{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:46:24Z","timestamp":1782344784719,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2023\/01555-8"],"award-info":[{"award-number":["2023\/01555-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2020\/13467-8"],"award-info":[{"award-number":["2020\/13467-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006303","name":"Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006303","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.sleep.2026.108945","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:12:27Z","timestamp":1775059947000},"page":"108945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Obstructive sleep apnea is associated with disturbances in nutrition-related biochemical markers among eutrophic adults: Findings from the EPISONO cohort"],"prefix":"10.1016","volume":"144","author":[{"given":"Bianca Camilo","family":"Schimenes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tathiana A.","family":"Alvarenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Kalil","family":"Morelh\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan Saj","family":"Porcacchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Brasil","family":"Tufik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1894-6748","authenticated-orcid":false,"given":"Monica Levy","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.sleep.2026.108945_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/nu17030446","article-title":"Association of dietary intake with chronic disease and human health","volume":"17","author":"Tafuri","year":"2025","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.sleep.2026.108945_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/nu17091525","article-title":"Nutritional screening and assessment in different populations","volume":"17","author":"Aparicio","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.sleep.2026.108945_bib3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fnut.2020.00090","article-title":"Traditional self-reported dietary instruments are prone to inaccuracies and new approaches are needed","volume":"7","author":"Ravelli","year":"2020","journal-title":"Front Nutr"},{"issue":"6","key":"10.1016\/j.sleep.2026.108945_bib4","doi-asserted-by":"crossref","DOI":"10.3945\/jn.112.172858","article-title":"The CDC's second national report on biochemical indicators of diet and nutrition in the U.S. population is a valuable tool for researchers and policy makers","volume":"143","author":"Pfeiffer","year":"2013","journal-title":"J Nutr"},{"issue":"4 Suppl","key":"10.1016\/j.sleep.2026.108945_bib5","article-title":"Biochemical markers as additional measurements in studies of the accuracy of dietary questionnaire measurements: conceptual issues","volume":"65","author":"Kaaks","year":"1997","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"10.1016\/j.sleep.2026.108945_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/nu15061546","article-title":"Low-grade inflammation and ultra-processed foods consumption: a review","volume":"15","author":"Tristan Asensi","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.sleep.2026.108945_bib7","first-page":"45","article-title":"Impact of ultra-processed foods on micronutrient content in the Brazilian diet","volume":"49","author":"Louzada","year":"2015","journal-title":"Rev Saude Publica"},{"issue":"9","key":"10.1016\/j.sleep.2026.108945_bib8","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1016\/j.clnu.2024.07.007","article-title":"Ultra-processed food and drink consumption and lipoprotein subclass profiles: a cross-sectional study of a middle-to older-aged population","volume":"43","author":"Millar","year":"2024","journal-title":"Clin Nutr"},{"issue":"5","key":"10.1016\/j.sleep.2026.108945_bib9","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3945\/an.116.012336","article-title":"Effects of diet on sleep quality","volume":"7","author":"St-Onge","year":"2016","journal-title":"Adv Nutr"},{"issue":"1","key":"10.1016\/j.sleep.2026.108945_bib10","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1055\/s-0043-1777812","article-title":"Dietary inflammatory index of Obese individuals with obstructive sleep apnea: a descriptive study","volume":"17","author":"Sousa","year":"2024","journal-title":"Sleep Sci"},{"issue":"11","key":"10.1016\/j.sleep.2026.108945_bib11","doi-asserted-by":"crossref","first-page":"846","DOI":"10.7326\/0003-4819-141-11-200412070-00008","article-title":"Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite","volume":"141","author":"Spiegel","year":"2004","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.sleep.2026.108945_bib12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biopsych.2015.05.014","article-title":"Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation","volume":"80","author":"Irwin","year":"2016","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.sleep.2026.108945_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.70255","article-title":"Prevalence and risk factors for obstructive sleep apnea in S\u00e3o Paulo: findings from the 4th edition of the EPISONO study","author":"Tufik","year":"2026","journal-title":"J Sleep Res"},{"key":"10.1016\/j.sleep.2026.108945_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.11606\/s1518-8787.2023057004744","article-title":"Consumption of ultra-processed foods in Brazil: distribution and temporal evolution 2008-2018","volume":"57","author":"Louzada","year":"2023","journal-title":"Rev Saude Publica"},{"issue":"11","key":"10.1016\/j.sleep.2026.108945_bib15","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1590\/S0100-879X2006005000170","article-title":"Sleep habits and complaints of adults in the city of Sao Paulo, Brazil, in 1987 and 1995","volume":"40","author":"Pires","year":"2007","journal-title":"Braz J Med Biol Res"},{"issue":"6","key":"10.1016\/j.sleep.2026.108945_bib16","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.sleep.2009.12.011","article-title":"Increasing trends of sleep complaints in the city of Sao Paulo, Brazil","volume":"11","author":"Santos-Silva","year":"2010","journal-title":"Sleep Med"},{"issue":"4 Suppl 1","key":"10.1016\/j.sleep.2026.108945_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/abc.2013S010","article-title":"[V Brazilian Guidelines on Dyslipidemias and Prevention of Atherosclerosis]","volume":"101","author":"Xavier","year":"2013","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.sleep.2026.108945_bib18","volume":"2.2","author":"Berry","year":"2015"},{"issue":"3","key":"10.1016\/j.sleep.2026.108945_bib19","doi-asserted-by":"crossref","first-page":"479","DOI":"10.5664\/jcsm.6506","article-title":"Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American academy of sleep medicine clinical practice guideline","volume":"13","author":"Kapur","year":"2017","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"10.1016\/j.sleep.2026.108945_bib20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1023\/B:QURE.0000018486.91360.00","article-title":"The world health Organization's WHOQOL-BREF quality of life assessment: psychometric properties and results of the international field trial. A report from the WHOQOL group","volume":"13","author":"Skevington","year":"2004","journal-title":"Qual Life Res"},{"key":"10.1016\/j.sleep.2026.108945_bib21","series-title":"Evaluation of sleep disorders: elaboration and validation of a questionnaire","first-page":"9","author":"Braz","year":"1987"},{"key":"10.1016\/j.sleep.2026.108945_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2024.101996","article-title":"Obstructive sleep apnea and obesity: a review of epidemiology, pathophysiology and the effect of weight-loss treatments","volume":"78","author":"Messineo","year":"2024","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleep.2026.108945_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/164_2021_558","article-title":"Obesity and obstructive sleep apnea","volume":"274","author":"Bonsignore","year":"2022","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.sleep.2026.108945_bib24","series-title":"Obesity and overweight","author":"Organization","year":"2025"},{"key":"10.1016\/j.sleep.2026.108945_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.metop.2025.100375","article-title":"Obesity: prevalence, causes, consequences, management, preventive strategies and future research directions","volume":"27","author":"Ahmed","year":"2025","journal-title":"Metabolism Open"},{"key":"10.1016\/j.sleep.2026.108945_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41574-025-01143-7","article-title":"The role of ultra-processed food in obesity","author":"Juul","year":"2025","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.sleep.2026.108945_bib27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1590\/S0034-8910.2015049005572","article-title":"Consumption of ultra-processed foods and their impact on the diet of young adults","volume":"49","author":"Bielemann","year":"2015","journal-title":"Rev Saude Publica"},{"issue":"1","key":"10.1016\/j.sleep.2026.108945_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.20945\/2359-3997000000101","article-title":"Influence of obesity in pulmonary function and exercise tolerance in Obese women with obstructive sleep apnea","volume":"63","author":"Passos","year":"2019","journal-title":"Arch Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.sleep.2026.108945_bib29","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s11325-022-02738-4","article-title":"Obstructive sleep apnea and orofacial myofunctional aspects in obesity","volume":"27","author":"da Silva","year":"2023","journal-title":"Sleep Breath"},{"issue":"Suppl 3","key":"10.1016\/j.sleep.2026.108945_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/EP161365.GL","article-title":"American association of clinical endocrinologists and AMERICAN college of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity","volume":"22","author":"Garvey","year":"2016","journal-title":"Endocr Pract"},{"issue":"5","key":"10.1016\/j.sleep.2026.108945_bib31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.31083\/j.rcm2505175","article-title":"Non-linear association between obstructive sleep apnea risk and lipid profile: data from the 2015-2018 national health and nutrition examination survey","volume":"25","author":"Ge","year":"2024","journal-title":"Rev Cardiovasc Med"},{"issue":"5","key":"10.1016\/j.sleep.2026.108945_bib32","doi-asserted-by":"crossref","first-page":"475","DOI":"10.5664\/jcsm.3690","article-title":"Effect of obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis","volume":"10","author":"Nadeem","year":"2014","journal-title":"J Clin Sleep Med"},{"issue":"10","key":"10.1016\/j.sleep.2026.108945_bib33","first-page":"48","article-title":"[Lipid status and oxidative stress in menopausal women with obstructive apnea syndrome]","volume":"91","author":"Kolesnikova","year":"2019","journal-title":"Ter Arkh"},{"issue":"6","key":"10.1016\/j.sleep.2026.108945_bib34","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/eurheartj\/ehr097","article-title":"Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea","volume":"33","author":"Drager","year":"2012","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.sleep.2026.108945_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.12874","article-title":"Effect of 5-year continuous positive airway pressure treatment on the lipid profile of patients with obstructive sleep apnea: a pilot study","volume":"29","author":"Simon","year":"2020","journal-title":"J Sleep Res"},{"issue":"4","key":"10.1016\/j.sleep.2026.108945_bib36","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1210\/jc.2010-2061","article-title":"Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones","volume":"96","author":"Wang","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.sleep.2026.108945_bib37","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.physbeh.2009.02.017","article-title":"Sex differences in the regulation of body weight","volume":"97","author":"Shi","year":"2009","journal-title":"Physiol Behav"},{"key":"10.1016\/j.sleep.2026.108945_bib38","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-3-319-70178-3_12","article-title":"Role of estrogens in the regulation of liver lipid metabolism","volume":"1043","author":"Palmisano","year":"2017","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.sleep.2026.108945_bib39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12902-025-01850-2","article-title":"Menopause and obstructive sleep apnea: revealing an independent mediating role of visceral fat beyond body mass index","volume":"25","author":"Wang","year":"2025","journal-title":"BMC Endocr Disord"},{"issue":"2","key":"10.1016\/j.sleep.2026.108945_bib40","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s11325-014-1045-2","article-title":"Serum levels of trace minerals and heavy metals in severe obstructive sleep apnea patients: correlates and clinical implications","volume":"19","author":"Asker","year":"2015","journal-title":"Sleep Breath"},{"key":"10.1016\/j.sleep.2026.108945_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2025.108158","article-title":"Magnesium is a key trace element in obstructive sleep apnea: evidence from Mendelian randomization analysis and NHANES database","volume":"244","author":"Ma","year":"2025","journal-title":"Respir Med"},{"issue":"9","key":"10.1016\/j.sleep.2026.108945_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10092273","article-title":"Serum magnesium levels in patients with obstructive sleep apnoea: a systematic review and meta-analysis","volume":"10","author":"Al Wadee","year":"2022","journal-title":"Biomedicines"},{"issue":"8","key":"10.1016\/j.sleep.2026.108945_bib43","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s12603-013-0023-x","article-title":"Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea","volume":"17","author":"Chen","year":"2013","journal-title":"J Nutr Health Aging"},{"issue":"2","key":"10.1016\/j.sleep.2026.108945_bib44","doi-asserted-by":"crossref","first-page":"C270","DOI":"10.1152\/ajpcell.00460.2018","article-title":"Zinc deficiency promotes endothelin secretion and endothelial cell migration through nuclear hypoxia-inducible factor-1 translocation","volume":"317","author":"Morand","year":"2019","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"10.1016\/j.sleep.2026.108945_bib45","first-page":"1431","article-title":"Serum levels of leptin, zinc and tryptophan in obese subjects with sleep deficits","volume":"30","author":"Samad","year":"2017","journal-title":"Pak J Pharm Sci"},{"key":"10.1016\/j.sleep.2026.108945_bib46","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3389\/fendo.2018.00376","article-title":"Sex differences in the impact of obstructive sleep apnea on glucose metabolism","volume":"9","author":"Temple","year":"2018","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.sleep.2026.108945_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.792633","article-title":"Gender differences in the context of obstructive sleep apnea and metabolic diseases","volume":"12","author":"Martins","year":"2021","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.sleep.2026.108945_bib48","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13293-024-00613-3","article-title":"Sex-dependent effects of chronic intermittent hypoxia: implication for obstructive sleep apnea","volume":"15","author":"Mabry","year":"2024","journal-title":"Biol Sex Differ"},{"issue":"6","key":"10.1016\/j.sleep.2026.108945_bib49","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jclinepi.2014.12.014","article-title":"The number of subjects per variable required in linear regression analyses","volume":"68","author":"Austin","year":"2015","journal-title":"J Clin Epidemiol"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138994572600184X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138994572600184X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T22:48:38Z","timestamp":1782341318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138994572600184X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":49,"alternative-id":["S138994572600184X"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2026.108945","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Obstructive sleep apnea is associated with disturbances in nutrition-related biochemical markers among eutrophic adults: Findings from the EPISONO cohort","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2026.108945","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108945"}}