{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T04:20:49Z","timestamp":1745382049817,"version":"3.40.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00NR014675-04","R61AG080606-01"],"award-info":[{"award-number":["R00NR014675-04","R61AG080606-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.sleep.2025.02.006","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T17:18:03Z","timestamp":1738689483000},"page":"183-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Aminoacetone is associated with sleep latency"],"prefix":"10.1016","volume":"128","author":[{"given":"Sirui","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Pak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.sleep.2025.02.006_bib1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s11325-012-0733-z","article-title":"Factors associated with excessive daytime sleepiness in patients with severe obstructive sleep apnea","volume":"17","author":"Jacobsen","year":"2013","journal-title":"Sleep Breath"},{"issue":"4","key":"10.1016\/j.sleep.2025.02.006_bib2","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1161\/CIRCOUTCOMES.111.963801","article-title":"Daytime sleepiness and risk of stroke and vascular disease: findings from the Northern Manhattan Study (NOMAS)","volume":"5","author":"Boden-Albala","year":"2012","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"1","key":"10.1016\/j.sleep.2025.02.006_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11325-011-0481-5","article-title":"Epworth Sleepiness Scale may be an indicator for blood pressure profile and prevalence of coronary artery disease and cerebrovascular disease in patients with obstructive sleep apnea","volume":"16","author":"Feng","year":"2012","journal-title":"Sleep Breath"},{"key":"10.1016\/j.sleep.2025.02.006_bib4","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.2147\/NSS.S319675","article-title":"Excessive daytime sleepiness and cardiovascular mortality in us adults: a NHANES 2005-2008 follow-up study","volume":"13","author":"Li","year":"2021","journal-title":"Nat Sci Sleep"},{"key":"10.1016\/j.sleep.2025.02.006_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.sleep.2024.02.004","article-title":"Excessive daytime sleepiness is associated with increased residual cardiovascular risks among coronary artery disease patients with obstructive sleep apnea","volume":"115","author":"Sun","year":"2024","journal-title":"Sleep Med"},{"issue":"2","key":"10.1016\/j.sleep.2025.02.006_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007221","article-title":"Excessive daytime sleepiness independently predicts increased cardiovascular risk after myocardial infarction","volume":"7","author":"Xie","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"12","key":"10.1016\/j.sleep.2025.02.006_bib7","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.5664\/jcsm.9620","article-title":"Recommended protocols for the multiple sleep latency test and maintenance of wakefulness test in adults: guidance from the American Academy of sleep medicine","volume":"17","author":"Krahn","year":"2021","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2025.02.006_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.sleep.2017.10.004","article-title":"Lower plasma choline levels are associated with sleepiness symptoms","volume":"44","author":"Pak","year":"2018","journal-title":"Sleep Med"},{"issue":"2","key":"10.1016\/j.sleep.2025.02.006_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.21101\/cejph.a3647","article-title":"Associations of subjective sleep quality with depression score, anxiety, physical symptoms and sleep onset latency in students","volume":"19","author":"Augner","year":"2011","journal-title":"Cent Eur J Publ Health"},{"key":"10.1016\/j.sleep.2025.02.006_bib10","first-page":"2012","volume":"vol. 176","author":"Iber","year":"2007"},{"issue":"4","key":"10.1016\/j.sleep.2025.02.006_bib11","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00310-2019","article-title":"Daytime sleepiness predicts inflammation and ambulatory blood pressure in sleep apnoea","volume":"6","author":"Pak","year":"2020","journal-title":"ERJ Open Res"},{"issue":"4","key":"10.1016\/j.sleep.2025.02.006_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11306-021-01860-w","article-title":"Sphinganine is associated with 24-h MAP in the non-sleepy with OSA","volume":"18","author":"Pak","year":"2022","journal-title":"Metabolomics"},{"issue":"2","key":"10.1016\/j.sleep.2025.02.006_bib13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res"},{"issue":"12","key":"10.1016\/j.sleep.2025.02.006_bib14","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.2215\/CJN.01340118","article-title":"Sleep quality and sleep duration with CKD are associated with progression to ESKD","volume":"13","author":"Yamamoto","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.sleep.2025.02.006_bib15","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014587","article-title":"Measures of poor sleep quality are associated with higher energy intake and poor diet quality in a diverse sample of women from the go red for women strategically focused research network","volume":"9","author":"Zuraikat","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"10.1016\/j.sleep.2025.02.006_bib16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41370-018-0102-5","article-title":"Metabolomic assessment of exposure to near-highway ultrafine particles","volume":"29","author":"Walker","year":"2019","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"10.1016\/j.sleep.2025.02.006_bib17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.taap.2018.12.001","article-title":"Metabolome-wide association study of anti-epileptic drug treatment during pregnancy","volume":"363","author":"Walker","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"issue":"24","key":"10.1016\/j.sleep.2025.02.006_bib18","doi-asserted-by":"crossref","first-page":"11725","DOI":"10.1021\/ac402503m","article-title":"Metabolite profiling of a NIST Standard Reference Material for human plasma (SRM 1950): GC-MS, LC-MS, NMR, and clinical laboratory analyses, libraries, and web-based resources","volume":"85","author":"Sim\u00f3n-Manso","year":"2013","journal-title":"Anal Chem"},{"key":"10.1016\/j.sleep.2025.02.006_bib19","doi-asserted-by":"crossref","first-page":"g6284","DOI":"10.1136\/bmj.g6284","article-title":"Multiple hypothesis testing and Bonferroni's correction","volume":"349","author":"Sedgwick","year":"2014","journal-title":"Br Med J"},{"issue":"4","key":"10.1016\/j.sleep.2025.02.006_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10040170","article-title":"Identification of metabolic alterations in breast cancer using mass spectrometry-based metabolomic analysis","volume":"10","author":"Fan","year":"2020","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/j.sleep.2025.02.006_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/abio.1999.4058","article-title":"Assessment of the deamination of aminoacetone, an endogenous substrate for semicarbazide-sensitive amine oxidase","volume":"270","author":"Deng","year":"1999","journal-title":"Anal Biochem"},{"issue":"35","key":"10.1016\/j.sleep.2025.02.006_bib22","doi-asserted-by":"crossref","first-page":"16428","DOI":"10.1016\/S0021-9258(18)66584-6","article-title":"Interaction between L-threonine dehydrogenase and aminoacetone synthetase and mechanism of aminoacetone production","volume":"261","author":"Tressel","year":"1986","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.sleep.2025.02.006_bib23","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1021\/tx8001753","article-title":"Aminoacetone, a putative endogenous source of methylglyoxal, causes oxidative stress and death to insulin-producing RINm5f cells","volume":"21","author":"Sartori","year":"2008","journal-title":"Chem Res Toxicol"},{"issue":"6","key":"10.1016\/j.sleep.2025.02.006_bib24","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3109\/00498251003710269","article-title":"Metabolism, pharmacokinetics and excretion of the GABA(A) receptor partial agonist [(14)C]CP-409,092 in rats","volume":"40","author":"Kamel","year":"2010","journal-title":"Xenobiotica"},{"key":"10.1016\/j.sleep.2025.02.006_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2018.00070","article-title":"Conflicting effects of methylglyoxal and potential significance of miRNAs for seizure treatment [Mini review]","volume":"11","author":"Tao","year":"2018","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"10.1016\/j.sleep.2025.02.006_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/sleep\/22.1.33","article-title":"Role of GABAA receptors in the regulation of sleep: initial sleep responses to peripherally administered modulators and agonists","volume":"22","author":"Lancel","year":"1999","journal-title":"Sleep"},{"issue":"1","key":"10.1016\/j.sleep.2025.02.006_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/13880209.2018.1557698","article-title":"GABA and l-theanine mixture decreases sleep latency and improves NREM sleep","volume":"57","author":"Kim","year":"2019","journal-title":"Pharm Biol"},{"issue":"2","key":"10.1016\/j.sleep.2025.02.006_bib28","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0306-4522(02)00034-9","article-title":"GABA mechanisms and sleep","volume":"111","author":"Gottesmann","year":"2002","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.sleep.2025.02.006_bib29","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3177\/jnsv.61.182","article-title":"The improvement of sleep by oral intake of GABA and Apocynum venetum leaf extract","volume":"61","author":"Yamatsu","year":"2015","journal-title":"J Nutr Sci Vitaminol"},{"issue":"6","key":"10.1016\/j.sleep.2025.02.006_bib30","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1172\/JCI61319","article-title":"Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal","volume":"122","author":"Distler","year":"2012","journal-title":"J Clin Investig"},{"issue":"11","key":"10.1016\/j.sleep.2025.02.006_bib31","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1093\/sleep\/31.11.1499","article-title":"Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS)","volume":"31","author":"Winkelman","year":"2008","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2025.02.006_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2023.1134434","article-title":"Impairment of GABA inhibition in insomnia disorders: evidence from the peripheral blood system","volume":"14","author":"Xiang","year":"2023","journal-title":"Front Psychiatr"},{"issue":"1","key":"10.1016\/j.sleep.2025.02.006_bib33","first-page":"68","article-title":"Sleep medicine: insomnia and sleep","volume":"116","author":"Bollu","year":"2019","journal-title":"Mo Med"},{"issue":"12","key":"10.1016\/j.sleep.2025.02.006_bib34","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s00702-009-0326-6","article-title":"Glycine as a neurotransmitter in the forebrain: a short review","volume":"116","author":"Hernandes","year":"2009","journal-title":"J Neural Transm (Vienna)"},{"issue":"12","key":"10.1016\/j.sleep.2025.02.006_bib35","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/iub.128","article-title":"Glycine transporters and synaptic function","volume":"60","author":"Zafra","year":"2008","journal-title":"IUBMB Life"},{"key":"10.1016\/j.sleep.2025.02.006_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108631","article-title":"Glycine agonism in ionotropic glutamate receptors","volume":"193","author":"Stroebel","year":"2021","journal-title":"Neuropharmacology"},{"issue":"27","key":"10.1016\/j.sleep.2025.02.006_bib37","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.1523\/JNEUROSCI.0350-21.2022","article-title":"NMDA receptors in the lateral preoptic hypothalamus are essential for sustaining NREM and REM sleep","volume":"42","author":"Miracca","year":"2022","journal-title":"J Neurosci"},{"issue":"12","key":"10.1016\/j.sleep.2025.02.006_bib38","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1523\/JNEUROSCI.19-12-05124.1999","article-title":"Activation of NMDA receptors in the suprachiasmatic nucleus produces light-like phase shifts of the circadian clock in vivo","volume":"19","author":"Mintz","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.sleep.2025.02.006_bib39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3389\/fphys.2019.00361","article-title":"Modulation of NMDA-mediated clock resetting in the suprachiasmatic nuclei of mPer2 (Luc) mouse by endocannabinoids","volume":"10","author":"Sl\u00e1dek","year":"2019","journal-title":"Front Physiol"},{"issue":"6","key":"10.1016\/j.sleep.2025.02.006_bib40","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/npp.2014.326","article-title":"The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus","volume":"40","author":"Kawai","year":"2015","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.sleep.2025.02.006_bib41","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1249\/MSS.0000000000003040","article-title":"Nutritional modulation of sleep latency, duration, and efficiency: a randomized, repeated-measures, double-blind deception study","volume":"55","author":"Langan-Evans","year":"2023","journal-title":"Med Sci Sports Exerc"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945725000516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945725000516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:06:39Z","timestamp":1745366799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945725000516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":41,"alternative-id":["S1389945725000516"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2025.02.006","relation":{},"ISSN":["1389-9457"],"issn-type":[{"type":"print","value":"1389-9457"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aminoacetone is associated with sleep latency","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2025.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}