{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:56:18Z","timestamp":1789797378862,"version":"4.0.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024339","name":"Monash Addiction Research Centre, Monash University","doi-asserted-by":"publisher","award":["31807"],"award-info":[{"award-number":["31807"]}],"id":[{"id":"10.13039\/501100024339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020821","name":"Monash University Monash Biomedicine Discovery Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020821","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.sleep.2025.106542","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T02:09:45Z","timestamp":1745806185000},"page":"106542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["The impact of acetazolamide and dronabinol on the physiological endotypes responsible for obstructive sleep apnea"],"prefix":"10.1016","volume":"132","author":[{"given":"Luke D.J.","family":"Thomson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane A.","family":"Landry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Maddison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Bleackley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garun S.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9383-1644","authenticated-orcid":false,"given":"Bradley A.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2025.106542_bib1","article-title":"A randomised dose finding study of combination dronabinol and acetazolamide for the treatment of obstructive sleep apnoea","author":"Walsh","year":"2024","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2025.106542_bib2","article-title":"Acetazolamide for obstructive and central sleep apnea: a comprehensive systematic review and meta-analysis","author":"Schmickl","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.sleep.2025.106542_bib3","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1113\/jphysiol.2011.223925","article-title":"Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea","volume":"590","author":"Edwards","year":"2012","journal-title":"J Physiol"},{"key":"10.1016\/j.sleep.2025.106542_bib4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/thorax-2023-220184","article-title":"Combination pharmacological therapy targeting multiple mechanisms of sleep apnoea: a randomised controlled cross-over trial","volume":"79","author":"Sands","year":"2024","journal-title":"Thorax"},{"key":"10.1016\/j.sleep.2025.106542_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpsyt.2013.00001","article-title":"Proof of concept trial of dronabinol in obstructive sleep apnea","volume":"4","author":"Prasad","year":"2013","journal-title":"Front Psychiatr"},{"key":"10.1016\/j.sleep.2025.106542_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx184","article-title":"Pharmacotherapy of apnea by cannabimimetic enhancement, the PACE clinical trial: effects of dronabinol in obstructive sleep apnea","volume":"41","author":"Carley","year":"2018","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2025.106542_bib7","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1152\/jn.1995.73.2.907","article-title":"Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons","volume":"73","author":"Fan","year":"1995","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.sleep.2025.106542_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/sleep\/25.4.388","article-title":"Functional role for cannabinoids in respiratory stability during sleep","volume":"25","author":"Carley","year":"2002","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2025.106542_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.5664\/jcsm.2172","article-title":"Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. Deliberations of the sleep apnea definitions task force of the American academy of sleep medicine","volume":"8","author":"Berry","year":"2012","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2025.106542_bib11","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1183\/09031936.00062914","article-title":"Quantifying the ventilatory control contribution to sleep apnoea using polysomnography","volume":"45","author":"Terrill","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.sleep.2025.106542_bib12","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1164\/rccm.201707-1435OC","article-title":"Phenotyping pharyngeal pathophysiology using polysomnography in patients with obstructive sleep apnea","volume":"197","author":"Sands","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2025.106542_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx183","article-title":"Quantifying the arousal threshold using polysomnography in obstructive sleep apnea","volume":"41","author":"Sands","year":"2018","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2025.106542_bib14","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.chest.2020.10.080","article-title":"Assessing the physiologic endotypes responsible for REM- and NREM-based OSA","volume":"159","author":"Joosten","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.sleep.2025.106542_bib15","article-title":"The physiological phenotype of obstructive sleep apnea differs between Caucasian and Chinese patients","volume":"42","author":"O'Driscoll","year":"2019","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2025.106542_bib16","article-title":"Effects of acetazolamide on control of breathing in sleep apnea patients: mechanistic insights using meta-analyses and physiological model simulations","volume":"9","author":"Schmickl","year":"2021","journal-title":"Phys Rep"},{"key":"10.1016\/j.sleep.2025.106542_bib17","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.chest.2023.09.022","article-title":"Modification of endotypic traits in OSA by the carbonic anhydrase inhibitor sulthiame","volume":"165","author":"Hoff","year":"2024","journal-title":"Chest"},{"key":"10.1016\/j.sleep.2025.106542_bib18","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1164\/rccm.201601-0099OC","article-title":"Upper-airway collapsibility and loop gain predict the response to oral appliance therapy in patients with obstructive sleep apnea","volume":"194","author":"Edwards","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2025.106542_bib19","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/resp.14280","article-title":"Examining the impact of multilevel upper airway surgery on the obstructive sleep apnoea endotypes and their utility in predicting surgical outcomes","volume":"27","author":"Wong","year":"2022","journal-title":"Respirology (Carlton, Vic."},{"key":"10.1016\/j.sleep.2025.106542_bib20","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.5664\/jcsm.10528","article-title":"The combination of atomoxetine and dronabinol for the treatment of obstructive sleep apnea: a dose-escalating, open-label trial","volume":"19","author":"Messineo","year":"2023","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2025.106542_bib21","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0200-2021","article-title":"European Respiratory Society guideline on non-CPAP therapies for obstructive sleep apnoea","volume":"30","author":"Randerath","year":"2021","journal-title":"Eur Respir Rev"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945725002114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945725002114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:58:30Z","timestamp":1762545510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945725002114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":20,"alternative-id":["S1389945725002114"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2025.106542","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of acetazolamide and dronabinol on the physiological endotypes responsible for obstructive sleep apnea","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2025.106542","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106542"}}