{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:31:20Z","timestamp":1778128280064,"version":"3.51.4"},"reference-count":185,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004012","name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Immunology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.smim.2019.101337","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:42:07Z","timestamp":1574124127000},"page":"101337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Regulation of the complement system and immunological tolerance in pregnancy"],"prefix":"10.1016","volume":"45","author":[{"given":"Laura","family":"Teiril\u00e4","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenni","family":"Heikkinen-Eloranta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Kotimaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seppo","family":"Meri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Inkeri","family":"Lokki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0005","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.preghy.2014.02.001","article-title":"The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP","volume":"4","author":"Tranquilli","year":"2014","journal-title":"Pregnancy Hypertens."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0010","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists\u2019 Task Force on Hypertension in Pregnancy","volume":"122","year":"2013","journal-title":"Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0015","doi-asserted-by":"crossref","first-page":"544.e1","DOI":"10.1016\/j.ajog.2013.08.019","article-title":"Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease","volume":"209","author":"Lisonkova","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0020","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1600-0897.2010.00831.x","article-title":"Immunology of pre-eclampsia","volume":"63","author":"Redman","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"issue":"9741","key":"10.1016\/j.smim.2019.101337_bib0025","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.smim.2019.101337_bib0030","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1471-0528.1981.tb02222.x","article-title":"Morphological changes of the spiral arteries in the placentae bed in relation to pre\u2010eclampsia and fetal growth retardation","volume":"88","author":"Gerretsen","year":"1981","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0035","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ajog.2004.08.015","article-title":"Remodeling of myometrial radial arteries in preeclampsia","volume":"192","author":"Ong","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0040","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.placenta.2009.02.009","article-title":"Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy","volume":"30","author":"Burton","year":"2009","journal-title":"Placenta."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0045","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jsgi.2004.03.003","article-title":"Placental oxidative stress: from miscarriage to preeclampsia","volume":"11","author":"Burton","year":"2004","journal-title":"J. Soc. Gynecol. Investig."},{"issue":"4 S9.e1","key":"10.1016\/j.smim.2019.101337_bib0050","first-page":"S9","article-title":"Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity","volume":"213","author":"Redman","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"10","key":"10.1016\/j.smim.2019.101337_bib0055","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2174\/1389201019666180427110547","article-title":"The critical role of abnormal trophoblast development in the etiology of preeclampsia","volume":"19","author":"Huppertz","year":"2018","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"8","key":"10.1016\/j.smim.2019.101337_bib0060","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.4049\/jimmunol.178.9.5949","article-title":"Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles","volume":"178","author":"Germain","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2019.101337_bib0065","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jri.2016.08.008","article-title":"Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsia","volume":"119","author":"Tannetta","year":"2017","journal-title":"J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0070","first-page":"28","article-title":"Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta, Taiwan","volume":"48","author":"Burton","year":"2009","journal-title":"J. Obstet. Gynecol."},{"key":"10.1016\/j.smim.2019.101337_bib0075","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fimmu.2014.00173","article-title":"Stimulation of monocytes by placental microparticles involves toll-like receptors and nuclear factor kappa-light-chain-enhancer of activated B cells","volume":"5","author":"Joerger-Messerli","year":"2014","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0080","first-page":"941","article-title":"Plasma levels of von Willebrand factor and fibronectin as markers of persisting endothelial damage in preeclampsia","volume":"84","author":"Deng","year":"1994","journal-title":"Obstet. Gynecol."},{"issue":"24","key":"10.1016\/j.smim.2019.101337_bib0085","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1161\/CIRCULATIONAHA.109.853127","article-title":"Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease","volume":"123","author":"Powe","year":"2011","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0090","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.molmed.2014.11.009","article-title":"Molecular mechanisms of maternal vascular dysfunction in preeclampsia","volume":"21","author":"Goulopoulou","year":"2015","journal-title":"Trends Mol. Med."},{"issue":"14","key":"10.1016\/j.smim.2019.101337_bib0095","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJM200104053441406","article-title":"Complement. First of two parts","volume":"344","author":"Walport","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.smim.2019.101337_bib0100","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.3389\/fimmu.2018.03046","article-title":"Pentraxins in complement activation and regulation","volume":"9","author":"Ma","year":"2018","journal-title":"Front. Immunol."},{"issue":"15","key":"10.1016\/j.smim.2019.101337_bib0105","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1002\/1873-3468.12284","article-title":"Self-nonself discrimination by the complement system","volume":"590","author":"Meri","year":"2016","journal-title":"FEBS Lett."},{"key":"10.1016\/j.smim.2019.101337_bib0110","series-title":"Complement Regulatory Proteins and Related Diseases","author":"Meri","year":"2013"},{"key":"10.1016\/j.smim.2019.101337_bib0115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fimmu.2013.00093","article-title":"Properdin and factor h: opposing players on the alternative complement pathway \u201csee-saw\u201d","volume":"4","author":"Kouser","year":"2013","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0120","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.semnephrol.2013.08.001","article-title":"Overview of complement activation and regulation","volume":"33","author":"Noris","year":"2013","journal-title":"Semin. Nephrol."},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0125","first-page":"1","article-title":"Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers","volume":"71","author":"Meri","year":"1990","journal-title":"Immunology"},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0130","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ejim.2013.05.009","article-title":"Complement activation in diseases presenting with thrombotic microangiopathy","volume":"24","author":"Meri","year":"2013","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.smim.2019.101337_bib0135","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/asheducation-2011.1.9","article-title":"Too much of a good thing at the site of tissue injury: the instructive example of the complement system predisposing to thrombotic microangiopathy","volume":"2011","author":"Liszewski","year":"2011","journal-title":"Hematology"},{"key":"10.1016\/j.smim.2019.101337_bib0140","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1182\/asheducation-2015.1.644","article-title":"Syndromes of thrombotic microangiopathy associated with pregnancy","volume":"2015","author":"George","year":"2015","journal-title":"Hematology"},{"issue":"5728","key":"10.1016\/j.smim.2019.101337_bib0145","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.smim.2019.101337_bib0150","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11906-017-0784-4","article-title":"The complement system and preeclampsia","volume":"19","author":"Regal","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0155","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.placenta.2015.02.004","article-title":"Increased expression of perforin, granzyme B, and C5b-9 in villitis of unknown etiology","volume":"36","author":"Ito","year":"2015","journal-title":"Placenta"},{"issue":"10","key":"10.1016\/j.smim.2019.101337_bib0160","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.placenta.2008.07.008","article-title":"The C5b-9 membrane attack complex of complement activation localizes to villous trophoblast injury in vivo and modulates human trophoblast function in vitro","volume":"29","author":"Rampersad","year":"2008","journal-title":"Placenta"},{"issue":"Suppl 2","key":"10.1016\/j.smim.2019.101337_bib0165","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/humrep\/14.suppl_2.59","article-title":"Invasive cytotrophoblast apoptosis in pre-eclampsia","volume":"14","author":"Genbacev","year":"1999","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0170","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.imbio.2015.04.006","article-title":"The membrane attack complex as an inflammatory trigger","volume":"221","author":"Morgan","year":"2016","journal-title":"Immunobiology."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0175","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1161\/HYPERTENSIONAHA.112.202747","article-title":"Complement activation in pregnancy: too much of a good thing?","volume":"60","author":"Gilbert","year":"2012","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0180","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00281-017-0645-x","article-title":"Complement activation, a threat to pregnancy","volume":"40","author":"Girardi","year":"2017","journal-title":"Semin. Immunopathol."},{"issue":"7\u20138","key":"10.1016\/j.smim.2019.101337_bib0185","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.molimm.2010.01.021","article-title":"Activation of the complement system in normal pregnancy and preeclampsia","volume":"47","author":"Derzsy","year":"2010","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0190","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.molimm.2015.02.030","article-title":"The complement system and adverse pregnancy outcomes","volume":"67","author":"Regal","year":"2015","journal-title":"Mol. Immunol."},{"issue":"5452","key":"10.1016\/j.smim.2019.101337_bib0195","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1126\/science.287.5452.498","article-title":"A critical role for murine complement regulator crry in fetomaternal tolerance","volume":"287","author":"Xu","year":"2000","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0200","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0165-0378(03)00052-4","article-title":"Seminal \u201cpriming\u201d for protection from pre-eclampsia-a unifying hypothesis","volume":"59","author":"Robertson","year":"2003","journal-title":"J. Reprod. Immunol."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0205","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/eji.201243196","article-title":"Analysis of genes coding for CD46, CD55, and C4b-binding protein in patients with idiopathic, recurrent, spontaneous pregnancy loss","volume":"43","author":"Mohlin","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.smim.2019.101337_bib0210","article-title":"Analysis of complement C3 gene reveals susceptibility to severe preeclampsia","volume":"8","author":"Inkeri Lokki","year":"2017","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0215","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/HYPERTENSIONAHA.107.102905","article-title":"Trophoblasts reduce the vascular smooth muscle cell proatherogenic response","volume":"51","author":"Hering","year":"2008","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0220","doi-asserted-by":"crossref","first-page":"e1001013","DOI":"10.1371\/journal.pmed.1001013","article-title":"Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort","volume":"8","author":"Salmon","year":"2011","journal-title":"PLoS Med."},{"key":"10.1016\/j.smim.2019.101337_bib0225","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00312","article-title":"Complement activation and regulation in preeclamptic placenta","volume":"5","author":"Lokki","year":"2014","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.smim.2019.101337_bib0230","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.4049\/jimmunol.1500455","article-title":"The complement inhibitor factor H generates an anti-inflammatory and tolerogenic state in monocyte-derived dendritic cells","volume":"196","author":"Olivar","year":"2016","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0235","first-page":"351","article-title":"Managing the female patient with hereditary angioedema","volume":"12","author":"Banerji","year":"2016","journal-title":"Womens Health"},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0240","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1055\/s-0038-1647471","article-title":"C1-esterase inhibitor in uncomplicated pregnancy and mild and moderate preeclampsia","volume":"65","author":"Halbmayer","year":"1991","journal-title":"Thromb. Haemost."},{"issue":"4","key":"10.1016\/j.smim.2019.101337_bib0245","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/10641955.2016.1190845","article-title":"Correlations between complement system\u2019s activation factors and anti-angiogenesis factors in plasma of patients with early\/late-onset severe preeclampsia","volume":"35","author":"He","year":"2016","journal-title":"Hypertens. Pregnancy"},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/AOG.0000000000002980","article-title":"Terminal complement activation in preeclampsia","volume":"132","author":"Burwick","year":"2018","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0255","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/HYPERTENSIONAHA.115.05484","article-title":"Classical complement pathway activation in the kidneys of women with preeclampsia","volume":"66","author":"Penning","year":"2015","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.smim.2019.101337_bib0260","doi-asserted-by":"crossref","first-page":"385.e1","DOI":"10.1016\/j.ajog.2007.10.793","article-title":"Alternative complement pathway activation fragment Bb in early pregnancy as a predictor of preeclampsia","volume":"198","author":"Lynch","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0265","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/aji.12162","article-title":"Maternal and fetal alternative complement pathway activation in early severe preeclampsia","volume":"71","author":"Hoffman","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0270","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1161\/HYPERTENSIONAHA.112.194324","article-title":"Preeclampsia is characterized by placental complement dysregulation","volume":"60","author":"Buurma","year":"2012","journal-title":"Hypertension."},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0275","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.1016\/S0272-6386(01)90003-4","article-title":"C4d and C4bp deposition along the glomerular capillary walls in a patient with preeclampsia","volume":"37","author":"Joyama","year":"2001","journal-title":"Am. J. Kidney Dis."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0280","doi-asserted-by":"crossref","first-page":"e0199305","DOI":"10.1371\/journal.pone.0199305","article-title":"Clinical features of patients with homozygous complement C4A or C4B deficiency","volume":"13","author":"Liesmaa","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0285","first-page":"175","article-title":"Immunological studies of human placentae: complement components in pre-eclamptic chorionic villi","volume":"56","author":"Sinha","year":"1984","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0290","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jri.2009.06.124","article-title":"Complement production by trophoblast cells at the feto-maternal interface","volume":"82","author":"Bulla","year":"2009","journal-title":"J. Reprod. Immunol."},{"issue":"7","key":"10.1016\/j.smim.2019.101337_bib0295","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.4049\/jimmunol.0903215","article-title":"An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development","volume":"185","author":"Agostinis","year":"2010","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0300","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.placenta.2012.11.014","article-title":"Eculizumab for the treatment of preeclampsia\/HELLP syndrome","volume":"34","author":"Burwick","year":"2013","journal-title":"Placenta."},{"issue":"23","key":"10.1016\/j.smim.2019.101337_bib0305","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1182\/blood-2014-07-589366","article-title":"Eculizumab fails to inhibit generation of C5a in vivo","volume":"124","author":"Burwick","year":"2014","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0310","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1084\/jem.192.2.259","article-title":"Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy","volume":"192","author":"Ashkar","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.smim.2019.101337_bib0315","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fimmu.2012.00055","article-title":"The complement system at the embryo implantation site: friend or foe?","volume":"3","author":"Bulla","year":"2012","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.smim.2019.101337_bib0320","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/14767050500072722","article-title":"Normal pregnancy is characterized by systemic activation of the complement system","volume":"17","author":"Richani","year":"2005","journal-title":"J. Matern. Fetal. Neonatal. Med."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0325","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s004180050311","article-title":"Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta","volume":"110","author":"Huppertz","year":"1998","journal-title":"Histochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0330","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.placenta.2004.04.004","article-title":"A comparative study of the effect of three different syncytiotrophoblast micro-particles preparations on endothelial cells","volume":"26","author":"Rusterholz","year":"2005","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0335","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.molimm.2007.09.008","article-title":"Role of complement and complement regulators in the removal of apoptotic cells","volume":"45","author":"Trouw","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.smim.2019.101337_bib0340","first-page":"93","article-title":"The biology of immune complexes and their possible role in pregnancy","volume":"70","author":"Theofilopoulos","year":"1981","journal-title":"Prog. Clin. Biol. Res."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0345","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1042\/CS20030073","article-title":"Association of maternal and\/or fetal factor V Leiden and G20210A prothrombin mutation with HELLP syndrome and intrauterine growth restriction","volume":"105","author":"Schlembach","year":"2003","journal-title":"Clin. Sci."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0350","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1042\/CS20030181","article-title":"Aetiology of pre-eclampsia and thrombophilic genetic mutations","volume":"105","author":"Hayashi","year":"2003","journal-title":"Clin. Sci."},{"issue":"11","key":"10.1016\/j.smim.2019.101337_bib0355","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.imbio.2016.06.002","article-title":"Role of collectins and complement protein C1q in pregnancy and parturition","volume":"221","author":"Madhukaran","year":"2016","journal-title":"Immunobiology"},{"issue":"Suppl 1","key":"10.1016\/j.smim.2019.101337_bib0360","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/S0049-3848(17)30067-1","article-title":"Impact of haemostatic mechanisms on pathophysiology of preeclampsia","volume":"151","author":"Gardiner","year":"2017","journal-title":"Thromb. Res."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0365","doi-asserted-by":"crossref","DOI":"10.1016\/S1286-4579(00)00299-9","article-title":"CR3: a general purpose adhesion-recognition receptor essential for innate immunity","volume":"2","author":"Ehlers","year":"2000","journal-title":"Microbes Infect."},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0370","doi-asserted-by":"crossref","first-page":"e00644","DOI":"10.1128\/IAI.00644-16","article-title":"Distinct effects of integrins \u03b1X\u03b22 and \u03b1M\u03b22 on leukocyte subpopulations during inflammation and antimicrobial responses","volume":"85","author":"Jawhara","year":"2017","journal-title":"Infect. Immun."},{"issue":"12","key":"10.1016\/j.smim.2019.101337_bib0375","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1182\/blood.V95.12.3868.012k43_3868_3877","article-title":"Engagement of CD11b and CD11c beta2 integrin by antibodies or soluble CD23 induces IL-1beta production on primary human monocytes through mitogen-activated protein kinase-dependent pathways","volume":"95","author":"Rezzonico","year":"2000","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.smim.2019.101337_bib0380","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1182\/blood.V97.10.2932","article-title":"Ligation of CD11b and CD11c \u03b22 integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1\u03b1 (MIP-1\u03b1) and MIP-1\u03b2 production in primary human monocytes through a pathway dependent on nuclear factor-\u03baB","volume":"97","author":"Rezzonico","year":"2001","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0385","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1074-7613(00)80278-2","article-title":"A novel role for the beta 2 integrin CD11b\/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation","volume":"5","author":"Coxon","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2019.101337_bib0390","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3389\/fimmu.2019.00254","article-title":"Beta2-Integrins and interacting proteins in leukocyte trafficking, immune suppression, and immunodeficiency disease","volume":"10","author":"Fagerholm","year":"2019","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0395","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1182\/blood-2002-06-1769","article-title":"Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production","volume":"101","author":"Morelli","year":"2003","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0400","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/eji.200838951","article-title":"iC3b-opsonized apoptotic cells mediate a distinct anti-inflammatory response and transcriptional NF-\u03baB-dependent blockade","volume":"40","author":"Amarilyo","year":"2010","journal-title":"Eur. J. Immunol."},{"issue":"4","key":"10.1016\/j.smim.2019.101337_bib0405","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.immuni.2010.03.014","article-title":"Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins","volume":"32","author":"Wang","year":"2010","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.smim.2019.101337_bib0410","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/ni.1908","article-title":"Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b","volume":"11","author":"Han","year":"2010","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0415","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/eji.201242550","article-title":"\u03b2(2) integrins inhibit TLR responses by regulating NF-\u03baB pathway and p38 MAPK activation","volume":"43","author":"Yee","year":"2013","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0420","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1182\/blood-2005-12-4812","article-title":"The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function","volume":"108","author":"Skoberne","year":"2006","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0425","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1182\/blood-2007-10-117184","article-title":"The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity","volume":"111","author":"Behrens","year":"2007","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0430","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1182\/blood-2005-12-023044","article-title":"Active MAC-1 (CD11b\/CD18) on DCs inhibits full T-cell activation","volume":"109","author":"Varga","year":"2007","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0435","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.4049\/jimmunol.0802167","article-title":"Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1\/ICAM-1-dependent mechanism","volume":"183","author":"Podgrabinska","year":"2009","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.smim.2019.101337_bib0440","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1172\/JCI20741","article-title":"Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2\/Mac-1 is critical for host inflammatory response in vivo","volume":"113","author":"Flick","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0445","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/ni796","article-title":"In vivo developmental stages in murine natural killer cell maturation","volume":"3","author":"Kim","year":"2002","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.smim.2019.101337_bib0450","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1084\/jem.20052507","article-title":"Evidence for discrete stages of human natural killer cell differentiation in vivo","volume":"203","author":"Freud","year":"2006","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.smim.2019.101337_bib0455","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.imbio.2014.03.018","article-title":"Expression and regulation of complement receptors by human natural killer cells","volume":"219","author":"Min","year":"2014","journal-title":"Immunobiology"},{"key":"10.1016\/j.smim.2019.101337_bib0460","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.3389\/fimmu.2017.01602","article-title":"Complement receptor 3 has negative impact on tumor surveillance through suppression of natural killer cell function","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.smim.2019.101337_bib0465","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/imm.12224","article-title":"Subsets of human natural killer cells and their regulatory effects","volume":"141","author":"Fu","year":"2014","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0470","doi-asserted-by":"crossref","first-page":"E231","DOI":"10.1073\/pnas.1206322110","article-title":"Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface","volume":"110","author":"Fu","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2019.101337_bib0475","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.semcdb.2017.11.025","article-title":"Non-identical twins: different faces of CR3 and CR4 in myeloid and lymphoid cells of mice and men","volume":"85","author":"Erdei","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.smim.2019.101337_bib0480","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02630","article-title":"The immunogenetic conundrum of preeclampsia","volume":"9","author":"Lokki","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2019.101337_bib0485","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00545","article-title":"Upregulation of early and downregulation of terminal pathway complement genes in subcutaneous adipose tissue and adipocytes in acquired obesity","volume":"8","author":"Kaye","year":"2017","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0490","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.placenta.2007.12.010","article-title":"Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta","volume":"29","author":"Challier","year":"2008","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0495","first-page":"105","article-title":"Decidual macrophages and their roles at the maternal-fetal interface","volume":"85","author":"Houser","year":"2012","journal-title":"Yale J. Biol. Med."},{"issue":"12","key":"10.1016\/j.smim.2019.101337_bib0500","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New insights into the immunopathogenesis of systemic lupus erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"14","key":"10.1016\/j.smim.2019.101337_bib0505","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2147\/TCRM.S160760","article-title":"Management and outcomes of pregnancy with or without lupus nephritis: a systematic review and meta-analysis","volume":"11","author":"Wu","year":"2018","journal-title":"Ther. Clin. Risk Manag."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0510","doi-asserted-by":"crossref","first-page":"164","DOI":"10.7326\/M19-0120","article-title":"Trends in maternal and fetal outcomes among pregnant women with systemic lupus erythematosus in the United States","volume":"171","author":"Mehta","year":"2019","journal-title":"Ann. Intern. Med."},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0515","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ng.81","article-title":"Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci","volume":"40","author":"J.B. International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN)","year":"2008","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0520","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/ng.71","article-title":"A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus","volume":"40","author":"Nath","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.smim.2019.101337_bib0525","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1038\/ncomms3813","article-title":"Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance","volume":"4","author":"Ding","year":"2013","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.smim.2019.101337_bib0530","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1136\/annrheumdis-2012-201390","article-title":"The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes","volume":"71","author":"Rhodes","year":"2012","journal-title":"Ann. Rheum. Dis."},{"issue":"10","key":"10.1016\/j.smim.2019.101337_bib0535","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.celrep.2015.02.037","article-title":"A lupus-associated Mac-1 variant has defects in integrin allostery and interaction with ligands under force","volume":"10","author":"Rosetti","year":"2015","journal-title":"Cell Rep."},{"issue":"19","key":"10.1016\/j.smim.2019.101337_bib0540","doi-asserted-by":"crossref","first-page":"17303","DOI":"10.1074\/jbc.M110.182998","article-title":"A systemic lupus erythematosus-associated R77H substitution in the CD11b chain of the Mac-1 integrin compromises leukocyte adhesion and phagocytosis","volume":"286","author":"MacPherson","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.smim.2019.101337_bib0545","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1172\/JCI88442","article-title":"CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus","volume":"127","author":"Faridi","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.smim.2019.101337_bib0550","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1002\/art.38117","article-title":"Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils","volume":"65","author":"Zhou","year":"2013","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.smim.2019.101337_bib0555","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.autrev.2004.10.007","article-title":"Impaired clearance of dying cells in systemic lupus erythematosus","volume":"4","author":"Gaipl","year":"2005","journal-title":"Autoimmun. Rev."},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0560","doi-asserted-by":"crossref","first-page":"540","DOI":"10.4049\/jimmunol.1400931","article-title":"IL-17 promotes murine lupus","volume":"193","author":"Amarilyo","year":"2014","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0565","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/ng.71","article-title":"A nonsynonymous functional variant in integrin-\u03b1M (encoded by ITGAM) is associated with systemic lupus erythematosus","volume":"40","author":"Nath","year":"2008","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0570","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fmed.2018.00052","article-title":"CD11b activity modulates pathogenesis of lupus nephritis","volume":"15","author":"Khan","year":"2018","journal-title":"Front. Med."},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0575","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jri.2012.01.006","article-title":"The predominance of Th17 lymphocytes and decreased number and function of Treg cells in preeclampsia","volume":"93","author":"Darmochwal-Kolarz","year":"2012","journal-title":"J. Reprod. Immunol."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0580","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.autrev.2013.12.004","article-title":"Th17 and regulatory T cell balance in autoimmune and inflammatory diseases","volume":"13","author":"Noack","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.smim.2019.101337_bib0585","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jaut.2018.05.005","article-title":"Modulation of human Th17 cell responses through complement receptor 3 (CD11 b\/CD18) ligation on monocyte-derived dendritic cells","volume":"92","author":"Nowatzky","year":"2018","journal-title":"J. Autoimmun."},{"issue":"7","key":"10.1016\/j.smim.2019.101337_bib0590","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1084\/jem.20062292","article-title":"CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation","volume":"204","author":"Ehirchiou","year":"2007","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.smim.2019.101337_bib0595","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/eji.201646565","article-title":"CD11b regulates the Treg\/Th17 balance in murine arthritis via IL-6","volume":"47","author":"Stevanin","year":"2017","journal-title":"Eur. J. Immunol."},{"issue":"8","key":"10.1016\/j.smim.2019.101337_bib0600","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/rheumatology\/keu150","article-title":"Increased risk of rheumatoid arthritis in women with pregnancy complications and poor self-rated health: a study within the Danish National Birth Cohort","volume":"53","author":"Jorgensen","year":"2014","journal-title":"Rheumatology"},{"key":"10.1016\/j.smim.2019.101337_bib0605","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3389\/fimmu.2019.00659","article-title":"Feto-maternal microchimerism: the pre-eclampsia conundrum","volume":"10","author":"Hahn","year":"2019","journal-title":"Front. Immunol."},{"issue":"32","key":"10.1016\/j.smim.2019.101337_bib0610","doi-asserted-by":"crossref","first-page":"13451","DOI":"10.1073\/pnas.0901984106","article-title":"Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells","volume":"106","author":"Rakhmanov","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0615","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.clim.2004.05.010","article-title":"A new CD21low B cell population in the peripheral blood of patients with SLE","volume":"113","author":"Wehr","year":"2004","journal-title":"Clin. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.smim.2019.101337_bib0620","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.molimm.2012.07.002","article-title":"Human complement receptor 2 (CR2\/CD21) as a receptor for DNA: implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE)","volume":"53","author":"Asokan","year":"2013","journal-title":"Mol. Immunol."},{"issue":"1\u20133","key":"10.1016\/j.smim.2019.101337_bib0625","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.molimm.2006.07.003","article-title":"Complement receptor 2, natural antibodies and innate immunity: inter-relationships in B cell selection and activation","volume":"44","author":"Holers","year":"2007","journal-title":"Mol. Immunol."},{"issue":"24","key":"10.1016\/j.smim.2019.101337_bib0630","doi-asserted-by":"crossref","first-page":"10054","DOI":"10.1073\/pnas.86.24.10054","article-title":"Epstein-Barr virus\/complement fragment C3d receptor (CR2) reacts with p53, a cellular antioncogene-encoded membrane phosphoprotein: detection by polyclonal anti-idiotypic anti-CR2 antibodies","volume":"86","author":"Barel","year":"1989","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2019.101337_bib0635","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-immunol-032713-120154","article-title":"Complement and its receptors: new insights into human disease","volume":"32","author":"Holers","year":"2014","journal-title":"Annu. Rev. Immunol."},{"issue":"2 Pt B","key":"10.1016\/j.smim.2019.101337_bib0640","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.molimm.2015.07.016","article-title":"Role of complement receptor 1 (CR1; CD35) on epithelial cells: a model for understanding complement-mediated damage in the kidney","volume":"67","author":"Java","year":"2015","journal-title":"Mol. Immunol."},{"issue":"7","key":"10.1016\/j.smim.2019.101337_bib0645","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.4049\/jimmunol.1202451","article-title":"Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway","volume":"190","author":"Jacquet","year":"2013","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0650","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S1074-7613(00)80356-8","article-title":"Complement receptor type 1 (CR1, CD35) is a receptor for C1q","volume":"7","author":"Klickstein","year":"1997","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.smim.2019.101337_bib0655","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.192.12.1797","article-title":"Complement receptor 1\/CD35 is a receptor for mannan-binding lectin","volume":"192","author":"Ghiran","year":"2000","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0660","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1084\/jem.153.5.1138","article-title":"Complement receptor is an inhibitor of the complement cascade","volume":"153","author":"Iida","year":"1981","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0665","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1084\/jem.159.6.1669","article-title":"Control of the function of substrate-bound C4b-C3b by the complement receptor Cr1","volume":"159","author":"Medof","year":"1984","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0670","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.4049\/jimmunol.129.5.2051","article-title":"Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity","volume":"129","author":"Ross","year":"1982","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2019.101337_bib0675","doi-asserted-by":"crossref","DOI":"10.1034\/j.1600-065X.2001.1800110.x","article-title":"Structure-function relationships of complement receptor type 1","volume":"180","author":"Krych-Goldberg","year":"2001","journal-title":"Immunol. Rev."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0680","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.molimm.2008.09.026","article-title":"Complement Receptor 1: disease associations and therapeutic implications","volume":"46","author":"Khera","year":"2009","journal-title":"Mol. Immunol."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0685","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1600-0897.2005.00318.x","article-title":"Low erythrocyte complement receptor type 1 (CR1, CD35) expression in preeclamptic gestations","volume":"54","author":"Feinberg","year":"2005","journal-title":"Am. J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0690","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1073\/pnas.0305306101","article-title":"A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria","volume":"101","author":"Cockburn","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.smim.2019.101337_bib0695","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1089\/jwh.2014.4749","article-title":"Differences in preeclampsia rates between African American and Caucasian women: trends from the National Hospital Discharge Survey","volume":"23","author":"Breathett","year":"2014","journal-title":"J. Womens. Health (Larchmt)"},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0700","doi-asserted-by":"crossref","first-page":"e91198","DOI":"10.1371\/journal.pone.0091198","article-title":"Risk factors of pre-eclampsia\/eclampsia and its adverse outcomes in low- and middle-income countries: a WHO secondary analysis","volume":"9","author":"Bilano","year":"2014","journal-title":"PLoS One"},{"issue":"38","key":"10.1016\/j.smim.2019.101337_bib0705","doi-asserted-by":"crossref","first-page":"14488","DOI":"10.1073\/pnas.0803657105","article-title":"Natural selection of FLT1 alleles and their association with malaria resistance in utero","volume":"105","author":"Muehlenbachs","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0710","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/trstmh\/trv019","article-title":"Risk factors for malaria and adverse birth outcomes in a prospective cohort of pregnant women resident in a high malaria transmission area of Papua New Guinea","volume":"109","author":"Stanisic","year":"2015","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"8","key":"10.1016\/j.smim.2019.101337_bib0715","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/nm731","article-title":"Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1","volume":"8","author":"Luttun","year":"2002","journal-title":"Nat. Med."},{"issue":"11","key":"10.1016\/j.smim.2019.101337_bib0720","doi-asserted-by":"crossref","first-page":"e446","DOI":"10.1371\/journal.pmed.0030446","article-title":"Hypertension and maternal-fetal conflict during placental malaria","volume":"3","author":"Muehlenbachs","year":"2006","journal-title":"PLoS Med."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0725","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.smim.2019.101337_bib0730","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a023473","article-title":"Molecular mechanisms of preeclampsia","volume":"5","author":"Hod","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"10","key":"10.1016\/j.smim.2019.101337_bib0735","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.tig.2013.03.001","article-title":"Many ways to die, one way to arrive: how selection acts through pregnancy","volume":"29","author":"Brown","year":"2013","journal-title":"Trends Genet."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0740","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1084\/jem.20060375","article-title":"Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality","volume":"203","author":"Yano","year":"2006","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.smim.2019.101337_bib0745","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1084\/jem.20061022","article-title":"Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction","volume":"203","author":"Girardi","year":"2006","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0750","doi-asserted-by":"crossref","first-page":"e13033","DOI":"10.1111\/aji.13033","article-title":"Upregulation and release of soluble fms-like tyrosine kinase receptor 1 mediated by complement activation in human syncytiotrophoblast cells","volume":"80","author":"Banadakoppa","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0755","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/10641955.2019.1640725","article-title":"Placental sFLT1 is associated with complement activation and syncytiotrophoblast damage in preeclampsia","volume":"38","author":"Yonekura Collier","year":"2019","journal-title":"Hypertens Pregnancy"},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0760","doi-asserted-by":"crossref","first-page":"e0191040","DOI":"10.1371\/journal.pone.0191040","article-title":"VEGF may contribute to macrophage recruitment and M2 polarization in the decidua","volume":"13","author":"Wheeler","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0765","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/HYPERTENSIONAHA.117.09406","article-title":"Protective low-frequency variants for preeclampsia in the Fms related tyrosine kinase 1 gene in the Finnish population","volume":"70","author":"Inkeri Lokki","year":"2017","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.smim.2019.101337_bib0770","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/ng.3895","article-title":"Variants in the fetal genome near FLT1 are associated with risk of preeclampsia","volume":"49","author":"McGinnis","year":"2017","journal-title":"Nat. Genet."},{"issue":"9076","key":"10.1016\/j.smim.2019.101337_bib0775","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","article-title":"Presence of fetal DNA in maternal plasma and serum","volume":"350","author":"Lo","year":"1997","journal-title":"Lancet"},{"issue":"Suppl","key":"10.1016\/j.smim.2019.101337_bib0780","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/j.placenta.2013.10.014","article-title":"Review: where is the maternofetal interface?","volume":"35","author":"Chamley","year":"2014","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0785","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1081\/PRG-120002911","article-title":"The levels of circulatory fetal dna in maternal plasma are elevated prior to the onset of preeclampsia","volume":"21","author":"Zhong","year":"2002","journal-title":"Hypertens. Pregnancy"},{"issue":"11","key":"10.1016\/j.smim.2019.101337_bib0790","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.4049\/jimmunol.1103454","article-title":"TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia","volume":"188","author":"Scharfe-Nugent","year":"2012","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.smim.2019.101337_bib0795","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1084\/jem.20050189","article-title":"C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation","volume":"201","author":"Trouw","year":"2005","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0800","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1523\/JNEUROSCI.3732-10.2011","article-title":"HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration","volume":"31","author":"Gao","year":"2011","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.smim.2019.101337_bib0805","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nm0497-414","article-title":"Mac-1 (CD11b\/CD18) is an oligodeoxynucleotide-binding protein","volume":"3","author":"Benimetskaya","year":"1997","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0810","doi-asserted-by":"crossref","first-page":"e0178442","DOI":"10.1371\/journal.pone.0178442","article-title":"Increase in complement iC3b is associated with anti-inflammatory cytokine expression during late pregnancy in mice","volume":"12","author":"Nakamura","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.smim.2019.101337_bib0815","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin -10 and the interleukin -10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.smim.2019.101337_bib0820","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.molmed.2007.08.005","article-title":"TGFbeta1 and Treg cells: alliance for tolerance","volume":"13","author":"Bommireddy","year":"2007","journal-title":"Trends Mol. Med."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0825","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1046\/j.1365-2249.1996.57761.x","volume":"104","author":"Thornton","year":"1996","journal-title":"Clin. Exp. Immunol."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0830","first-page":"532","article-title":"Distribution of protectin (CD59), a complement membrane attack inhibitor, in normal human tissues","volume":"65","author":"Meri","year":"1991","journal-title":"Lab. Invest."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0835","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1515\/jpm-2015-0062","article-title":"Association between decreased plasma levels of soluble human leukocyte antigen-G and severe pre-eclampsia","volume":"44","author":"He","year":"2016","journal-title":"J. Perinat. Med."},{"issue":"8","key":"10.1016\/j.smim.2019.101337_bib0840","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1084\/jem.20041214","article-title":"Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success","volume":"200","author":"Hiby","year":"2004","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.smim.2019.101337_bib0845","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1172\/JCI43998","article-title":"Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2","volume":"120","author":"Hiby","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0850","first-page":"133","article-title":"Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution","volume":"13","author":"Parham","year":"2013","journal-title":"Nat. Rev."},{"issue":"1\u20132","key":"10.1016\/j.smim.2019.101337_bib0855","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jri.2007.08.002","article-title":"Inadequate tolerance induction may induce pre-eclampsia","volume":"76","author":"Saito","year":"2007","journal-title":"J. Reprod. Immunol."},{"issue":"11","key":"10.1016\/j.smim.2019.101337_bib0860","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.4049\/jimmunol.1601279","article-title":"Activating KIR2DS4 is expressed by uterine nk cells and contributes to successful pregnancy","volume":"197","author":"Kennedy","year":"2016","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.smim.2019.101337_bib0865","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.4049\/jimmunol.1501229","article-title":"Tissue-specific education of decidual NK cells","volume":"195","author":"Sharkey","year":"2015","journal-title":"J. Immunol."},{"issue":"7731","key":"10.1016\/j.smim.2019.101337_bib0870","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature."},{"key":"10.1016\/j.smim.2019.101337_bib0875","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3389\/fimmu.2019.00573","article-title":"New paradigm in the role of regulatory T cells during pregnancy","volume":"10","author":"Tsuda","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2019.101337_bib0880","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00792","article-title":"Macrophage polarization in physiological and pathological pregnancy","volume":"10","author":"Yao","year":"2019","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2019.101337_bib0885","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jfma.2017.03.011","article-title":"M1 macrophages decrease in the deciduae from normal pregnancies but not from spontaneous abortions or unexplained recurrent spontaneous abortions","volume":"117","author":"Tsao","year":"2018","journal-title":"J. Formos. Med. Assoc."},{"issue":"4","key":"10.1016\/j.smim.2019.101337_bib0890","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.4049\/jimmunol.1003153","article-title":"Two unique human decidual macrophage populations","volume":"186","author":"Houser","year":"2011","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.smim.2019.101337_bib0895","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/aji.12586","article-title":"Complement component C1q as potential diagnostic but not predictive marker of preeclampsia","volume":"76","author":"Agostinis","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0900","first-page":"412","article-title":"Tumor necrosis factor-alpha, interleukin-6, and interleukin-10 levels are altered in preeclampsia: a systematic review and meta-analysis","volume":"70","author":"Lau","year":"2013","journal-title":"Am. J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2019.101337_bib0905","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1365-2249.1996.d01-809.x","article-title":"Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy","volume":"106","author":"Marzi","year":"1996","journal-title":"Clin. Exp. Immunol."},{"issue":"5","key":"10.1016\/j.smim.2019.101337_bib0910","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/aji.12481","article-title":"Effect of indoleamine 2,3-dioxygenase expressed in HTR-8\/SVneo cells on decidual NK cell cytotoxicity","volume":"75","author":"Ban","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.smim.2019.101337_bib0915","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2051-1426-2-21","article-title":"The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma","volume":"2","author":"Li","year":"2014","journal-title":"J. Immunother. Cancer"},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0920","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.placenta.2012.11.016","article-title":"Role of corin and atrial natriuretic peptide in preeclampsia","volume":"34","author":"Zhou","year":"2013","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.smim.2019.101337_bib0925","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jri.2011.01.002","article-title":"Trophoblast deportation: just a waste disposal system or antigen sharing?","volume":"88","author":"Chamley","year":"2011","journal-title":"J. Reprod. Immunol."}],"container-title":["Seminars in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532319300375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532319300375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T23:16:21Z","timestamp":1760915781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044532319300375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":185,"alternative-id":["S1044532319300375"],"URL":"https:\/\/doi.org\/10.1016\/j.smim.2019.101337","relation":{},"ISSN":["1044-5323"],"issn-type":[{"value":"1044-5323","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of the complement system and immunological tolerance in pregnancy","name":"articletitle","label":"Article Title"},{"value":"Seminars in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.smim.2019.101337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101337"}}