{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:41:07Z","timestamp":1774345267806,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Medicine Reviews"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.smrv.2005.04.002","type":"journal-article","created":{"date-parts":[[2005,7,6]],"date-time":"2005-07-06T18:02:27Z","timestamp":1120672947000},"page":"227-230","source":"Crossref","is-referenced-by-count":20,"title":["Hypocretin\/orexin: maintenance of wakefulness and a multiplicity of other roles"],"prefix":"10.1016","volume":"9","author":[{"given":"Thomas S.","family":"Kilduff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.smrv.2005.04.002_bib1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"de Lecea","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.smrv.2005.04.002_bib2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.smrv.2005.04.002_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)81965-0","article-title":"The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene","volume":"98","author":"Lin","year":"1999","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.smrv.2005.04.002_bib4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation","volume":"98","author":"Chemelli","year":"1999","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.smrv.2005.04.002_bib5","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/79690","article-title":"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains","volume":"6","author":"Peyron","year":"2000","journal-title":"Nat Med"},{"issue":"9197","key":"10.1016\/j.smrv.2005.04.002_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0140-6736(99)05582-8","article-title":"Hypocretin (orexin) deficiency in human narcolepsy","volume":"355","author":"Nishino","year":"2000","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.smrv.2005.04.002_bib7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","article-title":"Reduced number of hypocretin neurons in human narcolepsy","volume":"27","author":"Thannickal","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.smrv.2005.04.002_bib8","doi-asserted-by":"crossref","unstructured":"Sakurai T. Roles of orexin\/hypocretin in regulation of sleep\/wakefulness and energy homeostasis. Sleep Med Rev; 2005;9:231-41.","DOI":"10.1016\/j.smrv.2004.07.007"},{"issue":"1","key":"10.1016\/j.smrv.2005.04.002_bib9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0006-291X(03)00299-7","article-title":"Regulation of orexin neurons by the monoaminergic and cholinergic systems","volume":"303","author":"Yamanaka","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.smrv.2005.04.002_bib10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0896-6273(01)00293-8","article-title":"Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity","volume":"30","author":"Hara","year":"2001","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.smrv.2005.04.002_bib11","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1210\/jc.87.2.805","article-title":"Reduction of plasma leptin levels and loss of its circadian rhythmicity in hypocretin (orexin)-deficient narcoleptic humans","volume":"87","author":"Kok","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.smrv.2005.04.002_bib12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0896-6273(03)00331-3","article-title":"Hypothalamic orexin neurons regulate arousal according to energy balance in mice","volume":"38","author":"Yamanaka","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.smrv.2005.04.002_bib13","doi-asserted-by":"crossref","unstructured":"Baumann CR, Bassetti CL. Hypocretins (orexins): clinical impact of the discovery of a neurotransmitter. Sleep Med Rev; 2005;9:253-68.","DOI":"10.1016\/j.smrv.2005.01.005"},{"issue":"1","key":"10.1016\/j.smrv.2005.04.002_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/hmg\/ddi004","article-title":"Orexin loss in Huntington's disease","volume":"14","author":"Petersen","year":"2005","journal-title":"Hum Mol Genet"},{"issue":"1","key":"10.1016\/j.smrv.2005.04.002_bib15","first-page":"25","article-title":"Hypocretinergic neurons are primarily involved in activation of the somatomotor system","volume":"26","author":"Torterolo","year":"2003","journal-title":"Sleep"},{"key":"10.1016\/j.smrv.2005.04.002_bib16","doi-asserted-by":"crossref","unstructured":"Nishino S, Kanbayashi T. Symptomatic narcolepsy, cataplexy and hypersomnia and their implications in the hypothalamic hypocretin\/orexin system. Sleep Med Rev; 2005;9:269-310.","DOI":"10.1016\/j.smrv.2005.03.004"},{"key":"10.1016\/j.smrv.2005.04.002_bib17","doi-asserted-by":"crossref","unstructured":"Samson WK, Taylor MM, Ferguson AV. Non-sleep effects of hypocretin\/orexin. Sleep Med Rev; 2005;9:243-52.","DOI":"10.1016\/j.smrv.2004.07.006"},{"issue":"1\u20132","key":"10.1016\/j.smrv.2005.04.002_bib18","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0006-8993(99)01457-2","article-title":"Cardiovascular regulatory actions of the hypocretins in brain","volume":"831","author":"Samson","year":"1999","journal-title":"Brain Res"},{"issue":"50","key":"10.1016\/j.smrv.2005.04.002_bib19","doi-asserted-by":"crossref","first-page":"11439","DOI":"10.1523\/JNEUROSCI.3459-04.2004","article-title":"Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating the stress response","volume":"24","author":"Winsky-Sommerer","year":"2004","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.smrv.2005.04.002_bib20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.neuron.2004.08.005","article-title":"Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects","volume":"43","author":"Xu","year":"2004","journal-title":"Neuron"}],"container-title":["Sleep Medicine Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1087079205000341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1087079205000341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T14:50:22Z","timestamp":1548341422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1087079205000341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S1087079205000341"],"URL":"https:\/\/doi.org\/10.1016\/j.smrv.2005.04.002","relation":{},"ISSN":["1087-0792"],"issn-type":[{"value":"1087-0792","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}