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Rev. Immunol."},{"key":"10.1016\/j.smim.2017.09.007_bib0485","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nri3818","article-title":"The ins and outs of MHC class II \u2212 mediated antigen processing and presentation","volume":"15","author":"Roche","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2017.09.007_bib0490","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nri3254","article-title":"Cross-presentation by dendritic cells","volume":"12","author":"Joffre","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2017.09.007_bib0495","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.immunol.25.022106.141548","article-title":"Effector and memory CTL differentiation","volume":"25","author":"Williams","year":"2007","journal-title":"Annu. Rev. 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Nanomed."},{"key":"10.1016\/j.smim.2017.09.007_bib0605","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jconrel.2013.03.025","article-title":"Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses","volume":"168","author":"Li","year":"2013","journal-title":"J. Control. 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Biotechnol."},{"key":"10.1016\/j.smim.2017.09.007_bib0640","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature09737","article-title":"Programming the magnitude and persistence of antibody responses with innate immunity","volume":"470","author":"Kasturi","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.smim.2017.09.007_bib0645","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2217\/nnm.13.98","article-title":"Nanoengineering approaches to the design of artificial antigen-presenting cells","volume":"8","author":"Sunshine","year":"2013","journal-title":"Nanomedicine"},{"key":"10.1016\/j.smim.2017.09.007_bib0650","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.nano.2013.06.015","article-title":"Nanoscale artificial antigen presenting cells for T cell immunotherapy","volume":"10","author":"Perica","year":"2014","journal-title":"Nanomed. Nanotechnol. Biol. 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Lett."},{"key":"10.1016\/j.smim.2017.09.007_bib0685","first-page":"315","article-title":"Immunopotentiation of the humoral response by liposomes: encapsulation versus covalent linkage","volume":"65","author":"Shahum","year":"1988","journal-title":"Immunology"},{"key":"10.1016\/j.smim.2017.09.007_bib0690","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0165-2478(88)90120-4","article-title":"Antibody responses to liposome-associated antigen","volume":"19","author":"Vannier","year":"1988","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.smim.2017.09.007_bib0695","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/0264-410X(90)90008-A","article-title":"Liposomal vaccine: influence of antigen association on the kinetics of the humoral response","volume":"8","author":"Th\u00e9rien","year":"1990","journal-title":"Vaccine"},{"key":"10.1016\/j.smim.2017.09.007_bib0700","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1128\/jvi.64.2.680-685.1990","article-title":"Influence of peptide acylation, liposome incorporation, and synthetic immunomodulators on the immunogenicity of a 1\u201323 peptide of glycoprotein D of herpes simplex virus: implications for subunit vaccines","volume":"64","author":"Brynestad","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2017.09.007_bib0705","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/eji.1830210128","article-title":"Parameters affecting the immunogenicity of a liposome-associated synthetic hexapeptide antigen","volume":"21","author":"Frisch","year":"1991","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.smim.2017.09.007_bib0710","first-page":"25","article-title":"Comparison of the immune response against polio peptides covalently-surface-linked to and internally-entrapped in liposomes","volume":"9","author":"Tan","year":"1991","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"10.1016\/j.smim.2017.09.007_bib0715","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/0264-410X(94)90183-X","article-title":"Correlation between in vitro and in vivo behaviour of liposomal antigens","volume":"12","author":"Shahum","year":"1994","journal-title":"Vaccine"},{"key":"10.1016\/j.smim.2017.09.007_bib0720","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0192-0561(94)00082-Y","article-title":"Liposomal adjuvanticity: effect of encapsulation and surface-linkage on antibody production and proliferative response","volume":"17","author":"Shahum","year":"1995","journal-title":"Int. J. 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Sci."},{"key":"10.1016\/j.smim.2017.09.007_bib0825","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1023\/A:1018820507379","article-title":"A novel system based on a poloxamer\/PLGA blend as a tetanus toxoid delivery vehicle","volume":"16","author":"Tob\u00edo","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.smim.2017.09.007_bib0830","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.2042-7158.1993.tb05532.x","article-title":"Immune response to nasal delivery of antigenically intact tetanus toxoid associated with poly(L-lactic acid) microspheres in rats, rabbits and guinea-pigs","volume":"45","author":"Almeida","year":"1993","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.smim.2017.09.007_bib0835","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0168-3659(01)00486-2","article-title":"Design of biodegradable particles for protein delivery","volume":"78","author":"Vila","year":"2002","journal-title":"J. Control. 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Invest."},{"key":"10.1016\/j.smim.2017.09.007_bib1200","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.biomaterials.2013.10.046","article-title":"The nanomaterial-dependent modulation of dendritic cells and its potential influence on therapeutic immunosuppression in lupus","volume":"35","author":"Look","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.smim.2017.09.007_bib1205","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1177\/0961203316636468","article-title":"A liposomal steroid nano-drug for treating systemic lupus erythematosus","volume":"25","author":"Moallem","year":"2016","journal-title":"Lupus"},{"key":"10.1016\/j.smim.2017.09.007_bib1210","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1681\/ASN.2009030295","article-title":"siRNA-based therapy ameliorates glomerulonephritis","volume":"21","author":"Shimizu","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.smim.2017.09.007_bib1215","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/08916930801929021","article-title":"Molecular mechanisms of autoimmunity","volume":"41","author":"Atassi","year":"2008","journal-title":"Autoimmunity"},{"key":"10.1016\/j.smim.2017.09.007_bib1220","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/imr.12398","article-title":"T-cell selection in the thymus: a spatial and temporal perspective","volume":"271","author":"Kurd","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.smim.2017.09.007_bib1225","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nri3667","article-title":"Positive and negative selection of the T cell repertoire: what thymocytes see (and don\u2019t see)","volume":"14","author":"Klein","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2017.09.007_bib1230","first-page":"25","article-title":"Breakdown of self-tolerance and the pathogenesis of autoimmunity","volume":"19","author":"Ring","year":"1999","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.smim.2017.09.007_bib1235","doi-asserted-by":"crossref","first-page":"a007401","DOI":"10.1101\/cshperspect.a007401","article-title":"Dendritic cells: arbiters of immunity and immunological tolerance","volume":"4","author":"Lewis","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.smim.2017.09.007_bib1240","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nri2343","article-title":"How regulatory T cells work","volume":"8","author":"Vignali","year":"2008","journal-title":"Nat. Rev. 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Immunol."},{"key":"10.1016\/j.smim.2017.09.007_bib1255","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.1279812","article-title":"Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy","volume":"258","author":"Gaur","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.smim.2017.09.007_bib1260","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.7509084","article-title":"T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis","volume":"263","author":"Critchfield","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.smim.2017.09.007_bib1265","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0896-8411(03)00114-8","article-title":"CD4 + CD25+ regulatory T cells generated in response to insulin B:9-23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells","volume":"21","author":"Mukherjee","year":"2003","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.smim.2017.09.007_bib1270","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1172\/JCI7209","article-title":"DNA immunization to prevent autoimmune diabetes","volume":"104","author":"Coon","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2017.09.007_bib1275","doi-asserted-by":"crossref","first-page":"9595","DOI":"10.1073\/pnas.0504131102","article-title":"Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis","volume":"102","author":"Smith","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.smim.2017.09.007_bib1280","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1126\/science.274.5295.2054","article-title":"Late complications of immune deviation therapy in a nonhuman primate","volume":"274","author":"Genain","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.smim.2017.09.007_bib1285","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri724","article-title":"Epitope spreading in immune-mediated diseases: implications for immunotherapy","volume":"2","author":"Vanderlugt","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2017.09.007_bib1290","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.1073\/pnas.91.14.6688","article-title":"Induction of anergy or active suppression following oral tolerance is determined by antigen dosage","volume":"91","author":"Friedman","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.smim.2017.09.007_bib1295","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.4049\/jimmunol.157.9.4230","article-title":"Suppression of murine chronic relapsing experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein","volume":"157","author":"Meyer","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2017.09.007_bib1300","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/(SICI)1097-4547(19960815)45:4<410::AID-JNR10>3.0.CO;2-4","article-title":"Inhibition of relapsing experimental autoimmune encephalomyelitis in SJL mice by feeding the immunodominant PLP 139\u2013151 peptide","volume":"45","author":"Karpus","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.smim.2017.09.007_bib1305","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0165-5728(97)00133-1","article-title":"Nasal administration of myelin basic protein prevents relapsing experimental autoimmune encephalomyelitis in DA rats by activating regulatory cells expressing IL-4 and TGF-beta mRNA","volume":"80","author":"Bai","year":"1997","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.smim.2017.09.007_bib1310","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1126\/science.7680493","article-title":"Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis","volume":"259","author":"Weiner","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.smim.2017.09.007_bib1315","unstructured":"National Multiple Sclerosis Society, What is MS?, (2014). http:\/\/www.nationalmssociety.org\/What-is-MS. (Accessed 18 April 2017)."},{"key":"10.1016\/j.smim.2017.09.007_bib1320","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0165-5728(86)90053-6","article-title":"Cell-mediated immunity to myelin-associated glycoprotein proteolipid protein, and myelin basic protein in multiple sclerosis","volume":"13","author":"Johnson","year":"1986","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.smim.2017.09.007_bib1325","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.23.021704.115707","article-title":"Immunology of multiple sclerosis","volume":"23","author":"Sospedra","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.smim.2017.09.007_bib1330","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/joim.12203","article-title":"Established and novel disease-modifying treatments in multiple sclerosis","volume":"275","author":"Cross","year":"2014","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.smim.2017.09.007_bib1335","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1586\/14737175.4.4.571","article-title":"Natalizumab: alpha 4-integrin antagonist selective adhesion molecule inhibitors for MS, Expert Rev","volume":"4","author":"Rudick","year":"2004","journal-title":"Neurother"},{"key":"10.1016\/j.smim.2017.09.007_bib1340","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12883-017-0932-0","article-title":"Association between multiple sclerosis, cancer risk, and immunosuppressant treatment: a cohort study","volume":"17","author":"Ragonese","year":"2017","journal-title":"BMC Neurol."},{"key":"10.1016\/j.smim.2017.09.007_bib1345","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.1016\/j.vaccine.2014.08.016","article-title":"Subcutaneous inverse vaccination with PLGA particles loaded with a MOG peptide and IL-10 decreases the severity of experimental autoimmune encephalomyelitis","volume":"32","author":"Cappellano","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.smim.2017.09.007_bib1350","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1016\/j.celrep.2016.08.033","article-title":"Reprogramming the local lymph node microenvironment promotes tolerance that is systemic and antigen specific","volume":"16","author":"Tostanoski","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.smim.2017.09.007_bib1355","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.jhep.2015.01.006","article-title":"Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice","volume":"62","author":"Carambia","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.smim.2017.09.007_bib1360","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.molimm.2013.08.006","article-title":"A novel nanoparticle containing MOG peptide with BTLA induces T cell tolerance and prevents multiple sclerosis","volume":"57","author":"Yuan","year":"2014","journal-title":"Mol. 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Sinai J. Med. A J. Transl. Pers. Med."},{"key":"10.1016\/j.smim.2017.09.007_bib1390","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/08916939809008041","article-title":"Cellular and molecular mechanisms for the initiation and progression of beta cell destruction resulting from the collaboration between macrophages and T cells","volume":"27","author":"Yoon","year":"1998","journal-title":"Autoimmunity"},{"key":"10.1016\/j.smim.2017.09.007_bib1395","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/jaut.1999.0323","article-title":"The role of CD4 and CD8 T cells in the development of autoimmune diabetes","volume":"13","author":"Dilts","year":"1999","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.smim.2017.09.007_bib1400","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007658","article-title":"Islet autoantigens: structure, function, localization, and regulation","volume":"2","author":"Arvan","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.smim.2017.09.007_bib1405","doi-asserted-by":"crossref","DOI":"10.1038\/srep13155","article-title":"A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice","volume":"5","author":"Yoon","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.smim.2017.09.007_bib1410","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2005.03.009","article-title":"Preparation and characterization of biodegradable nanoparticles entrapping immunodominant peptide conjugated with PEG for oral tolerance induction","volume":"105","author":"Lee","year":"2005","journal-title":"J. Control. Release."},{"key":"10.1016\/j.smim.2017.09.007_bib1415","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.4049\/jimmunol.0802972","article-title":"Antigen-specific suppression of inflammatory arthritis using liposomes","volume":"182","author":"Capini","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2017.09.007_bib1420","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1126\/science.8378772","article-title":"Effects of oral administration of type II collagen on rheumatoid arthritis","volume":"261","author":"Trentham","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.smim.2017.09.007_bib1425","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1073\/pnas.70.11.3240","article-title":"Construction of biologically functional bacterial plasmids in vitro","volume":"70","author":"Cohen","year":"1973","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2017.09.007_bib1430","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1126\/science.6337396","article-title":"Human insulin from recombinant DNA technology","volume":"219","author":"Johnson","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.smim.2017.09.007_bib1435","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nbt0910-917","article-title":"Biopharmaceutical benchmarks 2010","volume":"28","author":"Walsh","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.smim.2017.09.007_bib1440","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/nbt.3040","article-title":"Biopharmaceutical benchmarks 2014","volume":"32","author":"Walsh","year":"2014","journal-title":"Nat. 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Med."},{"key":"10.1016\/j.smim.2017.09.007_bib1460","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1056\/NEJMoa011931","article-title":"Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin","volume":"346","author":"Casadevall","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.smim.2017.09.007_bib1465","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/ndt\/gfh1072","article-title":"Epoetin-associated pure red cell aplasia in patients with chronic kidney disease: solving the mystery","volume":"20","author":"Boven","year":"2005","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.smim.2017.09.007_bib1470","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1023\/B:PHAM.0000008034.61317.02","article-title":"Micelle-associated protein in epoetin formulations: a risk factor for immunogenicity?","volume":"20","author":"Hermeling","year":"2003","journal-title":"Pharm. Res."},{"key":"10.1016\/j.smim.2017.09.007_bib1475","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1056\/NEJMoa040528","article-title":"Pure red-cell aplasia and epoetin therapy","volume":"351","author":"Bennett","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.smim.2017.09.007_bib1480","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/1547691X.2013.821564","article-title":"Immunogenicity of therapeutic proteins: influence of aggregation","volume":"11","author":"Ratanji","year":"2014","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.smim.2017.09.007_bib1485","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.xphs.2015.11.002","article-title":"Immunogenicity of therapeutic protein aggregates","volume":"105","author":"Moussa","year":"2016","journal-title":"J. Pharm. 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