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Cell Res."},{"key":"10.1016\/j.smim.2023.101809_bib72","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nm.3866","article-title":"KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis","volume":"21","author":"Shankman","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.smim.2023.101809_bib73","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.bbrc.2018.03.005","article-title":"AIM2 accelerates the atherosclerotic plaque progressions in ApoE-\/- mice","volume":"498","author":"Pan","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.smim.2023.101809_bib74","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1093\/eurheartj\/ehx362","article-title":"Infections, atherosclerosis, and coronary heart disease","volume":"38","author":"Pothineni","year":"2017","journal-title":"Eur. 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Res."},{"key":"10.1016\/j.smim.2023.101809_bib81","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jdiacomp.2015.12.018","article-title":"Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications","volume":"30","author":"Domingueti","year":"2016","journal-title":"J. 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Rev."},{"key":"10.1016\/j.smim.2023.101809_bib88","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41569-020-00492-2","article-title":"Pathophysiology of sepsis-induced cardiomyopathy","volume":"18","author":"Hollenberg","year":"2021","journal-title":"Nat. Rev. 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Sarcopenia Muscle"},{"key":"10.1016\/j.smim.2023.101809_bib92","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.immuni.2019.04.003","article-title":"Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis","volume":"50","author":"Wu","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2023.101809_bib93","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1152\/ajpheart.00731.2019","article-title":"PhospholipaseC\u03b31\/calcium-dependent membranous localization of Gsdmd-N drives endothelial pyroptosis, contributing to lipopolysaccharide-induced fatal outcome","volume":"319","author":"Liu","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.smim.2023.101809_bib94","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1093985","article-title":"The role of pyroptosis in endothelial dysfunction induced by diseases","volume":"13","author":"Ju","year":"2023","journal-title":"Front. 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