{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:08:03Z","timestamp":1791648483521,"version":"4.3.4"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.sleep.2024.12.021","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T16:38:25Z","timestamp":1734453505000},"page":"260-266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Sleep apnea endotypes and their implications for clinical practise"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9383-1644","authenticated-orcid":false,"given":"Bradley A.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane A.","family":"Landry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke D.J.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.sleep.2024.12.021_bib1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1164\/rccm.201901-0014TR","article-title":"More than the sum of the respiratory events: personalized medicine approaches for obstructive sleep apnea","volume":"200","author":"Edwards","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2024.12.021_bib2","doi-asserted-by":"crossref","DOI":"10.1152\/japplphysiol.00747.2012","article-title":"A simplified method for determining phenotypic traits in patients with obstructive sleep apnea","author":"Wellman","year":"2013","journal-title":"J Appl Physiol"},{"issue":"9","key":"10.1016\/j.sleep.2024.12.021_bib3","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1164\/rccm.201707-1435OC","article-title":"Phenotyping pharyngeal pathophysiology using polysomnography in patients with obstructive sleep apnea","volume":"197","author":"Sands","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.sleep.2024.12.021_bib4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1152\/jappl.1988.64.2.535","article-title":"Induction of upper airway occlusion in sleeping individuals with subatmospheric nasal pressure","volume":"64","author":"Schwartz","year":"1988","journal-title":"J Appl Physiol"},{"issue":"2","key":"10.1016\/j.sleep.2024.12.021_bib5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1152\/jappl.1988.64.2.789","article-title":"Upper airway pressure-flow relationships in obstructive sleep apnea","volume":"64","author":"Smith","year":"1988","journal-title":"J Appl Physiol"},{"issue":"6","key":"10.1016\/j.sleep.2024.12.021_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsac050","article-title":"Clinical polysomnographic methods for estimating pharyngeal collapsibility in obstructive sleep apnea","volume":"45","author":"Vena","year":"2022","journal-title":"Sleep"},{"issue":"9","key":"10.1016\/j.sleep.2024.12.021_bib7","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.5664\/jcsm.8600","article-title":"Discriminating the severity of pharyngeal collapsibility in men using anthropometric and polysomnographic indices","volume":"16","author":"Genta","year":"2020","journal-title":"J Clin Sleep Med"},{"issue":"6","key":"10.1016\/j.sleep.2024.12.021_bib8","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1164\/ajrccm\/143.6.1300","article-title":"Upper airway collapsibility in snorers and in patients with obstructive hypopnea and apnea. Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S","volume":"143","author":"Gleadhill","year":"1991","journal-title":"Am Rev Respir Dis"},{"issue":"6","key":"10.1016\/j.sleep.2024.12.021_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx056","article-title":"Therapeutic CPAP level predicts upper airway collapsibility in patients with obstructive sleep apnea","volume":"40","author":"Landry","year":"2017","journal-title":"Sleep"},{"issue":"10","key":"10.1016\/j.sleep.2024.12.021_bib10","first-page":"43","article-title":"An assessment of a simple clinical technique to estimate pharyngeal collapsibility in people with obstructive sleep apnea","author":"Osman","year":"2020","journal-title":"Sleep"},{"issue":"9","key":"10.1016\/j.sleep.2024.12.021_bib11","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1164\/rccm.202003-0589LE","article-title":"The effect of hypopnea scoring on the arousal threshold in patients with obstructive sleep apnea. Article","volume":"202","author":"Thomson","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.sleep.2024.12.021_bib12","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.chest.2020.10.080","article-title":"Assessing the physiologic endotypes responsible for REM- and NREM-based OSA","volume":"159","author":"Joosten","year":"2021","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.sleep.2024.12.021_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/sleep\/27.2.229","article-title":"Obstructive sleep-disordered breathing with a dominant cyclic alternating pattern--a recognizable polysomnographic variant with practical clinical implications","volume":"27","author":"Thomas","year":"2004","journal-title":"Sleep"},{"issue":"9","key":"10.1016\/j.sleep.2024.12.021_bib14","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.5664\/jcsm.6716","article-title":"Physiology-based modeling may predict surgical treatment outcome for obstructive sleep apnea","volume":"13","author":"Li","year":"2017","journal-title":"J Clin Sleep Med"},{"issue":"4","key":"10.1016\/j.sleep.2024.12.021_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsaa215","article-title":"Algorithm for automatic detection of self-similarity and prediction of residual central respiratory events during continuous positive airway pressure","volume":"44","author":"Oppersma","year":"2021","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2024.12.021_bib16","article-title":"Morphological prediction of CPAP associated acute respiratory instability","author":"Nassi","year":"2024","journal-title":"Annals of the American Thoracic Society"},{"issue":"17","key":"10.1016\/j.sleep.2024.12.021_bib17","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1113\/JP276206","article-title":"Breath-holding as a means to estimate the loop gain contribution to obstructive sleep apnoea. Article","volume":"596","author":"Messineo","year":"2018","journal-title":"J Physiol"},{"issue":"2","key":"10.1016\/j.sleep.2024.12.021_bib18","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1152\/japplphysiol.00282.2006","article-title":"Neuromechanical control of upper airway patency during sleep","volume":"102","author":"Patil","year":"2007","journal-title":"J Appl Physiol"},{"issue":"6","key":"10.1016\/j.sleep.2024.12.021_bib19","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/japplphysiol.00972.2010","article-title":"A method for measuring and modeling the physiological traits causing obstructive sleep apnea","volume":"110","author":"Wellman","year":"2011","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.sleep.2024.12.021_bib20","doi-asserted-by":"crossref","DOI":"10.5664\/jcsm.8600","article-title":"Discriminating the severity of pharyngeal collapsibility (Pcrit) using anthropometric and polysomnographic indices","author":"Genta","year":"2020","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"10.1016\/j.sleep.2024.12.021_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000079330","article-title":"Use of morphological indicators to predict outcomes of palatopharyngeal surgery in patients with obstructive sleep apnea","volume":"66","author":"Li","year":"2004","journal-title":"ORL J Oto-Rhino-Laryngol its Relat Specialties"},{"issue":"11","key":"10.1016\/j.sleep.2024.12.021_bib22","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1164\/rccm.201404-0718OC","article-title":"Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea","volume":"190","author":"Edwards","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2024.12.021_bib23","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.202003-0589LE","article-title":"The effect of hypopnea scoring on the arousal threshold in patients with obstructive sleep apnea","author":"Thomson","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.sleep.2024.12.021_bib24","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx183","article-title":"Quantifying the arousal threshold using polysomnography in obstructive sleep apnea","volume":"41","author":"Sands","year":"2018","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.sleep.2024.12.021_bib25","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1183\/09031936.00062914","article-title":"Quantifying the ventilatory control contribution to sleep apnoea using polysomnography","volume":"45","author":"Terrill","year":"2015","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.sleep.2024.12.021_bib26","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12890-022-01950-y","article-title":"Point-of-care prediction model of loop gain in patients with obstructive sleep apnea: development and validation","volume":"22","author":"Schmickl","year":"2022","journal-title":"BMC Pulm Med"},{"issue":"9","key":"10.1016\/j.sleep.2024.12.021_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsac129","article-title":"Within-night repeatability and long-term consistency of sleep apnea endotypes: the multi-ethnic study of atherosclerosis and osteoporotic fractures in men study","volume":"45","author":"Alex","year":"2022","journal-title":"Sleep"},{"issue":"4","key":"10.1016\/j.sleep.2024.12.021_bib28","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1513\/AnnalsATS.201906-436OC","article-title":"Effect of hypopnea scoring criteria on noninvasive assessment of loop gain and surgical outcome prediction","volume":"17","author":"Landry","year":"2020","journal-title":"Annals of the American Thoracic Society"},{"issue":"8","key":"10.1016\/j.sleep.2024.12.021_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsad058","article-title":"Night-to-night reliability and agreement of obstructive sleep apnea pathophysiologic mechanisms estimated with phenotyping using polysomnography in cognitively normal elderly participants","volume":"46","author":"Tolbert","year":"2023","journal-title":"Sleep"},{"issue":"5","key":"10.1016\/j.sleep.2024.12.021_bib30","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.chest.2022.12.029","article-title":"Night-to-Night variability of polysomnography-derived physiologic endotypic traits in patients with moderate to severe OSA","volume":"163","author":"Strassberger","year":"2023","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.sleep.2024.12.021_bib31","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1378\/chest.109.6.1490","article-title":"Sleep apnea impairs the arousal response to airway occlusion","volume":"109","author":"Berry","year":"1996","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.sleep.2024.12.021_bib32","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1164\/rccm.200810-1658OC","article-title":"Increased propensity for central apnea in patients with obstructive sleep apnea: effect of nasal continuous positive airway pressure","volume":"181","author":"Salloum","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.sleep.2024.12.021_bib33","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsz049","article-title":"Dose-dependent effects of mandibular advancement on upper airway collapsibility and muscle function in obstructive sleep apnea","volume":"42","author":"Bamagoos","year":"2019","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2024.12.021_bib34","doi-asserted-by":"crossref","DOI":"10.1513\/AnnalsATS.201903-190OC","article-title":"Polysomnographic endotyping to select obstructive sleep apnea patients for oral appliances","author":"Bamagoos","year":"2019","journal-title":"Annals of the American Thoracic Society"},{"issue":"3","key":"10.1016\/j.sleep.2024.12.021_bib35","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1513\/AnnalsATS.202003-220OC","article-title":"Mandibular advancement device treatment efficacy is associated with polysomnographic endotypes","volume":"18","author":"Op de Beeck","year":"2021","journal-title":"Annals of the American Thoracic Society"},{"issue":"11","key":"10.1016\/j.sleep.2024.12.021_bib36","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1164\/rccm.201601-0099OC","article-title":"Upper-airway collapsibility and loop gain predict the response to oral appliance therapy in patients with obstructive sleep apnea","volume":"194","author":"Edwards","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"issue":"22","key":"10.1016\/j.sleep.2024.12.021_bib37","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1113\/JP278164","article-title":"Structure and severity of pharyngeal obstruction determine oral appliance efficacy in sleep apnoea","volume":"597","author":"Marques","year":"2019","journal-title":"J Physiol"},{"issue":"1","key":"10.1016\/j.sleep.2024.12.021_bib38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1440-1843.2011.02037.x","article-title":"Phenotypes of patients with mild to moderate obstructive sleep apnoea as confirmed by cluster analysis. Comparative Study","volume":"17","author":"Joosten","year":"2012","journal-title":"Respirology"},{"key":"10.1016\/j.sleep.2024.12.021_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2023.101847","article-title":"A review of supine position related obstructive sleep apnea: classification, epidemiology, pathogenesis and treatment","volume":"72","author":"Landry","year":"2023","journal-title":"Sleep Med Rev"},{"issue":"8","key":"10.1016\/j.sleep.2024.12.021_bib40","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1111\/resp.13108","article-title":"Dynamic loop gain increases upon adopting the supine body position during sleep in patients with obstructive sleep apnoea","volume":"22","author":"Joosten","year":"2017","journal-title":"Respirology"},{"issue":"9","key":"10.1016\/j.sleep.2024.12.021_bib41","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.5665\/sleep.4992","article-title":"The effect of body position on physiological factors that contribute to obstructive sleep apnea","volume":"38","author":"Joosten","year":"2015","journal-title":"Sleep"},{"issue":"Supplement_1","key":"10.1016\/j.sleep.2024.12.021_bib42","doi-asserted-by":"crossref","first-page":"A22","DOI":"10.1093\/sleepadvances\/zpad035.057","article-title":"O057 the impact of surgical weight loss on the physiological endotypes causing obstructive sleep apnea","volume":"4","author":"Beatty","year":"2023","journal-title":"SLEEP Advances"},{"issue":"5","key":"10.1016\/j.sleep.2024.12.021_bib43","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx047","article-title":"Improvement in obstructive sleep apnea with weight loss is dependent on body position during sleep","volume":"40","author":"Joosten","year":"2017","journal-title":"Sleep"},{"issue":"10","key":"10.1016\/j.sleep.2024.12.021_bib44","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/resp.14280","article-title":"Examining the impact of multilevel upper airway surgery on the obstructive sleep apnoea endotypes and their utility in predicting surgical outcomes","volume":"27","author":"Wong","year":"2022","journal-title":"Respirology"},{"issue":"2","key":"10.1016\/j.sleep.2024.12.021_bib45","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1152\/japplphysiol.00076.2021","article-title":"Ansa cervicalis stimulation increases pharyngeal patency in patients with obstructive sleep apnea","volume":"131","author":"Kent","year":"2021","journal-title":"J Appl Physiol"},{"issue":"3","key":"10.1016\/j.sleep.2024.12.021_bib46","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.chest.2020.10.010","article-title":"Ansa cervicalis stimulation: a new direction in neurostimulation for OSA","volume":"159","author":"Kent","year":"2021","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.sleep.2024.12.021_bib47","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx094","article-title":"Loop gain predicts the response to upper airway surgery in patients with obstructive sleep apnea","volume":"40","author":"Joosten","year":"2017","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.sleep.2024.12.021_bib48","doi-asserted-by":"crossref","first-page":"907","DOI":"10.5664\/jcsm.7848","article-title":"The effect of upper airway surgery on loop gain in obstructive sleep apnea","volume":"15","author":"Li","year":"2019","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"10.1016\/j.sleep.2024.12.021_bib49","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/thorax-2023-220184","article-title":"Combination pharmacological therapy targeting multiple mechanisms of sleep apnoea: a randomised controlled cross-over trial","volume":"79","author":"Sands","year":"2024","journal-title":"Thorax"},{"issue":"Pt 5","key":"10.1016\/j.sleep.2024.12.021_bib50","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1113\/jphysiol.2011.223925","article-title":"Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea","volume":"590","author":"Edwards","year":"2012","journal-title":"J Physiol"},{"issue":"3","key":"10.1016\/j.sleep.2024.12.021_bib51","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.chest.2023.09.022","article-title":"Modification of endotypic traits in OSA by the carbonic anhydrase inhibitor Sulthiame","volume":"165","author":"Hoff","year":"2024","journal-title":"Chest"},{"issue":"10","key":"10.1016\/j.sleep.2024.12.021_bib52","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1164\/rccm.201808-1493OC","article-title":"The combination of atomoxetine and oxybutynin greatly reduces obstructive sleep apnea severity. A randomized, placebo-controlled, double-blind crossover trial","volume":"199","author":"Taranto-Montemurro","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"10.1016\/j.sleep.2024.12.021_bib53","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1164\/rccm.202306-1036OC","article-title":"The combination of aroxybutynin and atomoxetine in the treatment of obstructive sleep apnea (mariposa): a randomized controlled trial","volume":"208","author":"Schweitzer","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.sleep.2024.12.021_bib54","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1513\/AnnalsATS.202206-492OC","article-title":"One month dosing of atomoxetine plus oxybutynin in obstructive sleep apnea: a randomized, placebo-controlled trial","volume":"20","author":"Aishah","year":"2023","journal-title":"Annals of the American Thoracic Society"},{"issue":"12","key":"10.1016\/j.sleep.2024.12.021_bib55","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.5664\/jcsm.10250","article-title":"Combination of atomoxetine with the novel antimuscarinic aroxybutynin improves mild to moderate OSA","volume":"18","author":"Rosenberg","year":"2022","journal-title":"J Clin Sleep Med"},{"issue":"6","key":"10.1016\/j.sleep.2024.12.021_bib56","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.chest.2020.01.012","article-title":"Effects of the combination of atomoxetine and oxybutynin on OSA endotypic traits","volume":"157","author":"Taranto-Montemurro","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.sleep.2024.12.021_bib57","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.202403-0501OC","article-title":"Hypnotics on obstructive sleep apnea severity and endotypes: a systematic review and meta-analysis","author":"Messineo","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.sleep.2024.12.021_bib58","doi-asserted-by":"crossref","first-page":"H715","DOI":"10.1152\/ajpheart.00541.2023","article-title":"A novel TASK channel antagonist nasal spray reduces sleep apnea severity in physiological responders: a randomized, blinded, trial","volume":"326","author":"Osman","year":"2024","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"11","key":"10.1016\/j.sleep.2024.12.021_bib59","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.5665\/sleep.6226","article-title":"The combination of supplemental oxygen and a hypnotic markedly improves obstructive sleep apnea in patients with a mild to moderate upper airway collapsibility","volume":"39","author":"Edwards","year":"2016","journal-title":"Sleep"},{"issue":"8","key":"10.1016\/j.sleep.2024.12.021_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/life14080963","article-title":"Acetazolamide as an add-on therapy following barbed reposition pharyngoplasty in obstructive sleep apnea: a randomized controlled trial","volume":"14","author":"Hellemans","year":"2024","journal-title":"Life"},{"issue":"2","key":"10.1016\/j.sleep.2024.12.021_bib61","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/resp.12900","article-title":"Variability of breathing during wakefulness while using CPAP predicts adherence","volume":"22","author":"Fujita","year":"2017","journal-title":"Respirology"},{"issue":"5","key":"10.1016\/j.sleep.2024.12.021_bib62","doi-asserted-by":"crossref","first-page":"809","DOI":"10.5664\/jcsm.7112","article-title":"Prevalence, associated clinical features, and impact on continuous positive airway pressure use of a low respiratory arousal threshold among male United States veterans with obstructive sleep apnea","volume":"14","author":"Zinchuk","year":"2018","journal-title":"J Clin Sleep Med"},{"issue":"11","key":"10.1016\/j.sleep.2024.12.021_bib63","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1164\/rccm.202003-0502LE","article-title":"The arousal threshold as a drug target to improve continuous positive airway pressure adherence: secondary analysis of a randomized trial","volume":"202","author":"Schmickl","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.sleep.2024.12.021_bib64","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1164\/rccm.202101-0055OC","article-title":"Physiological traits and adherence to sleep apnea therapy in individuals with coronary artery disease","volume":"204","author":"Zinchuk","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"10.1016\/j.sleep.2024.12.021_bib65","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1164\/rccm.201911-2203LE","article-title":"Physiological traits and adherence to obstructive sleep apnea treatment in patients with stroke","volume":"201","author":"Zinchuk","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.sleep.2024.12.021_bib66","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.13999","article-title":"Continuous positive airway pressure and adherence in patients with different endotypes of obstructive sleep apnea","volume":"33","author":"Cheng","year":"2024","journal-title":"J Sleep Res"},{"issue":"6","key":"10.1016\/j.sleep.2024.12.021_bib67","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1164\/rccm.202006-2176OC","article-title":"Endotypic mechanisms of successful hypoglossal nerve stimulation for obstructive sleep apnea","volume":"203","author":"Op de Beeck","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10.1016\/j.sleep.2024.12.021_bib68","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.5664\/jcsm.7814","article-title":"Therapeutic positive airway pressure level predicts response to hypoglossal nerve stimulation for obstructive sleep apnea","volume":"15","author":"Lee","year":"2019","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"10.1016\/j.sleep.2024.12.021_bib69","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00674-2018","article-title":"Identifying obstructive sleep apnoea patients responsive to supplemental oxygen therapy","volume":"52","author":"Sands","year":"2018","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1016\/j.sleep.2024.12.021_bib70","doi-asserted-by":"crossref","first-page":"281","DOI":"10.5665\/sleep.2390","article-title":"Acetazolamide attenuates the ventilatory response to arousal in patients with obstructive sleep apnea. Randomized Controlled Trial Research Support, N.I.H., Extramural","volume":"36","author":"Edwards","year":"2013","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.sleep.2024.12.021_bib71","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1513\/AnnalsATS.202305-437OC","article-title":"Loop gain as a predictor of blood pressure response in patients treated for obstructive sleep apnea: secondary analysis of a clinical trial","volume":"21","author":"Schmickl","year":"2024","journal-title":"Annals of the American Thoracic Society"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945724005732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945724005732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T12:35:56Z","timestamp":1737808556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945724005732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":71,"alternative-id":["S1389945724005732"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2024.12.021","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sleep apnea endotypes and their implications for clinical practise","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2024.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}