"2","author":"Plazzi","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"issue":"9","key":"10.1016\/j.sleep.2023.12.015_bib59","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.5664\/jcsm.10090","article-title":"Long-term safety and maintenance of efficacy of sodium oxybate in the treatment of narcolepsy with cataplexy in pediatric patients","volume":"18","author":"Lecendreux","year":"2022","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2023.12.015_bib60","series-title":"Effects of sodium oxybate treatment on sleep architecture in paediatric patients with narcolepsy [oral presentation]","author":"Mignot","year":"2019"},{"issue":"5","key":"10.1016\/j.sleep.2023.12.015_bib61","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.smrv.2011.09.001","article-title":"Narcolepsy and effectiveness of gamma-hydroxybutyrate (GHB): a systematic review and meta-analysis of randomized controlled trials","volume":"16","author":"Boscolo-Berto","year":"2012","journal-title":"Sleep Med Rev"},{"issue":"1","key":"10.1016\/j.sleep.2023.12.015_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/WNF.0b013e318203d415","article-title":"Long-term follow-up of patients with narcolepsy-cataplexy treated with sodium oxybate (Xyrem)","volume":"34","author":"Alshaikh","year":"2011","journal-title":"Clin Neuropharmacol"},{"issue":"3","key":"10.1016\/j.sleep.2023.12.015_bib63","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1530\/EJE-10-0913","article-title":"Sodium oxybate increases prolactin secretion in narcolepsy patients and healthy controls","volume":"164","author":"Donjacour","year":"2011","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"10.1016\/j.sleep.2023.12.015_bib64","doi-asserted-by":"crossref","first-page":"E1069","DOI":"10.1152\/ajpendo.00623.2010","article-title":"Effect of sodium oxybate on growth hormone secretion in narcolepsy patients and healthy controls","volume":"300","author":"Donjacour","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.sleep.2023.12.015_bib65","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3109\/07420528.2012.655869","article-title":"Altered circadian rhythm of melatonin concentrations in hypocretin-deficient men","volume":"29","author":"Donjacour","year":"2012","journal-title":"Chronobiol Int"},{"issue":"3","key":"10.1016\/j.sleep.2023.12.015_bib66","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000324549","article-title":"Sodium oxybate in narcolepsy with cataplexy: Zurich sleep center experience","volume":"65","author":"Poryazova","year":"2011","journal-title":"Eur Neurol"},{"issue":"abstract suppl","key":"10.1016\/j.sleep.2023.12.015_bib67","first-page":"A208","article-title":"Effect of gammahydroxybutyrate on cyclic alternating pattern (CAP) in patients with narcolepsy with cataplexy [abstract 0604]","volume":"34","author":"Tantrakul","year":"2011","journal-title":"Sleep"},{"issue":"11","key":"10.1016\/j.sleep.2023.12.015_bib68","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.5665\/sleep.6220","article-title":"Core body and skin temperature in type 1 narcolepsy in daily life; effects of sodium oxybate and prediction of sleep attacks","volume":"39","author":"van der Heide","year":"2016","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.sleep.2023.12.015_bib69","first-page":"35","article-title":"Long-term follow-up on the effects of sodium oxybate on daytime sleepiness and sleep architecture in patients with narcolepsy type 1","volume":"76","author":"Peraita-Adrados","year":"2023","journal-title":"Rev Neurol"},{"key":"10.1016\/j.sleep.2023.12.015_bib70","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.sleep.2019.06.017","article-title":"Gamma-hydroxybutyrate (GHB) for narcolepsy in adults: an updated systematic review and meta-analysis","volume":"64","author":"Xu","year":"2019","journal-title":"Sleep Med"},{"issue":"6","key":"10.1016\/j.sleep.2023.12.015_bib71","doi-asserted-by":"crossref","first-page":"zxy050","DOI":"10.1093\/sleep\/zsy050","article-title":"In-field assessment of sodium oxybate effect in pediatric type 1 narcolepsy: an actigraphic study","volume":"41","author":"Filardi","year":"2018","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2023.12.015_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2023.101762","article-title":"The evolving role of quantitative actigraphy in clinical sleep medicine","volume":"68","author":"Liguori","year":"2023","journal-title":"Sleep Med Rev"},{"issue":"2","key":"10.1016\/j.sleep.2023.12.015_bib73","doi-asserted-by":"crossref","first-page":"e250","DOI":"10.1212\/WNL.0000000000011157","article-title":"REM sleep behavior disorder in children with type 1 narcolepsy treated with sodium oxybate","volume":"96","author":"Antelmi","year":"2021","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.sleep.2023.12.015_bib74","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11325-009-0283-1","article-title":"Clinical perspective: monitoring sodium oxybate-treated narcolepsy patients for the development of sleep-disordered breathing","volume":"14","author":"Feldman","year":"2010","journal-title":"Sleep Breath"},{"key":"10.1016\/j.sleep.2023.12.015_bib75","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.sleep.2019.07.004","article-title":"Prevalence and neurophysiological correlates of sleep disordered breathing in pediatric type 1 narcolepsy","volume":"65","author":"Filardi","year":"2020","journal-title":"Sleep Med"},{"issue":"4","key":"10.1016\/j.sleep.2023.12.015_bib76","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s40263-023-00992-y","article-title":"Long-term safety and tolerability during a clinical trial and open-label extension of lower-sodium oxybate in participants with narcolepsy with cataplexy","volume":"37","author":"Bogan","year":"2023","journal-title":"CNS Drugs"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945723015794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945723015794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:46:22Z","timestamp":1761407182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945723015794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":76,"alternative-id":["S1389945723015794"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2023.12.015","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of oxybate dose and regimen on disrupted nighttime sleep and sleep architecture","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2023.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}