{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:04:48Z","timestamp":1793271888195,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.sleep.2025.106823","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:40:27Z","timestamp":1758703227000},"page":"106823","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Efficacy and safety of lemborexant in patients with insomnia: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2003-922X","authenticated-orcid":false,"given":"Allahdad","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shree","family":"Rath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0456-022X","authenticated-orcid":false,"given":"Umama","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8938-0435","authenticated-orcid":false,"given":"Hammad","family":"Javaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6821-5653","authenticated-orcid":false,"given":"Zaryab","family":"Bacha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4664-591X","authenticated-orcid":false,"given":"Asad Ali Ahmed","family":"Cheema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umair","family":"Hayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3199-7862","authenticated-orcid":false,"given":"Muhammad Abdullah","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Qadeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Dominic","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-7314","authenticated-orcid":false,"given":"Raheel","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.sleep.2025.106823_bib1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.mcna.2014.11.013","article-title":"Sleep problems in the elderly","volume":"99","author":"Rodriguez","year":"2015","journal-title":"Med Clin North Am"},{"issue":"2","key":"10.1016\/j.sleep.2025.106823_bib2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jsmc.2022.03.003","article-title":"Epidemiology of insomnia: prevalence, course, risk factors, and public health burden","volume":"17","author":"Morin","year":"2022","journal-title":"Sleep Med Clin"},{"issue":"5","key":"10.1016\/j.sleep.2025.106823_bib3","first-page":"487","article-title":"Clinical guideline for the evaluation and management of chronic insomnia in adults","volume":"4","author":"Schutte-Rodin","year":"2008","journal-title":"J Clin Sleep Med JCSM Off Publ Am Acad Sleep Med"},{"issue":"1","key":"10.1016\/j.sleep.2025.106823_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12793\/tcp.2024.32.e5","article-title":"Emerging and upcoming therapies in insomnia","volume":"32","author":"Kim","year":"2024","journal-title":"Transl Clin Pharmacol"},{"key":"10.1016\/j.sleep.2025.106823_bib5","doi-asserted-by":"crossref","unstructured":"Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American academy of sleep medicine clinical practice guideline. J Clin Sleep Med. 13(2):307\u2013349.","DOI":"10.5664\/jcsm.6470"},{"issue":"4","key":"10.1016\/j.sleep.2025.106823_bib6","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s13311-012-0148-3","article-title":"Insomnia pharmacotherapy","volume":"9","author":"Roehrs","year":"2012","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.sleep.2025.106823_bib7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jpsychires.2020.05.025","article-title":"Lemborexant vs suvorexant for insomnia: a systematic review and network meta-analysis","volume":"128","author":"Kishi","year":"2020","journal-title":"J Psychiatr Res"},{"issue":"4","key":"10.1016\/j.sleep.2025.106823_bib8","first-page":"241","article-title":"Lemborexant (Dayvigo) for the treatment of insomnia","volume":"103","author":"Rhodes","year":"2021","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.sleep.2025.106823_bib9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.sleep.2021.01.048","article-title":"Long-term effectiveness and safety of lemborexant in adults with insomnia disorder: results from a phase 3 randomized clinical trial","volume":"80","author":"Yardley","year":"2021","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2025.106823_bib10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2147\/NSS.S448871","article-title":"Assessing the real-world, long-term impact of lemborexant on sleep quality in a home-based clinical study","volume":"16","author":"Miyata","year":"2024","journal-title":"Nat Sci Sleep"},{"key":"10.1016\/j.sleep.2025.106823_bib11","unstructured":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews | BMJ [Internet]. [cited 2025 April 12]. Available from: https:\/\/www.bmj.com\/content\/372\/bmj.n71."},{"key":"10.1016\/j.sleep.2025.106823_bib12","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"7414","key":"10.1016\/j.sleep.2025.106823_bib13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.sleep.2025.106823_bib14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"issue":"4","key":"10.1016\/j.sleep.2025.106823_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsy260","article-title":"On-the-road driving performance the morning after bedtime administration of lemborexant in healthy adult and elderly volunteers","volume":"42","author":"Vermeeren","year":"2019","journal-title":"Sleep"},{"issue":"11","key":"10.1016\/j.sleep.2025.106823_bib16","doi-asserted-by":"crossref","DOI":"10.5664\/jcsm.6800","article-title":"Lemborexant, a dual orexin receptor antagonist (DORA) for the treatment of insomnia disorder: results from a Bayesian, adaptive, randomized, double-blind, placebo-controlled study","volume":"13","author":"Murphy","year":"2017","journal-title":"J Clin Sleep Med"},{"issue":"12","key":"10.1016\/j.sleep.2025.106823_bib17","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.18254","article-title":"Comparison of lemborexant with placebo and zolpidem tartrate extended release for the treatment of older adults with insomnia disorder: a phase 3 randomized clinical trial","volume":"2","author":"Rosenberg","year":"2019","journal-title":"JAMA Netw Open"},{"issue":"1","key":"10.1016\/j.sleep.2025.106823_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/npr2.12509","article-title":"Efficacy and safety of lemborexant in subjects with insomnia disorder receiving medications for depression or anxiety symptoms","volume":"45","author":"Krystal","year":"2025","journal-title":"Neuropsychopharmacol Rep"},{"issue":"9","key":"10.1016\/j.sleep.2025.106823_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsaa123","article-title":"Long-term efficacy and tolerability of lemborexant compared with placebo in adults with insomnia disorder: results from the phase 3 randomized clinical trial SUNRISE 2","volume":"43","author":"K\u00e4rpp\u00e4","year":"2020","journal-title":"Sleep"},{"issue":"1","key":"10.1016\/j.sleep.2025.106823_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/sleepadvances\/zpab011","article-title":"Assessment of morning sleep propensity with lemborexant in adults with insomnia disorder in a randomized, placebo-controlled crossover study","volume":"2","author":"Mayleben","year":"2021","journal-title":"Sleep Adv"},{"issue":"2","key":"10.1016\/j.sleep.2025.106823_bib21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s40268-024-00462-w","article-title":"Safety and efficacy of lemborexant in insomnia patients: results of a postmarketing observational study of Dayvigo\u00ae tablets","volume":"24","author":"Mishima","year":"2024","journal-title":"Drugs R&D"},{"issue":"5","key":"10.1016\/j.sleep.2025.106823_bib22","first-page":"1067","article-title":"Efficacy and safety of lemborexant in adults with insomnia: comparing Japanese and non-Japanese subgroups from the global, phase 3, randomized, double-blind, placebo-controlled SUNRISE 2 study","volume":"17","author":"Inoue","year":"2021","journal-title":"J Clin Sleep Med JCSM Off Publ Am Acad Sleep Med"},{"key":"10.1016\/j.sleep.2025.106823_bib23","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-025-04072-4","article-title":"Efficacy and safety of lemborexant vs placebo in treating adults with insomnia disorder: a systematic review and meta-analysis of 1976 patients","author":"Alsaied","year":"2025","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.sleep.2025.106823_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2021.101556","article-title":"Improving sleep quality leads to better mental health: a meta-analysis of randomised controlled trials","volume":"60","author":"Scott","year":"2021","journal-title":"Sleep Med Rev"},{"issue":"9","key":"10.1016\/j.sleep.2025.106823_bib25","first-page":"1296","article-title":"Comparative efficacy of lemborexant and other insomnia treatments: a network meta-analysis","volume":"27","author":"McElroy","year":"2021","journal-title":"J Manag Care Spec Pharm"},{"issue":"5","key":"10.1016\/j.sleep.2025.106823_bib26","first-page":"1533","article-title":"Comparative efficacy and safety of lemborexant 5 mg versus 10 mg for the treatment of insomnia: a systematic review","volume":"44","author":"Habiba","year":"2023","journal-title":"Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol"},{"issue":"5","key":"10.1016\/j.sleep.2025.106823_bib27","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1055\/s-0043-1768667","article-title":"Dual orexin receptor antagonists for the treatment of insomnia: systematic review and network meta-analysis","volume":"81","author":"Rocha","year":"2023","journal-title":"Arq Neuropsiquiatr"},{"issue":"2","key":"10.1016\/j.sleep.2025.106823_bib28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/10600280211008492","article-title":"Review of the efficacy and safety of lemborexant, a dual receptor orexin antagonist (DORA), in the treatment of adults with insomnia disorder","volume":"56","author":"Waters","year":"2022","journal-title":"Ann Pharmacother"},{"issue":"9","key":"10.1016\/j.sleep.2025.106823_bib29","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s40266-024-01135-8","article-title":"Efficacy and safety of insomnia treatment with lemborexant in older adults: analyses from three clinical trials","volume":"41","author":"Gotfried","year":"2024","journal-title":"Drugs Aging"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945725004988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945725004988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:47:14Z","timestamp":1781880434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945725004988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":29,"alternative-id":["S1389945725004988"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2025.106823","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of lemborexant in patients with insomnia: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2025.106823","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106823"}}