{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T05:18:15Z","timestamp":1774070295839,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.sleep.2024.12.026","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T17:49:38Z","timestamp":1734630578000},"page":"282-289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Sleep complaints in individuals with SYNGAP1-associated syndrome"],"prefix":"10.1016","volume":"126","author":[{"given":"Amanda Cristina","family":"Mosini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Moys\u00e9s-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica Nayara","family":"Goes de Araujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Guerreiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lais","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mal\u00fa","family":"Zamariolli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Doria","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Balbueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Berlim de Mello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Antonio","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica L.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2024.12.026_bib1","unstructured":"Patel, D.; Steinberg, J.; Patel, P. Insomnia in the elderly: A ReviewJournal of Clinical Sleep Medicine. [s.l: s.n.]."},{"issue":"9","key":"10.1016\/j.sleep.2024.12.026_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci11091229","article-title":"Sleep abnormalities in the synaptopathies\u2014syngap1-related intellectual disability and phelan\u2013mcdermid syndrome","volume":"11","author":"Smith-Hicks","year":"2021","journal-title":"Brain Sci"},{"key":"10.1016\/j.sleep.2024.12.026_bib3","article-title":"Autism, epilepsy, and synaptopathies: a not rare association. Neurological Sciences","volume":"1 ago","author":"Keller","year":"2017","journal-title":"Springer-Verlag Italia s.r.l."},{"key":"10.1016\/j.sleep.2024.12.026_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2012.02.002","article-title":"Synaptopathies: diseases of the synaptome","author":"Grant","year":"2012","journal-title":"Curr Opin Neurobiol"},{"issue":"4","key":"10.1016\/j.sleep.2024.12.026_bib5","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: position paper of the ILAE commission for classification and terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.sleep.2024.12.026_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/S1474-4422(15)00250-1","article-title":"The genetic landscape of the epileptic encephalopathies of infancy and childhood","author":"Mctague","year":"2016","journal-title":"The Lancet NeurologyLancet Publishing Group"},{"key":"10.1016\/j.sleep.2024.12.026_bib7","first-page":"1993","article-title":"SYNGAP1-Related intellectual disability","author":"Holder","year":"2019","journal-title":"Gene Reviews"},{"issue":"2","key":"10.1016\/j.sleep.2024.12.026_bib8","doi-asserted-by":"crossref","first-page":"E96","DOI":"10.1212\/WNL.0000000000006729","article-title":"SYNGAP1 encephalopathy: a distinctive generalized developmental and epileptic encephalopathy","volume":"92","author":"Vlaskamp","year":"2019","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.sleep.2024.12.026_bib9","doi-asserted-by":"crossref","DOI":"10.1186\/s11689-019-9276-y","article-title":"Phenotypic characterization of individuals with SYNGAP1 pathogenic variants reveals a potential correlation between posterior dominant rhythm and developmental progression","volume":"11","author":"Jimenez-Gomez","year":"2019","journal-title":"J Neurodev Disord"},{"key":"10.1016\/j.sleep.2024.12.026_bib10","article-title":"Twenty years of syngap research: from synapses to cognition","volume":"19 fev","author":"Gamache","year":"2020","journal-title":"Journal of Neuroscience Society for Neuroscience"},{"key":"10.1016\/j.sleep.2024.12.026_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smrv.2017.05.002","article-title":"The role of sleep in regulating structural plasticity and synaptic strength: implications for memory and cognitive function","volume":"39","author":"Raven","year":"2018","journal-title":"Sleep Med Rev"},{"issue":"1","key":"10.1016\/j.sleep.2024.12.026_bib12","doi-asserted-by":"crossref","DOI":"10.1186\/s12887-021-02529-y","article-title":"Sleep-related difficulties in healthy children and adolescents","volume":"21","author":"Lewien","year":"2021","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.sleep.2024.12.026_bib13","series-title":"Sleep, epilepsy, and autism","author":"Accardo","year":"2015"},{"issue":"1 jan","key":"10.1016\/j.sleep.2024.12.026_bib14","article-title":"Prevalence of sleep disorders in patients with epilepsy: a questionnaire-based cross-sectional study","volume":"114","author":"Lima","year":"2021","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.sleep.2024.12.026_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.euroneuro.2021.02.020","article-title":"A white paper on a neurodevelopmental framework for drug discovery in autism and other neurodevelopmental disorders","author":"D\u00edaz-Caneja","year":"2021","journal-title":"European Neuropsychopharmacology Elsevier B.V."},{"key":"10.1016\/j.sleep.2024.12.026_bib16","doi-asserted-by":"crossref","DOI":"10.5664\/jcsm.11246","article-title":"Subjective sleep assessment in individuals with SYNGAP1\u2013associated syndrome","author":"Mosini","year":"2024","journal-title":"J Clin Sleep Med"},{"issue":"1","key":"10.1016\/j.sleep.2024.12.026_bib17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jped.2013.06.009","article-title":"Portuguese Children's sleep habits questionnaire - validation and cross-cultural comparison","volume":"90","author":"Silva","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.sleep.2024.12.026_bib18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/978-1-4419-9893-4_82","article-title":"Sleep disturbance scale for children (SDSC)","author":"Shahid","year":"2011","journal-title":"STOP, THAT and One Hundred Other Sleep Scales"},{"key":"10.1016\/j.sleep.2024.12.026_bib19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse Charles","year":"1989","journal-title":"Psychiatr Res"},{"issue":"5","key":"10.1016\/j.sleep.2024.12.026_bib20","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.neuron.2020.02.033","article-title":"Autism-associated Shank3 is essential for homeostatic compensation in rodent V1","volume":"106","author":"Tatavarty","year":"2020","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/j.sleep.2024.12.026_bib21","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1136\/jmedgenet-2015-103451","article-title":"Genetic and neurodevelopmental spectrum of SYNGAP1-associated intellectual disability and epilepsy","volume":"53","author":"Mignot","year":"2016","journal-title":"J Med Genet"},{"issue":"1","key":"10.1016\/j.sleep.2024.12.026_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11689-022-09437-x","article-title":"Clinical and behavioural features of SYNGAP1-related intellectual disability: a parent and caregiver description","volume":"14","author":"Wright","year":"2022","journal-title":"J Neurodev Disord"},{"issue":"10216","key":"10.1016\/j.sleep.2024.12.026_bib23","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1016\/S0140-6736(19)31239-5","article-title":"Epileptic encephalopathies of infancy: welcome advances","volume":"394","author":"Berkovic","year":"2019","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.sleep.2024.12.026_bib24","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1002\/ajmg.a.37189","article-title":"De novo, heterozygous, loss-of-function mutations in SYNGAP1 cause a syndromic form of intellectual disability","volume":"167","author":"Parker","year":"2015","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.sleep.2024.12.026_bib25","article-title":"The reciprocal relationship between sleep and epilepsy","author":"Krutoshinskaya","year":"2024","journal-title":"Journal of Personalized Medicine Multidisciplinary Digital Publishing Institute (MDPI)"},{"key":"10.1016\/j.sleep.2024.12.026_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpn.2022.03.010","article-title":"Sleep in children with refractory epilepsy and epileptic encephalopathies: a systematic review of literature","author":"Proost","year":"2022","journal-title":"European J. Paediatric NeurologyW.B. Saunders Ltd"},{"issue":"12","key":"10.1016\/j.sleep.2024.12.026_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083941","article-title":"SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.sleep.2024.12.026_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.sleep.2023.04.008","article-title":"An exploratory study of sleep quality and quantity in children with causal variants in SYNGAP1, an autism risk gene","volume":"107","author":"Paasch","year":"2023","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2024.12.026_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-019-0474-9","article-title":"Sleep therapeutics and neuropsychiatric illness","author":"Krystal","year":"2020","journal-title":"Neuropsychopharmacology Springer Nature"},{"key":"10.1016\/j.sleep.2024.12.026_bib30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s40675-020-00194-8","article-title":"Sleep and memory in children","author":"Hoedlmoser","year":"2020","journal-title":"Current Sleep Medicine Reports"},{"issue":"8","key":"10.1016\/j.sleep.2024.12.026_bib31","first-page":"1","article-title":"The Children's sleep habits questionnaire (CSHQ): psychometric properties of A survey instrument for school-aged children","volume":"23","author":"Owens","year":"2000","journal-title":"J. Sleep Res. & Sleep Med."},{"issue":"4","key":"10.1016\/j.sleep.2024.12.026_bib32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2869.1996.00251.x","article-title":"The Sleep Disturbance Scale for Children (SDSC) construction and validation of an instrument to evaluate sleep disturbances in childhood and adolescence","volume":"5","author":"Bruni","year":"1996","journal-title":"J Sleep Res"},{"key":"10.1016\/j.sleep.2024.12.026_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.sleepx.2019.100006","article-title":"Factor structure of the sleep disturbance scale for children (SDSC) in those with attention deficit and hyperactivity disorder (ADHD)","volume":"1","author":"Mancini","year":"2019","journal-title":"Sleep Med X"},{"issue":"2","key":"10.1016\/j.sleep.2024.12.026_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/medicina57020095","article-title":"Sleep disorders in autism spectrum disorder pre-school children: an evaluation using the sleep disturbance scale for children","volume":"57","author":"Romeo","year":"2021","journal-title":"Medicina"},{"issue":"4","key":"10.1016\/j.sleep.2024.12.026_bib35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s40489-015-0057-6","article-title":"Sleep disturbances in autism spectrum disorders","volume":"2","author":"Deliens","year":"2015","journal-title":"Review Journal of Autism and Developmental Disorders"},{"key":"10.1016\/j.sleep.2024.12.026_bib36","article-title":"Sleep and epilepsy: a focused review of pathophysiology, clinical syndromes, Co-morbidities, and therapy","author":"Moore","year":"2021","journal-title":"Neurotherapeutics Springer Science and Business Media Deutschland GmbH"},{"issue":"7642","key":"10.1016\/j.sleep.2024.12.026_bib37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature21062","article-title":"Prevalence and architecture of de novo mutations in developmental disorders","volume":"542","author":"Mcrae","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.sleep.2024.12.026_bib38","unstructured":"Hae Kim, J. et al. SynGAP: a synaptic RasGAP that associates with the PSD-95\/SAP90 protein FamilyNeuron. [s.l: s.n.]."},{"issue":"12","key":"10.1016\/j.sleep.2024.12.026_bib39","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0600084103","article-title":"SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons","volume":"103","author":"Rumbaugh","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.sleep.2024.12.026_bib40","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.cell.2016.07.008","article-title":"Phase transition in postsynaptic densities underlies formation of synaptic complexes and synaptic plasticity","volume":"166","author":"Zeng","year":"2016","journal-title":"Cell"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945724005793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945724005793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T12:35:52Z","timestamp":1737808552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945724005793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":40,"alternative-id":["S1389945724005793"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2024.12.026","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sleep complaints in individuals with SYNGAP1-associated syndrome","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2024.12.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}