{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:16:55Z","timestamp":1787062615842,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/05804-5"],"award-info":[{"award-number":["2011\/05804-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["sleephealthjournal.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Sleep Health"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.sleh.2018.10.002","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T10:06:33Z","timestamp":1539597993000},"page":"572-578","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["PER3 gene regulation of sleep-wake behavior as a function of latitude"],"prefix":"10.1016","volume":"4","author":[{"given":"Mario Andre","family":"Leocadio-Miguel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno T\u00e9rcio","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Ximenes-da-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolnei","family":"Caumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Grassi-Kassisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Pedrazzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.sleh.2018.10.002_bb0005","first-page":"195","article-title":"A two process model of sleep regulation","volume":"1","author":"Borbely","year":"1982","journal-title":"Hum Neurobiol"},{"issue":"2 Pt 2","key":"10.1016\/j.sleh.2018.10.002_bb0010","first-page":"R161","article-title":"Timing of human sleep: recovery process gated by a circadian pacemaker","volume":"246","author":"Daan","year":"1984","journal-title":"Am J Physiol"},{"issue":"5","key":"10.1016\/j.sleh.2018.10.002_bb0015","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.conb.2013.05.002","article-title":"A role for clock genes in sleep homeostasis","volume":"23","author":"Franken","year":"2013","journal-title":"Curr Opin Neurobiol"},{"issue":"3","key":"10.1016\/j.sleh.2018.10.002_bb0020","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1177\/108155899904700310","article-title":"Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people","volume":"47","author":"Duffy","year":"1999","journal-title":"J Invest Med"},{"key":"10.1016\/j.sleh.2018.10.002_bb0025","doi-asserted-by":"crossref","first-page":"R271","DOI":"10.1093\/hmg\/ddl207","article-title":"Molecular components of the mammalian circadian clock","volume":"15","author":"Ko","year":"2006","journal-title":"Hum Mol Genet"},{"issue":"4","key":"10.1016\/j.sleh.2018.10.002_bb0030","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/sleep\/26.4.413","article-title":"A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference","volume":"26","author":"Archer","year":"2003","journal-title":"Sleep"},{"issue":"4","key":"10.1016\/j.sleh.2018.10.002_bb0035","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/embo-reports\/kve070","article-title":"Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome","volume":"2","author":"Ebisawa","year":"2001","journal-title":"EMBO Rep"},{"issue":"1","key":"10.1016\/j.sleh.2018.10.002_bb0040","first-page":"29","article-title":"Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it?","volume":"28","author":"Pereira","year":"2005","journal-title":"Sleep"},{"issue":"7091","key":"10.1016\/j.sleh.2018.10.002_bb0045","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature04727","article-title":"The DNA sequence and biological annotation of human chromosome 1","volume":"441","author":"Gregory","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.sleh.2018.10.002_bb0050","doi-asserted-by":"crossref","unstructured":"Sabino FC, Ribeiro AO, Tufik S, et al. Evolutionary history of the PER3 variable number of tandem repeats (VNTR): idiosyncratic aspect of primate molecular circadian clock. Cermakian N. PLoS One 2014;9(9):e107198. https:\/\/doi.org\/10.1371\/journal.pone.0107198","DOI":"10.1371\/journal.pone.0107198"},{"issue":"7","key":"10.1016\/j.sleh.2018.10.002_bb0055","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.cub.2007.01.073","article-title":"PER3 polymorphism predicts sleep structure and waking performance","volume":"17","author":"Viola","year":"2007","journal-title":"Curr Biol"},{"issue":"5","key":"10.1016\/j.sleh.2018.10.002_bb0060","doi-asserted-by":"crossref","first-page":"H2156","DOI":"10.1152\/ajpheart.00662.2008","article-title":"PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase","volume":"295","author":"Viola","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"10.1016\/j.sleh.2018.10.002_bb0065","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1080\/07420520902820970","article-title":"Association between specific diurnal preference questionnaire items and PER3 VNTR genotype","volume":"26","author":"Ellis","year":"2009","journal-title":"Chronobiol Int"},{"issue":"3","key":"10.1016\/j.sleh.2018.10.002_bb0070","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.smrv.2009.07.002","article-title":"PERIOD3, circadian phenotypes, and sleep homeostasis","volume":"14","author":"Dijk","year":"2010","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleh.2018.10.002_bb0075","article-title":"Phenotyping of PER3 variants reveals widespread effects on circadian preference, sleep regulation, and health","author":"Archer","year":"2017","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.sleh.2018.10.002_bb0080","series-title":"Biological Rhythms","first-page":"311","article-title":"The circadian system of man","author":"Aschoff","year":"1981"},{"key":"10.1016\/j.sleh.2018.10.002_bb0085","series-title":"Biological Rhythms","first-page":"95","article-title":"Circadian systems: entrainment","author":"Pittendrigh","year":"1981"},{"issue":"2","key":"10.1016\/j.sleh.2018.10.002_bb0090","doi-asserted-by":"crossref","first-page":"R44","DOI":"10.1016\/j.cub.2006.12.011","article-title":"The human circadian clock entrains to sun time","volume":"17","author":"Roenneberg","year":"2007","journal-title":"Curr Biol"},{"issue":"3","key":"10.1016\/j.sleh.2018.10.002_bb0095","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/0748730411401736","article-title":"Effects of light on cognitive brain responses depend on circadian phase and sleep homeostasis","volume":"26","author":"Vandewalle","year":"2011","journal-title":"J Biol Rhythms"},{"issue":"2","key":"10.1016\/j.sleh.2018.10.002_bb0100","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0304-3940(87)90014-0","article-title":"Reduction of human sleep duration after bright light exposure in the morning","volume":"73","author":"Dijk","year":"1987","journal-title":"Neurosci Lett"},{"issue":"2","key":"10.1016\/j.sleh.2018.10.002_bb0105","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1523\/JNEUROSCI.20-02-00600.2000","article-title":"A novel human opsin in the inner retina","volume":"20","author":"Provencio","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.sleh.2018.10.002_bb0110","first-page":"1","article-title":"Nocturnal light pollution and underexposure to daytime sunlight: complementary mechanisms of circadian disruption and related diseases","author":"Smolensky","year":"2015","journal-title":"Chronobiol Int"},{"issue":"5","key":"10.1016\/j.sleh.2018.10.002_bb0115","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1080\/07420520903044315","article-title":"Daily and seasonal variation in the spectral composition of light exposure in humans","volume":"26","author":"Thorne","year":"2009","journal-title":"Chronobiol Int"},{"issue":"1765","key":"10.1016\/j.sleh.2018.10.002_bb0120","first-page":"20130433","article-title":"Latitudinal clines: an evolutionary view on biological rhythms","volume":"280","author":"Hut","year":"2013","journal-title":"Proc Biol Sci"},{"issue":"2","key":"10.1016\/j.sleh.2018.10.002_bb0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3109\/03014460.2013.832795","article-title":"Detecting chronotype differences associated to latitude: a comparison between Horne-\u00d6stberg and Munich Chronotype questionnaires","volume":"41","author":"Miguel","year":"2014","journal-title":"Ann Hum Biol"},{"issue":"6","key":"10.1016\/j.sleh.2018.10.002_bb0130","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1590\/S0004-27302005000600019","article-title":"Padroniza\u00e7\u00e3o da t\u00e9cnica de extra\u00e7\u00e3o de DNA de c\u00e9lulas de mucosa oral com NaCl: aplica\u00e7\u00e3o no estudo do gene PROP1","volume":"49","author":"Abr\u00e3o","year":"2005","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"1","key":"10.1016\/j.sleh.2018.10.002_bb0135","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/0748730402239679","article-title":"Life between clocks: daily temporal patterns of human chronotypes","volume":"18","author":"Roenneberg","year":"2003","journal-title":"J Biol Rhythms"},{"issue":"9","key":"10.1016\/j.sleh.2018.10.002_bb0140","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1590\/S1806-37132009000900009","article-title":"Portuguese-language version of the Epworth sleepiness scale: validation for use in Brazil","volume":"35","author":"Bertolazi","year":"2009","journal-title":"J Bras Pneumol"},{"key":"10.1016\/j.sleh.2018.10.002_bb0145","doi-asserted-by":"crossref","first-page":"39976","DOI":"10.1038\/srep39976","article-title":"Latitude affects morningness-eveningness: evidence for the environment hypothesis based on a systematic review","volume":"7","author":"Randler","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.sleh.2018.10.002_bb0150","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1038\/s41598-017-05797-w","article-title":"Latitudinal cline of chronotype","volume":"7","author":"Leocadio-Miguel","year":"2017","journal-title":"Sci Rep"},{"issue":"1\u20132","key":"10.1016\/j.sleh.2018.10.002_bb0155","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/07420520500545979","article-title":"Social jetlag: misalignment of biological and social time","volume":"23","author":"Wittmann","year":"2006","journal-title":"Chronobiol Int"},{"issue":"12","key":"10.1016\/j.sleh.2018.10.002_bb0160","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx165","article-title":"Linking light exposure and subsequent sleep: a field polysomnography study in humans","volume":"40","author":"Wams","year":"2017","journal-title":"Sleep"},{"issue":"7","key":"10.1016\/j.sleh.2018.10.002_bb0165","first-page":"638","article-title":"When the human circadian system is caught napping: evidence for endogenous rhythms close to 24 hours","volume":"16","author":"Campbell","year":"1993","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.sleh.2018.10.002_bb0170","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0304-3940(98)00971-9","article-title":"Intrinsic circadian period of adolescent humans measured in conditions of forced desynchrony","volume":"260","author":"Carskadon","year":"1999","journal-title":"Neurosci Lett"},{"issue":"5423","key":"10.1016\/j.sleh.2018.10.002_bb0175","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1126\/science.284.5423.2177","article-title":"Stability, precision, and Near-24-hour period of the human circadian pacemaker","volume":"284","author":"Czeisler","year":"1999","journal-title":"Science"},{"issue":"Pt 2","key":"10.1016\/j.sleh.2018.10.002_bb0180","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1469-7793.1999.0611v.x","article-title":"Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms","volume":"516","author":"Dijk","year":"1999","journal-title":"J Physiol"},{"issue":"4 Pt 2","key":"10.1016\/j.sleh.2018.10.002_bb0185","first-page":"R1118","article-title":"A functional model of the circadian system based on the degree of intercommunication in a complex system","volume":"267","author":"D\u00edez-Noguera","year":"1994","journal-title":"Am J Physiol"},{"issue":"25","key":"10.1016\/j.sleh.2018.10.002_bb0190","doi-asserted-by":"crossref","first-page":"7948","DOI":"10.1523\/JNEUROSCI.0229-09.2009","article-title":"Functional magnetic resonance imaging-assessed brain responses during an executive task depend on interaction of sleep homeostasis, circadian phase, and PER3 genotype","volume":"29","author":"Vandewalle","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.sleh.2018.10.002_bb0195","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fnbeh.2014.00059","article-title":"Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation","volume":"8","author":"Maire","year":"2014","journal-title":"Front Behav Neurosci"},{"issue":"3","key":"10.1016\/j.sleh.2018.10.002_bb0200","doi-asserted-by":"crossref","first-page":"E433","DOI":"10.1210\/jc.2011-2391","article-title":"Human melatonin and alerting response to blue-enriched light depend on a polymorphism in the clock gene PER3","volume":"97","author":"Chellappa","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.sleh.2018.10.002_bb0205","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0031-3955(16)33817-2","article-title":"Sleep and sleepiness in children and adolescents","volume":"27","author":"Anders","year":"1980","journal-title":"Pediatr Clin North Am"},{"issue":"4","key":"10.1016\/j.sleh.2018.10.002_bb0210","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431X20143001","article-title":"Chronotype ontogeny related to gender","volume":"47","author":"Duarte","year":"2014","journal-title":"Braz J Med Biol Res"},{"issue":"10","key":"10.1016\/j.sleh.2018.10.002_bb0215","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1590\/S0100-879X2008005000047","article-title":"Influence of chronotype and social zeitgebers on sleep\/wake patterns","volume":"41","author":"Korczak","year":"2008","journal-title":"Braz J Med Biol Res"},{"issue":"1734","key":"10.1016\/j.sleh.2018.10.002_bb0220","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2016.0251","article-title":"Sleep research goes wild: new methods and approaches to investigate the ecology, evolution and functions of sleep","volume":"372","author":"Rattenborg","year":"2017","journal-title":"Philos Trans R Soc Lond B Biol Sci"}],"container-title":["Sleep Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352721818301815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352721818301815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T20:03:22Z","timestamp":1775246602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352721818301815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S2352721818301815"],"URL":"https:\/\/doi.org\/10.1016\/j.sleh.2018.10.002","relation":{},"ISSN":["2352-7218"],"issn-type":[{"value":"2352-7218","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PER3 gene regulation of sleep-wake behavior as a function of latitude","name":"articletitle","label":"Article Title"},{"value":"Sleep Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sleh.2018.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}