{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:43:17Z","timestamp":1785876197022,"version":"3.56.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004896","name":"Eisai Incorporated","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Medicine: X"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.sleepx.2023.100098","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T22:41:02Z","timestamp":1703284862000},"page":"100098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Transitioning insomnia patients from zolpidem to lemborexant: A multicenter, open-label study evaluating a next-dose transition approach to insomnia pharmacotherapy"],"prefix":"10.1016","volume":"7","author":[{"given":"Maha","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Brendan","family":"Montano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Perdomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess","family":"Amchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Moline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.sleepx.2023.100098_bib1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/jsr.12594","article-title":"European guideline for the diagnosis and treatment of insomnia","volume":"26","author":"Riemann","year":"2017","journal-title":"J Sleep Res"},{"key":"10.1016\/j.sleepx.2023.100098_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.5664\/jcsm.6470","article-title":"Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine Clinical Practice Guideline","volume":"13","author":"Sateia","year":"2017","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleepx.2023.100098_bib3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1124\/pr.117.014381","article-title":"Drugs for insomnia beyond benzodiazepines: pharmacology, clinical applications, and discovery","volume":"70","author":"Atkin","year":"2018","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.sleepx.2023.100098_bib4","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/j.clinthera.2016.09.010","article-title":"Review of safety and efficacy of sleep medicines in older adults","volume":"38","author":"Schroeck","year":"2016","journal-title":"Clin Ther"},{"key":"10.1016\/j.sleepx.2023.100098_bib5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jsmc.2020.02.003","article-title":"Hypnotic discontinuation in chronic insomnia","volume":"15","author":"Hintze","year":"2020","journal-title":"Sleep Med Clin"},{"key":"10.1016\/j.sleepx.2023.100098_bib6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.5665\/sleep.3410","article-title":"National use of prescription medications for insomnia: NHANES 1999-2010","volume":"37","author":"Bertisch","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.sleepx.2023.100098_bib7","series-title":"HALCION (triazolam) tablets [prescribing information]","year":"2019"},{"key":"10.1016\/j.sleepx.2023.100098_bib8","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3389\/fpsyt.2019.00717","article-title":"Hypnotic discontinuation using a blinded (masked) tapering approach: a case series","volume":"10","author":"Fung","year":"2019","journal-title":"Front Psychiatr"},{"key":"10.1016\/j.sleepx.2023.100098_bib9","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s00228-017-2257-8","article-title":"A systematic review of interventions to deprescribe benzodiazepines and other hypnotics among older people","volume":"73","author":"Reeve","year":"2017","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.sleepx.2023.100098_bib10","doi-asserted-by":"crossref","first-page":"zsaa123","DOI":"10.1093\/sleep\/zsaa123","article-title":"Long-term efficacy and tolerability of LEM compared with placebo in adults with insomnia disorder: results from the phase 3 randomized clinical trial SUNRISE 2","volume":"43","author":"Karppa","year":"2020","journal-title":"Sleep"},{"key":"10.1016\/j.sleepx.2023.100098_bib11","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.18254","article-title":"Comparison of LEM with placebo and zolpidem tartrate extended release for the treatment of older adults with insomnia disorder: a phase 3 randomized clinical trial","volume":"2","author":"Rosenberg","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.sleepx.2023.100098_bib12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.sleep.2021.01.048","article-title":"Long-term effectiveness and safety of LEM in adults with insomnia disorder: results from a phase 3 randomized clinical trial","volume":"80","author":"Yardley","year":"2021","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleepx.2023.100098_bib13","series-title":"Diagnostic and statistical manual of mental disorders","year":"2013"},{"key":"10.1016\/j.sleepx.2023.100098_bib14","series-title":"DAYVIGOTM (LEM) tablets [prescribing information]","year":"2021"},{"key":"10.1016\/j.sleepx.2023.100098_bib15","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/ALN.0b013e31816d83e4","article-title":"STOP questionnaire: a tool to screen patients for obstructive sleep apnea","volume":"108","author":"Chung","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.sleepx.2023.100098_bib16","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1097\/ALN.0000000000000665","article-title":"Correlation between the STOP-Bang score and the severity of obstructive sleep apnea","volume":"122","author":"Chung","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.sleepx.2023.100098_bib17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.sleep.2005.12.011","article-title":"The reliability, validity and responsiveness of the International Restless Legs Syndrome Study Group rating scale and subscales in a clinical-trial setting","volume":"7","author":"Abetz","year":"2006","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleepx.2023.100098_bib18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/JGP.0b013e3181256b01","article-title":"Efficacy and safety of zolpidem extended release in elderly primary insomnia patients","volume":"16","author":"Walsh","year":"2008","journal-title":"Am J Geriatr Psychiatr"},{"key":"10.1016\/j.sleepx.2023.100098_bib19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1389-9457(00)00065-4","article-title":"Validation of the Insomnia Severity Index as an outcome measure for insomnia research","volume":"2","author":"Bastien","year":"2001","journal-title":"Sleep Med"},{"key":"10.1016\/j.sleepx.2023.100098_bib20","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/sleep\/34.5.601","article-title":"The Insomnia Severity Index: psychometric indicators to detect insomnia cases and evaluate treatment response","volume":"34","author":"Morin","year":"2011","journal-title":"Sleep"},{"key":"10.1016\/j.sleepx.2023.100098_bib21","series-title":"AMBIEN CR (zolpidem tartrate extended-release) tablets, for oral use [prescribing information]","author":"sanofi-aventis","year":"2016"},{"key":"10.1016\/j.sleepx.2023.100098_bib22","series-title":"Risk of next-morning impairment after use of insomnia drugs; FDA requires lower recommended doses for certain drugs containing zolpidem (Ambien, Ambien CR, Edluar, and Zolpimist): safety announcement","author":"US Food and Drug Administration","year":"2013"},{"key":"10.1016\/j.sleepx.2023.100098_bib23","doi-asserted-by":"crossref","first-page":"765","DOI":"10.5664\/jcsm.8294","article-title":"Safety of LEM versus placebo and zolpidem: effects on auditory awakening threshold, postural stability, and cognitive performance in healthy older participants in the middle of the night and upon morning awakening","volume":"16","author":"Murphy","year":"2020","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.sleepx.2023.100098_bib24","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.2147\/DDDT.S73224","article-title":"Profile of suvorexant in the management of insomnia","volume":"9","author":"Sutton","year":"2015","journal-title":"Drug Des Dev Ther"},{"key":"10.1016\/j.sleepx.2023.100098_bib25","doi-asserted-by":"crossref","DOI":"10.1177\/20503121211037903","article-title":"Characteristics of patients who were able to switch from benzodiazepine hypnotics to LEM","volume":"9","author":"Suzuki","year":"2021","journal-title":"SAGE Open Med"}],"container-title":["Sleep Medicine: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590142723000381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590142723000381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T08:07:12Z","timestamp":1778486832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590142723000381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":25,"alternative-id":["S2590142723000381"],"URL":"https:\/\/doi.org\/10.1016\/j.sleepx.2023.100098","relation":{},"ISSN":["2590-1427"],"issn-type":[{"value":"2590-1427","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transitioning insomnia patients from zolpidem to lemborexant: A multicenter, open-label study evaluating a next-dose transition approach to insomnia pharmacotherapy","name":"articletitle","label":"Article Title"},{"value":"Sleep Medicine: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleepx.2023.100098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100098"}}