{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:35:00Z","timestamp":1794270900040,"version":"4.9.0"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"am","delay-in-days":294,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI119015"],"award-info":[{"award-number":["R01AI119015"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI148491"],"award-info":[{"award-number":["R01AI148491"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Immunology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.smim.2023.101781","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T06:16:46Z","timestamp":1687328206000},"page":"101781","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":430,"special_numbering":"C","title":["Pyroptosis-induced inflammation and tissue damage"],"prefix":"10.1016","volume":"69","author":[{"given":"Swathy O.","family":"Vasudevan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Behl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay A.","family":"Rathinam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.smim.2023.101781_bib1","first-page":"1","article-title":"The gasdermins, a protein family executing cell death and inflammation","author":"Broz","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib3","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/ni.1960","article-title":"Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria","volume":"11","author":"Miao","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib4","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cell.2016.03.046","article-title":"Inflammasome complexes: emerging mechanisms and effector functions","volume":"165","author":"Rathinam","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.smim.2023.101781_bib5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib6","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.smim.2023.101781_bib7","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.smim.2023.101781_bib8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.smim.2023.101781_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature10558","article-title":"Non-canonical inflammasome activation targets caspase-11","volume":"479","author":"Kayagaki","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.smim.2023.101781_bib10","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1126\/science.1240988","article-title":"Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock","volume":"341","author":"Hagar","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.smim.2023.101781_bib11","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1126\/science.1240248","article-title":"Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4","volume":"341","author":"Kayagaki","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.smim.2023.101781_bib12","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res"},{"key":"10.1016\/j.smim.2023.101781_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.smim.2023.101781_bib14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-021-03218-7","article-title":"NINJ1 mediates plasma membrane rupture during lytic cell death","volume":"591","author":"Kayagaki","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.smim.2023.101781_bib15","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.aar7607","article-title":"ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation","volume":"362","author":"R\u00fchl","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.smim.2023.101781_bib16","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/s41586-022-04825-8","article-title":"Caspase-7 activates ASM to repair gasdermin and perforin pores","volume":"606","author":"Nozaki","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.smim.2023.101781_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.smim.2023.101781_bib18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-020-2071-9","article-title":"Gasdermin E suppresses tumour growth by activating anti-tumour immunity","volume":"579","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.smim.2023.101781_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13046-021-01959-x","article-title":"Pyroptosis: a new paradigm of cell death for fighting against cancer","volume":"40","author":"Tan","year":"2021","journal-title":"J. Exp. Clin. Canc Res."},{"key":"10.1016\/j.smim.2023.101781_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaz7548","article-title":"Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells","volume":"368","author":"Zhou","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.smim.2023.101781_bib21","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41422-021-00506-9","article-title":"The metabolite \u03b1-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8","volume":"31","author":"Zhang","year":"2021","journal-title":"Cell Res"},{"key":"10.1016\/j.smim.2023.101781_bib22","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.immuni.2022.03.009","article-title":"Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C","volume":"55","author":"Zhao","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2023.101781_bib23","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2026307118","article-title":"Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity","volume":"118","author":"Xi","year":"2021","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2023.101781_bib24","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.aau2818","article-title":"Pathogen blockade of TAK1 triggers caspase-8\u2013dependent cleavage of gasdermin D and cell death","volume":"362","author":"Orning","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.smim.2023.101781_bib25","doi-asserted-by":"crossref","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","article-title":"Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection","volume":"115","author":"Sarhan","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2023.101781_bib26","doi-asserted-by":"crossref","first-page":"2924 2936","DOI":"10.1016\/j.celrep.2018.02.067","article-title":"Gasdermin D exerts anti-inflammatory effects by promoting neutrophil death","volume":"22","author":"Kambara","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.smim.2023.101781_bib27","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-022-04717-x","article-title":"Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes","volume":"605","author":"LaRock","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.smim.2023.101781_bib28","first-page":"1","article-title":"Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis","author":"Deng","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.smim.2023.101781_bib29","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1084\/jem.20151613","article-title":"Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis","volume":"213","author":"Jorgensen","year":"2016","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.smim.2023.101781_bib30","article-title":"Role of pyroptosis and ferroptosis in the progression of atherosclerotic plaques","volume":"10","author":"Yang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.smim.2023.101781_bib31","article-title":"Role of pyroptosis in inflammatory bowel disease (IBD): from gasdermins to DAMPs","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.smim.2023.101781_bib32","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1172\/JCI94495","article-title":"Caspase-11\u2013mediated endothelial pyroptosis underlies endotoxemia-induced lung injury","volume":"127","author":"Cheng","year":"2017","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.smim.2023.101781_bib33","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.immuni.2015.10.009","article-title":"Caspase-11 Requires the Pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock","volume":"43","author":"Yang","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2023.101781_bib34","doi-asserted-by":"crossref","first-page":"16037","DOI":"10.1038\/nrdp.2016.37","article-title":"Disseminated intravascular coagulation","volume":"2","author":"Gando","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.smim.2023.101781_bib35","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/ATVBAHA.117.309846","article-title":"Tissue factor: an essential mediator of hemostasis and trigger of thrombosis","volume":"38","author":"Grover","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.smim.2023.101781_bib36","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1186\/cc12783","article-title":"A multicenter, prospective validation study of the Japanese Association for Acute Medicine disseminated intravascular coagulation scoring system in patients with severe sepsis","volume":"17","author":"Gando","year":"2013","journal-title":"Crit. Care"},{"key":"10.1016\/j.smim.2023.101781_bib37","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.immuni.2019.04.003","article-title":"Inflammasome activation triggers blood clotting and host death through pyroptosis","volume":"50","author":"Wu","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2023.101781_bib38","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.immuni.2019.11.005","article-title":"Bacterial endotoxin activates the coagulation cascade through gasdermin D-Dependent phosphatidylserine exposure","volume":"51","author":"Yang","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2023.101781_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.immuni.2017.11.013","article-title":"The pore-forming protein gasdermin D regulates interleukin-1 secretion from living macrophages","volume":"48","author":"Evavold","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2023.101781_bib40","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1126\/science.aaf3036","article-title":"An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells","volume":"352","author":"Zanoni","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.smim.2023.101781_bib41","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.chom.2020.02.004","article-title":"TMEM173 drives lethal coagulation in Sepsis","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.smim.2023.101781_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ni.2491","article-title":"STING and the innate immune response to nucleic acids in the cytosol","volume":"14","author":"Burdette","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib43","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.smim.2023.101781_bib44","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41576-019-0151-1","article-title":"DNA sensing by the cGAS\u2013STING pathway in health and disease","volume":"20","author":"Motwani","year":"2019","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.smim.2023.101781_bib45","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1182\/blood-2002-06-1887","article-title":"The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome","volume":"101","author":"Aird","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.smim.2023.101781_bib46","article-title":"Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs","volume":"112","author":"Andonegui","year":"2003","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.smim.2023.101781_bib47","doi-asserted-by":"crossref","first-page":"17485","DOI":"10.1074\/jbc.M115.641191","article-title":"Inhibition of Caspase-1 activation in endothelial cells improves angiogenesis","volume":"290","author":"Lopez-Pastrana","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.smim.2023.101781_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109012","article-title":"Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense","volume":"35","author":"Kumari","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.smim.2023.101781_bib49","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nrm2617","article-title":"Mechanisms of regulated unconventional protein secretion","volume":"10","author":"Nickel","year":"2009","journal-title":"Nat. Rev. Mol. Cell Bio."},{"key":"10.1016\/j.smim.2023.101781_bib50","doi-asserted-by":"crossref","first-page":"R406","DOI":"10.1016\/j.cub.2017.11.074","article-title":"Unconventional mechanisms of eukaryotic protein secretion","volume":"28","author":"Dimou","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.smim.2023.101781_bib51","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nri2938","article-title":"Immune cell regulation by autocrine purinergic signalling","volume":"11","author":"Junger","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib52","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1016\/S0021-9258(18)61477-2","article-title":"Extracellular ATP4- promotes cation fluxes in the J774 mouse macrophage cell line","volume":"262","author":"Steinberg","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.smim.2023.101781_bib53","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.185.3.579","article-title":"Purinergic modulation of interleukin-1\u03b2 release from microglial cells stimulated with bacterial endotoxin","volume":"185","author":"Ferrari","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.smim.2023.101781_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.70","article-title":"Extracellular ATP drives systemic inflammation, tissue damage and mortality","volume":"5","author":"Cauwels","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.smim.2023.101781_bib55","first-page":"2184","article-title":"Active release of eCIRP via Gasdermin D channels to induce inflammation in Sepsis","volume":"208","author":"Tan","year":"2021","journal-title":"J. Immunol. Balt. Md 1950"},{"key":"10.1016\/j.smim.2023.101781_bib56","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/JLB.3MIR1118-443R","article-title":"Extracellular CIRP (eCIRP) and inflammation","volume":"106","author":"Aziz","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.smim.2023.101781_bib57","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chom.2014.07.002","article-title":"Noncanonical Inflammasome Activation of Caspase-4\/Caspase-11 mediates epithelial defenses against enteric bacterial pathogens","volume":"16","author":"Knodler","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.smim.2023.101781_bib58","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"277","author":"Man","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.smim.2023.101781_bib59","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/infdis\/161.1.79","article-title":"Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever","volume":"161","author":"Cannon","year":"1990","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.smim.2023.101781_bib60","first-page":"463","article-title":"Acute inflammation and a Shwartzman-like reaction induced by interleukin-1 and tumor necrosis factor. Synergistic action of the cytokines in the induction of inflammation and microvascular injury","volume":"129","author":"Movat","year":"1987","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.smim.2023.101781_bib61","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1074\/mcp.M600455-MCP200","article-title":"Mass spectrometric analysis of the endogenous Type I Interleukin-1 (IL-1) receptor signaling complex formed after IL-1 Binding Identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components","volume":"6","author":"Brikos","year":"2007","journal-title":"Mol. Cell Proteom."},{"key":"10.1016\/j.smim.2023.101781_bib62","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.4049\/jimmunol.164.6.3330","article-title":"IFN-\u03b3-Dependent and -Independent mechanisms in adverse effects caused by concomitant administration of IL-18 and IL-12","volume":"164","author":"Nakamura","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib63","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41385-021-00386-7","article-title":"Interleukin-33 signaling exacerbates experimental infectious colitis by enhancing gut permeability and inhibiting protective Th17 immunity","volume":"14","author":"Palmieri","year":"2021","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib64","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3389\/fimmu.2020.00484","article-title":"Targeting inflammation driven by HMGB1","volume":"11","author":"Yang","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib65","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.immuni.2018.08.016","article-title":"The endotoxin delivery protein HMGB1 mediates Caspase-11-Dependent lethality in Sepsis","volume":"49","author":"Deng","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2023.101781_bib66","first-page":"60","article-title":"HMGB1 mediates acute liver injury in sepsis through pyroptosis of liver macrophages","volume":"10","author":"Huang","year":"2020","journal-title":"Int. J. BurnTrauma"},{"key":"10.1016\/j.smim.2023.101781_bib67","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1073\/pnas.2434651100","article-title":"Reversing established sepsis with antagonists of endogenous high-mobility group box 1","volume":"101","author":"Yang","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.smim.2023.101781_bib68","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1053\/gast.2002.35391","article-title":"HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice","volume":"123","author":"Sappington","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.smim.2023.101781_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109265","article-title":"Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn\u2019s disease by promoting intestinal inflammation","volume":"35","author":"Tan","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.smim.2023.101781_bib70","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41590-020-00844-7","article-title":"Intracellular immune sensing promotes inflammation via gasdermin D\u2013driven release of a lectin alarmin","volume":"22","author":"Russo","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0257558","article-title":"Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients","volume":"16","author":"Chou","year":"2021","journal-title":"PLos One"},{"key":"10.1016\/j.smim.2023.101781_bib72","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/s41598-021-04602-z","article-title":"Galectin-1 as the new player in staging and prognosis of COVID-19","volume":"12","author":"Markovic","year":"2022","journal-title":"Sci. Rep. -Uk"},{"key":"10.1016\/j.smim.2023.101781_bib73","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.4049\/jimmunol.1900212","article-title":"Gasdermin D drives the nonexosomal secretion of Galectin-3, an insulin signal antagonist","volume":"203","author":"Chen","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108826","article-title":"Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis","volume":"34","author":"Phulphagar","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.smim.2023.101781_bib75","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/s41564-020-00795-7","article-title":"Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling","volume":"5","author":"Zhou","year":"2020","journal-title":"Nat. Microbiol"},{"key":"10.1016\/j.smim.2023.101781_bib76","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1056\/NEJMra2026131","article-title":"Cytokine Storm","volume":"383","author":"Fajgenbaum","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.smim.2023.101781_bib77","doi-asserted-by":"crossref","first-page":"2207448","DOI":"10.1002\/advs.202207448","article-title":"Rapidly inhibiting the inflammatory cytokine storms and restoring cellular homeostasis to alleviate sepsis by blocking pyroptosis and mitochondrial apoptosis pathways","volume":"10","author":"Yan","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.smim.2023.101781_bib78","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","article-title":"DAMP-sensing receptors in sterile inflammation and inflammatory diseases","volume":"20","author":"Gong","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib79","doi-asserted-by":"crossref","DOI":"10.1093\/discim\/kyac005","article-title":"Looking into the IL-1 of the storm: are inflammasomes the link between immunothrombosis and hyperinflammation in cytokine storm syndromes?","volume":"1","author":"Gleeson","year":"2022","journal-title":"Discov. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib80","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.4049\/jimmunol.1000803","article-title":"Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia","volume":"185","author":"Lamkanfi","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib81","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/s41423-021-00665-0","article-title":"Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm","volume":"18","author":"Zhang","year":"2021","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib82","article-title":"Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients","volume":"218","author":"Rodrigues","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.smim.2023.101781_bib83","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.3389\/fimmu.2020.01518","article-title":"Targeting the NLRP3 inflammasome in severe COVID-19","volume":"11","author":"Freeman","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib84","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1038\/s41467-021-25015-6","article-title":"SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation","volume":"12","author":"Pan","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.smim.2023.101781_bib85","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/s41418-021-00916-7","article-title":"SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1","volume":"29","author":"Sun","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.smim.2023.101781_bib86","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.virol.2022.01.003","article-title":"SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway","volume":"568","author":"Xu","year":"2022","journal-title":"Virology"},{"key":"10.1016\/j.smim.2023.101781_bib87","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/s41590-021-00937-x","article-title":"TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines","volume":"22","author":"Zheng","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib88","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114150","article-title":"Long\u2010lived macrophage reprogramming drives spike protein\u2010mediated inflammasome activation in COVID\u201019","volume":"13","author":"Theobald","year":"2021","journal-title":"Embo Mol. Med."},{"key":"10.1016\/j.smim.2023.101781_bib89","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.smim.2023.101781_bib90","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.4049\/jimmunol.1201719","article-title":"Neutrophil extracellular traps: double-edged swords of innate immunity","volume":"189","author":"Kaplan","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib91","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aar6689","article-title":"Gasdermin D plays a vital role in the generation of neutrophil extracellular traps","volume":"3","author":"Sollberger","year":"2018","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib92","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aar6676","article-title":"Noncanonical inflammasome signaling elicits gasdermin D\u2013dependent neutrophil extracellular traps","volume":"3","author":"Chen","year":"2018","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib93","article-title":"Caspase-1-driven neutrophil pyroptosis promotes an incomplete NETosis upon Pseudomonas aeruginosa infection","author":"Santoni","year":"2022","journal-title":"Biorxiv"},{"key":"10.1016\/j.smim.2023.101781_bib94","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s44161-022-00108-7","article-title":"Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis","volume":"1","author":"Su","year":"2022","journal-title":"Nat. Cardiovasc Res."},{"key":"10.1016\/j.smim.2023.101781_bib95","doi-asserted-by":"crossref","first-page":"1030610","DOI":"10.3389\/fimmu.2022.1030610","article-title":"Histones: the critical players in innate immunity","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib96","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1002\/eji.201243224","article-title":"Histones trigger sterile inflammation by activating the NLRP3 inflammasome","volume":"43","author":"Allam","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib97","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.2147\/JIR.S321513","article-title":"Neutrophil extracellular traps augmented alveolar macrophage pyroptosis via AIM2 inflammasome activation in LPS-Induced ALI\/ARDS","volume":"14","author":"Li","year":"2021","journal-title":"J. Inflamm. Res"},{"key":"10.1016\/j.smim.2023.101781_bib98","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41419-018-0538-5","article-title":"Neutrophil extracellular traps promote macrophage pyroptosis in sepsis","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.smim.2023.101781_bib99","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat2738","article-title":"Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis","volume":"3","author":"Rathkey","year":"2018","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib100","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chom.2018.05.009","article-title":"Lipid peroxidation drives Gasdermin D-Mediated pyroptosis in lethal polymicrobial Sepsis","volume":"24","author":"Kang","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.smim.2023.101781_bib101","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41420-021-00428-w","article-title":"SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes","volume":"7","author":"Ferreira","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.smim.2023.101781_bib102","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.1038\/s41467-021-27034-9","article-title":"Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages","volume":"12","author":"Ding","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.smim.2023.101781_bib103","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2016","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.smim.2023.101781_bib104","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1084\/jem.20190377","article-title":"Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis","volume":"216","author":"Li","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.smim.2023.101781_bib105","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1038\/s41467-019-11895-2","article-title":"Caspase-11 signaling enhances graft-versus-host disease","volume":"10","author":"Lu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.smim.2023.101781_bib106","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2017.11.040","article-title":"Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice","volume":"68","author":"Xu","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.smim.2023.101781_bib107","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41419-020-2437-9","article-title":"Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia\u2013reperfusion injury","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.smim.2023.101781_bib108","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/jnr.24385","article-title":"Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro","volume":"97","author":"Zhang","year":"2019","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.smim.2023.101781_bib109","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41419-019-2021-3","article-title":"Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1\/RAGE\/cathespin B signaling pathway and NLRP3 inflammasome activation","volume":"10","author":"Jia","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.smim.2023.101781_bib110","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/s41419-018-1029-4","article-title":"Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.smim.2023.101781_bib111","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1126\/science.abb9818","article-title":"Succination inactivates gasdermin D and blocks pyroptosis","volume":"369","author":"Humphries","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.smim.2023.101781_bib112","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/cdd.2015.176","article-title":"Inflammasome-dependent IL-1\u03b2 release depends upon membrane permeabilisation","volume":"23","author":"Mart\u00edn-S\u00e1nchez","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.smim.2023.101781_bib113","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3389\/fendo.2019.00603","article-title":"TLR4\/NF-\u03baB Signaling Induces GSDMD-Related pyroptosis in tubular cells in diabetic kidney disease","volume":"10","author":"Wang","year":"2019","journal-title":"Front Endocrinol."},{"key":"10.1016\/j.smim.2023.101781_bib114","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0002-9343(90)90534-K","article-title":"Disulfiram treatment of alcoholism","volume":"88","author":"Wright","year":"1990","journal-title":"Am. J. Med."},{"key":"10.1016\/j.smim.2023.101781_bib115","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","article-title":"FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation","volume":"21","author":"Hu","year":"2020","journal-title":"Nat. Immunol."}],"container-title":["Seminars in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532323000726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532323000726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T23:23:24Z","timestamp":1760916204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044532323000726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":115,"alternative-id":["S1044532323000726"],"URL":"https:\/\/doi.org\/10.1016\/j.smim.2023.101781","relation":{},"ISSN":["1044-5323"],"issn-type":[{"value":"1044-5323","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pyroptosis-induced inflammation and tissue damage","name":"articletitle","label":"Article Title"},{"value":"Seminars in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.smim.2023.101781","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101781"}}