{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T07:09:20Z","timestamp":1788764960626,"version":"build-2803163510"},"reference-count":163,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2022NKEXAT"],"award-info":[{"award-number":["2022NKEXAT"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"AIRC Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["AIRC IG 30875"],"award-info":[{"award-number":["AIRC IG 30875"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["AIRC Start-UP 25828"],"award-info":[{"award-number":["AIRC Start-UP 25828"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministry of Health","doi-asserted-by":"publisher","award":["PNRR-MAD-2022-12375947"],"award-info":[{"award-number":["PNRR-MAD-2022-12375947"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministry of Health","doi-asserted-by":"publisher","award":["PNC-E3-2022-23683266 PNC-HLS-DA"],"award-info":[{"award-number":["PNC-E3-2022-23683266 PNC-HLS-DA"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011713","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","award":["25-0175"],"award-info":[{"award-number":["25-0175"]}],"id":[{"id":"10.13039\/100011713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009882","name":"Lombardy Region","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009882","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Immunology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.smim.2026.102051","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T15:38:54Z","timestamp":1786203534000},"page":"102051","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The IL-1 system in inflammation and cancer"],"prefix":"10.1016","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1510-7703","authenticated-orcid":false,"given":"Cecilia","family":"Garlanda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bonavita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Garuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Supino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Scavello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9255","key":"10.1016\/j.smim.2026.102051_bib1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","article-title":"Inflammation and cancer: back to Virchow?","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"issue":"6117","key":"10.1016\/j.smim.2026.102051_bib2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.1232227","article-title":"Neutralizing tumor-promoting chronic inflammation: a magic bullet?","volume":"339","author":"Coussens","year":"2013","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.smim.2026.102051_bib3","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrclinonc.2017.101","article-title":"The immune contexture in cancer prognosis and treatment","volume":"14","author":"Fridman","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and cancer: triggers, mechanisms, and consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib5","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"7203","key":"10.1016\/j.smim.2026.102051_bib6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.smim.2026.102051_bib7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.immuni.2019.06.021","article-title":"Pas de Deux: control of anti-tumor immunity by cancer-associated inflammation","volume":"51","author":"Shalapour","year":"2019","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.smim.2026.102051_bib9","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.immuni.2013.11.010","article-title":"The interleukin-1 family: back to the future","volume":"39","author":"Garlanda","year":"2013","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib10","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.immuni.2019.03.012","article-title":"Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity","volume":"50","author":"Mantovani","year":"2019","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s10555-006-9004-4","article-title":"The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions","volume":"25","author":"Apte","year":"2006","journal-title":"Cancer Metastas-.-. Rev."},{"key":"10.1016\/j.smim.2026.102051_bib12","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/imr.12606","article-title":"The family of the interleukin-1 receptors","volume":"281","author":"Boraschi","year":"2018","journal-title":"Immunol. Rev."},{"issue":"11","key":"10.1016\/j.smim.2026.102051_bib14","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/s41423-025-01358-8","article-title":"IL-1 family cytokines in inflammation and immunity","volume":"22","author":"Garlanda","year":"2025","journal-title":"Cell. Mol. Immunol."},{"issue":"6","key":"10.1016\/j.smim.2026.102051_bib15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.smim.2013.10.001","article-title":"Overview of the interleukin-1 family of ligands and receptors","volume":"25","author":"Dinarello","year":"2013","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.smim.2026.102051_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.872155","article-title":"What Is IL-1 for? The Functions of Interleukin-1 Across Evolution","volume":"13","author":"Boraschi","year":"2022","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41590-024-01777-1","article-title":"International nomenclature guidelines for the IL-1 family of cytokines and receptors","volume":"25","author":"Gaballa","year":"2024","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41584-023-01053-w","article-title":"Biological and clinical roles of IL-18 in inflammatory diseases","volume":"20","author":"Landy","year":"2024","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.smim.2026.102051_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155824","article-title":"Interleukin-38 in Health and Disease","volume":"152","author":"de Graaf","year":"2022","journal-title":"Cytokine"},{"issue":"5120","key":"10.1016\/j.smim.2026.102051_bib20","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.8332913","article-title":"Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4","volume":"261","author":"Colotta","year":"1993","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.smim.2026.102051_bib21","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1073\/pnas.0308680101","article-title":"Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family","volume":"101","author":"Garlanda","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.smim.2026.102051_bib22","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/ni968","article-title":"SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling","volume":"4","author":"Wald","year":"2003","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib23","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng756","article-title":"Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome","volume":"29","author":"Hoffman","year":"2001","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12621","article-title":"Overview of the IL-1 family in innate inflammation and acquired immunity","volume":"281","author":"Dinarello","year":"2018","journal-title":"Immunol. Rev."},{"issue":"11","key":"10.1016\/j.smim.2026.102051_bib25","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.cell.2023.04.025","article-title":"A 360 \u00b0 view of the inflammasome: mechanisms of activation, cell death, and diseases","volume":"186","author":"Barnett","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41577-024-01075-9","article-title":"Inflammasome components as new therapeutic targets in inflammatory disease","volume":"25","author":"Coll","year":"2025","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.immuni.2017.11.013","article-title":"The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages","volume":"48","author":"Evavold","year":"2018","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev-pathmechdis-042624-121548","article-title":"Gasdermins, executors of pyroptosis: a decade in perspective","volume":"21","author":"Zhou","year":"2026","journal-title":"Annu. Rev. Pathol."},{"issue":"6","key":"10.1016\/j.smim.2026.102051_bib29","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.immuni.2015.06.003","article-title":"Proteolytic processing of Interleukin-1 Family Cytokines: variations on a common theme","volume":"42","author":"Afonina","year":"2015","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib30","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.immuni.2019.03.003","article-title":"The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1alpha by Thrombin","volume":"50","author":"Burzynski","year":"2019","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib31","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41590-018-0067-5","article-title":"Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33","volume":"19","author":"Cayrol","year":"2018","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.smim.2026.102051_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108515","article-title":"The Proinflammatory Cytokine IL-36gamma Is a Global Discriminator of Harmless Microbes and Invasive Pathogens within Epithelial Tissues","volume":"33","author":"Macleod","year":"2020","journal-title":"Cell. Rep."},{"issue":"12","key":"10.1016\/j.smim.2026.102051_bib33","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1038\/s41590-025-02319-z","article-title":"Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1beta in human monocytes","volume":"26","author":"Vande Walle","year":"2025","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib34","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41590-025-02088-9","article-title":"Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants","volume":"26","author":"Feng","year":"2025","journal-title":"Nat. Immunol."},{"issue":"6417","key":"10.1016\/j.smim.2026.102051_bib35","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.aar7607","article-title":"ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation","volume":"362","author":"Ruhl","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.smim.2026.102051_bib36","article-title":"Uncoupled pyroptosis and IL-1beta secretion downstream of inflammasome signaling","volume":"14","author":"Li","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.smim.2026.102051_bib37","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.celrep.2014.06.028","article-title":"The neutrophil NLRC4 inflammasome selectively promotes IL-1beta maturation without pyroptosis during acute Salmonella challenge","volume":"8","author":"Chen","year":"2014","journal-title":"Cell. Rep."},{"issue":"108","key":"10.1016\/j.smim.2026.102051_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adq0043","article-title":"TNF switches homeostatic efferocytosis to lytic caspase-8-dependent pyroptosis and IL-1beta maturation","volume":"10","author":"Muendlein","year":"2025","journal-title":"Sci. Immunol."},{"issue":"8","key":"10.1016\/j.smim.2026.102051_bib39","doi-asserted-by":"crossref","DOI":"10.1172\/JCI198076","article-title":"GSDME-IL-18 pyroptotic axis prevents myosteatosis by expanding tissue-resident macrophages to promote muscle regeneration","volume":"136","author":"Cao","year":"2026","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib40","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41419-023-05680-9","article-title":"Honokiol suppresses the aberrant interactions between renal resident macrophages and tubular epithelial cells in lupus nephritis through the NLRP3\/IL-33\/ST2 axis","volume":"14","author":"Ma","year":"2023","journal-title":"Cell. Death Dis."},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib41","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ni.2215","article-title":"Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction","volume":"13","author":"Shi","year":"2012","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib42","doi-asserted-by":"crossref","DOI":"10.1111\/imr.13410","article-title":"Regulation of the NLRP3 inflammasome by autophagy and mitophagy","volume":"329","author":"Gupta","year":"2025","journal-title":"Immunol. Rev."},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib43","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2015.12.057","article-title":"NF-kappaB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria","volume":"164","author":"Zhong","year":"2016","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.smim.2026.102051_bib44","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.immuni.2013.08.001","article-title":"Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation","volume":"39","author":"Iyer","year":"2013","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib45","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2015632118","article-title":"Recruitment of pro-IL-1alpha to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation","volume":"118","author":"Dagvadorj","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib46","article-title":"NLRP3 inflammasome inhibits mitophagy during the progression of temporal lobe epilepsy","volume":"15","author":"Wu","year":"2025","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.smim.2026.102051_bib47","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/ncb3346","article-title":"Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal","volume":"18","author":"Pietras","year":"2016","journal-title":"Nat. Cell. Biol."},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib48","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.it.2017.01.004","article-title":"Regulation of Inflammation- and Infection-Driven Hematopoiesis","volume":"38","author":"Boettcher","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.smim.2026.102051_bib49","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.smim.2018.10.011","article-title":"Aging, inflammation and cancer","volume":"40","author":"Bottazzi","year":"2018","journal-title":"Semin. Immunol."},{"issue":"6","key":"10.1016\/j.smim.2026.102051_bib50","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib51","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1182\/blood.2021011570","article-title":"IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice","volume":"139","author":"Kovtonyuk","year":"2022","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.smim.2026.102051_bib52","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1182\/blood.2022016835","article-title":"Aging drives Tet2+\/- clonal hematopoiesis via IL-1 signaling","volume":"141","author":"Caiado","year":"2023","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.smim.2026.102051_bib53","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1182\/blood.2022017933","article-title":"Hematopoietic stem cell aging and leukemia transformation","volume":"142","author":"Colom Diaz","year":"2023","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib54","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1182\/blood.2023023105","article-title":"IL-1 in aging and pathologies of hematopoietic stem cells","volume":"144","author":"Caiado","year":"2024","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.smim.2026.102051_bib55","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1161\/ATVBAHA.114.303887","article-title":"Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes","volume":"34","author":"Bekkering","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1-2","key":"10.1016\/j.smim.2026.102051_bib56","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2017.12.031","article-title":"BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis","volume":"172","author":"Kaufmann","year":"2018","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.smim.2026.102051_bib57","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.cmet.2016.10.008","article-title":"Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity","volume":"24","author":"Arts","year":"2016","journal-title":"Cell. Metab."},{"issue":"1-2","key":"10.1016\/j.smim.2026.102051_bib58","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib59","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/ni.3659","article-title":"Postprandial macrophage-derived IL-1beta stimulates insulin, and both synergistically promote glucose disposal and inflammation","volume":"18","author":"Dror","year":"2017","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.smim.2026.102051_bib60","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1007\/s00125-006-0335-z","article-title":"Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes","volume":"49","author":"Lagathu","year":"2006","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib61","doi-asserted-by":"crossref","first-page":"E289","DOI":"10.1152\/ajpendo.00430.2013","article-title":"Interleukin-1beta mediates macrophage-induced impairment of insulin signaling in human primary adipocytes","volume":"307","author":"Gao","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"15","key":"10.1016\/j.smim.2026.102051_bib62","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1056\/NEJMoa065213","article-title":"Interleukin-1-receptor antagonist in type 2 diabetes mellitus","volume":"356","author":"Larsen","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"6577","key":"10.1016\/j.smim.2026.102051_bib63","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1126\/science.abg3067","article-title":"Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production","volume":"375","author":"Orecchioni","year":"2022","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.smim.2026.102051_bib64","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41575-021-00448-y","article-title":"The complex link between NAFLD and type 2 diabetes mellitus - mechanisms and treatments","volume":"18","author":"Targher","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.smim.2026.102051_bib65","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/nm1415","article-title":"Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance","volume":"12","author":"Netea","year":"2006","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib66","doi-asserted-by":"crossref","first-page":"7582","DOI":"10.1038\/s41467-022-35256-8","article-title":"Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib67","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.immuni.2017.10.015","article-title":"Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production","volume":"47","author":"Dalmas","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.smim.2026.102051_bib68","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1038\/ncomms5711","article-title":"IL-37 protects against obesity-induced inflammation and insulin resistance","volume":"5","author":"Ballak","year":"2014","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib69","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.ymthe.2026.01.001","article-title":"IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activity","volume":"34","author":"Barragan Bravo","year":"2026","journal-title":"Mol. Ther."},{"issue":"6782","key":"10.1016\/j.smim.2026.102051_bib70","doi-asserted-by":"crossref","DOI":"10.1126\/science.adq9006","article-title":"Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity","volume":"391","author":"Liu","year":"2026","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib71","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41575-025-01141-0","article-title":"IL-1 family of cytokines in gastrointestinal and liver disorders","volume":"23","author":"Schwarzler","year":"2026","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib72","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.immuni.2025.11.015","article-title":"Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages","volume":"59","author":"Verwaerde","year":"2026","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.smim.2026.102051_bib73","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.immuni.2026.01.005","article-title":"Commensal-myeloid crosstalk in neonatal skin regulates interleukin-1 signaling and cutaneous type 17 inflammation","volume":"59","author":"Dhariwala","year":"2026","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.smim.2026.102051_bib74","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/carcin\/bgp127","article-title":"Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability","volume":"30","author":"Colotta","year":"2009","journal-title":"Carcinogenesis"},{"issue":"8","key":"10.1016\/j.smim.2026.102051_bib75","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.ccell.2021.04.011","article-title":"Interleukin-1 in tumor progression, therapy, and prevention","volume":"39","author":"Garlanda","year":"2021","journal-title":"Cancer Cell."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib76","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/imr.12615","article-title":"Function and regulation of IL-1alpha in inflammatory diseases and cancer","volume":"281","author":"Malik","year":"2018","journal-title":"Immunol. Rev."},{"issue":"7986","key":"10.1016\/j.smim.2026.102051_bib77","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-023-06685-2","article-title":"IL-1beta(+) macrophages fuel pathogenic inflammation in pancreatic cancer","volume":"623","author":"Caronni","year":"2023","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib78","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12943-017-0606-y","article-title":"Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells","volume":"16","author":"Chung","year":"2017","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib79","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.immuni.2018.11.015","article-title":"Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer","volume":"50","author":"Dmitrieva-Posocco","year":"2019","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib80","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1007\/s10120-022-01297-7","article-title":"Ubiquitination of ADRalpha1d\/SerpinA1 complex stimulates hypoxia to induce gastric tumorigenesis with a combination of Helicobacter pylori and chronic stress through IL-1alpha","volume":"25","author":"Aziz","year":"2022","journal-title":"Gastric Cancer"},{"issue":"7955","key":"10.1016\/j.smim.2026.102051_bib81","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41586-023-05874-3","article-title":"Lung adenocarcinoma promotion by air pollutants","volume":"616","author":"Hill","year":"2023","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib82","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/jcp.24816","article-title":"IL-1beta promotes malignant transformation and tumor aggressiveness in oral cancer","volume":"230","author":"Lee","year":"2015","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib83","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.immuni.2007.02.012","article-title":"The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis","volume":"26","author":"Xiao","year":"2007","journal-title":"Immunity"},{"issue":"13","key":"10.1016\/j.smim.2026.102051_bib84","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1158\/0008-5472.CAN-07-0560","article-title":"Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family","volume":"67","author":"Garlanda","year":"2007","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.smim.2026.102051_bib85","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1158\/2326-6066.CIR-18-0698","article-title":"IL1R8 Deficiency Drives Autoimmunity-Associated Lymphoma Development","volume":"7","author":"Riva","year":"2019","journal-title":"Cancer Immunol. Res."},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib86","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1182\/blood-2011-01-329870","article-title":"Lack of TIR8\/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models","volume":"118","author":"Bertilaccio","year":"2011","journal-title":"Blood"},{"issue":"30","key":"10.1016\/j.smim.2026.102051_bib87","doi-asserted-by":"crossref","first-page":"49470","DOI":"10.18632\/oncotarget.17713","article-title":"High IL-1R8 expression in breast tumors promotes tumor growth and contributes to impaired antitumor immunity","volume":"8","author":"Campesato","year":"2017","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib88","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1158\/0008-5472.CAN-17-1887","article-title":"Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism","volume":"78","author":"Deswaerte","year":"2018","journal-title":"Cancer Res."},{"issue":"7817","key":"10.1016\/j.smim.2026.102051_bib89","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41586-020-2422-6","article-title":"IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy","volume":"583","author":"Zhou","year":"2020","journal-title":"Nature"},{"issue":"6501","key":"10.1016\/j.smim.2026.102051_bib90","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay1813","article-title":"Tumor-initiating cells establish an IL-33-TGF-beta niche signaling loop to promote cancer progression","volume":"369","author":"Taniguchi","year":"2020","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.smim.2026.102051_bib91","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1158\/0008-5472.CAN-16-1602","article-title":"IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment","volume":"77","author":"Fang","year":"2017","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib92","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/s41385-019-0176-y","article-title":"The IL-33\/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer","volume":"12","author":"Pastille","year":"2019","journal-title":"Mucosal Immunol."},{"issue":"56","key":"10.1016\/j.smim.2026.102051_bib93","doi-asserted-by":"crossref","first-page":"30894","DOI":"10.18632\/oncotarget.25768","article-title":"ST2\/IL-33 signaling promotes malignant development of experimental squamous cell carcinoma by decreasing NK cells cytotoxicity and modulating the intratumoral cell infiltrate","volume":"9","author":"Amor","year":"2018","journal-title":"Oncotarget"},{"issue":"8052","key":"10.1016\/j.smim.2026.102051_bib94","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s41586-024-08426-5","article-title":"IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer","volume":"638","author":"Amisaki","year":"2025","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.smim.2026.102051_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115837","article-title":"The IL-33\/ST2 axis and tissue Treg maintain epithelial homeostasis and restrain cancer development in the skin","volume":"44","author":"Ward","year":"2025","journal-title":"Cell. Rep."},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib96","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1158\/2326-6066.CIR-17-0218","article-title":"Interleukin 33 Signaling Restrains Sporadic Colon Cancer in an Interferon-gamma-Dependent Manner","volume":"6","author":"Eissmann","year":"2018","journal-title":"Cancer Immunol. Res."},{"issue":"15","key":"10.1016\/j.smim.2026.102051_bib97","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.3390\/cancers14153654","article-title":"Regulation of Interleukin-36gamma\/IL-36R Signaling Axis by PIN1 in Epithelial Cell Transformation and Breast Tumorigenesis","volume":"14","author":"Poudel","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib98","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cell.2021.01.010","article-title":"A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells","volume":"184","author":"Cheng","year":"2021","journal-title":"Cell"},{"issue":"18","key":"10.1016\/j.smim.2026.102051_bib99","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1016\/j.cell.2021.08.003","article-title":"Spatially organized multicellular immune hubs in human colorectal cancer","volume":"184","author":"Pelka","year":"2021","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib100","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1073\/pnas.1812266115","article-title":"Blocking IL-1beta reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation","volume":"116","author":"Kaplanov","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.smim.2026.102051_bib101","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/j.ccell.2024.10.014","article-title":"Interleukin-1alpha release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity","volume":"42","author":"Hanggi","year":"2024","journal-title":"Cancer Cell."},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib102","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s41590-024-01808-x","article-title":"An IL-1beta-driven neutrophil-stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma","volume":"25","author":"de Jong","year":"2024","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.smim.2026.102051_bib103","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.ccell.2025.04.007","article-title":"Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread","volume":"43","author":"Garner","year":"2025","journal-title":"Cancer Cell."},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib104","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1158\/2326-6066.CIR-25-0651","article-title":"IL1R2 Deficiency Unleashes Neutrophil-Mediated Antitumor Potential in Sarcoma","volume":"14","author":"Mariancini","year":"2026","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.smim.2026.102051_bib105","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The Dendritic Cell Lineage: ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting","volume":"31","author":"Merad","year":"2013","journal-title":"Annu. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib106","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ni.2514","article-title":"IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus","volume":"14","author":"Pang","year":"2013","journal-title":"Nat. Immunol."},{"issue":"22","key":"10.1016\/j.smim.2026.102051_bib107","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1182\/blood-2011-05-356873","article-title":"IL-36R ligands are potent regulators of dendritic and T cells","volume":"118","author":"Vigne","year":"2011","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.smim.2026.102051_bib108","doi-asserted-by":"crossref","first-page":"6053","DOI":"10.4049\/jimmunol.1301481","article-title":"IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin","volume":"192","author":"Foster","year":"2014","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.smim.2026.102051_bib109","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.immuni.2020.04.005","article-title":"Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection","volume":"52","author":"Bosteels","year":"2020","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib110","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.4049\/jimmunol.1501399","article-title":"Exogenous IL-33 Restores Dendritic Cell Activation and Maturation in Established Cancer","volume":"198","author":"Dominguez","year":"2017","journal-title":"J. Immunol."},{"issue":"15","key":"10.1016\/j.smim.2026.102051_bib111","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1158\/0008-5472.CAN-12-4366","article-title":"IL-18-primed helper NK cells collaborate with dendritic cells to promote recruitment of effector CD8+ T cells to the tumor microenvironment","volume":"73","author":"Wong","year":"2013","journal-title":"Cancer Res."},{"issue":"7822","key":"10.1016\/j.smim.2026.102051_bib112","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41586-020-2611-3","article-title":"cDC1 prime and are licensed by CD4(+) T cells to induce anti-tumour immunity","volume":"584","author":"Ferris","year":"2020","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib113","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.cell.2018.01.004","article-title":"NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control","volume":"172","author":"Bottcher","year":"2018","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib114","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cell.2019.02.005","article-title":"Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4(+) T Cell Immunity","volume":"177","author":"Binnewies","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib115","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1038\/s41467-023-39953-w","article-title":"IL1R1(+) cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer","volume":"14","author":"Koncina","year":"2023","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.smim.2026.102051_bib116","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009523","article-title":"Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment","volume":"12","author":"Hansen","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"7","key":"10.1016\/j.smim.2026.102051_bib117","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1158\/0008-5472.CAN-17-1366","article-title":"Tumor-Stroma IL1beta-IRAK4 feedforward circuitry drives tumor fibrosis, chemoresistance, and poor prognosis in pancreatic cancer","volume":"78","author":"Zhang","year":"2018","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.smim.2026.102051_bib118","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ccell.2022.01.004","article-title":"Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer","volume":"40","author":"Nicolas","year":"2022","journal-title":"Cancer Cell."},{"issue":"2","key":"10.1016\/j.smim.2026.102051_bib119","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1158\/2159-8290.CD-18-0710","article-title":"IL1-Induced JAK\/STAT Signaling Is Antagonized by TGFbeta to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma","volume":"9","author":"Biffi","year":"2019","journal-title":"Cancer Discov."},{"issue":"20","key":"10.1016\/j.smim.2026.102051_bib120","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122375","article-title":"Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis","volume":"3","author":"Andersson","year":"2018","journal-title":"JCI Insight"},{"issue":"23","key":"10.1016\/j.smim.2026.102051_bib121","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1158\/0008-5472.CAN-20-2116","article-title":"Fibroblast-Derived IL33 Facilitates Breast Cancer Metastasis by Modifying the Immune Microenvironment and Driving Type 2 Immunity","volume":"80","author":"Shani","year":"2020","journal-title":"Cancer Res."},{"issue":"19","key":"10.1016\/j.smim.2026.102051_bib122","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1422445112","article-title":"IL-33 activates tumor stroma to promote intestinal polyposis","volume":"112","author":"Maywald","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib123","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.ccell.2019.04.003","article-title":"Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation","volume":"35","author":"Segovia","year":"2019","journal-title":"Cancer Cell."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib124","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-64839-4","article-title":"Cancer cell-derived IL-1beta reverses chemo-immunotherapy resistance in non-small cell lung cancer","volume":"16","author":"Perrichet","year":"2025","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.smim.2026.102051_bib125","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1158\/2326-6066.CIR-19-1024","article-title":"Tumor-Derived IL33 Promotes Tissue-Resident CD8(+) T Cells and Is Required for Checkpoint Blockade Tumor Immunotherapy","volume":"8","author":"Chen","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.smim.2026.102051_bib126","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3389\/fimmu.2018.00763","article-title":"Unique Action of Interleukin-18 on T Cells and Other Immune Cells","volume":"9","author":"Nakanishi","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib127","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.184545","article-title":"Decoy-resistant IL-18 reshapes the tumor microenvironment and enhances rejection by anti-CTLA-4 in renal cell carcinoma","volume":"10","author":"Schoenfeld","year":"2024","journal-title":"JCI Insight"},{"issue":"10","key":"10.1016\/j.smim.2026.102051_bib128","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.trecan.2025.06.008","article-title":"IL-18 revives dysfunctional CAR-T cells","volume":"11","author":"Li","year":"2025","journal-title":"Trends Cancer"},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib129","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1158\/2326-6066.CIR-22-0398","article-title":"IL18 receptor signaling regulates tumor-reactive CD8+ T-cell exhaustion via activation of the IL2\/STAT5\/mTOR pathway in a pancreatic cancer model","volume":"11","author":"Lutz","year":"2023","journal-title":"Cancer Immunol. Res."},{"issue":"7678","key":"10.1016\/j.smim.2026.102051_bib130","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature24293","article-title":"IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity","volume":"551","author":"Molgora","year":"2017","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib131","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003858","article-title":"IL-1R8 silencing improves the anti-tumor function of freshly isolated human NK cells","volume":"10","author":"Landolina","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"24","key":"10.1016\/j.smim.2026.102051_bib132","doi-asserted-by":"crossref","DOI":"10.1172\/JCI190778","article-title":"Tissue-specific antitumor NK cell subsets identified in colorectal cancer liver metastases express candidate therapeutic targets","volume":"135","author":"Mikulak","year":"2025","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.smim.2026.102051_bib133","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1158\/2326-6066.CIR-17-0498","article-title":"Adaptive NK Cells Resist Regulatory T-cell Suppression Driven by IL37","volume":"6","author":"Sarhan","year":"2018","journal-title":"Cancer Immunol. Res."},{"issue":"7","key":"10.1016\/j.smim.2026.102051_bib134","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/s41591-018-0045-3","article-title":"Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing","volume":"24","author":"Guo","year":"2018","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib135","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.immuni.2016.10.032","article-title":"Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer","volume":"45","author":"Plitas","year":"2016","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib136","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.immuni.2016.10.021","article-title":"Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells","volume":"45","author":"De Simone","year":"2016","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.smim.2026.102051_bib137","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004585","article-title":"IL1R2 increases regulatory T cell population in the tumor microenvironment by enhancing MHC-II expression on cancer-associated fibroblasts","volume":"10","author":"Chen","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"23","key":"10.1016\/j.smim.2026.102051_bib138","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1158\/0008-5472.CAN-24-3095","article-title":"Depleting IL1R2 Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti-PD-1 Immunotherapy","volume":"85","author":"Arnouk","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.smim.2026.102051_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108545","article-title":"NLRP3 and cancer: Pathogenesis and therapeutic opportunities","volume":"251","author":"Tengesdal","year":"2023","journal-title":"Pharmacol. Ther."},{"issue":"10105","key":"10.1016\/j.smim.2026.102051_bib140","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0140-6736(17)32247-X","article-title":"Effect of interleukin-1beta inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial","volume":"390","author":"Ridker","year":"2017","journal-title":"Lancet"},{"issue":"21","key":"10.1016\/j.smim.2026.102051_bib141","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1016\/j.jacc.2018.03.002","article-title":"Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes","volume":"71","author":"Everett","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib142","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014941","article-title":"Interleukin-1 Blockade Inhibits the Acute Inflammatory Response in Patients With ST-Segment-Elevation Myocardial Infarction","volume":"9","author":"Abbate","year":"2020","journal-title":"J. Am. Heart Assoc."},{"issue":"10","key":"10.1016\/j.smim.2026.102051_bib143","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/s41591-021-01499-z","article-title":"Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial","volume":"27","author":"Kyriazopoulou","year":"2021","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib144","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1016\/S2665-9913(20)30065-5","article-title":"Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial","volume":"2","author":"Kluck","year":"2020","journal-title":"Lancet Rheumatol."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib145","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/FJC.0000000000000931","article-title":"Phase 1B, Randomized, Double-Blinded, Dose Escalation, Single-Center, Repeat Dose Safety and Pharmacodynamics Study of the Oral NLRP3 Inhibitor Dapansutrile in Subjects With NYHA II-III Systolic Heart Failure","volume":"77","author":"Wohlford","year":"2020","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.smim.2026.102051_bib146","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1200\/JCO.23.00980","article-title":"Canakinumab Versus Placebo in Combination With First-Line Pembrolizumab Plus Chemotherapy for Advanced Non-Small-Cell Lung Cancer: Results From the CANOPY-1 Trial","volume":"42","author":"Tan","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.smim.2026.102051_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2023.107451","volume":"189","author":"Paz-Ares","year":"2024","journal-title":"Lung Cancer"},{"issue":"2","key":"10.1016\/j.smim.2026.102051_bib148","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S1470-2045(17)30006-2","article-title":"MABp1 as a novel antibody treatment for advanced colorectal cancer: a randomised, double-blind, placebo-controlled, phase 3 study","volume":"18","author":"Hickish","year":"2017","journal-title":"Lancet Oncol."},{"issue":"10","key":"10.1016\/j.smim.2026.102051_bib149","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2000915118","article-title":"Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion","volume":"118","author":"Tengesdal","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.smim.2026.102051_bib150","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1158\/2767-9764.CRC-23-0065","article-title":"Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment","volume":"3","author":"Amo-Aparicio","year":"2023","journal-title":"Cancer Res. Commun."},{"issue":"5","key":"10.1016\/j.smim.2026.102051_bib151","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3390\/ph15050574","article-title":"Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers","volume":"15","author":"Tengesdal","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.smim.2026.102051_bib152","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108512","article-title":"NLRP3 promotes immune escape by regulating immune checkpoints: a pan-cancer analysis","volume":"104","author":"Ding","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"10118","key":"10.1016\/j.smim.2026.102051_bib153","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(17)32814-3","article-title":"Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial","volume":"391","author":"Ridker","year":"2018","journal-title":"Lancet"},{"issue":"31","key":"10.1016\/j.smim.2026.102051_bib154","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1093\/eurheartj\/ehaa160","article-title":"Comparison of interleukin-6, C-reactive protein, and low-density lipoprotein cholesterol as biomarkers of residual risk in contemporary practice: secondary analyses from the Cardiovascular Inflammation Reduction Trial","volume":"41","author":"Ridker","year":"2020","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.smim.2026.102051_bib155","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S2213-2600(20)30556-7","article-title":"Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial","volume":"9","author":"group","year":"2021","journal-title":"Lancet Respir. Med."},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib156","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1158\/2767-9764.CRC-24-0490","article-title":"The Impact of the Tumor Microenvironment on the Effect of IL-1beta Blockade in NSCLC: Biomarker Analyses from CANOPY-1 and CANOPY-N Trials","volume":"5","author":"Solomon","year":"2025","journal-title":"Cancer Res. Commun."},{"key":"10.1016\/j.smim.2026.102051_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2026.169941","article-title":"Clinical inflammasome biomarkers: Progress and prospects","author":"Coombs","year":"2026","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.smim.2026.102051_bib158","doi-asserted-by":"crossref","DOI":"10.1093\/cvr\/cvag135","article-title":"Associations of the inflammasome-dependent cytokine IL-18 with risk of coronary heart disease","author":"Bjorkbacka","year":"2026","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.smim.2026.102051_bib159","doi-asserted-by":"crossref","first-page":"H869","DOI":"10.1152\/ajpheart.00231.2024","article-title":"NLRP3 inflammasome-induced pyroptosis and serum ASC specks are increased in patients with cardiogenic shock","volume":"327","author":"Kogel","year":"2024","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.smim.2026.102051_bib160","doi-asserted-by":"crossref","DOI":"10.1080\/19420862.2023.2236265","article-title":"Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition","volume":"15","author":"Lipinski","year":"2023","journal-title":"MAbs"},{"issue":"7","key":"10.1016\/j.smim.2026.102051_bib161","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2025-011789","article-title":"Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy","volume":"13","author":"Bainbridge","year":"2025","journal-title":"J. Immunother. Cancer"},{"issue":"18","key":"10.1016\/j.smim.2026.102051_bib162","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1056\/NEJMoa2408771","article-title":"Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure","volume":"392","author":"Svoboda","year":"2025","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.smim.2026.102051_bib163","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1200\/JCO.23.00910","article-title":"Canakinumab as adjuvant therapy in patients with completely resected non-small-cell lung cancer: results from the CANOPY-a double-blind, randomized clinical trial","volume":"42","author":"Garon","year":"2024","journal-title":"J. Clin. Oncol."}],"container-title":["Seminars in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532326000382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1044532326000382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:42:10Z","timestamp":1788763330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1044532326000382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":163,"alternative-id":["S1044532326000382"],"URL":"https:\/\/doi.org\/10.1016\/j.smim.2026.102051","relation":{},"ISSN":["1044-5323"],"issn-type":[{"value":"1044-5323","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The IL-1 system in inflammation and cancer","name":"articletitle","label":"Article Title"},{"value":"Seminars in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.smim.2026.102051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102051"}}