{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:40:48Z","timestamp":1793144448909,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["WXLH202406006"],"award-info":[{"award-number":["WXLH202406006"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020207","name":"Sichuan Province Department of Health","doi-asserted-by":"publisher","award":["Q23057"],"award-info":[{"award-number":["Q23057"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.sleep.2025.106562","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T19:21:40Z","timestamp":1746818500000},"page":"106562","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Unraveling the bidirectional links between obstructive sleep apnea and mild cognitive impairment: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-6653","authenticated-orcid":false,"given":"Yan","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiumeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YaoXuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.sleep.2025.106562_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jcsm.13143","article-title":"A systematic review and meta-analysis of the prevalence and correlation of mild cognitive impairment in sarcopenia","volume":"14","author":"Yang","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"8","key":"10.1016\/j.sleep.2025.106562_bib2","article-title":"Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: a meta-analysis and systematic review of epidemiology studies","volume":"51","author":"Bai","year":"2022","journal-title":"Age Ageing"},{"issue":"12","key":"10.1016\/j.sleep.2025.106562_bib3","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1001\/archneurol.2009.266","article-title":"Mild cognitive impairment: ten years later","volume":"66","author":"Petersen","year":"2009","journal-title":"Arch Neurol"},{"issue":"3","key":"10.1016\/j.sleep.2025.106562_bib4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1212\/WNL.0000000000004826","article-title":"Practice guideline update summary: mild cognitive impairment: report of the guideline development, dissemination, and implementation subcommittee of the American academy of neurology","volume":"90","author":"Petersen","year":"2018","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.sleep.2025.106562_bib5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1513\/pats.200709-155MG","article-title":"The epidemiology of adult obstructive sleep apnea","volume":"5","author":"Punjabi","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.sleep.2025.106562_bib6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.smrv.2016.07.002","article-title":"Prevalence of obstructive sleep apnea in the general population: a systematic review","volume":"34","author":"Senaratna","year":"2017","journal-title":"Sleep Med Rev"},{"issue":"7","key":"10.1016\/j.sleep.2025.106562_bib7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jacc.2013.05.045","article-title":"Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome","volume":"62","author":"Drager","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.sleep.2025.106562_bib8","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jagp.2016.01.134","article-title":"Obstructive sleep apnea is linked to depression and cognitive impairment: evidence and potential mechanisms","volume":"24","author":"Kerner","year":"2016","journal-title":"Am J Geriatr Psychiatr"},{"issue":"2","key":"10.1016\/j.sleep.2025.106562_bib9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1164\/rccm.201801-0204PP","article-title":"Obstructive sleep apnea and the risk of cognitive decline in older adults","volume":"199","author":"Gosselin","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2025.106562_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2019.101250","article-title":"Obstructive sleep apnea, cognition and Alzheimer's disease: a systematic review integrating three decades of multidisciplinary research","volume":"50","author":"Bubu","year":"2020","journal-title":"Sleep Med Rev"},{"issue":"5","key":"10.1016\/j.sleep.2025.106562_bib11","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1513\/AnnalsATS.202004-313OC","article-title":"Cognitive function in a sleep clinic cohort of patients with obstructive sleep apnea","volume":"18","author":"Beaudin","year":"2021","journal-title":"Ann Am Thorac Soc"},{"issue":"5","key":"10.1016\/j.sleep.2025.106562_bib12","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/ene.15269","article-title":"Apolipoprotein E polymorphism \u03b54-stratified longitudinal association between daytime naps, sleep apnea and mild cognitive impairment: a prospective cohort study","volume":"29","author":"Duan","year":"2022","journal-title":"Eur J Neurol"},{"issue":"1","key":"10.1016\/j.sleep.2025.106562_bib13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000335363","article-title":"Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients","volume":"33","author":"Guarnieri","year":"2012","journal-title":"Dement Geriatr Cognit Disord"},{"issue":"2","key":"10.1016\/j.sleep.2025.106562_bib14","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3233\/JAD-132132","article-title":"Sleep-disordered breathing, sleep quality, and mild cognitive impairment in the general population","volume":"41","author":"Dlugaj","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.sleep.2025.106562_bib15","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.sleep.2020.05.002","article-title":"Severe obstructive sleep apnea in patients with chronic obstructive pulmonary disease is associated with an increased prevalence of mild cognitive impairment","volume":"75","author":"Wang","year":"2020","journal-title":"Sleep Med"},{"issue":"1","key":"10.1016\/j.sleep.2025.106562_bib16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12883-019-1422-3","article-title":"The prevalence of obstructive sleep apnea in mild cognitive impairment: a systematic review","volume":"19","author":"Mubashir","year":"2019","journal-title":"BMC Neurol"},{"key":"10.1016\/j.sleep.2025.106562_bib17","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Bmj"},{"issue":"4","key":"10.1016\/j.sleep.2025.106562_bib18","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/hep.30702","article-title":"Unexpected rapid increase in the burden of nafld in China from 2008 to 2018: a systematic review and meta-analysis","volume":"70","author":"Zhou","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.sleep.2025.106562_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101395","article-title":"Cross-sectional and longitudinal associations between adherence to Mediterranean diet with physical performance and cognitive function in older adults: a systematic review and meta-analysis","volume":"70","author":"Coelho-J\u00fanior","year":"2021","journal-title":"Ageing Res Rev"},{"issue":"5","key":"10.1016\/j.sleep.2025.106562_bib20","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1440-1843.2011.01979.x","article-title":"Neurocognitive impairment in Chinese patients with obstructive sleep apnoea hypopnoea syndrome","volume":"16","author":"Chen","year":"2011","journal-title":"Respirology"},{"issue":"1","key":"10.1016\/j.sleep.2025.106562_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-022-01153-x","article-title":"Paroxysmal slow wave events are associated with cognitive impairment in patients with obstructive sleep apnea","volume":"14","author":"Li","year":"2022","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.sleep.2025.106562_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.1022628","article-title":"Inherent regional brain activity changes in male obstructive sleep apnea with mild cognitive impairment: a resting-state magnetic resonance study","volume":"14","author":"Shu","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.sleep.2025.106562_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2023.137168","article-title":"Neuronal glutamate transporters are associated with cognitive impairment in obstructive sleep apnea patients without dementia","volume":"802","author":"Xue","year":"2023","journal-title":"Neurosci Lett"},{"issue":"3","key":"10.1016\/j.sleep.2025.106562_bib24","article-title":"Obstructive sleep apnea and chronic pain as risk factors of cognitive impairment in elderly population: a study from Indonesia","volume":"1","author":"Tiara","year":"2021","journal-title":"Narrat J"},{"key":"10.1016\/j.sleep.2025.106562_bib25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jocn.2019.06.014","article-title":"Do quantified sleep architecture abnormalities underlie cognitive disturbances in amnestic mild cognitive impairment?","volume":"67","author":"Menon","year":"2019","journal-title":"J Clin Neurosci"},{"issue":"1","key":"10.1016\/j.sleep.2025.106562_bib26","doi-asserted-by":"crossref","DOI":"10.5455\/medarh.2024.78.51-54","article-title":"Risk of obstructive sleep apnea and its relation to cognitive functions among Saudi older adults","volume":"78","author":"Alqurashi","year":"2024","journal-title":"Med Arch"},{"issue":"1","key":"10.1016\/j.sleep.2025.106562_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.228","article-title":"Prevalence of obstructive sleep apnea at an outpatient memory clinic","volume":"4","author":"Linssen","year":"2021","journal-title":"Health Sci Rep"},{"issue":"6","key":"10.1016\/j.sleep.2025.106562_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.13370","article-title":"Sleep macroarchitecture but not obstructive sleep apnea is independently associated with cognitive function in only older men of a population\u2010based cohort","volume":"30","author":"Parker","year":"2021","journal-title":"J Sleep Res"},{"issue":"6","key":"10.1016\/j.sleep.2025.106562_bib29","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1001\/jama.2011.1115","article-title":"Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women","volume":"306","author":"Yaffe","year":"2011","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.sleep.2025.106562_bib30","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsz048","article-title":"Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes","volume":"42","author":"Bubu","year":"2019","journal-title":"Sleep"},{"issue":"SUPPL 1","key":"10.1016\/j.sleep.2025.106562_bib31","doi-asserted-by":"crossref","first-page":"A430","DOI":"10.1093\/sleep\/zsaa056.1125","article-title":"Obstructive sleep apnea treatment and dementia risk in older adults","volume":"43","author":"Dunietz","year":"2020","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.sleep.2025.106562_bib32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5664\/jcsm.8174","article-title":"Nighttime hypoxia affects global cognition, memory, and executive function in community-dwelling individuals with hypertension","volume":"16","author":"Riba-Llena","year":"2020","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2025.106562_bib33","first-page":"756","article-title":"Association of obstructive sleep apnea with cognitive decline and age among non-demented older adults","author":"Pan","year":"2021","journal-title":"Neurosci Lett"},{"issue":"5","key":"10.1016\/j.sleep.2025.106562_bib34","article-title":"Sleep-disordered breathing risk with comorbid insomnia is associated with mild cognitive impairment","volume":"12","author":"Agudelo","year":"2022","journal-title":"Applied Sciences-Basel"},{"issue":"3","key":"10.1016\/j.sleep.2025.106562_bib35","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1249\/MSS.0000000000002802","article-title":"Mild cognitive impairment and dementia reported by former professional football players over 50 yr of age: an NFL-LONG study","volume":"54","author":"Walton","year":"2022","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.sleep.2025.106562_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104393","article-title":"Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study\/Study of Latinos","volume":"87","author":"Zhang","year":"2023","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.sleep.2025.106562_bib37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12974-020-01905-2","article-title":"The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome","volume":"17","author":"Liu","year":"2020","journal-title":"J Neuroinflammation"},{"issue":"8","key":"10.1016\/j.sleep.2025.106562_bib38","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1007\/s12035-023-03899-3","article-title":"Role of oxidative stress in the occurrence and development of cognitive dysfunction in patients with obstructive sleep apnea syndrome","volume":"61","author":"Zhang","year":"2024","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.sleep.2025.106562_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.902408","article-title":"Assessment of Alzheimer's disease-related biomarkers in patients with obstructive sleep apnea: a systematic review and meta-analysis","volume":"14","author":"Cui","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.sleep.2025.106562_bib40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.sleep.2024.02.021","article-title":"Are there any differences at gray matter sites between severe obstructive sleep apnea patients and healthy controls?","volume":"116","author":"Selcuk","year":"2024","journal-title":"Sleep Med"},{"issue":"1","key":"10.1016\/j.sleep.2025.106562_bib41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.5665\/sleep.3330","article-title":"Mapping gray matter reductions in obstructive sleep apnea: an activation likelihood estimation meta-analysis","volume":"37","author":"Weng","year":"2014","journal-title":"Sleep"},{"issue":"5","key":"10.1016\/j.sleep.2025.106562_bib42","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1037\/hea0000280","article-title":"Are we overestimating the prevalence of depression in chronic illness using questionnaires? Meta-analytic evidence in obstructive sleep apnoea","volume":"35","author":"Nanthakumar","year":"2016","journal-title":"Health Psychol"},{"issue":"4","key":"10.1016\/j.sleep.2025.106562_bib43","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1007\/s11325-022-02575-5","article-title":"Obstructive sleep apnea is associated with cognitive impairment in minor ischemic stroke","volume":"26","author":"Zhu","year":"2022","journal-title":"Sleep Breath"},{"key":"10.1016\/j.sleep.2025.106562_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2023.1212514","article-title":"Characteristics of macroscopic sleep structure in patients with mild cognitive impairment: a systematic review","volume":"14","author":"Liang","year":"2023","journal-title":"Front Psychiatr"},{"issue":"4","key":"10.1016\/j.sleep.2025.106562_bib45","first-page":"696","article-title":"Socio-emotional adaptation theory: charting the emotional process of alzheimer's disease","volume":"57","author":"Halpin","year":"2017","journal-title":"Gerontol"},{"issue":"10","key":"10.1016\/j.sleep.2025.106562_bib46","article-title":"Resilience in mild cognitive impairment (MCI): examining the level and the associations of resilience with subjective wellbeing and negative affect in early and late-stage MCI","volume":"13","author":"Tsormpatzoudi","year":"2023","journal-title":"Behav Sci (Basel)"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945725002370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945725002370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:59:36Z","timestamp":1762545576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945725002370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":46,"alternative-id":["S1389945725002370"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2025.106562","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unraveling the bidirectional links between obstructive sleep apnea and mild cognitive impairment: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2025.106562","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106562"}}