{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T17:33:45Z","timestamp":1792863225859,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["421152132"],"award-info":[{"award-number":["421152132"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ANR-10-LABX-46-EGID"],"award-info":[{"award-number":["ANR-10-LABX-46-EGID"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1423_TP_B02"],"award-info":[{"award-number":["CRC1423_TP_B02"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KU 2673\/2-2"],"award-info":[{"award-number":["KU 2673\/2-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KU 2673\/6.1"],"award-info":[{"award-number":["KU 2673\/6.1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KU 2673\/7-1"],"award-info":[{"award-number":["KU 2673\/7-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010215","name":"Deutsche Diabetes Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010215","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","soard.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery for Obesity and Related Diseases"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.soard.2021.04.020","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T02:15:06Z","timestamp":1620440106000},"page":"1449-1456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Long-term outcomes of bariatric surgery in patients with bi-allelic mutations in the POMC, LEPR, and MC4R genes"],"prefix":"10.1016","volume":"17","author":[{"given":"Christine","family":"Poitou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Puder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Dubern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Krabusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Genser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Wiegand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Verkindt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvid","family":"K\u00f6hn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner Jumpertz","family":"von Schwartzenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Fl\u00fcck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Pattou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Laville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"K\u00fchnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Cl\u00e9ment","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 2","key":"10.1016\/j.soard.2021.04.020_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000375143","article-title":"The global burden of obesity and the challenges of prevention","volume":"66","author":"Seidell","year":"2015","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.soard.2021.04.020_bib2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1056\/NEJMe1706095","article-title":"Global health effects of overweight and obesity","volume":"377","author":"Gregg","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.soard.2021.04.020_bib3","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/S0140-6736(10)60171-7","article-title":"Childhood obesity","volume":"375","author":"Han","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.soard.2021.04.020_bib4","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1016\/S2468-2667(17)30074-9","article-title":"Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe","volume":"2","author":"Kivimaki","year":"2017","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.soard.2021.04.020_bib5","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0140-6736(09)60318-4","article-title":"Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies","volume":"373","author":"Prospective Studies","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.soard.2021.04.020_bib6","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1001\/archinte.160.7.898","article-title":"Overweight, obesity, and health risk","volume":"160","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.soard.2021.04.020_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232990","article-title":"Identifying underlying medical causes of pediatric obesity: results of a systematic diagnostic approach in a pediatric obesity center","volume":"15","author":"Kleinendorst","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.soard.2021.04.020_bib8","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nrendo.2013.57","article-title":"From obesity genetics to the future of personalized obesity therapy","volume":"9","author":"El-Sayed Moustafa","year":"2013","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.soard.2021.04.020_bib9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000445061","article-title":"Rare genetic forms of obesity: clinical approach and current treatments in 2016","volume":"9","author":"Huvenne","year":"2016","journal-title":"Obes Facts"},{"key":"10.1016\/j.soard.2021.04.020_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ng0398-213","article-title":"A leptin missense mutation associated with hypogonadism and morbid obesity","volume":"18","author":"Strobel","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.soard.2021.04.020_bib11","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/32911","article-title":"A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction","volume":"392","author":"Clement","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.soard.2021.04.020_bib12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ng0797-303","article-title":"Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene","volume":"16","author":"Jackson","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.soard.2021.04.020_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/509","article-title":"Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans","volume":"19","author":"Krude","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.soard.2021.04.020_bib14","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.2337\/db08-0153","article-title":"Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees","volume":"57","author":"Stutzmann","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.soard.2021.04.020_bib15","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1056\/NEJMoa022050","article-title":"Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene","volume":"348","author":"Farooqi","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.soard.2021.04.020_bib16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1056\/NEJMoa063988","article-title":"Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor","volume":"356","author":"Farooqi","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.soard.2021.04.020_bib17","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-221067","article-title":"Young girl with severe early-onset obesity and hyperphagia","volume":"2017","author":"Kleinendorst","year":"2017","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.soard.2021.04.020_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neuroscience.2020.04.034","article-title":"Recent updates on obesity treatments: available drugs and future directions","volume":"437","author":"Dragano","year":"2020","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.soard.2021.04.020_bib19","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S2213-8587(20)30364-8","article-title":"Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials","volume":"8","author":"Clement","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.soard.2021.04.020_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.mayocp.2016.09.017","article-title":"Review of childhood obesity: from epidemiology, etiology, and comorbidities to clinical assessment and treatment","volume":"92","author":"Kumar","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.soard.2021.04.020_bib21","first-page":"CD001872","article-title":"Interventions for treating obesity in children","volume":"1","author":"Oude Luttikhuis","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.soard.2021.04.020_bib22","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1056\/NEJMe1905778","article-title":"In teens with severe obesity, can bariatric surgery wait until adulthood?","volume":"380","author":"Adams","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.soard.2021.04.020_bib23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s11695-019-04184-w","article-title":"Genetic obesity and bariatric surgery outcome in 1014 patients with morbid obesity","volume":"30","author":"Cooiman","year":"2020","journal-title":"Obes Surg"},{"key":"10.1016\/j.soard.2021.04.020_bib24","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11892-020-01327-7","article-title":"Bariatric surgery for monogenic non-syndromic and syndromic obesity disorders","volume":"20","author":"Vos","year":"2020","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.soard.2021.04.020_bib25","doi-asserted-by":"crossref","first-page":"E1023","DOI":"10.1210\/jc.2011-3432","article-title":"Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery","volume":"97","author":"Hatoum","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.soard.2021.04.020_bib26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1210\/en.2008-0721","article-title":"Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor","volume":"150","author":"Tan","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.soard.2021.04.020_bib27","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1365-2265.2007.02788.x","article-title":"A novel mutation Thr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population","volume":"66","author":"Ochoa","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.soard.2021.04.020_bib28","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/ijo.2015.230","article-title":"Melanocortin-4 receptor signaling is not required for short-term weight loss after sleeve gastrectomy in pediatric patients","volume":"40","author":"Jelin","year":"2016","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.soard.2021.04.020_bib29","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1056\/NEJMc1200116","article-title":"Pregnancy in a woman with a leptin-receptor mutation","volume":"366","author":"Nizard","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.soard.2021.04.020_bib30","doi-asserted-by":"crossref","first-page":"E757","DOI":"10.1210\/jc.2015-1036","article-title":"Seven novel deleterious LEPR mutations found in early-onset obesity: a DeltaExon6-8 shared by subjects from Reunion Island, France, suggests a founder effect","volume":"100","author":"Huvenne","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.soard.2021.04.020_bib31","doi-asserted-by":"crossref","first-page":"E397","DOI":"10.1210\/jc.2012-2779","article-title":"Homozygous leptin receptor mutation due to uniparental disomy of chromosome 1: response to bariatric surgery","volume":"98","author":"Le Beyec","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.soard.2021.04.020_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1210\/js.2018-00123","article-title":"Functional and phenotypic characteristics of human leptin receptor mutations","volume":"3","author":"Nunziata","year":"2019","journal-title":"J Endocr Soc"},{"key":"10.1016\/j.soard.2021.04.020_bib33","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/oby.2008.507","article-title":"Capacity for physical activity predicts weight loss after Roux-en-Y gastric bypass","volume":"17","author":"Hatoum","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.soard.2021.04.020_bib34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1053\/j.sempedsurg.2013.10.017","article-title":"Genetic modifiers of obesity and bariatric surgery outcomes","volume":"23","author":"Sevilla","year":"2014","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.soard.2021.04.020_bib35","doi-asserted-by":"crossref","first-page":"e12575","DOI":"10.1111\/ijpo.12575","article-title":"Bariatric surgery for Prader-Willi syndrome was ineffective in producing sustainable weight loss: long term results for up to 10 years","volume":"15","author":"Liu","year":"2020","journal-title":"Pediatr Obes"},{"key":"10.1016\/j.soard.2021.04.020_bib36","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.soard.2015.07.014","article-title":"Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi syndrome: a matched-control study","volume":"12","author":"Alqahtani","year":"2016","journal-title":"Surg Obes Relat Dis"},{"key":"10.1016\/j.soard.2021.04.020_bib37","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1007\/s11695-012-0725-x","article-title":"Ghrelin level and weight loss after laparoscopic sleeve gastrectomy and gastric mini-bypass for Prader-Willi syndrome in Chinese","volume":"22","author":"Fong","year":"2012","journal-title":"Obes Surg"},{"key":"10.1016\/j.soard.2021.04.020_bib38","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1210\/jc.2016-2573","article-title":"Pediatric obesity-assessment, treatment, and prevention: an Endocrine Society clinical practice guideline","volume":"102","author":"Styne","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.soard.2021.04.020_bib39","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ijo.2010.168","article-title":"Bariatric surgery in a patient with complete MC4R deficiency","volume":"35","author":"Aslan","year":"2011","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.soard.2021.04.020_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000342556","article-title":"Treatment options for children with monogenic forms of obesity","volume":"106","author":"Hainerova","year":"2013","journal-title":"World Rev Nutr Diet"},{"key":"10.1016\/j.soard.2021.04.020_bib41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/oby.20511","article-title":"Weight loss after bariatric surgery in morbidly obese adolescents with MC4R mutations","volume":"22","author":"Censani","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.soard.2021.04.020_bib42","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41591-018-0015-9","article-title":"MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency","volume":"24","author":"Clement","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.soard.2021.04.020_bib43","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1056\/NEJMoa1512693","article-title":"Proopiomelanocortin deficiency treated with a melanocortin-4 receptor agonist","volume":"375","author":"Kuhnen","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.soard.2021.04.020_bib44","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s001120170107","article-title":"Perzentile f\u00fcr den body-mass-index f\u00fcr das kindes- und jugendalter unter heranziehung verschiedener deutscher stichproben","volume":"149","author":"Kromeyer-Hauschild","year":"2001","journal-title":"Monatszeitschrift Kinderheilkude"}],"container-title":["Surgery for Obesity and Related Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550728921002331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550728921002331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:16:55Z","timestamp":1761553015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550728921002331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S1550728921002331"],"URL":"https:\/\/doi.org\/10.1016\/j.soard.2021.04.020","relation":{},"ISSN":["1550-7289"],"issn-type":[{"value":"1550-7289","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term outcomes of bariatric surgery in patients with bi-allelic mutations in the POMC, LEPR, and MC4R genes","name":"articletitle","label":"Article Title"},{"value":"Surgery for Obesity and Related Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.soard.2021.04.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}