{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:43:44Z","timestamp":1793231024297,"version":"4.5.0"},"reference-count":349,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012432","name":"Office for the Advancement of Research, John Jay College of Criminal Justice","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012432","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006084","name":"Office of AIDS Research","doi-asserted-by":"publisher","award":["AI31798"],"award-info":[{"award-number":["AI31798"]}],"id":[{"id":"10.13039\/100006084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1UM1AI26617"],"award-info":[{"award-number":["1UM1AI26617"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Immunology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.smim.2020.101412","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T13:02:05Z","timestamp":1600952525000},"page":"101412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"special_numbering":"C","title":["Immunological approaches to HIV cure"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7038-5597","authenticated-orcid":false,"given":"Adam R.","family":"Ward","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia M.","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Brad","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.smim.2020.101412_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007222","article-title":"HIV control: is getting there the same as staying there?","volume":"14","author":"Goulder","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0010","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1093\/infdis\/jiy479","article-title":"The control of HIV after antiretroviral medication pause (CHAMP) study: posttreatment controllers identified from 14 clinical studies","volume":"218","author":"Namazi","year":"2018","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib0015","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1097\/QAD.0b013e32833b61ba","article-title":"Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection","volume":"24","author":"Hocqueloux","year":"2010","journal-title":"AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003211","article-title":"Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI study","volume":"9","author":"S\u00e1ez-Ciri\u00f3n","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0025","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1001\/archinternmed.2012.2719","article-title":"Immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to HIV seroconversion","volume":"172","author":"Lodi","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0086719","article-title":"An evaluation of HIV elite controller definitions within a large seroconverter cohort collaboration","volume":"9","author":"Olson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.smim.2020.101412_bib0035","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.tips.2009.09.005","article-title":"Elucidating the elite: mechanisms of control in HIV-1 infection","volume":"30","author":"O\u2019Connell","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib0040","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1128\/JVI.00531-12","article-title":"Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses","volume":"86","author":"Ndhlovu","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0045","doi-asserted-by":"crossref","first-page":"6776","DOI":"10.1073\/pnas.0611244104","article-title":"HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype","volume":"104","author":"Saez-Cirion","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib0050","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01790-18","article-title":"Identification of NK cell subpopulations that differentiate HIV-Infected subject cohorts with diverse levels of virus control","author":"Pohlmeyer","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0055","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1038\/s41598-020-58696-y","article-title":"Permanent control of HIV-1 pathogenesis in exceptional elite controllers: a model of spontaneous cure","volume":"10","author":"Casado","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.smim.2020.101412_bib0060","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1086\/653677","article-title":"Infrequent recovery of HIV from but robust exogenous infection of activated CD4 + T cells in HIV elite controllers","volume":"51","author":"Julg","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib0065","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1182\/blood-2011-10-381996","article-title":"Comprehensive analysis of unique cases with extraordinary control over HIV replication","volume":"119","author":"Mendoza","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.smim.2020.101412_bib0070","doi-asserted-by":"crossref","first-page":"15109","DOI":"10.1073\/pnas.96.26.15109","article-title":"HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression","volume":"96","author":"Davey","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib0075","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/44755","article-title":"Re-emergence of HIV after stopping therapy","volume":"401","author":"Chun","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib0080","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1093\/jac\/dkz138","article-title":"Analytical treatment interruption in chronic HIV-1 infection: time and magnitude of viral rebound in adults with 10 years of undetectable viral load and low HIV-DNA (APACHE study)","volume":"74","author":"Castagna","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.smim.2020.101412_bib0085","doi-asserted-by":"crossref","first-page":"13193","DOI":"10.1073\/pnas.94.24.13193","article-title":"Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy","volume":"94","author":"Chun","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.smim.2020.101412_bib0090","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1126\/science.278.5341.1295","article-title":"Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy","volume":"278","author":"Finzi","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib0095","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1126\/science.278.5341.1291","article-title":"Recovery of replication-competent HIV despite prolonged suppression of plasma viremia","volume":"278","author":"Wong","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib0100","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nm880","article-title":"Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells","volume":"9","author":"Siliciano","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0105","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007096","article-title":"HIV latency","volume":"1","author":"Siliciano","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0110","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf6517","article-title":"Latency reversal and viral clearance to cure HIV-1","volume":"353","author":"Margolis","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib0115","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1172\/JCI80565","article-title":"Molecular mechanisms of HIV latency","volume":"126","author":"Cary","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib0120","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.chom.2017.12.004","article-title":"Getting the \u201ckill\u201d into \u201cshock and kill\u201d: strategies to eliminate latent HIV","volume":"23","author":"Kim","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.smim.2020.101412_bib0125","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.immuni.2018.04.030","article-title":"Targeting the latent reservoir for HIV-1","volume":"48","author":"Sengupta","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2020.101412_bib0130","doi-asserted-by":"crossref","DOI":"10.1097\/COH.0b013e328340ffbb","article-title":"The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit","author":"Karn","year":"2011","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib0135","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/sj.emboj.7600900","article-title":"NF-\u03baB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation","volume":"25","author":"Williams","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.smim.2020.101412_bib0140","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1097-2765(02)00477-X","article-title":"The phosphorylation status of nuclear NF-KB determines its association with CBP\/p300 or HDAC-1","volume":"9","author":"Zhong","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.smim.2020.101412_bib0145","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M511773200","article-title":"Transcriptional repression of human immunodeficiency virus type 1 by AP-4","author":"Imai","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.smim.2020.101412_bib0150","doi-asserted-by":"crossref","first-page":"6790","DOI":"10.1128\/JVI.74.15.6790-6799.2000","article-title":"The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1","volume":"74","author":"Coull","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0155","doi-asserted-by":"crossref","DOI":"10.1038\/sj.emboj.7601516","article-title":"Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing","author":"Marban","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.smim.2020.101412_bib0160","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01208-07","article-title":"C-myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter","author":"Jiang","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0165","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aap9927","article-title":"HIV latency in isolated patient CD4 + T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing","volume":"10","author":"Yukl","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0170","doi-asserted-by":"crossref","first-page":"9105","DOI":"10.1128\/JVI.78.17.9105-9114.2004","article-title":"Analysis of human immunodeficiency virus type 1 transcriptional elongation in resting CD4+ T cells in vivo","volume":"78","author":"Lassen","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0175","doi-asserted-by":"crossref","first-page":"8227","DOI":"10.1128\/JVI.77.15.8227-8236.2003","article-title":"Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of tat on the host and reservoir","volume":"77","author":"Lin","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jviromet.2016.12.017","article-title":"Assays for precise quantification of total (including short) and elongated HIV-1 transcripts","volume":"242","author":"Kaiser","year":"2017","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.smim.2020.101412_bib0185","doi-asserted-by":"crossref","DOI":"10.1006\/viro.1999.9647","article-title":"Limitation of Tat-associated transcriptional processivity in HIV- infected PBMC","author":"Adams","year":"1999","journal-title":"Virology"},{"key":"10.1016\/j.smim.2020.101412_bib0190","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1073\/pnas.91.9.3862","article-title":"Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts","volume":"91","author":"Adams","year":"1994","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007357","article-title":"Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency","volume":"14","author":"Telwatte","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007991","article-title":"Latency reversal agents affect differently the latent reservoir present in distinct CD4+ t subpopulations","author":"Grau-Exp\u00f3sito","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0205","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/j.celrep.2019.10.101","article-title":"Latency-reversing agents induce differential responses in distinct memory CD4 T cell subsets in individuals on antiretroviral therapy","volume":"29","author":"Pardons","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.smim.2020.101412_bib0210","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1172\/JCI136227","article-title":"The multifaceted nature of HIV latency","volume":"130","author":"Dufour","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib0215","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1073\/pnas.0800050105","article-title":"Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy","volume":"105","author":"Palmer","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib0220","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1086\/425983","article-title":"Cellular viral rebound after cessation of potent antiretroviral therapy predicted by levels of multiply spliced HIV\u20101 RNA encoding nef","volume":"190","author":"Fischer","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib0225","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.virol.2010.12.041","article-title":"HIV reservoirs and latency models","volume":"411","author":"Pace","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.smim.2020.101412_bib0230","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.chom.2020.03.014","article-title":"The biology of the HIV-1 latent reservoir and implications for cure strategies","volume":"27","author":"Cohn","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.smim.2020.101412_bib0235","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12977-018-0397-2","article-title":"What do we measure when we measure cell-associated HIV RNA","volume":"15","author":"Pasternak","year":"2018","journal-title":"Retrovirology"},{"key":"10.1016\/j.smim.2020.101412_bib0240","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.omtm.2019.07.008","article-title":"HIV-specific T cell responses are highly stable on antiretroviral therapy","volume":"15","author":"Xu","year":"2019","journal-title":"Mol. Ther. \u2013 Methods Clin. Dev."},{"key":"10.1016\/j.smim.2020.101412_bib0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006629","article-title":"T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy","volume":"13","author":"Thomas","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0250","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41467-019-08431-7","article-title":"Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion","volume":"10","author":"Pinzone","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.smim.2020.101412_bib0255","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/387183a0","article-title":"Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection","volume":"387","author":"Chun","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib0260","doi-asserted-by":"crossref","first-page":"7824","DOI":"10.1128\/JVI.74.17.7824-7833.2000","article-title":"Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1","volume":"74","author":"Pierson","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0265","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1128\/JVI.78.3.1160-1168.2004","article-title":"T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis","volume":"78","author":"Brenchley","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0270","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nm.1972","article-title":"HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation","volume":"15","author":"Chomont","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0275","series-title":"Human Retrovirus Protocols","first-page":"003","article-title":"Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individuals","author":"Siliciano","year":"2005"},{"key":"10.1016\/j.smim.2020.101412_bib0280","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.immuni.2017.09.014","article-title":"Transcriptional reprogramming during effector-to-memory transition renders CD4+ T cells permissive for latent HIV-1 infection","volume":"47","author":"Shan","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2020.101412_bib0285","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.celrep.2017.09.081","article-title":"Identification of genetically intact HIV-1 proviruses in specific CD4 + T cells from effectively treated participants","volume":"21","author":"Hiener","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.smim.2020.101412_bib0290","doi-asserted-by":"crossref","first-page":"14070","DOI":"10.1128\/JVI.01900-14","article-title":"Quantitation of replication-competent HIV-1 in populations of resting CD4+ T cells","volume":"88","author":"Soriano-Sarabia","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0295","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nm.3445","article-title":"HIV-1 persistence in CD4+ T cells with stem cell\u2013like properties","volume":"20","author":"Buzon","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0300","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1172\/JCI93289","article-title":"Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells","volume":"127","author":"Lee","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib0305","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1097\/01.aids.0000183125.93958.26","article-title":"Persistence of distinct HIV-1 populations in blood monocytes and naive and memory CD4 T cells during prolonged suppressive HAART","volume":"19","author":"Delobel","year":"2005","journal-title":"AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib0310","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1093\/cid\/ciz108","article-title":"Naive CD4+ T cells harbor a large inducible reservoir of latent, replication-competent human immunodeficiency virus type 1","volume":"69","author":"Zerbato","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib0315","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1093\/cid\/ciz378","article-title":"Genetic evidence that naive T cells can contribute significantly to the human immunodeficiency virus intact reservoir: time to Re-evaluate their role","volume":"69","author":"Venanzi Rullo","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib0320","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax6795","article-title":"Different human resting memory CD4 + T cell subsets show similar low inducibility of latent HIV-1 proviruses","volume":"12","author":"Kwon","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0325","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41564-018-0335-z","article-title":"HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy","volume":"4","author":"Ganor","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.smim.2020.101412_bib0330","article-title":"The HIV reservoir in monocytes and macrophages","volume":"10","author":"Wong","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0335","doi-asserted-by":"crossref","first-page":"9981","DOI":"10.1073\/pnas.1917034117","article-title":"A minor population of macrophage-tropic HIV-1 variants is identified in recrudescing viremia following analytic treatment interruption","volume":"117","author":"Andrade","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib0340","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s11481-018-9809-2","article-title":"Macrophages but not astrocytes harbor HIV DNA in the brains of HIV-1-infected aviremic individuals on suppressive antiretroviral therapy","volume":"14","author":"Ko","year":"2019","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.smim.2020.101412_bib0345","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s13365-018-0691-8","article-title":"Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium","volume":"24","author":"Al-Harti","year":"2018","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.smim.2020.101412_bib0350","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1128\/JVI.03333-13","article-title":"Epigenetic regulation of HIV-1 latency in astrocytes","volume":"88","author":"Narasipura","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0355","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/glia.23310","article-title":"Astrocytes sustain long-term productive HIV-1 infection without establishment of reactivable viral latency","volume":"66","author":"Barat","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.smim.2020.101412_bib0360","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/13550280600748946","article-title":"Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues","volume":"12","author":"Churchill","year":"2006","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.smim.2020.101412_bib0365","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2174\/1570162X14666161006121455","article-title":"Astrocytes as an HIV reservoir: mechanism of HIV infection","volume":"14","author":"Li","year":"2016","journal-title":"Curr. HIV Res."},{"key":"10.1016\/j.smim.2020.101412_bib0370","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1172\/JCI134815","article-title":"HIV persists throughout deep tissues with repopulation from multiple anatomical sources","volume":"130","author":"Chaillon","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib0375","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01186-17","article-title":"Brain macrophages in simian immunodeficiency virus-infected, antiretroviral-suppressed macaques: a functional latent reservoir","volume":"8","author":"Avalos","year":"2017","journal-title":"MBio"},{"key":"10.1016\/j.smim.2020.101412_bib0380","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s11904-018-0412-1","article-title":"CNS persistence of HIV-1 in children: the untapped reservoir","volume":"15","author":"Chahroudi","year":"2018","journal-title":"Curr. HIVAIDS Rep."},{"key":"10.1016\/j.smim.2020.101412_bib0385","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/NEN.0000000000000148","article-title":"Neuroinflammation and virus replication in the spinal cord of simian immunodeficiency virus\u2013infected macaques","volume":"74","author":"Mangus","year":"2015","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.smim.2020.101412_bib0390","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1097\/QAD.0000000000001282","article-title":"Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults","volume":"30","author":"Jenabian","year":"2016","journal-title":"AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib0395","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1038\/s41467-019-12732-2","article-title":"Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa","volume":"10","author":"Cantero-P\u00e9rez","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.smim.2020.101412_bib0400","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11904-017-0359-7","article-title":"The lymph node in HIV pathogenesis","volume":"14","author":"Dimopoulos","year":"2017","journal-title":"Curr. HIVAIDS Rep."},{"key":"10.1016\/j.smim.2020.101412_bib0405","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02362","article-title":"Does B cell follicle exclusion of CD8+ T cells make lymph nodes sanctuaries of HIV replication?","volume":"10","author":"Beck","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0410","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/COH.0000000000000293","article-title":"Tissue reservoirs of HIV","volume":"11","author":"Wong","year":"2016","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib0415","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/nm.4411","article-title":"Defining total-body AIDS-virus burden with implications for curative strategies","volume":"23","author":"Estes","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0420","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1086\/527324","article-title":"Persistence of HIV in gut\u2010associated lymphoid tissue despite long\u2010term antiretroviral therapy","volume":"197","author":"Chun","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib0425","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1128\/JVI.02409-10","article-title":"The gut mucosal viral reservoir in HIV-infected patients is not the major source of rebound plasma viremia following interruption of highly active antiretroviral therapy","volume":"85","author":"Lerner","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0430","doi-asserted-by":"crossref","first-page":"E1126","DOI":"10.1073\/pnas.1414926112","article-title":"Large number of rebounding\/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption","volume":"112","author":"Rothenberger","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib0435","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00020","article-title":"The B-Cell follicle in HIV infection: barrier to a cure","volume":"9","author":"Bronnimann","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0440","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1084\/jem.20121932","article-title":"Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production","volume":"210","author":"Perreau","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0445","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.tim.2016.02.006","article-title":"TFH in HIV latency and as sources of replication-competent virus","volume":"24","author":"Miles","year":"2016","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.smim.2020.101412_bib0450","article-title":"X4-tropic latent HIV-1 is enriched in peripheral follicular helper T cells and is correlated with disease progression","volume":"94","author":"Yu","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0455","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/nm.3781","article-title":"B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers","volume":"21","author":"Fukazawa","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0460","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.178.11.6975","article-title":"CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue","author":"Connick","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0465","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.celrep.2017.11.075","article-title":"HIV-specific CD8+ T cells exhibit reduced and differentially regulated cytolytic activity in lymphoid tissue","volume":"21","author":"Reuter","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.smim.2020.101412_bib0470","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005285","article-title":"Follicular dendritic cells retain infectious HIV in cycling endosomes","volume":"11","author":"Heesters","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0475","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4049\/jimmunol.166.1.690","article-title":"Persistence of infectious HIV on follicular dendritic cells","volume":"166","author":"Smith","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0480","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1182\/bloodadvances.2017012971","article-title":"The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles","volume":"2","author":"Webb","year":"2018","journal-title":"Blood Adv."},{"key":"10.1016\/j.smim.2020.101412_bib0485","doi-asserted-by":"crossref","DOI":"10.1038\/nm.4421","article-title":"Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys","author":"Huot","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0490","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008339","article-title":"The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques","author":"Webb","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0495","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.coviro.2016.06.011","article-title":"Innate immune cell responses in non pathogenic versus pathogenic SIV infections","volume":"19","author":"Huot","year":"2016","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0500","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1600-0684.2004.00057.x","article-title":"Viral load in tissues during the early and chronic phase of non-pathogenic SIVagm infection","volume":"33","author":"Gueye","year":"2004","journal-title":"J. Med. Primatol."},{"key":"10.1016\/j.smim.2020.101412_bib0505","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1093\/infdis\/jiw275","article-title":"Immunologic biomarkers, morbidity, and mortality in treated HIV infection","volume":"214","author":"Hunt","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib0510","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/imr.12823","article-title":"T\u2010cell exhaustion in HIV infection","volume":"292","author":"Fenwick","year":"2019","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.smim.2020.101412_bib0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2016.04.022","article-title":"Costimulatory and coinhibitory receptor pathways in infectious disease","author":"Attanasio","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2020.101412_bib0520","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/ni1515","article-title":"Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction","volume":"8","author":"Kaufmann","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0525","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005349","article-title":"TIGIT marks exhausted T cells, correlates with disease progression, and serves as a target for immune restoration in HIV and SIV infection","author":"Chew","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0530","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/nm1482","article-title":"Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction","volume":"12","author":"Trautmann","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0535","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nri.2017.112","article-title":"Immune checkpoint blockade in infectious diseases","volume":"18","author":"Wykes","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0540","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20081398","article-title":"Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection","author":"Jones","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0545","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1084\/jem.20061496","article-title":"PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection","volume":"203","author":"Petrovas","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0550","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature05115","article-title":"PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression","volume":"443","author":"Day","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib0555","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12977-018-0458-6","article-title":"Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV-1 infection","volume":"15","author":"de Paula","year":"2018","journal-title":"Retrovirology"},{"key":"10.1016\/j.smim.2020.101412_bib0560","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/infdis\/jit311","article-title":"Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size","volume":"208","author":"Jain","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib0565","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1089\/aid.2016.0324","article-title":"Early and delayed antiretroviral therapy results in comparable reductions in CD8 + T cell exhaustion marker expression","volume":"33","author":"Rutishauser","year":"2017","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.smim.2020.101412_bib0570","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-019-0221-9","article-title":"Defining \u2018T cell exhaustion\u2019","author":"Blank","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0575","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0580","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0585","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.immuni.2008.10.010","article-title":"Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control","volume":"29","author":"Migueles","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2020.101412_bib0590","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1084\/jem.20070784","article-title":"Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover","volume":"204","author":"Almeida","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0595","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nature14053","article-title":"Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations","volume":"517","author":"Deng","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib0600","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1093\/cid\/cis253","article-title":"Increasingly successful highly active antiretroviral therapy delays the emergence of new HLA class I\u2013associated escape mutations in HIV-1","volume":"54","author":"Knapp","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib0605","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nm0297-205","article-title":"Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus","volume":"3","author":"Borrow","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0610","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.94.5.1890","article-title":"Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection","author":"Price","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.smim.2020.101412_bib0615","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.1069660","article-title":"Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level","volume":"296","author":"Moore","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib0620","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1172\/JCI126714","article-title":"HIV-1 in lymph nodes is maintained by cellular proliferation during antiretroviral therapy","volume":"129","author":"McManus","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib0625","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/QAD.0000000000002074","article-title":"Cerebrospinal fluid viral escape in aviremic HIV-infected patients receiving antiretroviral therapy","volume":"33","author":"P\u00e9rez-Valero","year":"2019","journal-title":"AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib0630","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiw454","article-title":"Asymptomatic cerebrospinal fluid HIV-1 viral blips and viral escape during antiretroviral therapy: a longitudinal study","author":"Ed\u00e9n","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib0635","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/8394","article-title":"Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy","volume":"5","author":"Finzi","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0640","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1038\/s41467-018-06843-5","article-title":"A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation","volume":"9","author":"Reeves","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.smim.2020.101412_bib0645","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1084\/jem.20170193","article-title":"Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: potential role in latent reservoir dynamics","volume":"214","author":"Hosmane","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0650","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006283","article-title":"Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir","volume":"13","author":"Bui","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0655","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1126\/science.1254194","article-title":"Specific HIV integration sites are linked to clonal expansion and persistence of infected cells","volume":"345","author":"Maldarelli","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib0660","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1126\/science.1256304","article-title":"Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection","volume":"345","author":"Wagner","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib0665","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200051","article-title":"Antigen-responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir","volume":"217","author":"Mendoza","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0670","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1038\/s41598-017-04160-3","article-title":"Anti-proliferative therapy for HIV cure: a compound interest approach","volume":"7","author":"Reeves","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.smim.2020.101412_bib0675","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0162-3109(00)00188-0","article-title":"Mycophenolate mofetil and its mechanisms of action","volume":"47","author":"Allison","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.smim.2020.101412_bib0680","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/77489","article-title":"Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo","volume":"6","author":"Chapuis","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0685","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1097\/00126334-200407010-00009","article-title":"Effect of mycophenolate mofetil on immune response and plasma and lymphatic tissue viral load during and after interruption of highly active antiretroviral therapy for patients with chronic HIV infection","volume":"36","author":"Garc\u00eda","year":"2004","journal-title":"JAIDS J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.smim.2020.101412_bib0690","doi-asserted-by":"crossref","DOI":"10.1038\/nri819","article-title":"Cytotoxic T lymphocytes: all roads lead to death","author":"Barry","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0695","doi-asserted-by":"crossref","DOI":"10.1038\/nature12940","article-title":"Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection","author":"Doitsh","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib0700","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.4049\/jimmunol.161.8.3936","article-title":"FLIP prevents apoptosis induced by death receptors but not by perforin\/granzyme B, chemotherapeutic drugs, and gamma irradiation","volume":"161","author":"Kataoka","year":"1998","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.smim.2020.101412_bib0705","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","article-title":"The Bcl-2 protein family: arbiters of cell survival","volume":"281","author":"Adams","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib0710","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1056\/NEJMoa1604958","article-title":"Mutations associated with acquired resistance to PD-1 blockade in melanoma","volume":"375","author":"Zaretsky","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0715","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/88.2.100","article-title":"Loss of functional beta2-microglobulin in metastatic melanomas from five patients receiving immunotherapy","author":"Restifo","year":"1996","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.smim.2020.101412_bib0720","article-title":"Differential susceptibility of leukocyte subsets to cytotoxic T cell killing: implications for HIV immunopathogenesis","author":"Liu","year":"2007","journal-title":"Cytom. Part A"},{"key":"10.1016\/j.smim.2020.101412_bib0725","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01842","article-title":"Have cells harboring the HIV reservoir been immunoedited?","volume":"10","author":"Huang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0730","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1172\/JCI97555","article-title":"Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells","volume":"128","author":"Huang","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib0735","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1172\/JCI132374","article-title":"BCL-2 antagonism sensitizes cytotoxic T cell\u2013resistant HIV reservoirs to elimination ex vivo","volume":"130","author":"Ren","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib0740","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2013.09.020","article-title":"Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure","volume":"155","author":"Ho","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.smim.2020.101412_bib0745","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nm.4156","article-title":"Defective proviruses rapidly accumulate during acute HIV-1 infection","volume":"22","author":"Bruner","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0750","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-019-0898-8","article-title":"A quantitative approach for measuring the reservoir of latent HIV-1 proviruses","volume":"566","author":"Bruner","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib0755","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006940","article-title":"HIV restriction factors and mechanisms of evasion","volume":"2","author":"Malim","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0760","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.chom.2017.03.008","article-title":"Defective HIV-1 proviruses are expressed and can be recognized by cytotoxic t lymphocytes, which shape the proviral landscape","volume":"21","author":"Pollack","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.smim.2020.101412_bib0765","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1073\/pnas.1609057113","article-title":"Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy","volume":"113","author":"Imamichi","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib0770","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1073\/pnas.1917876117","article-title":"Defective HIV-1 proviruses produce viral proteins","volume":"117","author":"Imamichi","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib0775","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1126\/science.283.5403.857","article-title":"Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes","volume":"283","author":"Schmitz","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib0780","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/487439a","article-title":"HIV: Shock and kill","volume":"487","author":"Deeks","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib0785","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.immuni.2012.01.014","article-title":"Stimulation of HIV-1-specific cytolytic t lymphocytes facilitates elimination of latent viral reservoir after virus reactivation","volume":"36","author":"Shan","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2020.101412_bib0790","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.virol.2013.08.002","article-title":"Anti-HIV designer T cells progressively eradicate a latently infected cell line by sequentially inducing HIV reactivation then killing the newly gp120-positive cells","volume":"446","author":"Sahu","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.smim.2020.101412_bib0795","doi-asserted-by":"crossref","first-page":"10844","DOI":"10.1038\/ncomms10844","article-title":"Elimination of HIV-1-infected cells by broadly neutralizing antibodies","volume":"7","author":"Bruel","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.smim.2020.101412_bib0800","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf1279","article-title":"Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo","author":"Lu","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib0805","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1172\/JCI80561","article-title":"Towards HIV-1 remission: potential roles for broadly neutralizing antibodies","volume":"126","author":"Halper-Stromberg","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib0810","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02717-15","article-title":"Antibody-dependent cellular cytotoxicity against reactivated HIV-1-infected cells","author":"Lee","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0815","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nature11286","article-title":"Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy","volume":"487","author":"Archin","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib0820","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/infdis\/jiu155","article-title":"HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat","volume":"210","author":"Archin","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib0825","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004473","article-title":"Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy","volume":"10","author":"Elliott","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0830","doi-asserted-by":"crossref","DOI":"10.1016\/S2352-3018(14)70014-1","article-title":"Panobinostat, a histone deacetylase inhibitor, for latent virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1\/2, single group, clinical trial","author":"Rasmussen","year":"2014","journal-title":"Lancet HIV"},{"key":"10.1016\/j.smim.2020.101412_bib0835","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005142","article-title":"The depsipeptide romidepsin reverses HIV-1 latency in vivo","volume":"11","author":"S\u00f8gaard","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0840","doi-asserted-by":"crossref","first-page":"e520","DOI":"10.1016\/S2352-3018(15)00226-X","article-title":"Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study","volume":"2","author":"Elliott","year":"2015","journal-title":"Lancet HIV"},{"key":"10.1016\/j.smim.2020.101412_bib0845","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/S0140-6736(19)32990-3","article-title":"Antiretroviral therapy alone versus antiretroviral therapy with a kick and kill approach, on measures of the HIV reservoir in participants with recent HIV infection (the RIVER trial): a phase 2, randomised trial","volume":"395","author":"Fidler","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.smim.2020.101412_bib0850","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1128\/JVI.02520-15","article-title":"HIV-1 virion production from single inducible proviruses following T-cell activation ex vivo","volume":"90","author":"Bui","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0855","doi-asserted-by":"crossref","first-page":"7078","DOI":"10.1073\/pnas.1402873111","article-title":"Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy","volume":"111","author":"Cillo","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib0860","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003834","article-title":"An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients","volume":"9","author":"Spina","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0865","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41586-020-1951-3","article-title":"Systemic HIV and SIV latency reversal via non-canonical NF-\u03baB signalling in vivo","volume":"578","author":"Nixon","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib0870","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004287","article-title":"Histone deacetylase inhibitors impair the elimination of hiv-infected cells by cytotoxic t-lymphocytes","author":"Jones","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib0875","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01845-19","article-title":"Integrated assessment of viral transcription, antigen presentation, and CD8 + T cell function reveals multiple limitations of class I-selective histone deacetylase inhibitors during HIV-1 latency reversal","volume":"94","author":"Mota","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0880","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01452","article-title":"Diverse impacts of HIV latency-reversing agents on CD8+ T-cell function: implications for HIV cure","volume":"9","author":"Clutton","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0885","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00823","article-title":"HIVconsv vaccines and romidepsin in early-treated HIV-1-infected individuals: safety, immunogenicity and effect on the viral reservoir (Study BCN02)","volume":"11","author":"Mothe","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0890","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-1-4939-3046-3_16","article-title":"Measuring the frequency of latent HIV-1 in resting CD4+ T cells using a limiting dilution coculture assay","author":"Laird","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.smim.2020.101412_bib0895","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ebiom.2017.07.019","article-title":"Vorinostat renders the replication-competent latent reservoir of human immunodeficiency virus (HIV) vulnerable to clearance by CD8 T cells","volume":"23","author":"Sung","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.smim.2020.101412_bib0900","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00012-17","article-title":"Maintenance of the HIV reservoir is antagonized by selective BCL2 inhibition","author":"Cummins","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0905","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1128\/JVI.03179-15","article-title":"Prime, shock, and kill: priming CD4 T cells from HIV patients with a BCL-2 antagonist before HIV reactivation reduces HIV reservoir size","volume":"90","author":"Cummins","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0910","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2018.04.004","article-title":"Anti-apoptotic protein BIRC5 maintains survival of HIV-1-Infected CD4+ T cells","author":"Kuo","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2020.101412_bib0915","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz0802","article-title":"Single-cell transcriptional landscapes reveal HIV-1\u2013driven aberrant host gene transcription as a potential therapeutic target","volume":"12","author":"Liu","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0920","doi-asserted-by":"crossref","DOI":"10.1007\/s10495-007-0087-3","article-title":"The inhibitors of apoptosis (IAPs) as cancer targets","author":"Hunter","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.smim.2020.101412_bib0925","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1128\/JVI.77.3.2081-2092.2003","article-title":"Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load","volume":"77","author":"Addo","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0930","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/ni.3543","article-title":"CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles","volume":"17","author":"Leong","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib0935","article-title":"Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection","author":"He","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib0940","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1073\/pnas.1621418114","article-title":"Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection","volume":"114","author":"Mylvaganam","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib0945","doi-asserted-by":"crossref","first-page":"11168","DOI":"10.1128\/JVI.01332-16","article-title":"Simian immunodeficiency virus-producing cells in follicles are partially suppressed by CD8 + cells in vivo","volume":"90","author":"Li","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0950","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax4077","article-title":"Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells","author":"Nguyen","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0955","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1097\/QAD.0b013e32833c3219","article-title":"HLA-B alleles associate consistently with HIV heterosexual transmission, viral load, and progression to AIDS, but not susceptibility to infection","volume":"24","author":"Gao","year":"2010","journal-title":"AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib0960","doi-asserted-by":"crossref","DOI":"10.1038\/nm992","article-title":"HIV evolution: CTL escape mutation and reversion after transmission","author":"Leslie","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib0965","article-title":"HLA-B57\/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphotye recognition","author":"Miura","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0970","doi-asserted-by":"crossref","first-page":"12382","DOI":"10.1128\/JVI.01543-07","article-title":"Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication","volume":"81","author":"Schneidewind","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0975","doi-asserted-by":"crossref","first-page":"e403","DOI":"10.1371\/journal.pmed.0030403","article-title":"HLA alleles associated with delayed progression to AIDS contribute strongly to the initial CD8+ T cell response against HIV-1","volume":"3","author":"Altfeld","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.smim.2020.101412_bib0980","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1097\/00002030-200312050-00005","article-title":"Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection","volume":"17","author":"Altfeld","year":"2003","journal-title":"AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib0985","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1126\/science.1195271","article-title":"The major genetic determinants of HIV-1 control affect HLA class i peptide presentation","volume":"330","author":"Pereyra","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib0990","doi-asserted-by":"crossref","first-page":"12937","DOI":"10.1128\/JVI.01004-14","article-title":"HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes","volume":"88","author":"Pereyra","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib0995","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/354453a0","article-title":"Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition","volume":"354","author":"Phillips","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib1000","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1126\/science.aav5095","article-title":"Structural topology defines protective CD8 + T cell epitopes in the HIV proteome","volume":"364","author":"Gaiha","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib1005","doi-asserted-by":"crossref","DOI":"10.1038\/nature11443","article-title":"Vaccine-induced CD8+ T cells control AIDS virus replication","author":"Mudd","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib1010","doi-asserted-by":"crossref","DOI":"10.2139\/ssrn.3596601","article-title":"A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies","author":"McCann","year":"2020","journal-title":"SSRN Electron. J."},{"key":"10.1016\/j.smim.2020.101412_bib1015","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm1147","article-title":"Therapeutic dendritic-cell vaccine for chronic HIV-1 infection","volume":"10","author":"Lu","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib1020","doi-asserted-by":"crossref","DOI":"10.1097\/QAD.0b013e32832d9b00","article-title":"Induction of novel CD8+ T-cell responses during chronic untreated HIV-1 infection by immunization with subdominant cytotoxic T-lymphocyte epitopes","author":"Kloverpris","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib1025","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004682","article-title":"A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication","author":"Garc\u00eda","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.smim.2020.101412_bib1030","doi-asserted-by":"crossref","DOI":"10.1002\/eji.201344433","article-title":"Dendritic cell-based therapeutic vaccine elicits polyfunctional HIV-specific T-cell immunity associated with control of viral load","author":"L\u00e9vy","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1035","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1093\/infdis\/jiv582","article-title":"Therapeutic vaccination with dendritic cells loaded with autologous HIV type 1\u2013infected apoptotic cells","volume":"213","author":"Macatangay","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib1040","doi-asserted-by":"crossref","DOI":"10.1038\/nature20583","article-title":"Ad26\/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys","author":"Borducchi","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib1045","doi-asserted-by":"crossref","DOI":"10.1038\/nature10003","article-title":"Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine","author":"Hansen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib1050","doi-asserted-by":"crossref","DOI":"10.1126\/science.1237874","article-title":"Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms","volume":"340","author":"Hansen","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib1055","doi-asserted-by":"crossref","DOI":"10.1126\/science.aac9475","article-title":"Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E","author":"Hansen","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib1060","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2016.09.015","article-title":"Antiviral CD8+ T cells restricted by human leukocyte antigen class II exist during natural HIV infection and exhibit clonal expansion","author":"Ranasinghe","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2020.101412_bib1065","doi-asserted-by":"crossref","first-page":"6685","DOI":"10.1128\/JVI.00474-15","article-title":"Novel CD4-based bispecific chimeric antigen receptor designed for enhanced anti-HIV potency and absence of HIV entry receptor activity","volume":"89","author":"Liu","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006613","article-title":"Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor","volume":"13","author":"Leibman","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib1075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02310","article-title":"CAR talk: how cancer-specific CAR T cells can instruct how to build CAR T cells to cure HIV","volume":"10","author":"Kim","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1080","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jcyt.2016.04.007","article-title":"T-cell therapies for HIV: preclinical successes and current clinical strategies","volume":"18","author":"Patel","year":"2016","journal-title":"Cytotherapy"},{"key":"10.1016\/j.smim.2020.101412_bib1085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcyt.2013.11.010","article-title":"The time is now: moving toward virus-specific T cells after allogeneic hematopoietic stem cell transplantation as the standard of care","author":"Saglio","year":"2014","journal-title":"Cytotherapy"},{"key":"10.1016\/j.smim.2020.101412_bib1090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ymthe.2018.08.015","article-title":"HIV-specific, ex vivo expanded T cell therapy: feasibility, safety, and efficacy in ART-suppressed HIV-infected individuals","author":"Sung","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.smim.2020.101412_bib1095","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1172\/JCI32103","article-title":"Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates","volume":"118","author":"Berger","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib1100","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1818488116","article-title":"Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRV\u03b41 and TCRV\u03b42 \u03b3\u03b4 T lymphocytes","author":"Pizzolato","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.smim.2020.101412_bib1105","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41467-019-08604-4","article-title":"Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions","volume":"10","author":"Gutierrez-Arcelus","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.smim.2020.101412_bib1110","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00756","article-title":"Unique and common features of innate-like human V\u03b42+ \u03b3\u03b4T cells and mucosal-associated invariant T cells","volume":"9","author":"Provine","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1115","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.4049\/jimmunol.175.4.2144","article-title":"Activation of V gamma 9V delta 2 T cells by NKG2D","volume":"175","author":"Rincon-Orozco","year":"2005","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.smim.2020.101412_bib1120","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-3083.2007.01963.x","article-title":"Lysis of a broad range of epithelial tumour cells by human?\u202f? T cells: involvement of NKG2D ligands and T-cell receptor- versus NKG2D-dependent recognition","volume":"66","author":"Wrobel","year":"2007","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1125","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.120121","article-title":"\u03b3\u03b4 T cells: an immunotherapeutic approach for HIV cure strategies","author":"Garrido","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.smim.2020.101412_bib1130","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3389\/fcimb.2020.00233","article-title":"What can gamma delta T cells contribute to an HIV cure?","volume":"10","author":"Juno","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.smim.2020.101412_bib1135","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/QAD.0b013e3283244619","article-title":"Zoledronic acid and interleukin-2 treatment improves immunocompetence in HIV-infected persons by activating V\u03b39V\u03b42 T cells","volume":"23","author":"Poccia","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib1140","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02717","article-title":"Universal ready-to-use immunotherapeutic approach for the treatment of cancer: expanded and activated polyclonal \u03b3\u03b4 memory T cells","author":"Polito","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1145","doi-asserted-by":"crossref","DOI":"10.1158\/1078-0432.CCR-13-3451","article-title":"Activating and propagating polyclonal gamma delta T cells with broad specificity for malignancies","author":"Deniger","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.smim.2020.101412_bib1150","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1158\/1078-0432.CCR-16-0597","article-title":"Delta one T cells for immunotherapy of chronic lymphocytic leukemia: clinical-grade expansion\/differentiation and preclinical proof of concept","volume":"22","author":"Almeida","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.smim.2020.101412_bib1155","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01401","article-title":"current advances in \u03b3\u03b4 T cell-based tumor immunotherapy","volume":"8","author":"lo Presti","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1160","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nature07662","article-title":"Enhancing SIV-specific immunity in vivo by PD-1 blockade","volume":"458","author":"Velu","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib1165","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122940","article-title":"Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV","author":"Mylvaganam","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.smim.2020.101412_bib1170","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1182\/blood-2006-04-010637","article-title":"CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques","volume":"108","author":"Hryniewicz","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.smim.2020.101412_bib1175","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/QAD.0000000000000562","article-title":"Effect of ipilimumab on the HIV reservoir in an HIV-infected individual with metastatic melanoma","volume":"29","author":"Wightman","year":"2015","journal-title":"AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib1180","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/infdis\/jix191","article-title":"Clinical trial of the Anti-PD-L1 antibody BMS-936559 in HIV-1 infected participants on suppressive antiretroviral therapy","volume":"215","author":"Gay","year":"2017","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib1185","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41591-020-0782-y","article-title":"CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption","volume":"26","author":"Harper","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib1190","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41586-020-1946-0","article-title":"Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells","volume":"578","author":"McBrien","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib1195","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1172\/JCI85996","article-title":"IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection","volume":"126","author":"Younes","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib1200","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00235-18","article-title":"Interleukin-15-stimulated natural killer cells clear HIV-1-Infected cells following latency reversal ex vivo","volume":"92","author":"Garrido","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1205","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/eji.201747172","article-title":"Mechanisms of CD8 + T cell\u2010mediated suppression of HIV\/SIV replication","volume":"48","author":"McBrien","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1210","first-page":"628","article-title":"A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication","volume":"66","author":"Walker","year":"1989","journal-title":"Immunology"},{"key":"10.1016\/j.smim.2020.101412_bib1215","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.4049\/jimmunol.144.8.2961","article-title":"CD8+ T cells inhibit HIV replication in naturally infected CD4+ T cells. Evidence for a soluble inhibitor","volume":"144","author":"Brinchmann","year":"1990","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.smim.2020.101412_bib1220","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1073\/pnas.98.1.253","article-title":"Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategies","volume":"98","author":"Chun","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib1225","doi-asserted-by":"crossref","first-page":"10165","DOI":"10.1128\/JVI.72.12.10165-10170.1998","article-title":"HLA compatibility requirements for CD8+-T-cell-mediated suppression of human immunodeficiency virus replication","volume":"72","author":"Mackewicz","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1230","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/381667a0","article-title":"HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5","volume":"381","author":"Dragic","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib1235","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1126\/science.270.5243.1811","article-title":"Identification of RANTES, MIP-1alpha, and MIP-1beta as the major HIV-suppressive factors produced by CD8+ T cells","volume":"270","author":"Cocchi","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib1240","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.93.26.15341","article-title":"CD8+ T-cell-derived soluble factor(s), but not \u03b2-chemokines RANTES, MIP-1\u03b1, and MIP-1\u03b2, suppress HIV-1 replication in monocyte\/macrophages","author":"Moriuchi","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.smim.2020.101412_bib1245","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1073\/pnas.97.7.3503","article-title":"CD8+ T cell-mediated suppressive activity inhibits HIV-1 after virus entry with kinetics indicating effects on virus gene expression","volume":"97","author":"Tomaras","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib1250","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1089\/aid.1993.9.1079","article-title":"CD8 + T lymphocyte-mediated inhibition of HIV-1 long terminal repeat transcription: a novel antiviral mechanism","volume":"9","author":"Chen","year":"1993","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.smim.2020.101412_bib1255","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1073\/pnas.92.6.2308","article-title":"CD8+ T cells suppress human immunodeficiency virus replication by inhibiting viral transcription","volume":"92","author":"Mackewicz","year":"1995","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib1260","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00755-20","article-title":"Combination of CD8\u03b2 depletion and IL-15 superagonist N-803 induces virus reactivation in SHIV-infected, long-term ART-treated rhesus macaques","author":"McBrien","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1265","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-immunol-051116-052433","article-title":"Signaling by antibodies: recent progress","author":"Bournazos","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1270","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/imr.12502","article-title":"B-cell responses to HIV infection","volume":"275","author":"Moir","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.smim.2020.101412_bib1275","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1086\/651144","article-title":"Cross\u2010reactive neutralizing humoral immunity does not protect from HIV type 1 disease progression","volume":"201","author":"Euler","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib1280","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/8b3b24b5-d4ed-483a-b233-0a88513ad499","article-title":"Characteristics of the earliest cross-neutralizing antibody response to HIV-1","author":"Mikell","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib1285","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1128\/JVI.02036-08","article-title":"Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection","volume":"83","author":"Sather","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1290","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00002030-199002000-00002","article-title":"Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera","volume":"4","author":"Albert","year":"1990","journal-title":"AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib1295","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1146\/annurev-immunol-080219-023629","article-title":"Vaccines and broadly neutralizing antibodies for HIV-1 prevention","volume":"38","author":"Stephenson","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1300","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/QAD.0000000000000106","article-title":"Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection","volume":"28","author":"Hraber","year":"2014","journal-title":"AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib1305","doi-asserted-by":"crossref","first-page":"7538","DOI":"10.1128\/jvi.66.12.7538-7542.1992","article-title":"Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody","volume":"66","author":"Gorny","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1310","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.7973652","article-title":"Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody","volume":"266","author":"Burton","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib1315","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1128\/jvi.70.2.1100-1108.1996","article-title":"Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1","volume":"70","author":"Trkola","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1320","article-title":"Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41","author":"Zwick","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1325","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nri.2017.148","article-title":"Passive immunotherapy of viral infections: \u201csuper-antibodies\u201d enter the fray","volume":"18","author":"Walker","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1330","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41591-019-0412-8","article-title":"Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic","volume":"25","author":"Caskey","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib1335","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/COH.0000000000000600","article-title":"Broadly neutralizing antibodies for the treatment and prevention of HIV infection","volume":"15","author":"Caskey","year":"2020","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib1340","doi-asserted-by":"crossref","DOI":"10.1111\/imr.12506","article-title":"HIV antibodies for treatment of HIV infection","author":"Margolis","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.smim.2020.101412_bib1345","doi-asserted-by":"crossref","DOI":"10.1038\/nature18929","article-title":"HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption","author":"Scheid","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib1350","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1084\/jem.20180936","article-title":"Relationship between latent and rebound viruses in a clinical trial of anti\u2013HIV-1 antibody 3BNC117","volume":"215","author":"Cohen","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.smim.2020.101412_bib1355","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1056\/NEJMoa1608243","article-title":"Effect of HIV antibody VRC01 on viral rebound after treatment interruption","volume":"375","author":"Bar","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.smim.2020.101412_bib1360","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00895-18","article-title":"Susceptibility to neutralization by broadly neutralizing antibodies generally correlates with infected cell binding for a panel of clade B HIV reactivated from latent reservoirs","volume":"92","author":"Ren","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1365","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.cell.2014.08.023","article-title":"Broadly neutralizing anti-HIV-1 antibodies require fc effector functions for in vivo activity","volume":"158","author":"Bournazos","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.smim.2020.101412_bib1370","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1001\/jama.2019.5397","article-title":"Durable control of HIV infection in the absence of antiretroviral therapy","volume":"322","author":"Chun","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.smim.2020.101412_bib1375","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-018-0531-2","article-title":"Combination therapy with anti-HIV-1 antibodies maintains viral suppression","author":"Mendoza","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib1380","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.chom.2017.07.010","article-title":"Macaques, and men: broadly neutralizing antibody immunotherapy for HIV-1","volume":"22","author":"Nishimura","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.smim.2020.101412_bib1385","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nm.4063","article-title":"Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques","volume":"22","author":"Hessell","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib1390","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature21435","article-title":"Early antibody therapy can induce long-lasting immunity to SHIV","volume":"543","author":"Nishimura","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib1395","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41591-019-0747-1","article-title":"Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity","volume":"26","author":"Niessl","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib1400","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.cell.2016.05.024","article-title":"Engineered bispecific antibodies with exquisite HIV-1-neutralizing activity","volume":"165","author":"Huang","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.smim.2020.101412_bib1405","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.aan8630","article-title":"Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques","volume":"358","author":"Xu","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib1410","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.03080-19","article-title":"A bispecific antibody that simultaneously recognizes the V2- and V3-glycan epitopes of the HIV-1 envelope glycoprotein is broader and more potent than its parental antibodies","volume":"11","author":"Davis-Gardner","year":"2020","journal-title":"MBio"},{"key":"10.1016\/j.smim.2020.101412_bib1415","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005233","article-title":"Targeting HIV reservoir in infected CD4 t cells by dual-affinity Re-targeting molecules (DARTs) that bind HIV envelope and recruit cytotoxic T cells","volume":"11","author":"Sloan","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib1420","doi-asserted-by":"crossref","DOI":"10.1172\/JCI82314","article-title":"Dual-affinity Re-targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells","author":"Sung","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib1425","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.coviro.2019.07.007","article-title":"The potential of engineered antibodies for HIV-1 therapy and cure","volume":"38","author":"Grobben","year":"2019","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1430","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ymeth.2018.10.010","article-title":"Bispecific antibodies: potential immunotherapies for HIV treatment","volume":"154","author":"Fabozzi","year":"2019","journal-title":"Methods"},{"key":"10.1016\/j.smim.2020.101412_bib1435","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002493","article-title":"Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: a phase 1 open-label clinical trial in healthy adults","volume":"15","author":"Gaudinski","year":"2018","journal-title":"PLoS Med."},{"key":"10.1016\/j.smim.2020.101412_bib1440","doi-asserted-by":"crossref","first-page":"e667","DOI":"10.1016\/S2352-3018(19)30181-X","article-title":"Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial","volume":"6","author":"Gaudinski","year":"2019","journal-title":"Lancet HIV"},{"key":"10.1016\/j.smim.2020.101412_bib1445","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1001\/jama.2015.2427","article-title":"Broadly neutralizing antibodies and the development of vaccines","volume":"313","author":"Haynes","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.smim.2020.101412_bib1450","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.00176","article-title":"Promise and progress of an HIV-1 cure by adeno-associated virus vector delivery of anti-HIV-1 biologics","volume":"10","author":"Gardner","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.smim.2020.101412_bib1455","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1172\/JCI132779","article-title":"In vivo delivery of synthetic DNA\u2013encoded antibodies induces broad HIV-1\u2013neutralizing activity","volume":"130","author":"Wise","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib1460","doi-asserted-by":"crossref","first-page":"e230","DOI":"10.1016\/S2352-3018(19)30003-7","article-title":"Adeno-associated virus vectored immunoprophylaxis to prevent HIV in healthy adults: a phase 1 randomised controlled trial","volume":"6","author":"Priddy","year":"2019","journal-title":"Lancet HIV"},{"key":"10.1016\/j.smim.2020.101412_bib1465","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00443-19","article-title":"eCD4-ig limits HIV-1 escape more effectively than CD4-Ig or a broadly neutralizing antibody","volume":"93","author":"Fellinger","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1470","doi-asserted-by":"crossref","DOI":"10.1016\/j.jim.2020.112764","article-title":"Implementation of a three-tiered approach to identify and characterize anti-drug antibodies raised against HIV-specific broadly neutralizing antibodies","author":"Bharadwaj","year":"2020","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.smim.2020.101412_bib1475","doi-asserted-by":"crossref","DOI":"10.1016\/j.jim.2020.112736","article-title":"Optimization and qualification of a functional anti-drug antibody assay for HIV-1 bnAbs","volume":"479","author":"Seaman","year":"2020","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.smim.2020.101412_bib1480","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1128\/JVI.03230-13","article-title":"Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity","volume":"88","author":"Veillette","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1485","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1128\/JVI.02868-14","article-title":"The HIV-1 gp120 CD4-bound conformation is preferentially targeted by antibody-dependent cellular cytotoxicity-mediating antibodies in sera from HIV-1-infected individuals","volume":"89","author":"Veillette","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1490","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.1128\/JVI.00449-14","article-title":"HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells","volume":"88","author":"Alvarez","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1495","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1073\/pnas.1321507111","article-title":"Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity","volume":"111","author":"Arias","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib1500","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1172\/JCI125955","article-title":"Glycan-dependent HIV-specific neutralizing antibodies bind to cells of uninfected individuals","volume":"129","author":"Blazkova","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib1505","doi-asserted-by":"crossref","DOI":"10.1002\/eji.200324141","article-title":"The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44)","author":"de Maria","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1510","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4049\/jimmunol.1301247","article-title":"Anti-HIV antibody\u2013dependent activation of NK cells impairs NKp46 expression","volume":"192","author":"Parsons","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1515","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1200458","article-title":"Virologically suppressed HIV patients show activation of NK cells and persistent innate immune activation","author":"Lichtfuss","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1520","doi-asserted-by":"crossref","first-page":"12655","DOI":"10.1038\/s41598-017-12883-6","article-title":"Non-neutralizing antibodies targeting the V1V2 domain of HIV exhibit strong antibody-dependent cell-mediated cytotoxic activity","volume":"7","author":"Mayr","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.smim.2020.101412_bib1525","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1056\/NEJMoa1802264","article-title":"Effect of anti-CD4 antibody UB-421 on HIV-1 rebound after treatment interruption","volume":"380","author":"Wang","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.smim.2020.101412_bib1530","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01380","article-title":"T follicular helper cells and B cell dysfunction in aging and HIV-1 infection","volume":"8","author":"Pallikkuth","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1535","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2016.00522","article-title":"The dynamics of T and B cells in lymph node during chronic HIV infection: TFH and HIV, unhappy dance partners?","volume":"7","author":"Hong","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1540","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1172\/JCI65175","article-title":"HIV and T follicular helper cells: a dangerous relationship","volume":"122","author":"Vinuesa","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib1545","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/infdis\/jiw163","article-title":"Maintenance of HIV-specific memory B-cell responses in elite controllers despite low viral burdens","volume":"214","author":"Buckner","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib1550","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.virol.2009.11.003","article-title":"Loss of HIV-specific memory B-cells as a potential mechanism for the dysfunction of the humoral immune response against HIV","volume":"397","author":"Bussmann","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.smim.2020.101412_bib1555","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12396","article-title":"Regulation of germinal center B-cell differentiation","volume":"270","author":"Zhang","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.smim.2020.101412_bib1560","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nri3804","article-title":"Dynamics of B cells in germinal centres","volume":"15","author":"de Silva","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1565","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2014.10.004","article-title":"T follicular helper cell differentiation, function, and roles in disease","author":"Crotty","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2020.101412_bib1570","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","article-title":"Follicular helper CD4 T cells (T FH)","volume":"29","author":"Crotty","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1575","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000107","article-title":"Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection","volume":"6","author":"Levesque","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.smim.2020.101412_bib1580","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1097\/00002030-199911120-00004","article-title":"Lymph node architecture preceding and following 6 months of potent antiviral therapy: follicular hyperplasia persists in parallel with p24 antigen restoration after involution and CD4 cell depletion in an AIDS patient","volume":"13","author":"Orenstein","year":"1999","journal-title":"AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib1585","doi-asserted-by":"crossref","DOI":"10.1590\/S0074-02761996000300023","article-title":"Spectrum of morphologic changes of lymph nodes in HIV infection","author":"Paiva","year":"1996","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.smim.2020.101412_bib1590","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/jmp.12109","article-title":"PAS-positive extracellular deposits within germinal centers of hyperplastic follicles during SIV infection in a rhesus macaque","volume":"43","author":"Hong","year":"2014","journal-title":"J. Med. Primatol."},{"key":"10.1016\/j.smim.2020.101412_bib1595","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.4049\/jimmunol.1103138","article-title":"Spatial alterations between CD4 + T follicular helper, B, and CD8 + T cells during simian immunodeficiency virus infection: T\/B cell homeostasis, activation, and potential mechanism for viral escape","volume":"188","author":"Hong","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1600","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1172\/JCI64314","article-title":"Expansion of HIV-specific T follicular helper cells in chronic HIV infection","volume":"122","author":"Lindqvist","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib1605","doi-asserted-by":"crossref","DOI":"10.1172\/JCI63039","article-title":"CD4 T follicular helper cell dynamics during SIV infection","author":"Petrovas","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib1610","doi-asserted-by":"crossref","DOI":"10.1097\/COH.0000000000000092","article-title":"B-cell exhaustion in HIV infection: the role of immune activation","author":"Moir","year":"2014","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib1615","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2003-07-2375","article-title":"Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection","author":"de Milito","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.smim.2020.101412_bib1620","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1182\/blood-2005-11-013383","article-title":"Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection","volume":"108","author":"Titanji","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.smim.2020.101412_bib1625","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nm.3109","article-title":"Inadequate T follicular cell help impairs B cell immunity during HIV infection","volume":"19","author":"Cubas","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2020.101412_bib1630","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.4049\/jimmunol.179.3.1979","article-title":"Programmed death 1 expression on HIV-specific CD4 + T cells is driven by viral replication and associated with T cell dysfunction","volume":"179","author":"D\u2019Souza","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1635","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1093\/infdis\/jiu840","article-title":"HIV infection worsens age-associated defects in antibody responses to influenza vaccine","volume":"211","author":"George","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib1640","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1126\/science.2847316","article-title":"HIV-infected cells are killed by rCD4-ricin A chain","volume":"242","author":"Till","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.smim.2020.101412_bib1645","doi-asserted-by":"crossref","DOI":"10.1038\/335369a0","article-title":"Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein","author":"Chaudhary","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.smim.2020.101412_bib1650","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.4049\/jimmunol.142.9.3070","article-title":"Treatment of HIV tissue culture infection with monoclonal antibody-ricin A chain conjugates","volume":"142","author":"Pincus","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1655","first-page":"384","article-title":"Specific killing of HIV-infected lymphocytes by a recombinant immunotoxin directed against the HIV-1 envelope glycoprotein","volume":"4","author":"Bera","year":"1998","journal-title":"Mol. Med. (Cambridge, Mass.)"},{"key":"10.1016\/j.smim.2020.101412_bib1660","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1089\/aid.1990.6.795","article-title":"Recombinant CD4- pseudomonas exotoxin hybrid protein displays HIV-specific cytotoxicity without affecting MHC class II-dependent functions","volume":"6","author":"Berger","year":"1990","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.smim.2020.101412_bib1665","doi-asserted-by":"crossref","first-page":"9539","DOI":"10.1073\/pnas.86.23.9539","article-title":"CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses","volume":"86","author":"Berger","year":"1989","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2020.101412_bib1670","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1089\/aid.1993.9.1091","article-title":"Continuous presence of CD4-PE40 is required for antiviral activity against single-passage HIV isolates and infected peripheral blood mononuclear cells","volume":"9","author":"Winters","year":"1993","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.smim.2020.101412_bib1675","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/infdis\/170.4.1009","article-title":"Failure of short-term Cd4-Pe40 infusions to reduce virus load in human immunodeficiency virus-infected persons","volume":"170","author":"Ramachandran","year":"1994","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2020.101412_bib1680","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000803","article-title":"Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs","volume":"6","author":"Berger","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib1685","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01955-16","article-title":"Identification of human anti-HIV gp160 monoclonal antibodies that make effective immunotoxins","volume":"91","author":"Pincus","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1690","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-08037-3","article-title":"Selective cytotoxicity of a novel immunotoxin based on pulchellin A chain for cells expressing HIV envelope","author":"Sadraeian","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.smim.2020.101412_bib1695","doi-asserted-by":"crossref","DOI":"10.1016\/j.trsl.2020.04.008","article-title":"Therapeutic vaccines for the treatment of HIV","author":"Chen","year":"2020","journal-title":"Transl. Res."},{"key":"10.1016\/j.smim.2020.101412_bib1700","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/COH.0000000000000491","article-title":"Therapeutic vaccination for HIV","volume":"13","author":"Stephenson","year":"2018","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.smim.2020.101412_bib1705","doi-asserted-by":"crossref","DOI":"10.1172\/JCI99005","article-title":"TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs","author":"Cheng","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.smim.2020.101412_bib1710","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao4521","article-title":"TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy","volume":"10","author":"Lim","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.smim.2020.101412_bib1715","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02166-16","article-title":"Toll-like receptor 7 agonist GS-9620 induces HIV expression and HIV-specific immunity in cells from HIV-infected individuals on suppressive antiretroviral therapy","volume":"91","author":"Tsai","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.smim.2020.101412_bib1720","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005545","article-title":"A subset of latency-reversing agents expose HIV-infected resting CD4+ T-cells to recognition by cytotoxic T-lymphocytes","volume":"12","author":"Jones","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.smim.2020.101412_bib1725","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.4049\/jimmunol.179.4.2097","article-title":"NK cell lysis of HIV-1-infected autologous CD4 primary T cells: requirement for IFN-mediated NK activation by plasmacytoid dendritic cells","volume":"179","author":"Tomescu","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1730","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02450","article-title":"Targeting cellular and tissue HIV reservoirs with toll-like receptor agonists","volume":"10","author":"Macedo","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1735","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.3389\/fimmu.2020.01112","article-title":"The use of toll-like receptor agonists in HIV-1 cure strategies","volume":"11","author":"Martinsen","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2020.101412_bib1740","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1172\/JCI80566","article-title":"HIV-specific CD8+ T cells and HIV eradication","volume":"126","author":"Jones","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.smim.2020.101412_bib1745","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1016\/S2352-3018(19)30052-9","article-title":"Recommendations for analytical antiretroviral treatment interruptions in HIV research trials\u2014report of a consensus meeting","volume":"6","author":"Boris","year":"2019","journal-title":"Lancet HIV"}],"container-title":["Seminars in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532320300282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532320300282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T23:17:55Z","timestamp":1760915875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044532320300282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":349,"alternative-id":["S1044532320300282"],"URL":"https:\/\/doi.org\/10.1016\/j.smim.2020.101412","relation":{},"ISSN":["1044-5323"],"issn-type":[{"value":"1044-5323","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunological approaches to HIV cure","name":"articletitle","label":"Article Title"},{"value":"Seminars in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.smim.2020.101412","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101412"}}