{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:49:08Z","timestamp":1791391748880,"version":"4.3.3"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100003305","name":"ResMed Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017647","name":"ResMed","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.sleep.2026.108976","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T15:05:16Z","timestamp":1776697516000},"page":"108976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Weight reduction drives improvement in insulin resistance independent of OSA phenotype and CPAP treatment in the RICCADSA cohort"],"prefix":"10.1016","volume":"144","author":[{"given":"Aylin","family":"Pihtili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeliz","family":"Celik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Thunstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-6538","authenticated-orcid":false,"given":"Y\u00fcksel","family":"Peker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.sleep.2026.108976_bib1","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","article-title":"Insulin resistance and human disease","volume":"37","author":"Reaven","year":"1988","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.sleep.2026.108976_bib2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2337\/diacare.14.3.173","article-title":"Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia, and atherosclerotic cardiovascular disease","volume":"14","author":"DeFronzo","year":"1991","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.sleep.2026.108976_bib3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1172\/JCI10583","article-title":"Cellular mechanisms of insulin resistance","volume":"106","author":"Shulman","year":"2000","journal-title":"J Clin Investig"},{"issue":"9918","key":"10.1016\/j.sleep.2026.108976_bib4","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0140-6736(13)60734-5","article-title":"Adult obstructive sleep apnoea","volume":"383","author":"Jordan","year":"2014","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.sleep.2026.108976_bib5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1513\/pats.200708-139MG","article-title":"Obstructive sleep apnea and metabolic syndrome: alterations in glucose metabolism and inflammation","volume":"5","author":"Tasali","year":"2008","journal-title":"Proc Am Thorac Soc"},{"issue":"129","key":"10.1016\/j.sleep.2026.108976_bib6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1183\/09059180.00003413","article-title":"Sleep apnoea and metabolic dysfunction","volume":"22","author":"Bonsignore","year":"2013","journal-title":"Eur Respir Rev"},{"issue":"2","key":"10.1016\/j.sleep.2026.108976_bib7","first-page":"160","article-title":"Sleep-disordered breathing, glucose intolerance, and insulin resistance","volume":"169","author":"Punjabi","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.sleep.2026.108976_bib8","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1164\/ajrccm.165.5.2103001","article-title":"Obstructive sleep apnea is independently associated with insulin resistance","volume":"165","author":"Ip","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.sleep.2026.108976_bib9","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1378\/chest.13-2403","article-title":"Diabetes mellitus prevalence and control in sleep-disordered breathing: the European Sleep Apnea Cohort (ESADA)","volume":"146","author":"Kent","year":"2014","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.sleep.2026.108976_bib10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1513\/pats.200708-119MG","article-title":"Adherence to continuous positive airway pressure therapy","volume":"5","author":"Weaver","year":"2008","journal-title":"Proc Am Thorac Soc"},{"issue":"1","key":"10.1016\/j.sleep.2026.108976_bib11","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1183\/09031936.00027406","article-title":"Sleep apnoea as an independent risk factor for cardiovascular disease","volume":"29","author":"McNicholas","year":"2007","journal-title":"Eur Respir J"},{"issue":"11","key":"10.1016\/j.sleep.2026.108976_bib12","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1136\/thx.2006.074351","article-title":"Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes","volume":"62","author":"West","year":"2007","journal-title":"Thorax"},{"issue":"24","key":"10.1016\/j.sleep.2026.108976_bib13","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMoa1103944","article-title":"CPAP for the metabolic syndrome in patients with obstructive sleep apnea","volume":"365","author":"Sharma","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.sleep.2026.108976_bib14","article-title":"Effects of CPAP-respiration on markers of glucose metabolism in patients with obstructive sleep apnoea syndrome: a systematic review and meta-analysis","volume":"9","author":"Hecht","year":"2011","journal-title":"Ger Med Sci"},{"issue":"11","key":"10.1016\/j.sleep.2026.108976_bib15","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1136\/thx.2007.093740","article-title":"Insulin resistance and daytime sleepiness in patients with sleep apnoea","volume":"63","author":"Barcel\u00f3","year":"2008","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.sleep.2026.108976_bib16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/jama.2017.7967","article-title":"Association of positive airway pressure with cardiovascular events and death in adults with sleep apnea: a systematic review and meta-analysis","volume":"318","author":"Yu","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.sleep.2026.108976_bib17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.sleep.2018.12.017","article-title":"Efficacy of continuous positive airway pressure (CPAP) preventing type 2 diabetes mellitus in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and insulin resistance: a systematic review and meta-analysis","volume":"62","author":"Abud","year":"2019","journal-title":"Sleep Med"},{"issue":"7121","key":"10.1016\/j.sleep.2026.108976_bib18","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","author":"Kahn","year":"2006","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.sleep.2026.108976_bib19","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1172\/JCI119628","article-title":"Insulin resistance and hypersecretion in obesity","volume":"100","author":"Ferrannini","year":"1997","journal-title":"J Clin Investig"},{"issue":"4","key":"10.1016\/j.sleep.2026.108976_bib20","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1164\/rccm.200805-669OC","article-title":"Lifestyle intervention with weight reduction: first-line treatment in mild obstructive sleep apnea","volume":"179","author":"Tuomilehto","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.sleep.2026.108976_bib21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the incidence of type 2 diabetes with lifestyle intervention","volume":"346","author":"Knowler","year":"2002","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.sleep.2026.108976_bib22","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.2337\/dc08-1776","article-title":"Obstructive sleep apnea among obese patients with type 2 diabetes","volume":"32","author":"Foster","year":"2009","journal-title":"Diabetes Care"},{"issue":"24","key":"10.1016\/j.sleep.2026.108976_bib23","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1056\/NEJMoa1306187","article-title":"CPAP, weight loss, or both for obstructive sleep apnea","volume":"370","author":"Chirinos","year":"2014","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.sleep.2026.108976_bib24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00125-019-05040-3","article-title":"Sex differences in metabolic regulation and diabetes susceptibility","volume":"63","author":"Tramunt","year":"2020","journal-title":"Diabetologia"},{"issue":"Suppl 1","key":"10.1016\/j.sleep.2026.108976_bib25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.genm.2009.02.002","article-title":"Gender differences in insulin resistance, body composition, and energy balance","volume":"6","author":"Geer","year":"2009","journal-title":"Gend Med"},{"key":"10.1016\/j.sleep.2026.108976_bib26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.physbeh.2017.08.016","article-title":"Gender differences in glucose homeostasis and diabetes","volume":"187","author":"Mauvais-Jarvis","year":"2018","journal-title":"Physiol Behav"},{"issue":"1","key":"10.1016\/j.sleep.2026.108976_bib27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/14017430802276106","article-title":"Rationale and design of the Randomized Intervention with CPAP in Coronary Artery Disease and Sleep Apnoea--RICCADSA trial","volume":"43","author":"Peker","year":"2009","journal-title":"Scand Cardiovasc J"},{"issue":"5","key":"10.1016\/j.sleep.2026.108976_bib28","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1164\/rccm.201601-0088OC","article-title":"Effect of positive airway pressure on cardiovascular outcomes in coronary artery disease patients with nonsleepy obstructive sleep apnea. The RICCADSA randomized controlled trial","volume":"194","author":"Peker","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.sleep.2026.108976_bib29","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A new method for measuring daytime sleepiness: the Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"10.1016\/j.sleep.2026.108976_bib30","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945726002157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945726002157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T22:52:01Z","timestamp":1782341521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945726002157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":30,"alternative-id":["S1389945726002157"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2026.108976","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Weight reduction drives improvement in insulin resistance independent of OSA phenotype and CPAP treatment in the RICCADSA cohort","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2026.108976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108976"}}