{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:26:27Z","timestamp":1762903587043,"version":"3.45.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024075","name":"Region Syddanmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024075","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["surgopensci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery Open Science"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.sopen.2023.09.003","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T11:36:40Z","timestamp":1694950600000},"page":"22-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Preoperative intravenous iron treatment \u2013 a cohort study on colorectal cancer recurrence"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-3994","authenticated-orcid":false,"given":"Magnus","family":"Ploug","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1113-195X","authenticated-orcid":false,"given":"Niels","family":"Qvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4358-7916","authenticated-orcid":false,"given":"Rasmus","family":"Kroijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-0115","authenticated-orcid":false,"given":"Torben","family":"Knudsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.sopen.2023.09.003_bb0005","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/codi.15467","article-title":"Iron deficiency in colorectal cancer patients: a cohort study on prevalence and associations","volume":"23","author":"Ploug","year":"2021","journal-title":"Colorectal Dis"},{"issue":"2","key":"10.1016\/j.sopen.2023.09.003_bb0010","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jamcollsurg.2010.09.013","article-title":"Does preoperative anemia adversely affect colon and rectal surgery outcomes?","volume":"212","author":"Leichtle","year":"2011","journal-title":"J Am Coll Surg"},{"issue":"9800","key":"10.1016\/j.sopen.2023.09.003_bb0015","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/S0140-6736(11)61381-0","article-title":"Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study","volume":"378","author":"Musallam","year":"2011","journal-title":"Lancet."},{"issue":"3","key":"10.1016\/j.sopen.2023.09.003_bb0020","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/ALN.0b013e31819878d3","article-title":"Risk associated with preoperative anemia in noncardiac surgery: a single-center cohort study","volume":"110","author":"Beattie","year":"2009","journal-title":"Anesthesiology."},{"issue":"2","key":"10.1016\/j.sopen.2023.09.003_bb0025","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/anae.13773","article-title":"International consensus statement on the peri-operative management of anaemia and iron deficiency","volume":"72","author":"Mu\u00f1oz","year":"2017","journal-title":"Anaesthesia."},{"issue":"3","key":"10.1016\/j.sopen.2023.09.003_bb0030","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/bjh.13623","article-title":"British Committee for Standards in Haematology guidelines on the identification and management of pre-operative Anaemia","volume":"171","author":"Kotz\u00e9","year":"2015","journal-title":"Br J Haematol"},{"year":"2020","series-title":"Perioperative care in adults [E] Evidence review for preoperative management of anaemia NICE guideline NG180 Perioperative care: FINAL Contents","key":"10.1016\/j.sopen.2023.09.003_bb0035"},{"year":"2022","series-title":"An\u00e6mi, jernbehandling og blodtransfusion","author":"Group DCC","key":"10.1016\/j.sopen.2023.09.003_bb0040"},{"key":"10.1016\/j.sopen.2023.09.003_bb0045","series-title":"Trials","first-page":"254","article-title":"PREVENTT: preoperative intravenous iron to treat anaemia in major surgery: study protocol for a randomised controlled trial","author":"Richards","year":"2015"},{"issue":"3","key":"10.1016\/j.sopen.2023.09.003_bb0050","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/bjs.10328","article-title":"Randomized clinical trial of preoperative oral versus intravenous iron in anaemic patients with colorectal cancer","volume":"104","author":"Keeler","year":"2017","journal-title":"Br J Surg"},{"issue":"1","key":"10.1016\/j.sopen.2023.09.003_bb0055","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/SLA.0000000000001646","article-title":"The important role for intravenous Iron in perioperative patient blood Management in Major Abdominal Surgery: a randomized controlled trial","volume":"264","author":"Froessler","year":"2016","journal-title":"Ann Surg"},{"key":"10.1016\/j.sopen.2023.09.003_bb0060","series-title":"Surgical Oncology","first-page":"96","article-title":"Long-term prognostic value of preoperative anemia in patients with colorectal cancer: A systematic review and meta-analysis","author":"Wilson","year":"2017"},{"key":"10.1016\/j.sopen.2023.09.003_bb0065","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3747\/co.26.4983","article-title":"Association of preoperative anemia and perioperative allogenic red blood cell transfusion with oncologic outcomes in patients with nonmetastatic colorectal cancer","author":"Kwon","year":"2019","journal-title":"Curr Oncol"},{"key":"10.1016\/j.sopen.2023.09.003_bb0070","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00384-016-2678-3","article-title":"Preoperative anaemia and perioperative red blood cell transfusion as prognostic factors for recurrence and mortality in colorectal cancer\u2014A Swedish cohort study","author":"M\u00f6rner","year":"2017","journal-title":"Int J Colorectal Dis"},{"issue":"11","key":"10.1016\/j.sopen.2023.09.003_bb0075","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1007\/s10147-021-01995-9","article-title":"Preoperative iron status is a prognosis factor for stage II and III colorectal cancer","volume":"26","author":"Sawayama","year":"2021","journal-title":"Int J Clin Oncol"},{"issue":"2","key":"10.1016\/j.sopen.2023.09.003_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/cells10020303","article-title":"Iron metabolism in the tumor microenvironment-implications for anti-cancer immune response","volume":"10","author":"Sacco","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.sopen.2023.09.003_bb0085","doi-asserted-by":"crossref","first-page":"109021","DOI":"10.1016\/j.cbi.2020.109021","article-title":"Iron and hepcidin mediate human colorectal cancer cell growth","volume":"319","author":"Sornjai","year":"2020","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.sopen.2023.09.003_bb0090","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mehy.2017.12.011","article-title":"Iron therapy as treatment of anemia: A potentially detrimental and hazardous strategy in colorectal cancer patients","author":"Wilson","year":"2018","journal-title":"Med Hypotheses"},{"issue":"2","key":"10.1016\/j.sopen.2023.09.003_bb0095","article-title":"Hepcidin-mediated hypoferremia disrupts immune responses to vaccination and infection","volume":"2","author":"Frost","year":"2021","journal-title":"Med (N Y)"},{"issue":"4","key":"10.1016\/j.sopen.2023.09.003_bb0100","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1080\/01635581.2018.1460685","article-title":"Biological and immunological aspects of iron deficiency anemia in cancer development: a narrative review","volume":"70","author":"Zohora","year":"2018","journal-title":"Nutr Cancer"},{"issue":"12","key":"10.1016\/j.sopen.2023.09.003_bb0105","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1111\/codi.15342","article-title":"Preoperative intravenous iron therapy and survival after colorectal cancer surgery: long-term results from the IVICA randomised controlled trial","volume":"22","author":"Dickson","year":"2020","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.sopen.2023.09.003_bb0110","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.suronc.2018.03.005","article-title":"The effect of intravenous iron therapy on long-term survival in anaemic colorectal cancer patients: results from a matched cohort study","author":"Wilson","year":"2018","journal-title":"Surg Oncol"},{"key":"10.1016\/j.sopen.2023.09.003_bb0115","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1186\/1471-2407-11-438","article-title":"Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival","volume":"11","author":"Birgisson","year":"2011","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.sopen.2023.09.003_bb0120","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12916-019-1379-5","article-title":"The long-term survival characteristics of a cohort of colorectal cancer patients and baseline variables associated with survival outcomes with or without time-varying effects","volume":"17","author":"Yu","year":"2019","journal-title":"BMC Med"},{"key":"10.1016\/j.sopen.2023.09.003_bb0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jss.2022.03.004","article-title":"Preoperative intravenous iron treatment in colorectal cancer: experience from clinical practice","volume":"277","author":"Ploug","year":"2022","journal-title":"J Surg Res"},{"author":"DCCG Yearly Report","key":"10.1016\/j.sopen.2023.09.003_bb0130"},{"key":"10.1016\/j.sopen.2023.09.003_bb0135","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1002\/ijc.29267","article-title":"A validated algorithm to ascertain colorectal cancer recurrence using registry resources in Denmark","author":"Lash","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1016\/j.sopen.2023.09.003_bb0140","series-title":"Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity","first-page":"1","author":"Organisation WH, WHO","year":"2011"},{"key":"10.1016\/j.sopen.2023.09.003_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijsu.2016.12.029","article-title":"Correction of iron-deficiency anaemia in colorectal surgery reduces perioperative transfusion rates: a before and after study","volume":"38","author":"Quinn","year":"2017","journal-title":"Int J Surg"},{"key":"10.1016\/j.sopen.2023.09.003_bb0150","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.blre.2017.02.004","article-title":"New insights into iron deficiency and iron deficiency anemia","volume":"31","author":"Camaschella","year":"2017","journal-title":"Blood Rev"},{"issue":"12","key":"10.1016\/j.sopen.2023.09.003_bb0155","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/ajg.2013.335","article-title":"A randomized, open-label, non-inferiority study of intravenous iron isomaltoside 1,000 (Monofer) compared with oral iron for treatment of anemia in IBD (PROCEED)","volume":"108","author":"Reinisch","year":"2013","journal-title":"Am J Gastroenterol"},{"issue":"10259","key":"10.1016\/j.sopen.2023.09.003_bb0160","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0140-6736(20)31539-7","article-title":"Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial","volume":"396","author":"Richards","year":"2020","journal-title":"Lancet"},{"issue":"7 Suppl","key":"10.1016\/j.sopen.2023.09.003_bb0165","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1403494811401482","article-title":"The Danish National Patient Register","volume":"39","author":"Lynge","year":"2011","journal-title":"Scand J Public Health"},{"issue":"7 Suppl","key":"10.1016\/j.sopen.2023.09.003_bb0170","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish civil registration system","volume":"39","author":"Pedersen","year":"2011","journal-title":"Scand J Public Health"},{"issue":"7 Suppl","key":"10.1016\/j.sopen.2023.09.003_bb0175","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/1403494810393562","article-title":"The Danish Cancer Registry","volume":"39","author":"Gjerstorff","year":"2011","journal-title":"Scand J Public Health"},{"key":"10.1016\/j.sopen.2023.09.003_bb0180","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2147\/CLEP.S9908","article-title":"Existing data sources for clinical epidemiology: the Danish National Pathology Registry and Data Bank","volume":"2","author":"Erichsen","year":"2010","journal-title":"Clin Epidemiol"}],"container-title":["Surgery Open Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589845023000684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589845023000684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:23:27Z","timestamp":1762903407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589845023000684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":36,"alternative-id":["S2589845023000684"],"URL":"https:\/\/doi.org\/10.1016\/j.sopen.2023.09.003","relation":{},"ISSN":["2589-8450"],"issn-type":[{"type":"print","value":"2589-8450"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preoperative intravenous iron treatment \u2013 a cohort study on colorectal cancer recurrence","name":"articletitle","label":"Article Title"},{"value":"Surgery Open Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.sopen.2023.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}