{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T22:52:29Z","timestamp":1772059949050,"version":"3.50.1"},"reference-count":186,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Alexion Rare Disease Innovation","award":["31-91010-584000-137015"],"award-info":[{"award-number":["31-91010-584000-137015"]}]},{"name":"Division of Human Genetics funds"},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["DFG; EXC\/2"],"award-info":[{"award-number":["DFG; EXC\/2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["IRTG 1911"],"award-info":[{"award-number":["IRTG 1911"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Immunology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.smim.2018.02.006","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T06:59:31Z","timestamp":1519369171000},"page":"30-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["An unexpected player in Gaucher disease: The multiple roles of complement in disease development"],"prefix":"10.1016","volume":"37","author":[{"given":"Manoj K.","family":"Pandey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Grabowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"K\u00f6hl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0005","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.immuni.2015.05.024","article-title":"Complement regulates nutrient influx and metabolic reprogramming during Th1 cell responses","volume":"42","author":"Kolev","year":"2015","journal-title":"Immunity"},{"issue":"6292","key":"10.1016\/j.smim.2018.02.006_bib0010","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad1210","article-title":"Autocrine NLRP3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-\u03b3 in CD4+ T cells","volume":"352","author":"Arbore","year":"2016","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0015","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.immuni.2013.10.018","article-title":"Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation","volume":"39","author":"Liszewski","year":"2013","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0020","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1073\/pnas.1316877111","article-title":"C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens","volume":"111","author":"Baudino","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.smim.2018.02.006_bib0025","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/cdd.2015.164","article-title":"Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes","volume":"23","author":"Martin","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.smim.2018.02.006_bib0030","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.molimm.2017.05.012","article-title":"Intracellular complement \u2013 the complosome \u2013 in immune cell regulation","volume":"89","author":"Arbore","year":"2017","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/imr.12467","article-title":"More than complementing tolls: complement-toll-like receptor synergy and crosstalk in innate immunity and inflammation","volume":"274","author":"Hajishengallis","year":"2016","journal-title":"Immunol. Rev."},{"issue":"9","key":"10.1016\/j.smim.2018.02.006_bib0040","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/nm.2862","article-title":"Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcgammaRIIB and dectin-1","volume":"18","author":"Karsten","year":"2012","journal-title":"Nat. Med."},{"issue":"11","key":"10.1016\/j.smim.2018.02.006_bib0045","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.imbio.2012.07.015","article-title":"The immunoglobulin IgG Fc receptor and complement triangle in autoimmune diseases","volume":"217","author":"Karsten","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.smim.2018.02.006_bib0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0006-291X(65)90743-6","article-title":"Metabolism of glucocerebrosides. ii. Evidence of an enzymatic deficiency in Gaucher's disease","volume":"18","author":"Brady","year":"1965","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7643","key":"10.1016\/j.smim.2018.02.006_bib0055","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature21368","article-title":"Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease","volume":"543","author":"Pandey","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bj.2016.12.004","article-title":"From Christian de Duve to Yoshinori Ohsumi: more to autophagy than just dining at home","volume":"40","author":"Harnett","year":"2017","journal-title":"Biomed. J."},{"key":"10.1016\/j.smim.2018.02.006_bib0065","series-title":"The Online Metabolic and Molecular Bases of Inherited Disease","author":"Valle","year":"2017"},{"issue":"8","key":"10.1016\/j.smim.2018.02.006_bib0070","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1080\/15548627.2016.1179405","article-title":"TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages","volume":"12","author":"Pastore","year":"2016","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.smim.2018.02.006_bib0075","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/eji.201546131","article-title":"A novel complement-metabolism-inflammasome axis as a key regulator of immune cell effector function","volume":"46","author":"Arbore","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.smim.2018.02.006_bib0080","doi-asserted-by":"crossref","first-page":"398483","DOI":"10.1155\/2015\/398483","article-title":"Cellular and molecular connections between autophagy and inflammation","volume":"2015","author":"Lapaquette","year":"2015","journal-title":"Mediators Inflamm."},{"issue":"16","key":"10.1016\/j.smim.2018.02.006_bib0085","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.1073\/pnas.0700907104","article-title":"Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins","volume":"104","author":"Sun","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"16","key":"10.1016\/j.smim.2018.02.006_bib0090","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1073\/pnas.0700899104","article-title":"Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig","volume":"104","author":"Radhakrishnan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"21","key":"10.1016\/j.smim.2018.02.006_bib0095","doi-asserted-by":"crossref","first-page":"8487","DOI":"10.1016\/S0021-9258(19)40786-2","article-title":"Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease","volume":"250","author":"Goldstein","year":"1975","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.smim.2018.02.006_bib0100","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1093\/hmg\/ddr306","article-title":"Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways","volume":"20","author":"Palmieri","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"5939","key":"10.1016\/j.smim.2018.02.006_bib0105","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"issue":"24","key":"10.1016\/j.smim.2018.02.006_bib0110","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.4161\/cc.8.24.10263","article-title":"Lysosomal enhancement: a CLEAR answer to cellular degradative needs","volume":"8","author":"Sardiello","year":"2009","journal-title":"Cell Cycle"},{"issue":"22","key":"10.1016\/j.smim.2018.02.006_bib0115","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1101\/gad.8.22.2770","article-title":"Microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family","volume":"8","author":"Hemesath","year":"1994","journal-title":"Genes Dev."},{"issue":"12","key":"10.1016\/j.smim.2018.02.006_bib0120","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.tcb.2014.06.006","article-title":"Lysosome: regulator of lipid degradation pathways","volume":"24","author":"Settembre","year":"2014","journal-title":"Trends Cell Biol."},{"issue":"6036","key":"10.1016\/j.smim.2018.02.006_bib0125","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"issue":"Pt 8","key":"10.1016\/j.smim.2018.02.006_bib0130","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1242\/jcs.125773","article-title":"Regulation of mTORC1 and its impact on gene expression at a glance","volume":"26","author":"Laplante","year":"2013","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0135","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbalip.2016.01.006","article-title":"Autophagy lipophagy and lysosomal lipid storage disorders","volume":"1861","author":"Ward","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.smim.2018.02.006_bib0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ceb.2015.04.014","article-title":"Beyond indigestion: emerging roles for lysosome-based signaling in human disease","volume":"35","author":"Ferguson","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.smim.2018.02.006_bib0145","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-cellbio-111315-125125","article-title":"The lysosome as a regulatory hub","volume":"32","author":"Perera","year":"2016","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0150","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1083\/jcb.201607005","article-title":"The lysosome as a command-and-control center for cellular metabolism","volume":"214","author":"Lim","year":"2016","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0155","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10545-008-1040-5","article-title":"Pathogenic cascades in lysosomal disease-why so complex?","volume":"32","author":"Walkley","year":"2009","journal-title":"J. Inherit. Metab. Dis."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0160","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cell.2015.05.051","article-title":"A conserved circular network of coregulated lipids modulates innate immune responses","volume":"162","author":"Koberlin","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.smim.2018.02.006_bib0165","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.imlet.2017.07.004","article-title":"Overview of immune abnormalities in lysosomal storage disorders","volume":"188","author":"Rigante","year":"2017","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.smim.2018.02.006_bib0170","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3389\/fnins.2015.00417","article-title":"Neuroinflammatory paradigms in lysosomal storage diseases","volume":"9","author":"Bosch","year":"2015","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0175","first-page":"301","article-title":"The transcription factor EB links cellular stress to the immune response","volume":"90","author":"Nabar","year":"2017","journal-title":"Yale J. Biol. Med."},{"issue":"5","key":"10.1016\/j.smim.2018.02.006_bib0180","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1083\/jcb.201208152","article-title":"The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction","volume":"199","author":"Platt","year":"2012","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0185","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.spen.2017.08.005","article-title":"Overview of inflammation in neurometabolic diseases","volume":"24","author":"Grabowski","year":"2017","journal-title":"Semin. Pediatr. Neurol."},{"key":"10.1016\/j.smim.2018.02.006_bib0190","series-title":"The Online Metabolic and Molecular Bases of Inherited Disease","article-title":"Gaucher disease","author":"Grabowski","year":"2010"},{"issue":"17","key":"10.1016\/j.smim.2018.02.006_bib0195","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease","volume":"361","author":"Sidransky","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.smim.2018.02.006_bib0200","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1182\/blood-2014-09-600270","article-title":"Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation","volume":"125","author":"Nair","year":"2015","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0205","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1056\/NEJMoa1508808","article-title":"Clonal immunoglobulin against lysolipids in the origin of myeloma","volume":"374","author":"Nair","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.smim.2018.02.006_bib0210","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.iy.11.040193.002441","article-title":"Origin of murine B cell lineages","volume":"11","author":"Kantor","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.smim.2018.02.006_bib0215","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1749-6632.1992.tb24592.x","article-title":"Location and function of B-cell lineages","volume":"651","author":"Kroese","year":"1992","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"11","key":"10.1016\/j.smim.2018.02.006_bib0220","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1002\/eji.1830191110","article-title":"Further evidence for coelomic-associated B lymphocytes","volume":"19","author":"Marcos","year":"1989","journal-title":"Eur. J. Immunol."},{"issue":"4797","key":"10.1016\/j.smim.2018.02.006_bib0225","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1126\/science.3105057","article-title":"Rheumatoid factor secretion from human Leu-1+ B cells","volume":"236","author":"Hardy","year":"1987","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.smim.2018.02.006_bib0230","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/art.1780310509","article-title":"B cells expressing CD5 are increased in Sjogren's syndrome","volume":"31","author":"Dauphinee","year":"1988","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0235","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1023\/A:1023234823783","article-title":"Presence of activated B-1 cells in chronic inflamed gingival tissue","volume":"18","author":"Aramaki","year":"1998","journal-title":"J. Clin. Immunol."},{"issue":"13","key":"10.1016\/j.smim.2018.02.006_bib0240","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1084\/jem.20110978","article-title":"A small CD11b+ human B1 cell subpopulation stimulates T cells and is expanded in lupus","volume":"208","author":"Griffin","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.smim.2018.02.006_bib0245","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3389\/fimmu.2016.00324","article-title":"B-1 cell heterogeneity and the regulation of natural and antigen-induced IgM production","volume":"7","author":"Baumgarth","year":"2016","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0250","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1084\/jem.157.1.202","article-title":"The Ly-1 B cell subpopulation in normal immunodefective, and autoimmune mice","volume":"157","author":"Hayakawa","year":"1983","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0255","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1084\/jem.161.6.1554","article-title":"Progenitors for Ly-1B cells are distinct from progenitors for other B cells","volume":"161","author":"Hayakawa","year":"1985","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0260","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0952-7915(00)00098-4","article-title":"Development and function of B-1 cells","volume":"12","author":"Hayakawa","year":"2000","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.smim.2018.02.006_bib0265","first-page":"37","article-title":"Identification of B-cell subsets: an exposition of 11-color (Hi-D) FACS methods","volume":"271","author":"Tung","year":"2004","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.smim.2018.02.006_bib0270","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1600-065X.1994.tb00660.x","article-title":"Distinctive developmental origins and specificities of murine CD5+ B cells","volume":"137","author":"Hardy","year":"1994","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0275","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1615\/CritRevImmunol.v31.i1.30","article-title":"CD5 expression in B cells from patients with systemic lupus erythematosus","volume":"31","author":"Youinou","year":"2011","journal-title":"Crit. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0280","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1084\/jem.168.2.687","article-title":"Normal mouse peritoneum contains a large population of Ly-1+ (CD5) B cells that recognize phosphatidyl choline. Relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes","volume":"168","author":"Mercolino","year":"1988","journal-title":"J. Exp. Med."},{"issue":"4797","key":"10.1016\/j.smim.2018.02.006_bib0285","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.3105056","article-title":"Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset","volume":"236","author":"Casali","year":"1987","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0290","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.4049\/jimmunol.166.4.2412","article-title":"Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds","volume":"166","author":"Qian","year":"2001","journal-title":"J. Immunol."},{"issue":"5424","key":"10.1016\/j.smim.2018.02.006_bib0295","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.285.5424.113","article-title":"Positive selection of natural autoreactive B cells","volume":"285","author":"Hayakawa","year":"1999","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.smim.2018.02.006_bib0300","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.4049\/jimmunol.140.12.4180","article-title":"Human monoclonal rheumatoid factor-like antibodies from CD5 (Leu-1)+ B cells are polyreactive","volume":"140","author":"Nakamura","year":"1988","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0305","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bcmd.2012.11.012","article-title":"Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease","volume":"50","author":"Rodic","year":"2013","journal-title":"Blood Cells Mol. Dis."},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0310","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ymgme.2013.09.002","article-title":"Gaucher disease: chemotactic factors and immunological cell invasion in a mouse model","volume":"111","author":"Pandey","year":"2014","journal-title":"Mol. Genet. Metab."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0315","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/path.4227","article-title":"B cell lymphoma and myeloma in murine Gaucher's disease","volume":"231","author":"Pavlova","year":"2013","journal-title":"J. Pathol."},{"key":"10.1016\/j.smim.2018.02.006_bib0320","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2164-12-20","article-title":"Global gene expression profile progression in Gaucher disease mouse models","volume":"12","author":"Xu","year":"2011","journal-title":"BMC Genomics"},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0325","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s11882-013-0387-3","article-title":"Molecular basis for downregulation of C5a-mediated inflammation by IgG1 immune complexes in allergy and asthma","volume":"13","author":"Pandey","year":"2013","journal-title":"Curr. Allergy Asthma Rep."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0330","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fcgamma receptors as regulators of immune responses","volume":"8","author":"Nimmerjahn","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.smim.2018.02.006_bib0335","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1016\/S0021-9258(17)37050-3","article-title":"Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells","volume":"269","author":"Ghazizadeh","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0340","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1084\/jem.180.3.1165","article-title":"Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn","volume":"180","author":"Wang","year":"1994","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0345","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1165\/rcmb.2005-0298OC","article-title":"Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation","volume":"34","author":"Matsubara","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1\u20133","key":"10.1016\/j.smim.2018.02.006_bib0350","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ejphar.2004.10.024","article-title":"A novel Syk kinase-selective inhibitor blocks antigen presentation of immune complexes in dendritic cells","volume":"505","author":"Nakashima","year":"2004","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0355","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1172\/JCI0215640","article-title":"Immune complex-mediated antigen presentation induces tumor immunity","volume":"110","author":"Rafiq","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.smim.2018.02.006_bib0360","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol."},{"issue":"7589","key":"10.1016\/j.smim.2018.02.006_bib0365","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature16549","article-title":"Schizophrenia risk from complex variation of complement component 4","volume":"530","author":"Sekar","year":"2016","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0370","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nm1419","article-title":"Generation of C5a in the absence of C3: a new complement activation pathway","volume":"12","author":"Huber-Lang","year":"2006","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0375","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.immuni.2005.02.006","article-title":"C5a negatively regulates toll-like receptor 4-induced immune responses","volume":"22","author":"Hawlisch","year":"2005","journal-title":"Immunity"},{"issue":"20","key":"10.1016\/j.smim.2018.02.006_bib0380","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1182\/blood-2013-05-502229","article-title":"C3a modulates IL-1beta secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation","volume":"122","author":"Asgari","year":"2013","journal-title":"Blood"},{"issue":"Pt 13","key":"10.1016\/j.smim.2018.02.006_bib0385","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1242\/jcs.124388","article-title":"The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation","volume":"26","author":"Triantafilou","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.smim.2018.02.006_bib0390","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.179291","article-title":"Complement-mediated bystander damage initiates host NLRP3 inflammasome activation","author":"Suresh","year":"2016","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0395","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.immuni.2012.08.002","article-title":"Regulation of humoral immunity by complement","volume":"37","author":"Carroll","year":"2012","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.smim.2018.02.006_bib0400","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/ni.1917","article-title":"Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells","volume":"11","author":"Cardone","year":"2010","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.smim.2018.02.006_bib0405","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/ni.2454","article-title":"The CD46-Jagged1 interaction is critical for human TH1 immunity","volume":"13","author":"Le Friec","year":"2012","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0410","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1172\/JCI26582","article-title":"A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma","volume":"116","author":"K\u00f6hl","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.smim.2018.02.006_bib0415","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/ni.1926","article-title":"Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma","volume":"11","author":"Lajoie","year":"2010","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0420","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ni.2499","article-title":"Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3(+) regulatory T cells","volume":"14","author":"Strainic","year":"2013","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.smim.2018.02.006_bib0425","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/ni.2140","article-title":"A platelet-mediated system for shuttling blood-borne bacteria to CD8alpha+ dendritic cells depends on glycoprotein GPIb and complement C3","volume":"12","author":"Verschoor","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.smim.2018.02.006_bib0430","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.23.021704.115835","article-title":"Role of C5a in inflammatory responses","volume":"23","author":"Guo","year":"2005","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0435","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1586\/eci.09.84","article-title":"A complex role for complement in allergic asthma","volume":"6","author":"Zhang","year":"2010","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.smim.2018.02.006_bib0440","doi-asserted-by":"crossref","first-page":"236075","DOI":"10.1155\/2012\/236075","article-title":"The contribution of allergen-specific IgG to the development of th2-mediated airway inflammation","volume":"2012","author":"Williams","year":"2012","journal-title":"J. Allergy"},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0445","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.immuni.2005.05.010","article-title":"FcgammaRIV: a novel FcR with distinct IgG subclass specificity","volume":"23","author":"Nimmerjahn","year":"2005","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0450","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.immuni.2005.11.010","article-title":"Fcgamma receptors: old friends and new family members","volume":"24","author":"Nimmerjahn","year":"2006","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0455","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2249.1993.tb03446.x","article-title":"Activation of human complement by mouse and mouse\/human chimeric monoclonal antibodies","volume":"94","author":"Seino","year":"1993","journal-title":"Clin. Exp. Immunol."},{"issue":"12","key":"10.1016\/j.smim.2018.02.006_bib0460","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1002\/eji.200939884","article-title":"Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a","volume":"39","author":"Syed","year":"2009","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0465","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0952-7915(95)80028-X","article-title":"Structure function and cellular expression of complement anaphylatoxin receptors","volume":"7","author":"Wetsel","year":"1995","journal-title":"Curr. Opin. Immunol."},{"issue":"9","key":"10.1016\/j.smim.2018.02.006_bib0470","doi-asserted-by":"crossref","first-page":"7165","DOI":"10.1074\/jbc.C100714200","article-title":"The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)","volume":"277","author":"Cain","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.smim.2018.02.006_bib0475","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/icb.2016.62","article-title":"Targeting the Dark Horse of complement: the first generation of functionally selective C5aR2 ligands","volume":"94","author":"Kemper","year":"2016","journal-title":"Immunol. Cell Biol."},{"issue":"8","key":"10.1016\/j.smim.2018.02.006_bib0480","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/icb.2016.43","article-title":"Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling","volume":"94","author":"Croker","year":"2016","journal-title":"Immunol. Cell Biol."},{"issue":"31","key":"10.1016\/j.smim.2018.02.006_bib0485","doi-asserted-by":"crossref","first-page":"9406","DOI":"10.1021\/bi034489v","article-title":"C5L2, a nonsignaling C5A binding protein","volume":"42","author":"Okinaga","year":"2003","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0490","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1096\/fj.12-220509","article-title":"C5L2: a controversial receptor of complement anaphylatoxin, C5a","volume":"27","author":"Li","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.smim.2018.02.006_bib0495","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3389\/fimmu.2012.00368","article-title":"New insights for C5a and C5a receptors in sepsis","volume":"3","author":"Yan","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2018.02.006_bib0500","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.molimm.2017.05.019","article-title":"Novel insights into the expression pattern of anaphylatoxin receptors in mice and men","volume":"89","author":"Laumonnier","year":"2017","journal-title":"Mol. Immunol."},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0505","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.4049\/jimmunol.1401401","article-title":"Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse","volume":"194","author":"Karsten","year":"2015","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.smim.2018.02.006_bib0510","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.4049\/jimmunol.1700710","article-title":"Monitoring C5aR2 expression using a floxed tdTomato-C5aR2 knock-in mouse","volume":"199","author":"Karsten","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2018.02.006_bib0515","doi-asserted-by":"crossref","first-page":"361279","DOI":"10.1155\/2011\/361279","article-title":"Coxarthritis as the presenting symptom of Gaucher disease type 1","volume":"2011","author":"Brisca","year":"2011","journal-title":"Arthritis"},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0520","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bcmd.2011.09.005","article-title":"Extended remission of B-cell lymphoma with monoclonal gammopathy in a patient with type 1 Gaucher disease treated with enzyme replacement therapy","volume":"48","author":"Camou","year":"2012","journal-title":"Blood Cells. Mol. Dis."},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0525","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.imbio.2009.07.002","article-title":"Uncoupling between CD1d upregulation induced by retinoic acid and conduritol-B-epoxide and iNKT cell responsiveness","volume":"215","author":"Balreira","year":"2010","journal-title":"Immunobiology"},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0530","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1615\/CritRevOncog.2013004503","article-title":"Immunological cells and functions in Gaucher disease","volume":"18","author":"Pandey","year":"2013","journal-title":"Crit. Rev. Oncog."},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0535","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ymgme.2012.04.020","article-title":"Immunological cell type characterization and Th1-Th17 cytokine production in a mouse model of Gaucher disease","volume":"106","author":"Pandey","year":"2012","journal-title":"Mol. Genet. Metab."},{"issue":"45","key":"10.1016\/j.smim.2018.02.006_bib0540","doi-asserted-by":"crossref","first-page":"19473","DOI":"10.1073\/pnas.1003308107","article-title":"Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage","volume":"107","author":"Mistry","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0545","first-page":"B4411","article-title":"Granulocyte-colony stimulating factor therapy to induce neovascularization in ischemic heart disease","volume":"59","author":"Ripa","year":"2012","journal-title":"Dan. Med. J."},{"issue":"9","key":"10.1016\/j.smim.2018.02.006_bib0550","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/jama.295.9.1003","article-title":"Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial","volume":"295","author":"Zohlnhofer","year":"2006","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0555","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0268-960X(92)90007-D","article-title":"Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF): receptor biology signal transduction, and neutrophil activation","volume":"6","author":"Rapoport","year":"1992","journal-title":"Blood Rev."},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0560","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1182\/blood.V84.6.1737.1737","article-title":"Mice lacking granulocyte colony-stimulating factor have chronic neutropenia granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization","volume":"84","author":"Lieschke","year":"1994","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.smim.2018.02.006_bib0565","first-page":"2735","volume":"5","author":"Avigan","year":"1999","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0570","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The many roles of chemokines and chemokine receptors in inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.smim.2018.02.006_bib0575","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nri1964","article-title":"Tuning inflammation and immunity by chemokine sequestration: decoys and more","volume":"6","author":"Mantovani","year":"2006","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0580","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.clim.2012.01.011","article-title":"G-CSF stem cell mobilization in human donors induces polymorphonuclear and mononuclear myeloid-derived suppressor cells","volume":"143","author":"Luyckx","year":"2012","journal-title":"Clin. Immunol."},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0585","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1189\/jlb.68.4.568","article-title":"Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4+ T cells","volume":"68","author":"Yamamoto","year":"2000","journal-title":"J. Leukoc. Biol."},{"issue":"7","key":"10.1016\/j.smim.2018.02.006_bib0590","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1002\/(SICI)1521-4141(199807)28:07<2197::AID-IMMU2197>3.0.CO;2-F","article-title":"The chemokine SDF-1alpha triggers a chemotactic response and induces cell polarization in human B lymphocytes","volume":"28","author":"Vicente-Manzanares","year":"1998","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.smim.2018.02.006_bib0595","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.bbi.2010.10.002","article-title":"The lymphoid chemokine CXCL13, is dispensable for the initial recruitment of B cells to the acutely inflamed central nervous system","volume":"25","author":"Rainey-Barger","year":"2011","journal-title":"Brain Behav. Immun."},{"issue":"1\u20132","key":"10.1016\/j.smim.2018.02.006_bib0600","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jneuroim.2011.12.014","article-title":"Key role of CXCL13\/CXCR5 axis for cerebrospinal fluid B cell recruitment in pediatric OMS","volume":"243","author":"Pranzatelli","year":"2012","journal-title":"J. Neuroimmunol."},{"issue":"6294","key":"10.1016\/j.smim.2018.02.006_bib0605","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/347669a0","article-title":"Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES","volume":"347","author":"Schall","year":"1990","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0610","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0092-8674(93)90118-A","article-title":"Molecular cloning functional expression, and signaling characteristics of a C-C chemokine receptor","volume":"72","author":"Neote","year":"1993","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0615","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.4049\/jimmunol.156.6.2104","article-title":"Chemokines and T lymphocyte activation: II. Facilitation of human T cell trafficking in severe combined immunodeficiency mice","volume":"156","author":"Murphy","year":"1996","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0620","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.4049\/jimmunol.159.4.1993","article-title":"Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines","volume":"159","author":"Sozzani","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2018.02.006_bib0625","first-page":"93","article-title":"Cyclophilin A cooperates with MIP-2 to augment neutrophil migration","volume":"4","author":"Heine","year":"2011","journal-title":"J. Inflamm. Res."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0630","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.185.1.99","article-title":"Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1","volume":"185","author":"Sarafi","year":"1997","journal-title":"J. Exp. Med."},{"issue":"6799","key":"10.1016\/j.smim.2018.02.006_bib0635","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/35023175","article-title":"A role for the C3a anaphylatoxin receptor in the effector phase of asthma","volume":"406","author":"Humbles","year":"2000","journal-title":"Nature"},{"issue":"10 Pt 1","key":"10.1016\/j.smim.2018.02.006_bib0640","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1164\/ajrccm.164.10.2010096","article-title":"Complement factors C3a and C5a are increased in bronchoalveolar lavage fluid after segmental allergen provocation in subjects with asthma","volume":"64","author":"Krug","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0645","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.4049\/jimmunol.165.4.2183","article-title":"Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils","volume":"165","author":"Eglite","year":"2000","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0650","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.clim.2003.11.007","article-title":"Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a","volume":"110","author":"Woolhiser","year":"2004","journal-title":"Clin. Immunol."},{"issue":"25","key":"10.1016\/j.smim.2018.02.006_bib0655","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.1073\/pnas.1200941109","article-title":"Gaucher disease gene GBA functions in immune regulation","volume":"109","author":"Liu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0660","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3346\/jkms.2006.21.4.733","article-title":"Upregulation of proinflammatory cytokines in the fetal brain of the Gaucher mouse","volume":"21","author":"Hong","year":"2006","journal-title":"J. Korean Med. Sci."},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0665","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1309\/BG5VA8JRDQH1M7HN","article-title":"Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages","volume":"122","author":"Boven","year":"2004","journal-title":"Am. J. Clin. Pathol."},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0670","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF01541326","article-title":"Natural autoantibodies in sera of patients with Gaucher's disease","volume":"15","author":"Shoenfeld","year":"1995","journal-title":"J. Clin. Immunol."},{"issue":"8","key":"10.1016\/j.smim.2018.02.006_bib0675","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1212\/WNL.45.8.1622","article-title":"Antisulfatide antibody and neuropathy in a patient with Gaucher's disease","volume":"45","author":"McAlarney","year":"1995","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0680","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bcmd.2003.10.007","article-title":"Effect of enzyme replacement therapy on gammopathies in Gaucher disease","volume":"32","author":"Brautbar","year":"2004","journal-title":"Blood Cells Mol. Dis."},{"issue":"7","key":"10.1016\/j.smim.2018.02.006_bib0685","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/MPH.0b013e31806451d3","article-title":"Hyperimmunoglobulinemia in pediatric-onset type 1 Gaucher disease and effects of enzyme replacement therapy","volume":"29","author":"Wine","year":"2007","journal-title":"J. Pediatr. Hematol. Oncol."},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0690","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/pbc.22863","article-title":"Immunoglobulin abnormalities and effects of enzyme replacement therapy in children with Gaucher disease","volume":"56","author":"Arikan-Ayyildiz","year":"2011","journal-title":"Pediatr. Blood Cancer"},{"issue":"12","key":"10.1016\/j.smim.2018.02.006_bib0695","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/bjs.1800831236","article-title":"Impact of splenectomy on circulating immunoglobulin levels and the development of postoperative infection following total gastrectomy for gastric cancer","volume":"83","author":"Fujita","year":"1996","journal-title":"Br. J. Surg."},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0700","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.immuni.2008.02.001","article-title":"Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells","volume":"28","author":"Strainic","year":"2008","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0705","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/eji.200939333","article-title":"C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells","volume":"40","author":"Weaver","year":"2010","journal-title":"Eur. J. Immunol."},{"issue":"6292","key":"10.1016\/j.smim.2018.02.006_bib0710","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad1210","article-title":"T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4(+) T cells","volume":"352","author":"Arbore","year":"2016","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0715","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri1269","article-title":"The dark side of C5a in sepsis","volume":"4","author":"Ward","year":"2004","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.smim.2018.02.006_bib0720","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1073\/pnas.75.8.3943","article-title":"Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes","volume":"75","author":"Chenoweth","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.smim.2018.02.006_bib0725","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1159\/000317194","article-title":"The harmful role of c5a on innate immunity in sepsis","volume":"2","author":"Ward","year":"2010","journal-title":"J. Innate Immun."},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0730","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/eji.201040355","article-title":"Complement fragments C3a and C5a: the salt and pepper of the immune response","volume":"40","author":"Sacks","year":"2010","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0735","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/cr.2009.139","article-title":"Complement and its role in innate and adaptive immune responses","volume":"20","author":"Dunkelberger","year":"2010","journal-title":"Cell Res."},{"key":"10.1016\/j.smim.2018.02.006_bib0740","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.smim.2018.02.006_bib0745","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1182\/blood-2008-05-078154","article-title":"CD4 T cells: fates, functions, and faults","volume":"112","author":"Zhu","year":"2008","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0750","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1182\/blood-2003-05-1612","article-title":"Marked elevation of the chemokine CCL18\/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention","volume":"103","author":"Boot","year":"2004","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0755","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1165\/rcmb.2003-0078OC","article-title":"Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts","volume":"29","author":"Atamas","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.smim.2018.02.006_bib0760","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","article-title":"Follicular helper CD4T cells (TFH)","volume":"29","author":"Crotty","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.smim.2018.02.006_bib0765","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1146\/annurev.immunol.26.021607.090344","article-title":"T follicular helper (TFH) cells in normal and dysregulated immune responses","volume":"26","author":"King","year":"2008","journal-title":"Annu. Rev. Immunol."},{"issue":"5943","key":"10.1016\/j.smim.2018.02.006_bib0770","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1175870","article-title":"Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation","volume":"325","author":"Johnston","year":"2009","journal-title":"Science"},{"issue":"5943","key":"10.1016\/j.smim.2018.02.006_bib0775","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.1176676","article-title":"Bcl6 mediates the development of T follicular helper cells","volume":"325","author":"Nurieva","year":"2009","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0780","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.immuni.2009.07.002","article-title":"The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment","volume":"31","author":"Yu","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2018.02.006_bib0785","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3389\/fimmu.2017.01510","article-title":"T follicular helper cells as a new target for immunosuppressive therapies","volume":"8","author":"Yan","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2018.02.006_bib0790","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-immunol-041015-055605","article-title":"Follicular helper T cells","volume":"34","author":"Vinuesa","year":"2016","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.smim.2018.02.006_bib0795","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-immunol-032414-112008","article-title":"The immunology of CD1- and MR1-restricted T cells","volume":"34","author":"Mori","year":"2016","journal-title":"Annu. Rev. Immunol."},{"issue":"21","key":"10.1016\/j.smim.2018.02.006_bib0800","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1056\/NEJM199105233242104","article-title":"Replacement therapy for inherited enzyme deficiency\u2013macrophage-targeted glucocerebrosidase for Gaucher's disease","volume":"324","author":"Barton","year":"1991","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0805","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ymgme.2014.08.011","article-title":"CNS lung, and lymph node involvement in Gaucher disease type 3 after 11 years of therapy: clinical, histopathologic, and biochemical findings","volume":"114","author":"Burrow","year":"2015","journal-title":"Mol. Genet. Metab."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0810","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/BC.2008.009","article-title":"A counterintuitive approach to treat enzyme deficiencies: use of enzyme inhibitors for restoring mutant enzyme activity","volume":"389","author":"Fan","year":"2008","journal-title":"Biol. Chem."},{"issue":"11","key":"10.1016\/j.smim.2018.02.006_bib0815","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/ajh.24877","article-title":"Outcomes after 18 months of eliglustat therapy in treatment-naive adults with Gaucher disease type 1: the phase 3 ENGAGE trial","volume":"92","author":"Mistry","year":"2017","journal-title":"Am. J. Hematol."},{"issue":"11","key":"10.1016\/j.smim.2018.02.006_bib0820","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1136\/jmedgenet-2017-104826","article-title":"Reduction of podocyte globotriaosylceramide content in adult male patients with Fabry disease with amenable GLA mutations following 6 months of migalastat treatment","volume":"54","author":"Mauer","year":"2017","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.smim.2018.02.006_bib0825","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bcmd.2017.01.006","article-title":"A pooled analysis of adverse events in 393 adults with Gaucher disease type 1 from four clinical trials of oral eliglustat: evaluation of frequency, timing, and duration","volume":"68","author":"Judith Peterschmitt","year":"2018","journal-title":"Blood Cells. Mol. Dis."},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0830","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/jmedgenet-2016-104178","article-title":"Oral pharmacological chaperone migalastat compared with enzyme replacement therapy in Fabry disease: 18-month results from the randomised phase III ATTRACT study","volume":"54","author":"Hughes","year":"2017","journal-title":"J. Med. Genet."},{"issue":"17","key":"10.1016\/j.smim.2018.02.006_bib0835","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-12-758409","article-title":"Eliglustat maintains long-term clinical stability in patients with Gaucher disease type 1 stabilized on enzyme therapy","volume":"129","author":"Cox","year":"2017","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0840","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/jcp.1041410316","article-title":"Effects of D-threo-PDMP an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells","volume":"141","author":"Inokuchi","year":"1989","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0845","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/bj2540297","article-title":"The inhibition of glucosylceramide beta-glucosidase and other acid hydrolases by nucleic acids","volume":"254","author":"Sano","year":"1988","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.smim.2018.02.006_bib0850","doi-asserted-by":"crossref","first-page":"e10750","DOI":"10.1371\/journal.pone.0010750","article-title":"Comparative therapeutic effects of velaglucerase alfa and imiglucerase in a Gaucher disease mouse model","volume":"5","author":"Xu","year":"2010","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0855","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ymgme.2007.04.001","article-title":"A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease","volume":"91","author":"McEachern","year":"2007","journal-title":"Mol. Genet. Metab."},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0860","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.therap.2016.09.019","article-title":"Type 1 Gaucher disease (CYP2D6-eliglustat)","volume":"72","author":"Becquemont","year":"2017","journal-title":"Therapie"},{"issue":"16","key":"10.1016\/j.smim.2018.02.006_bib0865","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1093\/hmg\/dds193","article-title":"Microarray expression analysis and identification of serum biomarkers for Niemann-Pick disease type C1","volume":"21","author":"Cluzeau","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0870","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nri2231","article-title":"Complement driven by conformational changes","volume":"8","author":"Gros","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.smim.2018.02.006_bib0875","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nrd4657","article-title":"Complement, a target for therapy in inflammatory and degenerative diseases","volume":"14","author":"Morgan","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.smim.2018.02.006_bib0880","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.smim.2016.06.001","article-title":"New milestones ahead in complement-targeted therapy","volume":"28","author":"Ricklin","year":"2016","journal-title":"Semin. Immunol."},{"issue":"9","key":"10.1016\/j.smim.2018.02.006_bib0885","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1681\/ASN.2016111179","article-title":"Randomized trial of C5a receptor inhibitor avacopan in ANCA-associated vasculitis","volume":"28","author":"Jayne","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.smim.2018.02.006_bib0890","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1046\/j.1365-2796.1999.00607.x","article-title":"Systemic AL amyloidosis in Gaucher disease. A case report and review of the literature","volume":"246","author":"Kaloterakis","year":"1999","journal-title":"J. Intern. Med."},{"issue":"10","key":"10.1016\/j.smim.2018.02.006_bib0895","first-page":"1108","article-title":"Multiple myeloma arising from monoclonal gammopathy of undetermined significance in a patient with Gaucher's disease","volume":"121","author":"Brady","year":"1997","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"8","key":"10.1016\/j.smim.2018.02.006_bib0900","first-page":"388","article-title":"Gaucher's disease: a disease with chronic stimulation of the immune system","volume":"106","author":"Shoenfeld","year":"1982","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0905","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bcmd.2003.10.007","article-title":"Effect of enzyme replacement therapy on gammopathies in Gaucher disease","volume":"32","author":"Brautbar","year":"2004","journal-title":"Blood Cells Mol. Dis."},{"issue":"5","key":"10.1016\/j.smim.2018.02.006_bib0910","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1182\/blood.V31.5.633.633","article-title":"Immunoglobulin abnormalities in Gaucher's disease. Report of 16 cases","volume":"31","author":"Pratt","year":"1968","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.smim.2018.02.006_bib0915","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ajh.2830290403","article-title":"Polyclonal B-cell lymphocytosis and hypergammaglobulinemia in patients with Gaucher disease","volume":"29","author":"Marti","year":"1988","journal-title":"Am. J. Hematol."},{"issue":"2","key":"10.1016\/j.smim.2018.02.006_bib0920","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/pbc.24098","article-title":"Hyperimmunoglobulinemia in pediatric patients with Gaucher disease in Southern Brazil","volume":"59","author":"Arikan-Ayyildiz","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"issue":"11","key":"10.1016\/j.smim.2018.02.006_bib0925","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V104.11.2391.2391","article-title":"High prevalence of B-cell clonality in patients with Gaucher\u2019s disease","volume":"104","author":"Hughes","year":"2004","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.smim.2018.02.006_bib0930","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10545-009-1207-8","article-title":"IgM monoclonal component associated with type I Gaucher disease resolved after enzyme replacement therapy: a case report","volume":"32","author":"Martinez-Redondo","year":"2009","journal-title":"J. Inherit. Metab. Dis."}],"container-title":["Seminars in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532317301045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532317301045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:32:31Z","timestamp":1693553551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044532317301045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":186,"alternative-id":["S1044532317301045"],"URL":"https:\/\/doi.org\/10.1016\/j.smim.2018.02.006","relation":{},"ISSN":["1044-5323"],"issn-type":[{"value":"1044-5323","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An unexpected player in Gaucher disease: The multiple roles of complement in disease development","name":"articletitle","label":"Article Title"},{"value":"Seminars in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.smim.2018.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}