{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:45:42Z","timestamp":1790934342008,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgonc.theclinics.com","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgical Oncology Clinics of North America"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.soc.2025.05.006","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T15:46:33Z","timestamp":1750693593000},"page":"181-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Palliative Care and Patient Quality of Life in Pancreatic Adenocarcinoma"],"prefix":"10.1016","volume":"35","author":[{"given":"Renee M.","family":"Maina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Wancata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.soc.2025.05.006_bib1","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1158\/0008-5472.CAN-14-0155","article-title":"Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States","volume":"74","author":"Rahib","year":"2014","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.soc.2025.05.006_bib2","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"issue":"44","key":"10.1016\/j.soc.2025.05.006_bib3","doi-asserted-by":"crossref","first-page":"9694","DOI":"10.3748\/wjg.v22.i44.9694","article-title":"Epidemiology of pancreatic cancer","volume":"22","author":"Ilic","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"19","key":"10.1016\/j.soc.2025.05.006_bib5","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMoa1011923","article-title":"FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer","volume":"364","author":"Conroy","year":"2011","journal-title":"N Engl J Med"},{"issue":"25","key":"10.1016\/j.soc.2025.05.006_bib6","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1056\/NEJMoa1809775","article-title":"FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer","volume":"379","author":"Conroy","year":"2018","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.soc.2025.05.006_bib7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s12885-021-08031-z","volume":"21","author":"Janssen","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.soc.2025.05.006_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejca.2022.12.014","article-title":"A randomised phase II study of modified FOLFIRINOX versus gemcitabine plus nab-paclitaxel for locally advanced pancreatic cancer (JCOG1407)","volume":"181","author":"Ozaka","year":"2023","journal-title":"Eur J Cancer"},{"issue":"9","key":"10.1016\/j.soc.2025.05.006_bib9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jama.2021.13027","article-title":"Pancreatic cancer: a review","volume":"326","author":"Park","year":"2021","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.soc.2025.05.006_bib10","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.hoc.2022.07.009","article-title":"Palliative and supportive care for individuals with pancreatic adenocarcinoma","volume":"36","author":"Nipp","year":"2022","journal-title":"Hematol Oncol Clin N Am"},{"issue":"1","key":"10.1016\/j.soc.2025.05.006_bib11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1055-3207(18)30294-1","article-title":"Palliative therapy for pancreatic cancer","volume":"7","author":"Lillemoe","year":"1998","journal-title":"Surg Oncol Clin N Am"},{"issue":"1","key":"10.1016\/j.soc.2025.05.006_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/107327480401100106","article-title":"Palliative care in pancreatic cancer","volume":"11","author":"Brescia","year":"2004","journal-title":"Cancer Control"},{"issue":"4","key":"10.1016\/j.soc.2025.05.006_bib13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.suronc.2007.08.003","article-title":"Palliative care for patients with advanced pancreatic and biliary cancers","volume":"16","author":"Nakakura","year":"2007","journal-title":"Surg Oncol"},{"issue":"7\u20138","key":"10.1016\/j.soc.2025.05.006_bib14","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/ans.18906","article-title":"Best supportive care in advanced pancreas cancer: a systematic review to define a patient-care bundle","volume":"94","author":"Law","year":"2024","journal-title":"ANZ J Surg"},{"issue":"6","key":"10.1016\/j.soc.2025.05.006_bib16","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.suc.2016.07.012","article-title":"Palliative care for pancreatic and periampullary cancer","volume":"96","author":"Perone","year":"2016","journal-title":"Surg Clin North Am"},{"issue":"11","key":"10.1016\/j.soc.2025.05.006_bib17","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s12094-017-1682-6","article-title":"Supportive care in pancreatic ductal adenocarcinoma","volume":"19","author":"Laquente","year":"2017","journal-title":"Clin Transl Oncol"},{"issue":"6","key":"10.1016\/j.soc.2025.05.006_bib18","first-page":"Cd011129","article-title":"Early palliative care for adults with advanced cancer","volume":"6","author":"Haun","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"10.1016\/j.soc.2025.05.006_bib19","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1007\/BF02574487","article-title":"A prospective evaluation of patients undergoing surgery for the palliation of an advanced malignancy","volume":"9","author":"Miner","year":"2002","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"10.1016\/j.soc.2025.05.006_bib20","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1001\/archsurg.2011.92","article-title":"The palliative triangle: improved patient selection and outcomes associated with palliative operations","volume":"146","author":"Miner","year":"2011","journal-title":"Arch Surg"},{"key":"10.1016\/j.soc.2025.05.006_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejca.2016.06.007","article-title":"Systematic versus on-demand early palliative care: results from a multicentre, randomised clinical trial","volume":"65","author":"Maltoni","year":"2016","journal-title":"Eur J Cancer"},{"issue":"4","key":"10.1016\/j.soc.2025.05.006_bib22","first-page":"250","article-title":"The impact of early palliative care on the quality of life of patients with advanced pancreatic cancer: the IMPERATIVE case-crossover study","volume":"31","author":"Kim","year":"2023","journal-title":"Support Care Cancer"},{"issue":"5","key":"10.1016\/j.soc.2025.05.006_bib23","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/PPO.0b013e3182a76b9c","article-title":"Integrating palliative care in oncology: the oncologist as a primary palliative care provider","volume":"19","author":"Rangachari","year":"2013","journal-title":"Cancer J"},{"issue":"8","key":"10.1016\/j.soc.2025.05.006_bib24","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.4240\/wjgs.v16.i8.2369","article-title":"Role of endoscopic ultrasound-guided biliary drainage for palliation of malignant biliary obstruction","volume":"16","author":"Singh","year":"2024","journal-title":"World J Gastrointest Surg"},{"issue":"2","key":"10.1016\/j.soc.2025.05.006_bib25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jpainsymman.2013.03.013","article-title":"A meta-analysis of randomized trials: immediate stent placement vs. surgical bypass in the palliative management of malignant biliary obstruction","volume":"47","author":"Glazer","year":"2014","journal-title":"J Pain Symptom Manag"},{"issue":"6","key":"10.1016\/j.soc.2025.05.006_bib26","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/PPO.0b013e3182745ad4","article-title":"Endoscopic palliation of pancreatic cancer","volume":"18","author":"Cot\u00e9","year":"2012","journal-title":"Cancer J"},{"issue":"3 Suppl","key":"10.1016\/j.soc.2025.05.006_bib27","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.jviscsurg.2013.03.005","article-title":"Palliation of biliary and duodenal obstruction in patients with unresectable pancreatic cancer: endoscopy or surgery?","volume":"150","author":"Maire","year":"2013","journal-title":"J Vis Surg"},{"issue":"10","key":"10.1016\/j.soc.2025.05.006_bib28","doi-asserted-by":"crossref","first-page":"581","DOI":"10.4253\/wjge.v14.i10.581","article-title":"Endoscopic palliation of malignant biliary obstruction","volume":"14","author":"Canakis","year":"2022","journal-title":"World J Gastrointest Endosc"},{"issue":"2","key":"10.1016\/j.soc.2025.05.006_bib29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.gie.2011.03.1249","article-title":"Meta-analysis of randomized trials comparing the patency of covered and uncovered self-expandable metal stents for palliation of distal malignant bile duct obstruction","volume":"74","author":"Saleem","year":"2011","journal-title":"Gastrointest Endosc"},{"issue":"11","key":"10.1016\/j.soc.2025.05.006_bib30","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1038\/ajg.2013.305","article-title":"Covered self-expandable metal stents with an anti-migration system improve patency duration without increased complications compared with uncovered stents for distal biliary obstruction caused by pancreatic carcinoma: a randomized multicenter trial","volume":"108","author":"Kitano","year":"2013","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"10.1016\/j.soc.2025.05.006_bib31","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1055\/a-0754-5763","article-title":"Efficacy of a paclitaxel-eluting biliary metal stent with sodium caprate in malignant biliary obstruction: a prospective randomized comparative study","volume":"51","author":"Jang","year":"2019","journal-title":"Endoscopy (Stuttg)"},{"issue":"1","key":"10.1016\/j.soc.2025.05.006_bib32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1053\/j.seminoncol.2014.12.014","article-title":"Endoscopic and operative palliation strategies for pancreatic ductal adenocarcinoma","volume":"42","author":"Stark","year":"2015","journal-title":"Semin Oncol"},{"issue":"22","key":"10.1016\/j.soc.2025.05.006_bib33","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1002\/cncr.32423","article-title":"Pancreatic cancer-A disease in need: optimizing and integrating supportive care","volume":"125","author":"Moffat","year":"2019","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.soc.2025.05.006_bib34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.4251\/wjgo.v8.i3.240","article-title":"Endoscopic palliation of malignant biliary strictures","volume":"8","author":"Salgado","year":"2016","journal-title":"World J Gastrointest Oncol"},{"issue":"1","key":"10.1016\/j.soc.2025.05.006_bib35","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1001\/jamaoncol.2015.3670","article-title":"Comparison of adverse events for endoscopic vs percutaneous biliary drainage in the treatment of malignant biliary tract obstruction in an inpatient national cohort","volume":"2","author":"Inamdar","year":"2016","journal-title":"JAMA Oncol"},{"issue":"10","key":"10.1016\/j.soc.2025.05.006_bib36","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1055\/s-2001-17324","article-title":"Endoscopic ultrasound-guided bilioduodenal anastomosis: a new technique for biliary drainage","volume":"33","author":"Giovannini","year":"2001","journal-title":"Endoscopy (Stuttg)"},{"issue":"1","key":"10.1016\/j.soc.2025.05.006_bib37","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2020-000428","article-title":"Relief of biliary obstruction: choosing between endoscopic ultrasound and endoscopic retrograde cholangiopancreatography","volume":"7","author":"Canakis","year":"2020","journal-title":"BMJ Open Gastroenterol"},{"issue":"3","key":"10.1016\/j.soc.2025.05.006_bib38","doi-asserted-by":"crossref","first-page":"226","DOI":"10.5946\/ce.2019.003","article-title":"Endoscopic palliation for biliary and pancreatic malignancies: recent advances","volume":"52","author":"Nabi","year":"2019","journal-title":"Clin Endosc"},{"issue":"12","key":"10.1016\/j.soc.2025.05.006_bib39","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1007\/s00464-016-4913-y","article-title":"Endoscopic ultrasound-guided biliary drainage versus percutaneous transhepatic biliary drainage: predictors of successful outcome in patients who fail endoscopic retrograde cholangiopancreatography","volume":"30","author":"Sharaiha","year":"2016","journal-title":"Surg Endosc"},{"issue":"3","key":"10.1016\/j.soc.2025.05.006_bib40","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11938-017-0145-z","article-title":"Endoscopic palliation of pancreatic cancer","volume":"15","author":"Gohil","year":"2017","journal-title":"Curr Treat Options Gastroenterol"},{"key":"10.1016\/j.soc.2025.05.006_bib41","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-230X-7-18","article-title":"Stent versus gastrojejunostomy for the palliation of gastric outlet obstruction: a systematic review","volume":"7","author":"Jeurnink","year":"2007","journal-title":"BMC Gastroenterol"},{"issue":"2","key":"10.1016\/j.soc.2025.05.006_bib42","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00464-009-0577-1","article-title":"A systematic review of methods to palliate malignant gastric outlet obstruction","volume":"24","author":"Ly","year":"2010","journal-title":"Surg Endosc"},{"issue":"6","key":"10.1016\/j.soc.2025.05.006_bib43","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/01.sla.0000098617.21801.95","article-title":"The need for a prophylactic gastrojejunostomy for unresectable periampullary cancer: a prospective randomized multicenter trial with special focus on assessment of quality of life","volume":"238","author":"Van Heek","year":"2003","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.soc.2025.05.006_bib44","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.gie.2009.09.042","article-title":"Surgical gastrojejunostomy or endoscopic stent placement for the palliation of malignant gastric outlet obstruction (SUSTENT study): a multicenter randomized trial","volume":"71","author":"Jeurnink","year":"2010","journal-title":"Gastrointest Endosc"},{"issue":"3","key":"10.1016\/j.soc.2025.05.006_bib45","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.gie.2015.01.026","article-title":"Survival and clinical outcome after endoscopic duodenal stent placement for malignant gastric outlet obstruction: comparison of pancreatic cancer and nonpancreatic cancer","volume":"82","author":"Oh","year":"2015","journal-title":"Gastrointest Endosc"},{"issue":"4","key":"10.1016\/j.soc.2025.05.006_bib46","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.pan.2018.04.008","article-title":"Pain in pancreatic ductal adenocarcinoma: a multidisciplinary, International guideline for optimized management","volume":"18","author":"Drewes","year":"2018","journal-title":"Pancreatology"},{"key":"10.1016\/j.soc.2025.05.006_bib47","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2147\/JPR.S97759","article-title":"Effectiveness of the World Health Organization cancer pain relief guidelines: an integrative review","volume":"9","author":"Carlson","year":"2016","journal-title":"J Pain Res"},{"issue":"3","key":"10.1016\/j.soc.2025.05.006_bib48","article-title":"Celiac plexus block for pancreatic cancer pain in adults","volume":"2011","author":"Arcidiacono","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"10.1016\/j.soc.2025.05.006_bib49","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1007\/s10620-008-0651-x","article-title":"EUS-guided celiac plexus neurolysis for pain due to chronic pancreatitis or pancreatic cancer pain: a meta-analysis and systematic review","volume":"54","author":"Puli","year":"2009","journal-title":"Dig Dis Sci"},{"issue":"1","key":"10.1016\/j.soc.2025.05.006_bib50","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1136\/gut.42.1.92","article-title":"Placebo controlled trial of enteric coated pancreatin microsphere treatment in patients with unresectable cancer of the pancreatic head region","volume":"42","author":"Bruno","year":"1998","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.soc.2025.05.006_bib51","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/jcsm.13500","article-title":"Dose-dependent effect of megestrol acetate supplementation in cancer patients with anorexia-cachexia syndrome: a meta-analysis","volume":"15","author":"Talebi","year":"2024","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"10.1016\/j.soc.2025.05.006_bib52","article-title":"Megestrol acetate for treatment of anorexia-cachexia syndrome","volume":"2013","author":"Ruiz Garcia","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.1016\/j.soc.2025.05.006_bib53","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/PPO.0000000000000293","article-title":"Symptom management and palliative care in pancreatic cancer","volume":"23","author":"Rabow","year":"2017","journal-title":"Cancer J"},{"issue":"9","key":"10.1016\/j.soc.2025.05.006_bib54","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1200\/JCO.18.02235","article-title":"Role of hospice care at the end of life for people with cancer","volume":"38","author":"Currow","year":"2020","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.soc.2025.05.006_bib55","first-page":"6871","article-title":"Optimal timing for hospice-shared care initiation in terminal cancer patients","volume":"29","author":"Dai","year":"2021","journal-title":"Support Care Cancer"}],"container-title":["Surgical Oncology Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1055320725000602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1055320725000602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T16:28:04Z","timestamp":1763051284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1055320725000602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1055320725000602"],"URL":"https:\/\/doi.org\/10.1016\/j.soc.2025.05.006","relation":{},"ISSN":["1055-3207"],"issn-type":[{"value":"1055-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Palliative Care and Patient Quality of Life in Pancreatic Adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Surgical Oncology Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.soc.2025.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}