{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:01:28Z","timestamp":1786996888108,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T00:00:00Z","timestamp":1688256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine: X"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.sleepx.2023.100080","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T21:38:30Z","timestamp":1688765910000},"page":"100080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Sleep disruption, use of sleep-promoting medication and circadian desynchronization in spaceflight crewmembers: Evidence in low-Earth orbit and concerns for future deep-space exploration missions"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-9595","authenticated-orcid":false,"given":"Manuel","family":"Albornoz-Miranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Parrao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"Taverne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.sleepx.2023.100080_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41526-019-0069-0","article-title":"Local sleep-like events during wakefulness and their relationship to decreased alertness in astronauts on ISS","volume":"5","author":"Petit","year":"2019","journal-title":"npj Microgravity"},{"issue":"1","key":"10.1016\/j.sleepx.2023.100080_bib2","article-title":"On-orbit sleep problems of astronauts and countermeasures","volume":"5","author":"Wu","year":"2018","journal-title":"Mil. Med. Res."},{"issue":"9","key":"10.1016\/j.sleepx.2023.100080_bib3","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S1474-4422(14)70122-X","article-title":"Prevalence of sleep deficiency and use of hypnotic drugs in astronauts before, during, and after spaceflight: an observational study","volume":"13","author":"Barger","year":"2014","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.sleepx.2023.100080_bib4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mehy.2019.03.027","article-title":"Hypothetical role of gravity in rapid eye movements during sleep","volume":"127","author":"Gonfalone","year":"2019","journal-title":"Med Hypotheses"},{"issue":"3","key":"10.1016\/j.sleepx.2023.100080_bib5","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1080\/09291016.2018.1533730","article-title":"Characterization of sleep-wake patterns in crew members under a short-duration spaceflight","volume":"51","author":"Chen","year":"2018","journal-title":"Biol Rhythm Res"},{"key":"10.1016\/j.sleepx.2023.100080_bib6","series-title":"Sleep, circadian rhythms, and performance during space shuttle missions. The neurolab spacelab mission: neuroscience research in space results from the STS-90, neurolab spacelab mission","author":"Dijk","year":"2003"},{"key":"10.1016\/j.sleepx.2023.100080_bib7","doi-asserted-by":"crossref","first-page":"A105","DOI":"10.1093\/sleep\/zsaa056.276","article-title":"Changes in sleep architecture during long-duration spaceflight","volume":"43","author":"Piltch","year":"2020","journal-title":"Sleep"},{"key":"10.1016\/j.sleepx.2023.100080_bib8","first-page":"S82","article-title":"REM sleep and sleep efficiency are reduced during space flight","volume":"22","author":"Stickgold","year":"1999","journal-title":"Sleep"},{"issue":"1","key":"10.1016\/j.sleepx.2023.100080_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/npjmgrav.2015.19","article-title":"Circadian misalignment affects sleep and medication use before and during spaceflight","volume":"2","author":"Flynn-Evans","year":"2016","journal-title":"npj Microgravity"},{"key":"10.1016\/j.sleepx.2023.100080_bib10","series-title":"Behavioral issues associated with long-duration space expeditions: review and analysis of astronaut journals experiment 01-E104 final report","first-page":"32","author":"Stuster","year":"2010"},{"issue":"6","key":"10.1016\/j.sleepx.2023.100080_bib11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3357\/AMHP.4169.2015","article-title":"Low back pain in microgravity and bed rest studies","volume":"86","author":"Pool-Goudzwaard","year":"2015","journal-title":"Aerosp Med Hum Perform"},{"key":"10.1016\/j.sleepx.2023.100080_bib12","series-title":"Survey of On-orbit sleep quality (Sleep quiality questionnaire) (sleep_Quality). NASA ground based investigations: behavior and performance program","author":"Locke","year":"2009"},{"issue":"11","key":"10.1016\/j.sleepx.2023.100080_bib13","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1096\/fj.14-264838","article-title":"Medication use by U.S. Crewmembers on the international space station","volume":"29","author":"Wotring","year":"2015","journal-title":"Faseb J"},{"key":"10.1016\/j.sleepx.2023.100080_bib14","series-title":"The Apollo medical operations project: recommendations to improve crew health and performance for future exploration missions and lunar surface operations","author":"Scheuring","year":"2007"},{"key":"10.1016\/j.sleepx.2023.100080_bib17","series-title":"2005 IEEE aerospace conference","first-page":"4174","article-title":"Choosing Mars time: analysis of the Mars exploration rover experience","author":"Bass","year":"2005"},{"issue":"2","key":"10.1016\/j.sleepx.2023.100080_bib18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijpsycho.2014.04.008","article-title":"How stressful are 105 days of isolation? Sleep EEG patterns and tonic cortisol in healthy volunteers simulating manned flight to Mars","volume":"93","author":"Gemignani","year":"2014","journal-title":"Int J Psychophysiol"},{"key":"10.1016\/j.sleepx.2023.100080_bib19","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.actaastro.2013.07.002","article-title":"Sleep and cognitive function of crewmembers and mission controllers working 24-h shifts during a simulated 105-day spaceflight mission","volume":"93","author":"Barger","year":"2014","journal-title":"Acta Astronaut"},{"issue":"7","key":"10.1016\/j.sleepx.2023.100080_bib20","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1073\/pnas.1212646110","article-title":"Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing","volume":"110","author":"Basner","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.sleepx.2023.100080_bib22","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pss.2017.07.006","article-title":"Illumination conditions at the lunar poles: implications for future exploration","volume":"162","author":"Gl\u00e4ser","year":"2018","journal-title":"Planet Space Sci"},{"issue":"42","key":"10.1016\/j.sleepx.2023.100080_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc0865","article-title":"When the Moon had a magnetosphere","volume":"6","author":"Green","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.sleepx.2023.100080_bib24","volume":"2","author":"Saenger","year":"1970"},{"key":"10.1016\/j.sleepx.2023.100080_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.icarus.2020.114059","article-title":"The Mars Dust Activity Database (MDAD): a comprehensive statistical study of dust storm sequences","volume":"354","author":"Battalio","year":"2021","journal-title":"Icarus"},{"issue":"8","key":"10.1016\/j.sleepx.2023.100080_bib26","article-title":"Martian year 34 column dust climatology from Mars climate sounder observations: reconstructed maps and model simulations","volume":"125","author":"Montabone","year":"2020","journal-title":"J\u00a0Geophys Res Planets"},{"key":"10.1016\/j.sleepx.2023.100080_bib27","series-title":"The mars global dust storm of 2018","author":"Smith","year":"2019"},{"key":"10.1016\/j.sleepx.2023.100080_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.pepi.2020.106595","article-title":"The Marsquake catalogue from InSight, sols 0\u2013478","volume":"310","author":"Clinton","year":"2021","journal-title":"Phys Earth Planet In"},{"key":"10.1016\/j.sleepx.2023.100080_bib29","series-title":"2020 Congreso Internacional de Innovaci\u00f3n y Tendencias en Ingenier\u00eda (CONIITI)","article-title":"Preliminary approach to assess the seismic hazard on the Moon","author":"Cadena","year":"2020"},{"key":"10.1016\/j.sleepx.2023.100080_bib30","series-title":"Sleep medication use in adults aged 18 and over: United States, 2020. NCHS Data Brief, no 462","author":"Reuben","year":"2023"},{"key":"10.1016\/j.sleepx.2023.100080_bib31","series-title":"Dragonfly: NASA and the crisis aboard Mir","author":"Burrough","year":"1998"},{"key":"10.1016\/j.sleepx.2023.100080_bib32","series-title":"Report of the presidential commission on the space shuttle challenger accident II","year":"1986"},{"key":"10.1016\/j.sleepx.2023.100080_bib33","series-title":"Sleep quality questionnaire short- duration flyers","author":"Whitmire","year":"2013"},{"issue":"12","key":"10.1016\/j.sleepx.2023.100080_bib34","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1503\/cmaj.081125","article-title":"The space-flight environment: the international space station and beyond","volume":"180","author":"Thirsk","year":"2009","journal-title":"Can Med Assoc J"}],"container-title":["Sleep Medicine: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590142723000204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590142723000204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T02:27:25Z","timestamp":1762914445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590142723000204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":31,"alternative-id":["S2590142723000204"],"URL":"https:\/\/doi.org\/10.1016\/j.sleepx.2023.100080","relation":{},"ISSN":["2590-1427"],"issn-type":[{"value":"2590-1427","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sleep disruption, use of sleep-promoting medication and circadian desynchronization in spaceflight crewmembers: Evidence in low-Earth orbit and concerns for future deep-space exploration missions","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleepx.2023.100080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100080"}}