{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:40:25Z","timestamp":1761007225331,"version":"build-2065373602"},"reference-count":64,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgonc.theclinics.com","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgical Oncology Clinics of North America"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.soc.2023.03.003","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T15:42:27Z","timestamp":1680795747000},"page":"587-598","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Advances in Proton Therapy for the Management of Head and Neck Tumors"],"prefix":"10.1016","volume":"32","author":[{"given":"Jacob","family":"Trotter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.soc.2023.03.003_bib1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1148\/47.5.487","article-title":"Radiological use of fast protons","volume":"47","author":"Wilson","year":"1946","journal-title":"Radiology"},{"key":"10.1016\/j.soc.2023.03.003_bib2","first-page":"121","article-title":"Pituitary irradiation with high-energy proton beams: a preliminary report","volume":"18","author":"Lawrence","year":"1958","journal-title":"Cancer Res"},{"key":"10.1016\/j.soc.2023.03.003_bib3","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3109\/0284186X.2013.862596","article-title":"Late toxicity following craniospinal radiation for early-stage medulloblastoma","volume":"53","author":"Christopherson","year":"2014","journal-title":"Acta Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib4","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.ijrobp.2020.09.049","article-title":"A\u00a0Multi-institutional Comparative Analysis of Proton and Photon Therapy-Induced Hematologic Toxicity in Patients With Medulloblastoma","volume":"109","author":"Liu","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0360-3016(01)01613-3","article-title":"The benefits and pitfalls of ipsilateral radiotherapy in carcinoma of the tonsillar region","volume":"51","author":"O'Sullivan","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijrobp.2005.06.014","article-title":"Radiotherapy for early glottic carcinoma (T1N0M0): results of prospective randomized study of radiation fraction size and overall treatment time","volume":"64","author":"Yamazaki","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib7","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"350","author":"Bernier","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.soc.2023.03.003_bib8","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.soc.2023.03.003_bib9","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/hed.20279","article-title":"Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)","volume":"27","author":"Bernier","year":"2005","journal-title":"Head Neck"},{"key":"10.1016\/j.soc.2023.03.003_bib10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0360-3016(97)00817-1","article-title":"Combined neck dissection and postoperative radiation therapy in the management of the high-risk neck: a matched-pair analysis","volume":"40","author":"Lundahl","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib11","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa031317","article-title":"Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer","volume":"349","author":"Forastiere","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.soc.2023.03.003_bib12","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJM199106133242402","article-title":"Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer","volume":"324","author":"Wolf","year":"1991","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.soc.2023.03.003_bib13","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1200\/JCO.1998.16.4.1310","article-title":"Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099","volume":"16","author":"Al-Sarraf","year":"1998","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib14","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1200\/JCO.2002.20.1.282","article-title":"Increased risk of ischemic stroke after radiotherapy on the neck in patients younger than 60 years","volume":"20","author":"Dorresteijn","year":"2002","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0360-3016(02)02712-8","article-title":"Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer","volume":"53","author":"Eisbruch","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0360-3016(03)00361-4","article-title":"Quality of life after parotid-sparing IMRT for head-and-neck cancer: a prospective longitudinal study","volume":"57","author":"Lin","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib17","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1200\/JCO.2008.16.6546","article-title":"Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy","volume":"26","author":"Smith","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib18","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/hed.21066","article-title":"Hypothyroidism in older patients with head and neck cancer after treatment with radiation: a population-based study","volume":"31","author":"Smith","year":"2009","journal-title":"Head Neck"},{"key":"10.1016\/j.soc.2023.03.003_bib19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ijrobp.2012.05.032","article-title":"Osteoradionecrosis and radiation dose to the mandible in patients with oropharyngeal cancer","volume":"85","author":"Tsai","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib20","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/hed.23342","article-title":"Risk of fatal cerebrovascular accidents after external beam radiation therapy for early-stage glottic laryngeal cancer","volume":"36","author":"Swisher-McClure","year":"2014","journal-title":"Head Neck"},{"key":"10.1016\/j.soc.2023.03.003_bib21","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1200\/JCO.2015.61.6995","article-title":"Epidemiology of Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma","volume":"33","author":"Gillison","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib22","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1200\/JCO.2011.36.4596","article-title":"Human papillomavirus and rising oropharyngeal cancer incidence in the United States","volume":"29","author":"Chaturvedi","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.soc.2023.03.003_bib24","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1200\/JCO.2012.44.0164","article-title":"Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis","volume":"31","author":"O'Sullivan","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.14338\/IJPT-20-00071.1","article-title":"PTCOG Head and Neck Subcommittee Consensus Guidelines on Particle Therapy for the Management of Head and Neck Tumors","volume":"8","author":"Lin","year":"2021","journal-title":"Int J Part Ther"},{"key":"10.1016\/j.soc.2023.03.003_bib26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13014-016-0600-3","article-title":"Acute toxicity in comprehensive head and neck radiation for nasopharynx and paranasal sinus cancers: cohort comparison of 3D conformal proton therapy and intensity modulated radiation therapy","volume":"11","author":"McDonald","year":"2016","journal-title":"Radiat Oncol"},{"issue":"1","key":"10.1016\/j.soc.2023.03.003_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.14338\/IJPT-15-00011.1","article-title":"Proton Therapy Reduces Treatment-Related Toxicities for Patients with Nasopharyngeal Cancer: A Case-Match Control Study of Intensity-Modulated Proton Therapy and Intensity-Modulated Photon Therapy","volume":"2","author":"Holliday","year":"2015","journal-title":"International Journal of Particle Therapy"},{"key":"10.1016\/j.soc.2023.03.003_bib28","unstructured":"Shanghai Proton and Heavy Ion Center. Proton versus photon radiotherapy for nasopharyngeal carcinoma. ClinicalTrials.gov Identifier: NCT04528394. Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04528394. Accessed February 14, 2023."},{"key":"10.1016\/j.soc.2023.03.003_bib29","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ijrobp.2016.02.019","article-title":"Outcomes of Sinonasal Cancer Treated With Proton Therapy","volume":"95","author":"Dagan","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib30","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ijrobp.2016.02.042","article-title":"Long-Term Outcomes After Proton Beam Therapy for Sinonasal Squamous Cell Carcinoma","volume":"95","author":"Russo","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib31","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S1470-2045(14)70268-2","article-title":"Charged particle therapy versus photon therapy for paranasal sinus and nasal cavity malignant diseases: a systematic review and meta-analysis","volume":"15","author":"Patel","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.radonc.2016.05.022","article-title":"Intensity-modulated proton beam therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for patients with oropharynx cancer - A case matched analysis","volume":"120","author":"Blanchard","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.14338\/IJPT-18-00032.1","article-title":"Quality of Life of Postoperative Photon versus Proton Radiation Therapy for Oropharynx Cancer","volume":"5","author":"Sharma","year":"2018","journal-title":"Int J Part Ther"},{"key":"10.1016\/j.soc.2023.03.003_bib34","unstructured":"MD Anderson Cancer Center. Randomized trial of intensity-modulated proton beam therapy (IMPT) versus intensitymodulated photon therapy (IMRT) for the treatment of oropharyngeal cancer of the head and neck. ClinicalTrials.gov Identifier: NCT01893307. Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01893307. Accessed February 14, 2023."},{"key":"10.1016\/j.soc.2023.03.003_bib35","first-page":"147","article-title":"TORPEdO: A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer","volume":"38","author":"Thomson","year":"2023","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib36","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.radonc.2015.12.008","article-title":"Proton beam radiation therapy results in significantly reduced toxicity compared with intensity-modulated radiation therapy for head and neck tumors that require ipsilateral radiation","volume":"118","author":"Romesser","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib37","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijrobp.2016.03.053","article-title":"Reirradiation of Head and Neck Cancers With Proton Therapy: Outcomes and Analyses","volume":"96","author":"Phan","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib38","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.ijrobp.2016.07.037","article-title":"Reirradiation of Recurrent and Second Primary Head and Neck Cancer With Proton Therapy","volume":"96","author":"McDonald","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib39","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ijrobp.2016.02.036","article-title":"Proton Beam Reirradiation for Recurrent Head and Neck Cancer: Multi-institutional Report on Feasibility and Early Outcomes","volume":"95","author":"Romesser","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib40","doi-asserted-by":"crossref","first-page":"e165","DOI":"10.1016\/j.ijrobp.2012.10.038","article-title":"Proton beam therapy and accountable care: the challenges ahead","volume":"85","author":"Elnahal","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib41","first-page":"432","article-title":"Proton radiation therapy for chordomas and chondrosarcomas of the skull base","volume":"91","author":"Hug","year":"1999","journal-title":"J\u00a0Neurosurg"},{"year":"2017","series-title":"Budget impact analysis","author":"Kim","key":"10.1016\/j.soc.2023.03.003_bib42"},{"key":"10.1016\/j.soc.2023.03.003_bib43","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.jacr.2018.07.020","article-title":"Proton Facility Economics: Single-Room Centers","volume":"15","author":"Kerstiens","year":"2018","journal-title":"J\u00a0Am Coll Radiol"},{"key":"10.1016\/j.soc.2023.03.003_bib44","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jacr.2012.03.014","article-title":"Proton facility economics: the importance of \"simple\" treatments","volume":"9","author":"Johnstone","year":"2012","journal-title":"J\u00a0Am Coll Radiol"},{"key":"10.1016\/j.soc.2023.03.003_bib45","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1470-2045(16)00171-6","article-title":"Beyond a moonshot: insurance coverage for proton therapy","volume":"17","author":"Shah","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib46","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1200\/JCO.2018.77.7078","article-title":"Randomized Trials of Proton Therapy: Why They Are at Risk, Proposed Solutions, and Implications for Evaluating Advanced Technologies to Diagnose and Treat Cancer","volume":"36","author":"Bekelman","year":"2018","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib47","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.ijrobp.2018.12.019","article-title":"The Insurance Approval Process for Proton Radiation Therapy: A Significant Barrier to Patient Care","volume":"104","author":"Ning","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib48","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ijrobp.2018.12.021","article-title":"Insurance Approval for Proton Beam Therapy and its Impact on Delays in Treatment","volume":"104","author":"Gupta","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib49","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/cncr.29882","article-title":"A\u00a0systematic review of the cost and cost-effectiveness studies of proton radiotherapy","volume":"122","author":"Verma","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.soc.2023.03.003_bib50","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.ijrobp.2018.04.018","article-title":"Cost-Effectiveness Analysis of Intensity Modulated Radiation Therapy Versus Proton Therapy for Oropharyngeal Squamous Cell Carcinoma","volume":"101","author":"Sher","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib51","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.radonc.2013.05.007","article-title":"Selection of patients for radiotherapy with protons aiming at reduction of side effects: the model-based approach","volume":"107","author":"Langendijk","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib52","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijrobp.2015.10.004","article-title":"The Quest for Evidence for Proton Therapy: Model-Based Approach and Precision Medicine","volume":"95","author":"Widder","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib53","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ijrobp.2018.12.055","article-title":"A\u00a0Model-Based Approach to Predict Short-Term Toxicity Benefits With Proton Therapy for Oropharyngeal Cancer","volume":"104","author":"Rwigema","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib54","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.ijrobp.2016.08.049","article-title":"Spot-Scanning Proton Arc (SPArc) Therapy: The First Robust and Delivery-Efficient Spot-Scanning Proton Arc Therapy","volume":"96","author":"Ding","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib55","doi-asserted-by":"crossref","first-page":"e1036","DOI":"10.1002\/mp.12960","article-title":"In\u00a0vivo range verification in particle therapy","volume":"45","author":"Parodi","year":"2018","journal-title":"Med Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib56","doi-asserted-by":"crossref","first-page":"20190359","DOI":"10.1259\/bjr.20190359","article-title":"Proton therapy delivery: what is needed in the next ten years?","volume":"93","author":"Schreuder","year":"2020","journal-title":"Br J Radiol"},{"key":"10.1016\/j.soc.2023.03.003_bib57","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1667\/RR13464.1","article-title":"The effects of ultra-high dose rate proton irradiation on growth delay in the treatment of human tumor xenografts in nude mice","volume":"181","author":"Zlobinskaya","year":"2014","journal-title":"Radiat Res"},{"key":"10.1016\/j.soc.2023.03.003_bib58","doi-asserted-by":"crossref","first-page":"245ra93","DOI":"10.1126\/scitranslmed.3008973","article-title":"Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice","volume":"6","author":"Favaudon","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.soc.2023.03.003_bib59","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijrobp.2016.09.018","article-title":"Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator","volume":"97","author":"Sch\u00fcler","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib60","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1158\/1078-0432.CCR-17-3375","article-title":"The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients","volume":"25","author":"Vozenin","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.soc.2023.03.003_bib61","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.radonc.2019.04.008","article-title":"Clinical translation of FLASH radiotherapy: Why and how?","volume":"139","author":"Bourhis","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.soc.2023.03.003_bib62","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ijrobp.2019.10.049","article-title":"Design, Implementation, and in\u00a0Vivo Validation of a Novel Proton FLASH Radiation Therapy System","volume":"106","author":"Diffenderfer","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib63","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ijrobp.2018.06.403","article-title":"Experimental Set-up for FLASH Proton Irradiation of Small Animals Using a Clinical System","volume":"102","author":"Patriarca","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.soc.2023.03.003_bib64","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.radonc.2019.06.024","article-title":"Feasibility of proton FLASH effect tested by zebrafish embryo irradiation","volume":"139","author":"Beyreuther","year":"2019","journal-title":"Radiother Oncol"}],"container-title":["Surgical Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105532072300025X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105532072300025X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:06:30Z","timestamp":1760961990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105532072300025X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S105532072300025X"],"URL":"https:\/\/doi.org\/10.1016\/j.soc.2023.03.003","relation":{},"ISSN":["1055-3207"],"issn-type":[{"type":"print","value":"1055-3207"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in Proton Therapy for the Management of Head and Neck Tumors","name":"articletitle","label":"Article Title"},{"value":"Surgical Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.soc.2023.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}