{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:05:26Z","timestamp":1790521526926,"version":"4.1.0"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH Immunology and Infectious Diseases T32","award":["AI060519"],"award-info":[{"award-number":["AI060519"]}]},{"name":"NIH Immunology and Infectious Diseases T32","award":["HL124159"],"award-info":[{"award-number":["HL124159"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Immunology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.smim.2017.08.006","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T11:32:51Z","timestamp":1508239971000},"page":"37-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Too much of a good thing: How modulating LTB 4 actions restore host defense in homeostasis or disease"],"prefix":"10.1016","volume":"33","author":[{"given":"Stephanie L.","family":"Brandt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Henrique","family":"Serezani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 7","key":"10.1016\/j.smim.2017.08.006_bib0005","doi-asserted-by":"crossref","first-page":"S481","DOI":"10.1086\/432001","article-title":"Underlying disorders and their impact on the host response to infection","volume":"41","author":"Dhainaut","year":"2005","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.smim.2017.08.006_bib0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4066\/AMJ.2014.1906","article-title":"Clinical profile of urinary tract infections in diabetics and non-diabetics","volume":"7","author":"Aswani","year":"2014","journal-title":"Australas. Med. J."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0015","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s00125-010-1672-5","article-title":"Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost","volume":"53","author":"Lipsky","year":"2010","journal-title":"Diabetologia"},{"issue":"Suppl. 1","key":"10.1016\/j.smim.2017.08.006_bib0020","first-page":"S27","article-title":"Infections in patients with diabetes mellitus: a review of pathogenesis","volume":"16","author":"Casqueiro","year":"2012","journal-title":"Indian J. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.smim.2017.08.006_bib0025","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2174\/1568010023344959","article-title":"5-lipoxygenase: cellular biology and molecular pharmacology","volume":"1","author":"Werz","year":"2002","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"issue":"2","key":"10.1016\/j.smim.2017.08.006_bib0030","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0090-6980(90)90072-4","article-title":"THP-1 cells do not release LTB4, LTC4, or LTD4 in response to A23187","volume":"39","author":"Nolfo","year":"1990","journal-title":"Prostaglandins"},{"issue":"3","key":"10.1016\/j.smim.2017.08.006_bib0035","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S1734-1140(10)70306-6","article-title":"Transcellular biosynthesis of eicosanoids","volume":"62","author":"Sala","year":"2010","journal-title":"Pharmacol. Rep."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0040","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1073\/pnas.83.5.1349","article-title":"Erythrocyte-neutrophil interactions: formation of leukotriene B4 by transcellular biosynthesis","volume":"83","author":"McGee","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.smim.2017.08.006_bib0045","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/1523-1747.ep12469865","article-title":"Leukotriene B4 formation during human neutrophil keratinocyte interactions: evidence for transformation of leukotriene A4 by putative keratinocyte leukotriene A4 hydrolase","volume":"100","author":"Iversen","year":"1993","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.smim.2017.08.006_bib0050","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/1523-1747.ep12329890","article-title":"Human keratinocytes lack the components to produce leukotriene B4","volume":"106","author":"Breton","year":"1996","journal-title":"J. Invest. Dermatol."},{"issue":"15","key":"10.1016\/j.smim.2017.08.006_bib0055","doi-asserted-by":"crossref","first-page":"6966","DOI":"10.1073\/pnas.92.15.6966","article-title":"Expression of 5-lipoxygenase in differentiating human skin keratinocytes","volume":"92","author":"Janssen-Timmen","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5 Pt 2","key":"10.1016\/j.smim.2017.08.006_bib0060","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1164\/ajrccm\/146.5_Pt_2.S51","article-title":"The role of the endothelial cell in leukotriene biosynthesis","volume":"146","author":"Feinmark","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"issue":"4","key":"10.1016\/j.smim.2017.08.006_bib0065","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.bbalip.2014.09.002","article-title":"Transcellular biosynthesis of eicosanoid lipid mediators","volume":"1851","author":"Capra","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.smim.2017.08.006_bib0070","series-title":"Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications","first-page":"9","article-title":"5-Lipoxygenase and the nucleus: where, when, how, and why?","author":"Peters-Golden","year":"2001"},{"issue":"25","key":"10.1016\/j.smim.2017.08.006_bib0075","doi-asserted-by":"crossref","first-page":"15359","DOI":"10.1074\/jbc.270.25.15359","article-title":"Translocation of the 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE\/antigen","volume":"270","author":"Glover","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.smim.2017.08.006_bib0080","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1006\/bbrc.1993.2227","article-title":"Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation","volume":"196","author":"Peters-Golden","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0085","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1172\/JCI117889","article-title":"5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation","volume":"95","author":"Woods","year":"1995","journal-title":"J. Clin. Invest."},{"issue":"Pt 2","key":"10.1016\/j.smim.2017.08.006_bib0090","doi-asserted-by":"crossref","first-page":"S227","DOI":"10.1164\/ajrccm.157.6.mar4","article-title":"Cell biology of the 5-lipoxygenase pathway","volume":"6","author":"Peters-Golden","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2-3","key":"10.1016\/j.smim.2017.08.006_bib0095","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0952-3278(03)00070-X","article-title":"5-Lipoxygenase and FLAP","volume":"69","author":"Peters-Golden","year":"2003","journal-title":"Prostaglandins, Leukotrienes and Essential Fatty Acids"},{"issue":"6","key":"10.1016\/j.smim.2017.08.006_bib0100","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1182\/blood.V89.6.2122","article-title":"Epstein-Barr virus modulates 5-lipoxygenase product synthesis in human peripheral blood mononuclear cells","volume":"89","author":"Gosselin","year":"1997","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.smim.2017.08.006_bib0105","first-page":"400","article-title":"Modulation of leukotriene generation by invasive bacteria","volume":"77","author":"Grone","year":"1992","journal-title":"Immunology"},{"key":"10.1016\/j.smim.2017.08.006_bib0110","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1100\/tsw.2007.180","article-title":"Activation and regulation of cellular eicosanoid biosynthesis","volume":"7","author":"Brock","year":"2007","journal-title":"Sci. World J."},{"issue":"Suppl","key":"10.1016\/j.smim.2017.08.006_bib0115","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1194\/jlr.R800062-JLR200","article-title":"5-Lipoxygenase: mechanisms of regulation","volume":"50","author":"Radmark","year":"2009","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.smim.2017.08.006_bib0120","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/jb\/mvu078","article-title":"Two distinct leukotriene B4 receptors, BLT1 and BLT2","volume":"157","author":"Yokomizo","year":"2015","journal-title":"J. Biochem."},{"issue":"2-3","key":"10.1016\/j.smim.2017.08.006_bib0125","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0952-3278(03)00073-5","article-title":"BLT1 and BLT2: the leukotriene B(4) receptors","volume":"69","author":"Tager","year":"2003","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"issue":"8","key":"10.1016\/j.smim.2017.08.006_bib0130","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.4049\/jimmunol.179.8.5454","article-title":"Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions","volume":"179","author":"Peres","year":"2007","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.smim.2017.08.006_bib0135","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.4049\/jimmunol.1202932","article-title":"Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes","volume":"190","author":"Soares","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2017.08.006_bib0140","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.2741\/3327","article-title":"Mechanisms of neutrophil transendothelial migration","volume":"14","author":"Choi","year":"2009","journal-title":"Fron.t Biosci. (Landmark Ed)"},{"issue":"4819","key":"10.1016\/j.smim.2017.08.006_bib0145","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1126\/science.2820055","article-title":"Leukotrienes and lipoxins: structures, biosynthesis, and biological effects","volume":"237","author":"Samuelsson","year":"1987","journal-title":"Science"},{"issue":"6633","key":"10.1016\/j.smim.2017.08.006_bib0150","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/42506","article-title":"A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis","volume":"387","author":"Yokomizo","year":"1997","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.smim.2017.08.006_bib0155","doi-asserted-by":"crossref","first-page":"6273","DOI":"10.4049\/jimmunol.170.12.6273","article-title":"Transepithelial migration of neutrophils in response to leukotriene B4 is mediated by a reactive oxygen species-extracellular signal-regulated kinase-linked cascade","volume":"170","author":"Woo","year":"2003","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0160","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.devcel.2012.02.003","article-title":"LTB4 is a signal-relay molecule during neutrophil chemotaxis","volume":"22","author":"Afonso","year":"2012","journal-title":"Dev. Cell"},{"issue":"11","key":"10.1016\/j.smim.2017.08.006_bib0165","doi-asserted-by":"crossref","first-page":"6562","DOI":"10.4049\/jimmunol.1002400","article-title":"Leukotriene B4 mediates neutrophil migration induced by heme","volume":"186","author":"Monteiro","year":"2011","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.smim.2017.08.006_bib0170","doi-asserted-by":"crossref","first-page":"7050","DOI":"10.4049\/jimmunol.174.11.7050","article-title":"C5a-mediated leukotriene B4-amplified neutrophil chemotaxis is essential in tumor immunotherapy facilitated by anti-tumor monoclonal antibody and beta-glucan","volume":"174","author":"Allendorf","year":"2005","journal-title":"J. Immunol."},{"issue":"7454","key":"10.1016\/j.smim.2017.08.006_bib0175","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature12175","article-title":"Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo","volume":"498","author":"Lammermann","year":"2013","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.smim.2017.08.006_bib0180","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1515\/hsz-2015-0309","article-title":"Role of reverse transendothelial migration of neutrophils in inflammation","volume":"397","author":"Hirano","year":"2016","journal-title":"Biol. Chem."},{"issue":"6","key":"10.1016\/j.smim.2017.08.006_bib0185","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.immuni.2015.05.010","article-title":"Leukotriene B4-Neutrophil elastase axis drives neutrophil reverse transendothelial cell migration In vivo","volume":"42","author":"Colom","year":"2015","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.smim.2017.08.006_bib0190","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.4049\/jimmunol.134.3.1989","article-title":"Stimulatory effects of leukotriene B4 on macrophage association with and intracellular destruction of Trypanosoma cruzi","volume":"134","author":"Wirth","year":"1985","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.smim.2017.08.006_bib0195","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.4049\/jimmunol.157.12.5221","article-title":"Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities","volume":"157","author":"Bailie","year":"1996","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.smim.2017.08.006_bib0200","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.1128\/IAI.66.11.5140-5146.1998","article-title":"5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae","volume":"66","author":"Mancuso","year":"1998","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.smim.2017.08.006_bib0205","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1128\/IAI.69.4.2011-2016.2001","article-title":"Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumoniae","volume":"69","author":"Mancuso","year":"2001","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.smim.2017.08.006_bib0210","doi-asserted-by":"crossref","first-page":"e31701","DOI":"10.1371\/journal.pone.0031701","article-title":"5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection","volume":"7","author":"Secatto","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.smim.2017.08.006_bib0215","doi-asserted-by":"crossref","first-page":"e85083","DOI":"10.1371\/journal.pone.0085083","article-title":"The leukotriene B(4)\/BLT(1) axis is a key determinant in susceptibility and resistance to histoplasmosis","volume":"9","author":"Secatto","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.smim.2017.08.006_bib0220","doi-asserted-by":"crossref","first-page":"906","DOI":"10.4049\/jimmunol.1200257","article-title":"Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF\/PU.1 axis","volume":"189","author":"Serezani","year":"2012","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.smim.2017.08.006_bib0225","doi-asserted-by":"crossref","first-page":"e2390","DOI":"10.1371\/journal.pntd.0002390","article-title":"The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis","volume":"7","author":"Santos","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"11","key":"10.1016\/j.smim.2017.08.006_bib0230","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.micinf.2014.08.015","article-title":"Essential role of leukotriene B4 on Leishmania (Viannia) braziliensis killing by human macrophages","volume":"16","author":"Morato","year":"2014","journal-title":"Microbes Infect."},{"issue":"4","key":"10.1016\/j.smim.2017.08.006_bib0235","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/infdis\/jiu158","article-title":"Understanding the mechanisms controlling Leishmania amazonensis infection in vitro: the role of LTB4 derived from human neutrophils","volume":"210","author":"Tavares","year":"2014","journal-title":"J. Infect. Dis."},{"issue":"8","key":"10.1016\/j.smim.2017.08.006_bib0240","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1128\/IAI.70.8.4247-4253.2002","article-title":"Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection","volume":"70","author":"Talvani","year":"2002","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0245","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1182\/blood-2003-02-0534","article-title":"Syk activation is a leukotriene B4-regulated event involved in macrophage phagocytosis of IgG-coated targets but not apoptotic cells","volume":"102","author":"Canetti","year":"2003","journal-title":"Blood"},{"issue":"15","key":"10.1016\/j.smim.2017.08.006_bib0250","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1182\/blood-2009-01-199919","article-title":"FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions","volume":"114","author":"Serezani","year":"2009","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.smim.2017.08.006_bib0255","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.molimm.2008.11.024","article-title":"Differential kinase requirement for enhancement of Fc gammaR-mediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4","volume":"46","author":"Campos","year":"2009","journal-title":"Mol. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2017.08.006_bib0260","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1182\/blood-2004-08-3323","article-title":"Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase","volume":"106","author":"Serezani","year":"2005","journal-title":"Blood"},{"issue":"33","key":"10.1016\/j.smim.2017.08.006_bib0265","doi-asserted-by":"crossref","first-page":"28902","DOI":"10.1074\/jbc.M111.235309","article-title":"Leukotrienes target F-actin\/cofilin-1 to enhance alveolar macrophage anti-fungal activity","volume":"286","author":"Morato-Marques","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.smim.2017.08.006_bib0270","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1189\/jlb.1004587","article-title":"Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils","volume":"78","author":"Serezani","year":"2005","journal-title":"J. Leukoc. Biol."},{"issue":"7","key":"10.1016\/j.smim.2017.08.006_bib0275","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.rmed.2010.12.021","article-title":"LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects","volume":"105","author":"Widegren","year":"2011","journal-title":"Respir. Med."},{"issue":"11","key":"10.1016\/j.smim.2017.08.006_bib0280","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1096\/fj.06-7974com","article-title":"Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: novel lipid-peptide interactions in innate immune responses","volume":"21","author":"Wan","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.smim.2017.08.006_bib0285","first-page":"220","article-title":"Neutrophil biology: an update","volume":"14","author":"Kobayashi","year":"2015","journal-title":"EXCLI J."},{"issue":"1","key":"10.1016\/j.smim.2017.08.006_bib0290","first-page":"1","article-title":"Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit","volume":"76","author":"Yoshimura","year":"1985","journal-title":"J. Appl. Physiol."},{"issue":"9","key":"10.1016\/j.smim.2017.08.006_bib0295","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.4049\/jimmunol.180.9.6211","article-title":"Leukotriene B4 induces release of antimicrobial peptides in lungs of virally infected mice","volume":"180","author":"Gaudreault","year":"2008","journal-title":"J. Immunol."},{"issue":"25","key":"10.1016\/j.smim.2017.08.006_bib0300","doi-asserted-by":"crossref","first-page":"12048","DOI":"10.1016\/S0021-9258(18)45315-X","article-title":"The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process","volume":"262","author":"Wymann","year":"1987","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.smim.2017.08.006_bib0305","doi-asserted-by":"crossref","first-page":"8572","DOI":"10.1074\/jbc.M104766200","article-title":"Leukotriene B(4) stimulates Rac-ERK cascade to generate reactive oxygen species that mediates chemotaxis","volume":"277","author":"Woo","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0310","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1128\/IAI.01323-09","article-title":"Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia","volume":"78","author":"Mancuso","year":"2010","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0315","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.4049\/jimmunol.177.5.3201","article-title":"Leukotrienes are essential for the control of leishmania amazonensis infection and contribute to strain variation in susceptibility","volume":"177","author":"Serezani","year":"2006","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.smim.2017.08.006_bib0320","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1172\/JCI43302","article-title":"Leukotriene B4 amplifies NF-kappaB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression","volume":"121","author":"Serezani","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"361","key":"10.1016\/j.smim.2017.08.006_bib0325","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2005568","article-title":"Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes","volume":"8","author":"Filgueiras","year":"2015","journal-title":"Sci. Signal."},{"issue":"11","key":"10.1016\/j.smim.2017.08.006_bib0330","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/intimm\/dxs074","article-title":"TAK1 contributes to the enhanced responsiveness of LTB(4)-treated neutrophils to Toll-like receptor ligands","volume":"24","author":"Gaudreault","year":"2012","journal-title":"Int. Immunol."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0335","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1038\/cti.2016.22","article-title":"Toll-like receptors: the swiss army knife of immunity and vaccine development","volume":"5","author":"Dowling","year":"2016","journal-title":"Clin. Transl. Immunol."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0340","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1189\/jlb.2MR0316-117RR","article-title":"Molecular mechanisms of regulation of Toll-like receptor signaling","volume":"100","author":"Leifer","year":"2016","journal-title":"J. Leukoc Biol."},{"issue":"4","key":"10.1016\/j.smim.2017.08.006_bib0345","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.4049\/jimmunol.0804135","article-title":"Leukotriene B4 potentiates CpG signaling for enhanced cytokine secretion by human leukocytes","volume":"183","author":"Gaudreault","year":"2009","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.smim.2017.08.006_bib0350","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.semcdb.2008.07.010","article-title":"SOCS regulation of the JAK\/STAT signalling pathway","volume":"19","author":"Croker","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.smim.2017.08.006_bib0355","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/01.ATV.0000140063.06341.09","article-title":"Leukotriene B4 strongly increases monocyte chemoattractant protein-1 in human monocytes","volume":"24","author":"Huang","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0360","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.2353\/ajpath.2010.090839","article-title":"The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury","volume":"176","author":"Saiwai","year":"2010","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0365","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.4049\/jimmunol.1302982","article-title":"Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation","volume":"192","author":"Wang","year":"2014","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.smim.2017.08.006_bib0370","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/MCO.0b013e32834777fa","article-title":"The 5-lipoxygenase\/leukotriene pathway in obesity, insulin resistance, and fatty liver disease","volume":"14","author":"Martinez-Clemente","year":"2011","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.smim.2017.08.006_bib0375","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/978-1-4614-5441-0_19","article-title":"Molecular mechanisms of insulin resistance in diabetes","volume":"771","author":"Soumaya","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"issue":"4","key":"10.1016\/j.smim.2017.08.006_bib0380","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.4049\/jimmunol.1100196","article-title":"Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity","volume":"187","author":"Spite","year":"2011","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.smim.2017.08.006_bib0385","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/BF00923346","article-title":"Relationship between leukotriene B4 and immunological parameters in rheumatoid synovial fluids","volume":"15","author":"Ahmadzadeh","year":"1991","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.smim.2017.08.006_bib0390","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1084\/jem.20052371","article-title":"Neutrophil-derived leukotriene B4 is required for inflammatory arthritis","volume":"203","author":"Chen","year":"2006","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.smim.2017.08.006_bib0395","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.autrev.2007.03.005","article-title":"Role of leukotriene B4 receptors in rheumatoid arthritis","volume":"7","author":"Mathis","year":"2007","journal-title":"Autoimmun. Rev."},{"issue":"1","key":"10.1016\/j.smim.2017.08.006_bib0400","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/cvr\/cvn277","article-title":"Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis","volume":"81","author":"Sanchez-Galan","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0405","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.cell.2010.02.013","article-title":"The lta4\u2009h locus modulates susceptibility to mycobacterial infection in zebrafish and humans","volume":"140","author":"Tobin","year":"2010","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.smim.2017.08.006_bib0410","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cell.2011.12.023","article-title":"Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections","volume":"148","author":"Tobin","year":"2012","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.smim.2017.08.006_bib0415","doi-asserted-by":"crossref","first-page":"e67828","DOI":"10.1371\/journal.pone.0067828","article-title":"An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection","volume":"8","author":"Tobin","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.smim.2017.08.006_bib0420","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1165\/rcmb.2012-0525OC","article-title":"Pivotal role of the 5-lipoxygenase pathway in lung injury after experimental sepsis","volume":"50","author":"Monteiro","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.smim.2017.08.006_bib0425","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.jss.2014.09.013","article-title":"Dual role of leukotriene B4 receptor type 1 in experimental sepsis","volume":"193","author":"Li","year":"2015","journal-title":"J. Surg. Res."},{"issue":"2","key":"10.1016\/j.smim.2017.08.006_bib0430","doi-asserted-by":"crossref","first-page":"589","DOI":"10.4049\/jimmunol.174.2.589","article-title":"Leukotrienes: underappreciated mediators of innate immune responses","volume":"174","author":"Peters-Golden","year":"2005","journal-title":"J. Immunol."},{"issue":"18","key":"10.1016\/j.smim.2017.08.006_bib0435","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1056\/NEJMra071371","article-title":"Leukotrienes","volume":"357","author":"Peters-Golden","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"7614","key":"10.1016\/j.smim.2017.08.006_bib0440","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature18935","article-title":"CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis","volume":"536","author":"Kojima","year":"2016","journal-title":"Nature"},{"issue":"2010","key":"10.1016\/j.smim.2017.08.006_bib0445","article-title":"DAMPening inflammation by modulating TLR signalling","author":"Piccinini","year":"2010","journal-title":"Mediators Inflamm."},{"issue":"4","key":"10.1016\/j.smim.2017.08.006_bib0450","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000347132","article-title":"Damage-associated molecular patterns control neutrophil recruitment","volume":"5","author":"Pittman","year":"2013","journal-title":"J. Innate. Immun."},{"issue":"3","key":"10.1016\/j.smim.2017.08.006_bib0455","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.4049\/jimmunol.144.3.1052","article-title":"Alveolar macrophage function in rats with severe protein calorie malnutrition. Arachidonic acid metabolism, cytokine release, and antimicrobial activity","volume":"144","author":"Skerrett","year":"1990","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.smim.2017.08.006_bib0460","first-page":"662","article-title":"Multiple defects in arachidonate metabolism in alveolar macrophages from young asymptomatic smokers","volume":"114","author":"Balter","year":"1989","journal-title":"J. Lab. Clin. Med."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0465","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0090-6980(94)90031-0","article-title":"Reduced 5-lipoxygenase metabolism of arachidonic acid in macrophages rrom 1,25-dihydroxyvitamin D3-deficient rats","volume":"48","author":"Coffey","year":"1994","journal-title":"Prostaglandins"},{"issue":"4","key":"10.1016\/j.smim.2017.08.006_bib0470","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1172\/JCI2117","article-title":"Granulocyte colony-stimulating factor administration to HIV-infected subjects augments reduced leukotriene synthesis and anticryptococcal activity in neutrophils","volume":"102","author":"Coffey","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.smim.2017.08.006_bib0475","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00005-007-0001-2","article-title":"Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation","volume":"55","author":"Ballinger","year":"2007","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"issue":"12","key":"10.1016\/j.smim.2017.08.006_bib0480","doi-asserted-by":"crossref","first-page":"8036","DOI":"10.4049\/jimmunol.178.12.8036","article-title":"Leukotriene B4 triggers the in vitro and In vivo release of potent antimicrobial agents","volume":"178","author":"Flamand","year":"2007","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0485","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1172\/JCI114338","article-title":"Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability","volume":"84","author":"Martin","year":"1989","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.smim.2017.08.006_bib0490","doi-asserted-by":"crossref","first-page":"e1005368","DOI":"10.1371\/journal.ppat.1005368","article-title":"TNF drives monocyte dysfunction with age and results in impaired anti-pneumococcal immunity","volume":"12","author":"Puchta","year":"2016","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.smim.2017.08.006_bib0495","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1084\/jem.20091568","article-title":"Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice","volume":"207","author":"Yin","year":"2010","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.smim.2017.08.006_bib0500","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1378\/chest.111.5.1306","article-title":"Infections and the inflammatory response in acute respiratory distress syndrome","volume":"111","author":"Headley","year":"1997","journal-title":"Chest"},{"issue":"9","key":"10.1016\/j.smim.2017.08.006_bib0505","doi-asserted-by":"crossref","first-page":"e106813","DOI":"10.1371\/journal.pone.0106813","article-title":"Neutrophil-mediated phagocytic host defense defect in myeloid Cftr-inactivated mice","volume":"9","author":"Ng","year":"2014","journal-title":"PLoS One"},{"issue":"3-4","key":"10.1016\/j.smim.2017.08.006_bib0510","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1574-695X.1999.tb01397.x","article-title":"Immune dysfunction in patients with diabetes mellitus (DM)","volume":"26","author":"Geerlings","year":"1999","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"8","key":"10.1016\/j.smim.2017.08.006_bib0515","doi-asserted-by":"crossref","first-page":"e23366","DOI":"10.1371\/journal.pone.0023366","article-title":"Phagocytic activity is impaired in type 2 diabetes mellitus and increases after metabolic improvement","volume":"6","author":"Lecube","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.smim.2017.08.006_bib0520","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/art.33355","article-title":"NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout","volume":"64","author":"Amaral","year":"2012","journal-title":"Arthritis Rheum."}],"container-title":["Seminars in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532316300793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532316300793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T03:47:38Z","timestamp":1693108058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044532316300793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":104,"alternative-id":["S1044532316300793"],"URL":"https:\/\/doi.org\/10.1016\/j.smim.2017.08.006","relation":{},"ISSN":["1044-5323"],"issn-type":[{"value":"1044-5323","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Too much of a good thing: How modulating LTB4 actions restore host defense in homeostasis or disease","name":"articletitle","label":"Article Title"},{"value":"Seminars in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.smim.2017.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}