{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:54:12Z","timestamp":1791089652789,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.sleep.2026.109238","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:21:12Z","timestamp":1787923272000},"page":"109238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Structured management of dopamine agonist withdrawal in restless legs syndrome with augmentation: A prospective real-world cohort study"],"prefix":"10.1016","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3050-9396","authenticated-orcid":false,"given":"Raquel","family":"Mart\u00edn Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Boi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4690-7965","authenticated-orcid":false,"given":"Celia","family":"Garcia-Malo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.sleep.2026.109238_bib1","first-page":"80","article-title":"Restless legs syndrome","volume":"7","author":"Manconi","year":"2021","journal-title":"Nat Rev Dis Prim Nat Res"},{"key":"10.1016\/j.sleep.2026.109238_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.mayocp.2026.05.010","article-title":"An updated algorithm for the management of restless legs syndrome","author":"Silber","year":"2026","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"10.1016\/j.sleep.2026.109238_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1389-9457(03)00010-8","article-title":"Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the national institutes of health","volume":"4","author":"Allen","year":"2003","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2026.109238_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sleep.2016.01.017","article-title":"Guidelines for the first-line treatment of restless legs syndrome\/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation","volume":"21","author":"Garcia-Borreguero","year":"2016","journal-title":"Sleep Med"},{"issue":"3","key":"10.1016\/j.sleep.2026.109238_bib5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jsmc.2015.05.020","article-title":"Dopaminergic augmentation in restless legs Syndrome\/Willis-Ekbom disease: identification and management","volume":"10","author":"Garc\u00eda-Borreguero","year":"2015","journal-title":"Sleep Med Clin"},{"issue":"4","key":"10.1016\/j.sleep.2026.109238_bib6","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1111\/ene.15221","article-title":"Factors associated with augmentation in patients with restless legs syndrome","volume":"29","author":"Heim","year":"2022","journal-title":"Eur J Neurol"},{"issue":"5","key":"10.1016\/j.sleep.2026.109238_bib7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.sleep.2011.03.003","article-title":"Restless legs syndrome (RLS) augmentation associated with dopamine agonist and levodopa usage in a community sample","volume":"12","author":"Allen","year":"2011","journal-title":"Sleep Med"},{"issue":"1","key":"10.1016\/j.sleep.2026.109238_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5664\/jcsm.11390","article-title":"Treatment of restless legs syndrome and periodic limb movement disorder: an American academy of sleep medicine clinical practice guideline","volume":"21","author":"Winkelman","year":"2025","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"10.1016\/j.sleep.2026.109238_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jsmc.2021.02.012","article-title":"Akathisia and restless legs syndrome: solving the dopaminergic paradox","volume":"16","author":"Ferr\u00e9","year":"2021","journal-title":"Sleep Med Clin"},{"issue":"1","key":"10.1016\/j.sleep.2026.109238_bib10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mayocp.2017.11.007","article-title":"The appropriate use of opioids in the treatment of refractory restless legs syndrome","volume":"93","author":"Silber","year":"2018","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.sleep.2026.109238_bib11","first-page":"136","article-title":"Augmentation in restless legs syndrome: a comprehensive observational study of a Spanish cohort","volume":"1","author":"Mart\u00edn-Garc\u00eda","year":"2025","journal-title":"Sleep Med"},{"issue":"7","key":"10.1016\/j.sleep.2026.109238_bib12","article-title":"How effective are treatment guidelines for augmented RLS?","volume":"45","author":"Laiwah","year":"2022","journal-title":"Sleep"},{"issue":"9","key":"10.1016\/j.sleep.2026.109238_bib13","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/mds.20983","article-title":"Controlled withdrawal of pramipexole after 6 months of open-label treatment in patients with restless legs syndrome","volume":"21","author":"Trenkwalder","year":"2006","journal-title":"Mov Disord"},{"key":"10.1016\/j.sleep.2026.109238_bib14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.sleep.2016.05.004","article-title":"A method to switch from oral dopamine agonists to rotigotine in patients with restless legs syndrome and mild augmentation","volume":"24","author":"Winkelman","year":"2016","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2026.109238_bib15","first-page":"49","article-title":"Augmentation in restless legs syndrome: poor response to sudden withdrawal of dopaminergic therapy","author":"Kurlan","year":"2013","journal-title":"J Park Restless Legs Syndr"},{"issue":"52","key":"10.1016\/j.sleep.2026.109238_bib16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.sleep.2018.08.005","article-title":"Assessment of change in restless legs syndrome symptoms during the acute drug-withdrawal period","volume":"1","author":"Wang","year":"2018","journal-title":"Sleep Med"},{"issue":"10","key":"10.1016\/j.sleep.2026.109238_bib17","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1002\/mds.28668","article-title":"A randomized , placebo-controlled crossover study with dipyridamole for restless legs syndrome","volume":"36","author":"Garcia-Borreguero","year":"2021","journal-title":"Mov Disord"},{"key":"10.1016\/j.sleep.2026.109238_bib18","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.sleep.2018.02.002","article-title":"Treatment of restless legs syndrome\/Willis-Ekbom disease with the non-selective ENT1\/ENT2 inhibitor dipyridamole: testing the adenosine hypothesis","volume":"45","author":"Garcia-Borreguero","year":"2018","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2026.109238_bib19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.sleep.2017.03.012","article-title":"Treatment of restless legs syndrome with the selective AMPA receptor antagonist perampanel","volume":"34","author":"Garcia-Borreguero","year":"2017","journal-title":"Sleep Med"},{"issue":"4","key":"10.1016\/j.sleep.2026.109238_bib20","doi-asserted-by":"crossref","first-page":"728","DOI":"10.9758\/cpn.25.1316","article-title":"Aripiprazole has potential efficacy for antidepressant-induced restless legs syndrome: a case series","volume":"23","author":"Nagai","year":"2025","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"10.1016\/j.sleep.2026.109238_bib21","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2147\/NSS.S421189","article-title":"Aripiprazole, a novel option in the management of Restless Legs Syndrome (RLS) patients with augmentation and\/or severe RLS symptoms: a report of 4 cases","volume":"15","author":"Lee","year":"2023","journal-title":"Nat Sci Sleep"},{"issue":"5","key":"10.1016\/j.sleep.2026.109238_bib22","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.sleep.2007.03.022","article-title":"Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a world association of sleep medicine - international restless legs syndrome study group consensus conference at the max planck institute","volume":"8","author":"Garc\u00eda-Borreguero","year":"2007","journal-title":"Sleep Med"},{"issue":"2","key":"10.1016\/j.sleep.2026.109238_bib23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1389-9457(02)00258-7","article-title":"Validation of the international restless legs syndrome study group rating scale for restless legs syndrome","volume":"4","author":"Walters","year":"2003","journal-title":"Sleep Med"},{"issue":"6","key":"10.1016\/j.sleep.2026.109238_bib24","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/j.1365-2753.2007.00921.x","article-title":"The validity of the CGI severity and improvement scales as measures of clinical effectiveness suitable for routine clinical use","volume":"14","author":"Berk","year":"2008","journal-title":"J Eval Clin Pract"},{"issue":"6","key":"10.1016\/j.sleep.2026.109238_bib25","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A new method for measuring daytime sleepiness: the Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"issue":"7","key":"10.1016\/j.sleep.2026.109238_bib26","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/mds.29410","article-title":"Levodopa dose equivalency in parkinson's disease: updated systematic review and proposals","volume":"38","author":"Jost","year":"2023","journal-title":"Mov Disord"},{"issue":"2","key":"10.1016\/j.sleep.2026.109238_bib27","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/2049463720912496","article-title":"Gabapentinoids: pharmacokinetics, pharmacodynamics and considerations for clinical practice","volume":"14","author":"Chincholkar","year":"2020","journal-title":"Br J Pain"},{"key":"10.1016\/j.sleep.2026.109238_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.sleep.2017.11.1126","article-title":"Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome\/Willis-Ekbom disease in adults and children: an IRLSSG task force report","volume":"41","author":"Allen","year":"2018","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleep.2026.109238_bib29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1874205X01509010004","article-title":"Augmentation in restless legs syndrome: treatment with gradual medication modification","volume":"29","author":"Rosenstein","year":"2015","journal-title":"Open Neurol J"}],"container-title":["Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945726004776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1389945726004776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:26:18Z","timestamp":1791087978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1389945726004776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":29,"alternative-id":["S1389945726004776"],"URL":"https:\/\/doi.org\/10.1016\/j.sleep.2026.109238","relation":{},"ISSN":["1389-9457"],"issn-type":[{"value":"1389-9457","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structured management of dopamine agonist withdrawal in restless legs syndrome with augmentation: A prospective real-world cohort study","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleep.2026.109238","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109238"}}