{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:19:54Z","timestamp":1791206394374,"version":"4.1.0"},"reference-count":132,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI106761"],"award-info":[{"award-number":["AI106761"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI076327"],"award-info":[{"award-number":["AI076327"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Immunology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.smim.2014.10.003","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T00:20:55Z","timestamp":1414542055000},"page":"578-587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Understanding and overcoming the barriers to T cell-mediated immunity against tuberculosis"],"prefix":"10.1016","volume":"26","author":[{"given":"Kevin B.","family":"Urdahl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.smim.2014.10.003_bib0005","series-title":"Global tuberculosis report 2013","author":"WHO","year":"2013"},{"key":"10.1016\/j.smim.2014.10.003_bib0010","unstructured":"Evans TG. AERAS Annual Report 2013. http:\/\/wwwaerasorg\/annualreport20132014."},{"issue":"Suppl 2","key":"10.1016\/j.smim.2014.10.003_bib0015","doi-asserted-by":"crossref","first-page":"B223","DOI":"10.1016\/j.vaccine.2012.11.081","article-title":"Preventive vaccines for tuberculosis","volume":"31","author":"Evans","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.smim.2014.10.003_bib0020","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0140-6736(13)60177-4","article-title":"Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial","volume":"381","author":"Tameris","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.smim.2014.10.003_bib0025","unstructured":"Bill and Melinda Gates Foundation, Grand Challenges in Global Health, TB Vaccine Accelerator, 2012. http:\/\/www.grandchallenges.org\/GCGHDocs\/TB_VaccineAccelerator_Rules_and_Guidelines.pdf2012."},{"key":"10.1016\/j.smim.2014.10.003_bib0030","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.it.2014.04.006","article-title":"Tuberculosis vaccines \u2013 rethinking the current paradigm","volume":"35","author":"Andersen","year":"2014","journal-title":"Trends Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.tube.2014.05.001","article-title":"Memory T cell subsets in tuberculosis: what should we be targeting?","author":"Henao-Tamayo","year":"2014","journal-title":"Tuberculosis"},{"key":"10.1016\/j.smim.2014.10.003_bib0040","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.chom.2013.02.009","article-title":"Antibody-mediated immunity against tuberculosis: implications for vaccine development","volume":"13","author":"Achkar","year":"2013","journal-title":"Cell Host Microb"},{"key":"10.1016\/j.smim.2014.10.003_bib0045","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/mi.2013.99","article-title":"Harnessing local and systemic immunity for vaccines against tuberculosis","volume":"7","author":"Beverley","year":"2014","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0050","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/MCP.0000000000000041","article-title":"Tuberculosis vaccine development at a divide","volume":"20","author":"Kaufmann","year":"2014","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0055","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.micpath.2012.12.002","article-title":"Vaccination against tuberculosis: how can we better BCG","volume":"58","author":"Pitt","year":"2013","journal-title":"Microb Pathog"},{"key":"10.1016\/j.smim.2014.10.003_bib0060","doi-asserted-by":"crossref","first-page":"213sr216","DOI":"10.1126\/scitranslmed.3007402","article-title":"TB or not TB: that is no longer the question","volume":"5","author":"Modlin","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0065","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nrmicro3230","article-title":"In search of a new paradigm for protective immunity to TB","volume":"12","author":"Nunes-Alves","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.smim.2014.10.003_bib0070","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.immunol.021908.132703","article-title":"Cell-mediated immune responses in tuberculosis","volume":"27","author":"Cooper","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0075","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/mi.2011.10","article-title":"Initiation and regulation of T-cell responses in tuberculosis","volume":"4","author":"Urdahl","year":"2011","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0080","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev.genom.8.080706.092315","article-title":"Host genetics of mycobacterial diseases in mice and men: forward genetic studies of BCG-osis and tuberculosis","volume":"8","author":"Fortin","year":"2007","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.smim.2014.10.003_bib0085","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/2049-632X.12060","article-title":"Co-infection with Mycobacterium tuberculosis and human immunodeficiency virus: an overview and motivation for systems approaches","volume":"69","author":"Deffur","year":"2013","journal-title":"Pathog Dis"},{"key":"10.1016\/j.smim.2014.10.003_bib0090","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1615\/CritRevImmunol.v26.i4.30","article-title":"Mycobacterium tuberculosis-specific CD8+ T cells and their role in immunity","volume":"26","author":"Woodworth","year":"2006","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0095","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.immuni.2010.09.015","article-title":"Future vaccination strategies against tuberculosis: thinking outside the box","volume":"33","author":"Kaufmann","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2014.10.003_bib0100","doi-asserted-by":"crossref","first-page":"e1000392","DOI":"10.1371\/journal.ppat.1000392","article-title":"A critical role for CD8 T cells in a nonhuman primate model of tuberculosis","volume":"5","author":"Chen","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.smim.2014.10.003_bib0105","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.4049\/jimmunol.1301236","article-title":"Cutting edge: direct recognition of infected cells by CD4 T cells is required for control of intracellular Mycobacterium tuberculosis in vivo","volume":"191","author":"Srivastava","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0110","first-page":"311","article-title":"Some clinical features of tuberculosis I. Incubation period","volume":"24","author":"Poulsen","year":"1950","journal-title":"Acta Tubercul Scand"},{"key":"10.1016\/j.smim.2014.10.003_bib0115","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0041-3879(48)80033-4","article-title":"The time-table of tuberculosis","volume":"29","author":"Wallgren","year":"1948","journal-title":"Tubercle"},{"key":"10.1016\/j.smim.2014.10.003_bib0120","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.coi.2010.03.003","article-title":"From the thymus to longevity in the periphery","volume":"22","author":"Wakim","year":"2010","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0125","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.immuni.2008.02.020","article-title":"Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines","volume":"28","author":"Miller","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2014.10.003_bib0130","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.4049\/jimmunol.173.2.1209","article-title":"Activation, differentiation, and migration of naive virus-specific CD8+ T cells during pulmonary influenza virus infection","volume":"173","author":"Lawrence","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0135","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.20071367","article-title":"Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs","volume":"205","author":"Wolf","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0140","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1073\/pnas.0801496105","article-title":"ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes","volume":"105","author":"Reiley","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.smim.2014.10.003_bib0145","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1128\/IAI.70.8.4501-4509.2002","article-title":"Dissemination of Mycobacterium tuberculosis is influenced by host factors and precedes the initiation of T-cell immunity","volume":"70","author":"Chackerian","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.smim.2014.10.003_bib0150","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrmicro2387","article-title":"Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy","volume":"8","author":"Behar","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.smim.2014.10.003_bib0155","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nri3211","article-title":"Revisiting the role of the granuloma in tuberculosis","volume":"12","author":"Ramakrishnan","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0160","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature12799","article-title":"Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids","volume":"505","author":"Cambier","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.smim.2014.10.003_bib0165","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.4049\/jimmunol.179.4.2509","article-title":"Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo","volume":"179","author":"Wolf","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0170","doi-asserted-by":"crossref","first-page":"7110","DOI":"10.4049\/jimmunol.1100001","article-title":"Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection","volume":"186","author":"Blomgran","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0175","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.chom.2011.11.012","article-title":"Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells","volume":"11","author":"Blomgran","year":"2012","journal-title":"Cell Host Microb"},{"key":"10.1016\/j.smim.2014.10.003_bib0180","doi-asserted-by":"crossref","first-page":"e01086","DOI":"10.7554\/eLife.01086","article-title":"Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming","volume":"2","author":"Samstein","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.smim.2014.10.003_bib0185","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.chom.2014.05.007","article-title":"Cell-to-cell transfer of M. tuberculosis antigens optimizes CD4 T cell priming","volume":"15","author":"Srivastava","year":"2014","journal-title":"Cell Host Microb"},{"key":"10.1016\/j.smim.2014.10.003_bib0190","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1084\/jem.20091885","article-title":"Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis","volume":"207","author":"Shafiani","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0195","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.immuni.2013.06.003","article-title":"Expansion and subsequent culling of pathogen-specific regulatory T cells during Mycobacterium tuberculosis infection","volume":"38","author":"Shafiani","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2014.10.003_bib0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-1-4614-6111-1_9","article-title":"Foxp3(+) regulatory T cells in tuberculosis","volume":"783","author":"Larson","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.smim.2014.10.003_bib0205","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nm.3412","article-title":"Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing","volume":"20","author":"Lin","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0210","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/mi.2011.7","article-title":"The role of IL-10 in immune regulation during M. tuberculosis infection","volume":"4","author":"Redford","year":"2011","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0215","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/clin.1998.4528","article-title":"The role of TGF beta in the pathogenesis of human tuberculosis","volume":"87","author":"Toossi","year":"1998","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.smim.2014.10.003_bib0220","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1172\/JCI23949","article-title":"Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production","volume":"115","author":"Bafica","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.smim.2014.10.003_bib0225","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0230","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nm.2299","article-title":"Dominant TNF-alpha+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease","volume":"17","author":"Harari","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0235","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1002\/eji.201243262","article-title":"Mycobacterium tuberculosis-specific CD8+ T cells are functionally and phenotypically different between latent infection and active disease","volume":"43","author":"Rozot","year":"2013","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0240","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/eji.201243090","article-title":"Lack of Mycobacterium tuberculosis-specific interleukin-17A-producing CD4+ T cells in active disease","volume":"43","author":"Perreau","year":"2013","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0245","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1128\/IAI.00480-13","article-title":"Differentiation of antigen-specific T cells with limited functional capacity during Mycobacterium tuberculosis infection","volume":"82","author":"Jeong","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.smim.2014.10.003_bib0250","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1164\/rccm.201302-0249OC","article-title":"Increased frequency of myeloid-derived suppressor cells during active tuberculosis and after recent mycobacterium tuberculosis infection suppresses T-cell function","volume":"188","author":"du Plessis","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0255","doi-asserted-by":"crossref","first-page":"e80669","DOI":"10.1371\/journal.pone.0080669","article-title":"Gr1(int)CD11b+ myeloid-derived suppressor cells in Mycobacterium tuberculosis infection","volume":"8","author":"Obregon-Henao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.smim.2014.10.003_bib0260","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.4049\/jimmunol.1301365","article-title":"Gr-1dimCD11b+ immature myeloid-derived suppressor cells but not neutrophils are markers of lethal tuberculosis infection in mice","volume":"192","author":"Tsiganov","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0265","doi-asserted-by":"crossref","first-page":"21653","DOI":"10.1073\/pnas.1007967107","article-title":"Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells","volume":"107","author":"Raghuvanshi","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.smim.2014.10.003_bib0270","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1084\/jem.20062105","article-title":"Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis","volume":"204","author":"Scott-Browne","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0275","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.4049\/jimmunol.178.5.2661","article-title":"Cutting edge: regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis","volume":"178","author":"Kursar","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0280","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4049\/jimmunol.179.1.522","article-title":"The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation","volume":"179","author":"Ordway","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0285","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1128\/CVI.05127-11","article-title":"Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells","volume":"18","author":"Ordway","year":"2011","journal-title":"Clin Vaccine Immunol: CVI"},{"key":"10.1016\/j.smim.2014.10.003_bib0290","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.tube.2011.06.001","article-title":"Increased Foxp3 expression in guinea pigs infected with W-Beijing strains of M. tuberculosis","volume":"91","author":"Shang","year":"2011","journal-title":"Tuberculosis"},{"key":"10.1016\/j.smim.2014.10.003_bib0295","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1128\/CVI.00250-12","article-title":"Beijing sublineages of Mycobacterium tuberculosis differ in pathogenicity in the guinea pig","volume":"19","author":"Kato-Maeda","year":"2012","journal-title":"Clin Vaccine Immunol: CVI"},{"key":"10.1016\/j.smim.2014.10.003_bib0300","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.tube.2010.05.003","article-title":"Regulatory T cell frequency and modulation of IFN-gamma and IL-17 in active and latent tuberculosis","volume":"90","author":"Marin","year":"2010","journal-title":"Tuberculosis"},{"key":"10.1016\/j.smim.2014.10.003_bib0305","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1365-3083.2010.02496.x","article-title":"T regulatory cells and immune activation in Mycobacterium tuberculosis infection and the effect of preventive therapy","volume":"73","author":"Wergeland","year":"2011","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0310","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1164\/rccm.200508-1294OC","article-title":"Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis","volume":"173","author":"Guyot-Revol","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0315","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2249.2006.03027.x","article-title":"A role for CD4+ CD25+ T cells in regulation of the immune response during human tuberculosis","volume":"144","author":"Ribeiro-Rodrigues","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0320","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1365-2249.2007.03399.x","article-title":"FOXP3 gene expression in a tuberculosis case contact study","volume":"149","author":"Burl","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0325","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.clim.2006.11.009","article-title":"CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease","volume":"123","author":"Chen","year":"2007","journal-title":"Clin Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0330","doi-asserted-by":"crossref","first-page":"307631","DOI":"10.1155\/2011\/307631","article-title":"Immunopathology of postprimary tuberculosis: increased T-regulatory cells and DEC-205-positive foamy macrophages in cavitary lesions","volume":"2011","author":"Welsh","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0335","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1164\/rccm.200804-529OC","article-title":"FoxP3+ regulatory T cells suppress effector T-cell function at pathologic site in miliary tuberculosis","volume":"179","author":"Sharma","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0340","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.4049\/jimmunol.1400019","article-title":"Cutting edge: control of Mycobacterium tuberculosis infection by a subset of lung parenchyma-homing CD4 T cells","volume":"192","author":"Sakai","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0345","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1365-2567.2001.01305.x","article-title":"Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-gamma generation","volume":"104","author":"Leal","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.smim.2014.10.003_bib0350","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.trstmh.2004.08.006","article-title":"PPD induced in vitro interferon gamma production is not a reliable correlate of protection against Mycobacterium tuberculosis","volume":"99","author":"Elias","year":"2005","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.smim.2014.10.003_bib0355","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2174\/156652407780598520","article-title":"Correlates of immune protection from tuberculosis","volume":"7","author":"Fletcher","year":"2007","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0360","doi-asserted-by":"crossref","first-page":"12434","DOI":"10.1073\/pnas.0703510104","article-title":"Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis","volume":"104","author":"Mittrucker","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.smim.2014.10.003_bib0365","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","article-title":"IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge","volume":"8","author":"Khader","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0370","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cyto.2007.11.022","article-title":"IL-23 and IL-17 in tuberculosis","volume":"41","author":"Khader","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.smim.2014.10.003_bib0375","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/156652407780598557","article-title":"Th2 cytokines in susceptibility to tuberculosis","volume":"7","author":"Rook","year":"2007","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0380","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1084\/jem.20100687","article-title":"Tim3 binding to galectin-9 stimulates antimicrobial immunity","volume":"207","author":"Jayaraman","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0385","doi-asserted-by":"crossref","first-page":"e1002052","DOI":"10.1371\/journal.ppat.1002052","article-title":"A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo","volume":"7","author":"Gallegos","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.smim.2014.10.003_bib0390","doi-asserted-by":"crossref","first-page":"19408","DOI":"10.1073\/pnas.1006298107","article-title":"Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection","volume":"107","author":"Reiley","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.smim.2014.10.003_bib0395","doi-asserted-by":"crossref","first-page":"6311","DOI":"10.4049\/jimmunol.1300248","article-title":"Control of chronic Mycobacterium tuberculosis infection by CD4 KLRG1-IL-2-secreting central memory cells","volume":"190","author":"Lindenstrom","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0400","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.4049\/jimmunol.1300283","article-title":"Protective CD4 T cells targeting cryptic epitopes of Mycobacterium tuberculosis resist infection-driven terminal differentiation","volume":"192","author":"Woodworth","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0405","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-2567.2006.02355.x","article-title":"Expression levels of Mycobacterium tuberculosis antigen-encoding genes versus production levels of antigen-specific T cells during stationary level lung infection in mice","volume":"118","author":"Rogerson","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.smim.2014.10.003_bib0410","doi-asserted-by":"crossref","first-page":"e1002063","DOI":"10.1371\/journal.ppat.1002063","article-title":"Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo","volume":"7","author":"Bold","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.smim.2014.10.003_bib0415","doi-asserted-by":"crossref","first-page":"e1002607","DOI":"10.1371\/journal.ppat.1002607","article-title":"Vaccines against tuberculosis: where are we and where do we need to go?","volume":"8","author":"Ottenhoff","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.smim.2014.10.003_bib0420","doi-asserted-by":"crossref","first-page":"e27477","DOI":"10.1371\/journal.pone.0027477","article-title":"Simultaneous immunization against tuberculosis","volume":"6","author":"Tchilian","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.smim.2014.10.003_bib0425","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1002\/eji.201142158","article-title":"Nitric oxide inhibits the accumulation of CD4+ CD44hiTbet+ CD69lo T cells in mycobacterial infection","volume":"42","author":"Pearl","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0430","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/ng.590","article-title":"Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved","volume":"42","author":"Comas","year":"2010","journal-title":"Nat Genetics"},{"key":"10.1016\/j.smim.2014.10.003_bib0435","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00960-13","article-title":"Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition","volume":"5","author":"Copin","year":"2014","journal-title":"mBio"},{"key":"10.1016\/j.smim.2014.10.003_bib0440","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1128\/CMR.00042-10","article-title":"HIV and tuberculosis: a deadly human syndemic","volume":"24","author":"Kwan","year":"2011","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.smim.2014.10.003_bib0445","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-407707-2.00001-1","article-title":"The interdisciplinary science of T-cell recognition","volume":"119","author":"Huppa","year":"2013","journal-title":"Adv Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0450","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1056\/NEJMra1200894","article-title":"Tuberculosis","volume":"368","author":"Zumla","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0455","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nm.1894","article-title":"Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease","volume":"15","author":"Delgado","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0460","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/ni.2039","article-title":"Immunological mechanisms of vaccination","volume":"12","author":"Pulendran","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0465","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0962-8479(97)90006-X","article-title":"Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice","volume":"78","author":"Johnson","year":"1997","journal-title":"Tubercle Lung Dis"},{"key":"10.1016\/j.smim.2014.10.003_bib0470","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/35021239","article-title":"Vaccines against intracellular infections requiring cellular immunity","volume":"406","author":"Seder","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.smim.2014.10.003_bib0475","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1056\/NEJM199910143411602","article-title":"Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment","volume":"341","author":"van Rie","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0480","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/eji.201041377","article-title":"Memory T cells as an occupying force","volume":"41","author":"Bevan","year":"2011","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0485","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nri2496","article-title":"Migration, maintenance and recall of memory T cells in peripheral tissues","volume":"9","author":"Woodland","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0490","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.4049\/jimmunol.1102695","article-title":"Hidden memories: frontline memory T cells and early pathogen interception","volume":"188","author":"Masopust","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0495","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1084\/jem.20080353","article-title":"Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection","volume":"205","author":"Gallegos","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0500","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/mi.2012.19","article-title":"Mechanisms of delayed anti-tuberculosis protection in the lung of parenteral BCG-vaccinated hosts: a critical role of airway luminal T cells","volume":"5","author":"Horvath","year":"2012","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0505","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1164\/rccm.200910-1583OC","article-title":"Murine airway luminal antituberculosis memory CD8 T cells by mucosal immunization are maintained via antigen-driven in situ proliferation, independent of peripheral T cell recruitment","volume":"181","author":"Jeyanathan","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0510","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.it.2010.05.002","article-title":"Airway luminal T cells: a newcomer on the stage of TB vaccination strategies","volume":"31","author":"Jeyanathan","year":"2010","journal-title":"Trends Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0515","doi-asserted-by":"crossref","first-page":"e8235","DOI":"10.1371\/journal.pone.0008235","article-title":"Immunization of mice with a recombinant adenovirus vaccine inhibits the early growth of Mycobacterium tuberculosis after infection","volume":"4","author":"Ronan","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.smim.2014.10.003_bib0520","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/ni.2038","article-title":"Origins of CD4(+) effector and central memory T cells","volume":"12","author":"Pepper","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0525","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.4049\/jimmunol.1202183","article-title":"T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation","volume":"190","author":"Nelson","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0530","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrmicro1211","article-title":"The success and failure of BCG \u2013 implications for a novel tuberculosis vaccine","volume":"3","author":"Andersen","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.smim.2014.10.003_bib0535","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/infdis\/jir240","article-title":"Randomized trial of BCG vaccination at birth to low-birth-weight children: beneficial nonspecific effects in the neonatal period","volume":"204","author":"Aaby","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1016\/j.smim.2014.10.003_bib0540","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1586\/14760584.5.2.277","article-title":"Bacillus Calmette-Guerin vaccination and infant mortality","volume":"5","author":"Roth","year":"2006","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.smim.2014.10.003_bib0545","doi-asserted-by":"crossref","first-page":"c671","DOI":"10.1136\/bmj.c671","article-title":"Effect of revaccination with BCG in early childhood on mortality: randomised trial in Guinea-Bissau","volume":"340","author":"Roth","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.smim.2014.10.003_bib0550","first-page":"53","article-title":"History of BCG vaccine","volume":"8","author":"Luca","year":"2013","journal-title":"Maedica"},{"key":"10.1016\/j.smim.2014.10.003_bib0555","doi-asserted-by":"crossref","first-page":"e45888","DOI":"10.1371\/journal.pone.0045888","article-title":"Oral vaccination with lipid-formulated BCG induces a long-lived, multifunctional CD4(+) T cell memory immune response","volume":"7","author":"Ancelet","year":"2012","journal-title":"PLoS One"},{"issue":"Suppl 3","key":"10.1016\/j.smim.2014.10.003_bib0560","doi-asserted-by":"crossref","first-page":"S217","DOI":"10.1086\/313864","article-title":"Mucosal bacille calmette-Guerin vaccination of humans inhibits delayed-type hypersensitivity to purified protein derivative but induces mycobacteria-specific interferon-gamma responses","volume":"30","author":"Hoft","year":"2000","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.smim.2014.10.003_bib0565","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1172\/JCI24617","article-title":"Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin","volume":"115","author":"Grode","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.smim.2014.10.003_bib0570","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1586\/14760584.2014.905746","article-title":"The BCG replacement vaccine VPM1002: from drawing board to clinical trial","volume":"13","author":"Kaufmann","year":"2014","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.smim.2014.10.003_bib0575","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1016\/j.vaccine.2013.07.051","article-title":"Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials","volume":"31","author":"Arbues","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.smim.2014.10.003_bib0580","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature10003","article-title":"Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine","volume":"473","author":"Hansen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.smim.2014.10.003_bib0585","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.immuni.2010.10.008","article-title":"From vaccines to memory and back","volume":"33","author":"Sallusto","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2014.10.003_bib0590","doi-asserted-by":"crossref","first-page":"e67016","DOI":"10.1371\/journal.pone.0067016","article-title":"Human CD8 T cell antigens\/epitopes identified by a proteomic peptide library","volume":"8","author":"Lewinsohn","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.smim.2014.10.003_bib0595","doi-asserted-by":"crossref","first-page":"e1003130","DOI":"10.1371\/journal.ppat.1003130","article-title":"Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+ CCR6+ Th1 subset","volume":"9","author":"Lindestam Arlehamn","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.smim.2014.10.003_bib0600","doi-asserted-by":"crossref","first-page":"a018465","DOI":"10.1101\/cshperspect.a018465","article-title":"Antigens for CD4 and CD8 T cells in tuberculosis","volume":"4","author":"Lindestam Arlehamn","year":"2014","journal-title":"Cold Spring Harbor Persp Med"},{"key":"10.1016\/j.smim.2014.10.003_bib0605","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fimmu.2014.00256","article-title":"Innovative strategies to identify M. tuberculosis antigens and epitopes using genome-wide analyses","volume":"5","author":"Geluk","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0610","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1126\/science.291.5508.1544","article-title":"Induction of direct antimicrobial activity through mammalian toll-like receptors","volume":"291","author":"Thoma-Uszynski","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.smim.2014.10.003_bib0615","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1126\/science.1123933","article-title":"Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response","volume":"311","author":"Liu","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.smim.2014.10.003_bib0620","doi-asserted-by":"crossref","first-page":"e1002689","DOI":"10.1371\/journal.ppat.1002689","article-title":"Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy","volume":"8","author":"Campbell","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.smim.2014.10.003_bib0625","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3389\/fimmu.2014.00219","article-title":"The T-cell response to lipid antigens of Mycobacterium tuberculosis","volume":"5","author":"De Libero","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.smim.2014.10.003_bib0630","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0167-5699(99)01449-8","article-title":"Granulysin: a lethal weapon of cytolytic T cells","volume":"20","author":"Stenger","year":"1999","journal-title":"Immunol Today"},{"key":"10.1016\/j.smim.2014.10.003_bib0635","doi-asserted-by":"crossref","unstructured":"Ordway DJ, Orme IM. Animal models of mycobacteria infection. Current protocols in immunology\/edited by John E Coligan [et al]. 2011;Chapter 19:Unit19 15.","DOI":"10.1002\/0471142735.im1905s94"},{"key":"10.1016\/j.smim.2014.10.003_bib0640","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S1472-9792(02)00059-8","article-title":"Non-human primates: a model for tuberculosis research","volume":"83","author":"Flynn","year":"2003","journal-title":"Tuberculosis"},{"key":"10.1016\/j.smim.2014.10.003_bib0645","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1101\/sqb.2013.78.023283","article-title":"The zebrafish guide to tuberculosis immunity and treatment","volume":"78","author":"Ramakrishnan","year":"2013","journal-title":"Cold Spring Harbor Symp Quant Biol"},{"key":"10.1016\/j.smim.2014.10.003_bib0650","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.cell.2010.02.013","article-title":"The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans","volume":"140","author":"Tobin","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.smim.2014.10.003_bib0655","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cell.2011.12.023","article-title":"Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections","volume":"148","author":"Tobin","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.smim.2014.10.003_bib0660","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2013.03.022","article-title":"TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species","volume":"153","author":"Roca","year":"2013","journal-title":"Cell"}],"container-title":["Seminars in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532314000992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532314000992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T19:10:10Z","timestamp":1565982610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044532314000992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":132,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S1044532314000992"],"URL":"https:\/\/doi.org\/10.1016\/j.smim.2014.10.003","relation":{},"ISSN":["1044-5323"],"issn-type":[{"value":"1044-5323","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding and overcoming the barriers to T cell-mediated immunity against tuberculosis","name":"articletitle","label":"Article Title"},{"value":"Seminars in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.smim.2014.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}