{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:50:49Z","timestamp":1781884249385,"version":"3.54.5"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.sleep.2025.106809","type":"journal-article","created":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:24:17Z","timestamp":1757859857000},"page":"106809","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["DUSP21 expression is associated with obstructive sleep apnea in pediatric patients with obesity"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3520-1286","authenticated-orcid":false,"given":"Fabio","family":"Affaticati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"Vermeiren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Meysman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Bartholomeus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Van Hoorenbeeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benson","family":"Ogunjimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn","family":"Verhulst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Van Eyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleep.2025.106809_bib1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0026-0495(96)90060-8","article-title":"Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the bogalusa heart study","volume":"45","author":"Srinivasan","year":"1996","journal-title":"Metab Clin Exp"},{"key":"10.1016\/j.sleep.2025.106809_bib2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.smrv.2007.11.002","article-title":"The prevalence, anatomical correlates and treatment of sleep-disordered breathing in obese children and adolescents","volume":"12","author":"Verhulst","year":"2008","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleep.2025.106809_bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1513\/pats.200708-137MG","article-title":"Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approaches","volume":"5","author":"Schwartz","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.sleep.2025.106809_bib4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1164\/ajrccm.164.1.2008171","article-title":"Sleep-disordered breathing in children","volume":"164","author":"Marcus","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2025.106809_bib5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jpeds.2017.12.056","article-title":"Clinical predictors of residual sleep apnea after weight loss therapy in Obese adolescents","volume":"196","author":"Van Eyck","year":"2018","journal-title":"J Pediatr"},{"key":"10.1016\/j.sleep.2025.106809_bib6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/adc.2006.101089","article-title":"Sleep-disordered breathing in overweight and obese children and adolescents: prevalence, characteristics and the role of fat distribution","volume":"92","author":"Verhulst","year":"2007","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.sleep.2025.106809_bib7","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/oby.20337","article-title":"Metabolic disregulation in obese adolescents with sleep\u2010disordered breathing before and after weight loss","volume":"21","author":"Van Hoorenbeeck","year":"2013","journal-title":"Obesity"},{"key":"10.1016\/j.sleep.2025.106809_bib8","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.chest.2019.02.011","article-title":"OSA and cardiovascular risk in pediatrics","volume":"156","author":"Smith","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.sleep.2025.106809_bib9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1164\/rccm.200703-375OC","article-title":"Association between metabolic syndrome and sleep-disordered breathing in adolescents","volume":"176","author":"Redline","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2025.106809_bib10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1017\/S0007114508971282","article-title":"Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?","volume":"100","author":"Trayhurn","year":"2008","journal-title":"Br J Nutr"},{"key":"10.1016\/j.sleep.2025.106809_bib11","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41366-023-01443-w","article-title":"The role of adipose tissue and subsequent liver tissue hypoxia in obesity and early stage metabolic dysfunction associated steatotic liver disease","volume":"48","author":"Van Eyck","year":"2024","journal-title":"Int J Obes"},{"key":"10.1016\/j.sleep.2025.106809_bib12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1183\/23120541.00038-2016","article-title":"Sleep disordered breathing and autonomic function in overweight and obese children and adolescents","volume":"2","author":"Van Eyck","year":"2016","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.sleep.2025.106809_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0252353","article-title":"Metabolic alterations and systemic inflammation in overweight\/obese children with obstructive sleep apnea","volume":"16","author":"Bhatt","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.sleep.2025.106809_bib14","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1164\/rccm.201012-2033OC","article-title":"The inflammatory preatherosclerotic remodeling induced by intermittent hypoxia is attenuated by RANTES\/CCL5 inhibition","volume":"184","author":"Arnaud","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2025.106809_bib15","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01731-2016","article-title":"Intermittent hypoxia in obstructive sleep apnoea mediates insulin resistance through adipose tissue inflammation","volume":"49","author":"Murphy","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.sleep.2025.106809_bib16","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1113\/JP273312","article-title":"Adipose tissue inflammation by intermittent hypoxia: mechanistic link between obstructive sleep apnoea and metabolic dysfunction","volume":"595","author":"Ryan","year":"2017","journal-title":"J Physiol"},{"key":"10.1016\/j.sleep.2025.106809_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.794256","article-title":"Improving treatment outcome in children with obesity by an online self-control training: a randomized controlled trial","volume":"9","author":"Vermeiren","year":"2021","journal-title":"Front Pediatrics"},{"key":"10.1016\/j.sleep.2025.106809_bib18","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3109\/03014460903049074","article-title":"References for growth and pubertal development from birth to 21 years in flanders","volume":"36","author":"Roelants","year":"2009","journal-title":"Belgium Ann Hum Biol"},{"key":"10.1016\/j.sleep.2025.106809_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.320.7244.1240","article-title":"Establishing a standard definition for child overweight and obesity worldwide: international survey","volume":"320","author":"Cole","year":"2000","journal-title":"Br Med J"},{"key":"10.1016\/j.sleep.2025.106809_bib20","doi-asserted-by":"crossref","first-page":"665","DOI":"10.5664\/jcsm.6576","article-title":"AASM scoring manual updates for 2017 (version 2.4)","volume":"13","author":"Berry","year":"2017","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleep.2025.106809_bib21","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1164\/ajrccm.153.2.8564147","volume":"153","year":"1996","journal-title":"American Thoracic Society Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2025.106809_bib22","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.3390\/ijms20184372","article-title":"Dual specificity phosphatases: from molecular mechanisms to biological function","volume":"20","author":"Pulido","year":"2019","journal-title":"IJMS"},{"key":"10.1016\/j.sleep.2025.106809_bib23","first-page":"2536","article-title":"Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: insights from structure-based modeling and high throughput screening","volume":"15","author":"Bakan","year":"2008","journal-title":"Comput Mater Continua (CMC)"},{"key":"10.1016\/j.sleep.2025.106809_bib24","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/hep.26665","article-title":"RNA interference against cancer\/testis genes identifies dual specificity phosphatase 21 as a potential therapeutic target in Human hepatocellular carcinoma","volume":"59","author":"Deng","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.sleep.2025.106809_bib25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12920-016-0218-1","article-title":"A 19-Gene expression signature as a predictor of survival in colorectal cancer","volume":"9","author":"Abdul Aziz","year":"2016","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.sleep.2025.106809_bib26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3390\/life14040425","article-title":"Unraveling the complexities of oxidative stress and inflammation biomarkers in obstructive sleep apnea syndrome: a comprehensive review","volume":"14","author":"Lavalle","year":"2024","journal-title":"Life"},{"key":"10.1016\/j.sleep.2025.106809_bib27","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1164\/rccm.200909-1398OC","article-title":"Transcriptomic analysis identifies phosphatases as novel targets for adenotonsillar hypertrophy of pediatric obstructive sleep apnea","volume":"181","author":"Khalyfa","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2025.106809_bib28","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.atherosclerosis.2013.09.033","article-title":"Obstructive sleep apnea and intermittent hypoxia increase expression of dual specificity phosphatase 1","volume":"231","author":"Hoffmann","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.sleep.2025.106809_bib29","unstructured":"Wu X, Pan Z, Liu W, Zha S, Song Y, Zhang Q, et al. The discovery, validation, and Function of hypoxia-related gene biomarkers for obstructive sleep apnea n.d."},{"key":"10.1016\/j.sleep.2025.106809_bib30","doi-asserted-by":"crossref","first-page":"12890","DOI":"10.1074\/jbc.274.18.12890","article-title":"Mitogen-activated protein kinase Phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments","volume":"274","author":"Laderoute","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.sleep.2025.106809_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.631879","article-title":"SARS-CoV-2 switches \u2018on\u2019 MAPK and NF\u03baB signaling via the reduction of nuclear DUSP1 and DUSP5 expression","volume":"12","author":"Goel","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.sleep.2025.106809_bib32","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3390\/cancers15041061","article-title":"Potential pathophysiological pathways in the complex relationships between OSA and cancer","volume":"15","author":"S\u00e1nchez-de-la-Torre","year":"2023","journal-title":"Cancers"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945725004848?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945725004848?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:52:15Z","timestamp":1781880735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945725004848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":32,"alternative-id":["S1389945725004848"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2025.106809","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DUSP21 expression is associated with obstructive sleep apnea in pediatric patients with obesity","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2025.106809","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106809"}}