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Commun."},{"issue":"6","key":"10.1016\/j.smim.2026.102053_bib90","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41556-020-0511-2","article-title":"FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome","volume":"22","author":"Li","year":"2020","journal-title":"Nat. Cell. Biol."},{"issue":"8045","key":"10.1016\/j.smim.2026.102053_bib91","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41586-024-08317-9","article-title":"FBP1 controls liver cancer evolution from senescent MASH hepatocytes","volume":"637","author":"Gu","year":"2025","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.smim.2026.102053_bib92","doi-asserted-by":"crossref","first-page":"651","DOI":"10.21873\/anticanres.17452","article-title":"Clinical impact of cellular senescence and RNA dysregulation in HCC is associated with MASLD and HCV-SVR","volume":"45","author":"Miyashita","year":"2025","journal-title":"Anticancer. Res."},{"issue":"3","key":"10.1016\/j.smim.2026.102053_bib93","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.21037\/tcr-2025-335","article-title":"A gene signature associated with cellular senescence serves as an important prognostic indicator in hepatocellular carcinoma","volume":"14","author":"Yan","year":"2025","journal-title":"Transl. Cancer Res."},{"issue":"1","key":"10.1016\/j.smim.2026.102053_bib94","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003069","article-title":"Hepatic stellate cell activation and senescence induced by intrahepatic microbiota disturbances drive progression of liver cirrhosis toward hepatocellular carcinoma","volume":"10","author":"Liu","year":"2022","journal-title":"J. Immunother. 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Ageing Dev."},{"issue":"2","key":"10.1016\/j.smim.2026.102053_bib101","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ccr.2014.01.003","article-title":"UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma","volume":"25","author":"Mudbhary","year":"2014","journal-title":"Cancer Cell."},{"issue":"3","key":"10.1016\/j.smim.2026.102053_bib102","doi-asserted-by":"crossref","first-page":"eadn2811","DOI":"10.1126\/sciadv.adn2811","article-title":"SMARCA4 regulates the NK-mediated killing of senescent cells","volume":"11","author":"Reen","year":"2025","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.smim.2026.102053_bib103","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/s41467-018-03555-8","article-title":"Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells","volume":"9","author":"Takahashi","year":"2018","journal-title":"Nat. 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Commun."},{"issue":"5","key":"10.1016\/j.smim.2026.102053_bib107","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1053\/j.gastro.2015.05.061","article-title":"Genetic landscape and biomarkers of hepatocellular carcinoma","volume":"149","author":"Zucman-Rossi","year":"2015","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.smim.2026.102053_bib108","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/febs.16325","article-title":"p53 in senescence\u2013it's a marathon, not a sprint","volume":"290","author":"Sheekey","year":"2023","journal-title":"FEBS J."},{"issue":"7777","key":"10.1016\/j.smim.2026.102053_bib109","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-019-1607-3","article-title":"Inducing and exploiting vulnerabilities for the treatment of liver cancer","volume":"574","author":"Wang","year":"2019","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.smim.2026.102053_bib110","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3390\/ijms26020773","article-title":"Cellular Senescence in Hepatocellular Carcinoma: Immune Microenvironment Insights via Machine Learning and In Vitro Experiments","volume":"26","author":"Lu","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.smim.2026.102053_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150576","article-title":"The cellular senescence score (CSS) is a comprehensive biomarker to predict prognosis and assess senescence and immune characteristics in hepatocellular carcinoma (HCC)","volume":"739","author":"He","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.smim.2026.102053_bib112","first-page":"1","article-title":"Distinct senotypes in p16-and p21-positive cells across human and mouse aging tissues","author":"Saul","year":"2025","journal-title":"EMBO J."},{"key":"10.1016\/j.smim.2026.102053_bib113","first-page":"1","article-title":"Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implications","author":"Park","year":"2025","journal-title":"Exp. & Mol. 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Rep."},{"issue":"3","key":"10.1016\/j.smim.2026.102053_bib116","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.7150\/thno.91119","article-title":"Tumor cell senescence-induced macrophage CD73 expression is a critical metabolic immune checkpoint in the aging tumor microenvironment","volume":"14","author":"Deng","year":"2024","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.smim.2026.102053_bib117","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41419-025-07589-x","article-title":"HELLS controls mitochondrial dynamics and genome stability in liver cancer by collusion with MIEF1","volume":"16","author":"Choi","year":"2025","journal-title":"Cell. 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