{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:19:58Z","timestamp":1762100398767},"reference-count":175,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Pediatric Neurology"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.spen.2005.03.002","type":"journal-article","created":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T13:35:14Z","timestamp":1121434514000},"page":"72-87","source":"Crossref","is-referenced-by-count":17,"title":["Advances in the Pathophysiology of Developmental Epilepsies"],"prefix":"10.1016","volume":"12","author":[{"given":"Michael","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.spen.2005.03.002_bib1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S1474-4422(04)00881-6","article-title":"Susceptibility of immature and adult brains to seizure effects","volume":"3","author":"Haut","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1203\/00006450-200103000-00004","article-title":"The neurobiology and consequences of epilepsy in the developing brain","volume":"49","author":"Holmes","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1016\/j.spen.2005.03.002_bib3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0079-6123(02)35030-1","article-title":"Seizure-induced damage in the developing human","volume":"135","author":"Holmes","year":"2002","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1046\/j.1528-1157.2001.12000.x","article-title":"Maturational aspects of epilepsy mechanisms and consequences for the immature brain","volume":"42","author":"Sanchez","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1528-1157.1993.tb02586.x","article-title":"Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota","volume":"34","author":"Hauser","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0165-3806(84)90085-3","article-title":"Kainic-acid induced seizures","volume":"315","author":"Albala","year":"1984","journal-title":"Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0165-3806(87)90227-6","article-title":"The susceptibility of rats to pilocarpine-induced seizures is age-dependent","volume":"465","author":"Cavalheiro","year":"1987","journal-title":"Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0165-3806(83)90083-4","article-title":"Increased seizure susceptibility of the immature brain","volume":"283","author":"Moshe","year":"1983","journal-title":"Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib9","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/ana.410290610","article-title":"Epileptogenic effect of hypoxia in the immature rodent brain","volume":"29","author":"Jensen","year":"1991","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0920-1211(96)01010-8","article-title":"Increased susceptibility to tetanus toxin-induced seizures in immature rats","volume":"26","author":"Anderson","year":"1997","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.spen.2005.03.002_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0920-1211(92)90075-5","article-title":"Effects of antiepileptic drugs on 4-aminopyridine-induced epileptiform activity in young and adult rat hippocampus","volume":"12","author":"Fueta","year":"1992","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.spen.2005.03.002_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0165-3806(95)00069-P","article-title":"Properties of low Mg2+ induced epileptiform activity in rat hippocampal and enthorhinal cortex slices during adolescence","volume":"87","author":"Gloveli","year":"1995","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0165-3806(84)90046-4","article-title":"Penicillin-induced epileptogenesis in immature rat CA3 hippocampal pyramidal cells","volume":"12","author":"Swann","year":"1984","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0920-1211(95)00086-0","article-title":"Age dependence of NMDA receptor involvement in epileptiform activity in rat hippocampal slices","volume":"23","author":"Wang","year":"1996","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.spen.2005.03.002_bib15","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1152\/jn.1987.58.5.1052","article-title":"Spontaneous ictal-like discharges and sustained potential shifts in the developing rat neocortex","volume":"58","author":"Hablitz","year":"1987","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.spen.2005.03.002_bib16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0165-3806(01)00149-3","article-title":"Developmental characteristics of epileptiform activity in immature rat neocortex","volume":"128","author":"Wong","year":"2001","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0304-3940(82)90379-2","article-title":"Synaptogenesis in human visual cortex","volume":"33","author":"Huttenlocher","year":"1982","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.spen.2005.03.002_bib18","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1126\/science.3952506","article-title":"Concurrent overproduction of synapses in diverse regions of primate cortex","volume":"232","author":"Rakic","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.spen.2005.03.002_bib19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nn1218","article-title":"Neural activity and the dynamics of central nervous system development","volume":"7","author":"Hua","year":"2004","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0306-4522(90)90117-M","article-title":"The ontogeny of excitatory amino acid receptors in rat forebrain\u2014I. N-methyl-D-aspartate and quisqualate receptors","volume":"35","author":"Insel","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/j.spen.2005.03.002_bib21","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1073\/pnas.88.10.4157","article-title":"Differential expression of three glutamate receptors genes in developing rat brain","volume":"88","author":"Pellegrini-Giampietro","year":"1991","journal-title":"Proc Natl Acade Sci U S A"},{"key":"10.1016\/j.spen.2005.03.002_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-4886(90)90035-Q","article-title":"Differential ontogenic development of three receptors comprising the NMDA receptor\/channel complex in the rat hippocampus","volume":"110","author":"McDonald","year":"1990","journal-title":"Exp Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib23","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0896-6273(94)90210-0","article-title":"Developmental and regional expression in the rat brain and functional properties of four NMDA receptors","volume":"12","author":"Monyer","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.spen.2005.03.002_bib24","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1046\/j.1471-4159.1995.64020531.x","article-title":"Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain","volume":"64","author":"Zhong","year":"1995","journal-title":"J Neurochem"},{"key":"10.1016\/j.spen.2005.03.002_bib25","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1523\/JNEUROSCI.17-07-02469.1997","article-title":"NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex","volume":"17","author":"Flint","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0304-3940(92)90717-L","article-title":"Are Ca(2+)\u2013permeable kainate\/AMPA receptors more abundant in immature brain?","volume":"144","author":"Pellegrini-Giampietro","year":"1992","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.spen.2005.03.002_bib27","doi-asserted-by":"crossref","first-page":"8154","DOI":"10.1523\/JNEUROSCI.21-20-08154.2001","article-title":"Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures","volume":"15:21","author":"Sanchez","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib28","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0736-5748(90)90080-L","article-title":"GABA mediated excitation in immature rat CA3 hippocampal neurons","volume":"8","author":"Cherubini","year":"1990","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib29","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/(SICI)1097-4695(19971120)33:6<781::AID-NEU6>3.0.CO;2-5","article-title":"Expression of the Na-K-2Cl cotransporter is developmentally regulated in postnatal rat brains","volume":"33","author":"Plotkin","year":"1997","journal-title":"J Neurobiol"},{"key":"10.1016\/j.spen.2005.03.002_bib30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/16697","article-title":"The K+\/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation","volume":"397","author":"Rivera","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.spen.2005.03.002_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0165-3806(90)90055-4","article-title":"Bicuculline induced seizures in infant rats","volume":"57","author":"Baram","year":"1990","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0006-8993(89)90633-1","article-title":"Disinhibitory actions of the GABAA agonist muscimol in immature hippocampus","volume":"502","author":"Chesnut","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib33","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/(SICI)1096-9861(19960408)367:3<403::AID-CNE6>3.0.CO;2-9","article-title":"Enhanced early developmental expression of the metabotropic glutamate receptor mGluR5 in rat brain","volume":"367","author":"Romano","year":"1996","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1460-9568.1997.tb01348.x","article-title":"Expression and coupling to polyphosphoinositide hydrolysis of group I metabotropic glutamate receptors in early postnatal and adult rat brain","volume":"9","author":"Casabona","year":"1997","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib35","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0306-4522(94)90392-1","article-title":"Postnatal ontogeny of GABAB binding in rat brain","volume":"62","author":"Turgeon","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.spen.2005.03.002_bib36","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1523\/JNEUROSCI.17-21-08363.1997","article-title":"Glutamate transporter protein subtypes are expressed differentially during rat CNS development","volume":"17","author":"Furuta","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-3806(96)00192-7","article-title":"Immunoreactivity for GABA plasma membrane transporter, GAT-1, in the developing rat cerebral cortex","volume":"99","author":"Yan","year":"1997","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib38","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0887-8994(01)00348-4","article-title":"Development of GABAergic neurons and their transporter in human temporal cortex","volume":"25","author":"Hachiya","year":"2001","journal-title":"Pediatr Neurol."},{"key":"10.1016\/j.spen.2005.03.002_bib39","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0165-3806(95)00158-1","article-title":"Developmental profile of messenger RNA for the corticotropin-releasing hormone receptor in the rat limbic system","volume":"91","author":"Avishai-Eliner","year":"1996","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0736-5748(97)00040-3","article-title":"Postnatal development of somatostatin- and neuropeptide Y-immunoreactive neurons in rat cerebral cortex","volume":"16","author":"Lee","year":"1998","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0165-3806(98)00093-5","article-title":"A comparison of the adenosine-mediated synaptic inhibition in the CA3 area of immature and adult rat hippocampus","volume":"110","author":"Descombes","year":"1998","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib42","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1528-1157.2000.tb00283.x","article-title":"Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy","volume":"41","author":"Fujikawa","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib43","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/ana.10171","article-title":"Seizure-associated hippocampal volume loss","volume":"51","author":"Briellmann","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib44","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/ana.10509","article-title":"Hippocampal sclerosis is a progressive disorder","volume":"53","author":"Fuerst","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib45","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1212\/WNL.45.6.1134","article-title":"Serum neuron-specific enolase in human status epilepticus","volume":"45","author":"DeGiorgio","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.spen.2005.03.002_bib46","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1528-1157.1996.tb00002.x","article-title":"Neuron-specific enolase is increased after single seizures during inpatient video\/EEG monitoring","volume":"37","author":"Rabinowicz","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib47","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/ana.410140407","article-title":"Intelligence in epilepsy","volume":"14","author":"Bourgeois","year":"1983","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib48","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1528-1157.1985.tb05670.x","article-title":"Neuropsychological abilities of children with epilepsy","volume":"26","author":"Farwell","year":"1985","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib49","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0165-3806(94)90011-6","article-title":"Children with severe epilepsy","volume":"78","author":"Mathern","year":"1994","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib50","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1542\/peds.83.3.323","article-title":"Low morbidity and mortality of status epilepticus in children","volume":"83","author":"Maytal","year":"1989","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2005.03.002_bib51","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/088307380201700404","article-title":"Cerebrospinal fluid neuron-specific enolase following seizures in children","volume":"17","author":"Wong","year":"2002","journal-title":"J Child Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib52","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1046\/j.1528-1157.2003.21603.x","article-title":"Analysis of cerebrospinal fluid glial fibrillary acidic protein after seizures in children","volume":"44","author":"Gurnett","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib53","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/archneur.1973.00490260026003","article-title":"Systemic factors and epileptic brain damage. Prolonged seizures in paralyzed, artificially ventilated baboons","volume":"29","author":"Meldrum","year":"1973","journal-title":"Arch Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib54","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0014-4886(03)00099-2","article-title":"An animal model of generalized nonconvulsive status epilepticus","volume":"183","author":"Wong","year":"2003","journal-title":"Exp Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib55","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0306-4522(80)90181-5","article-title":"Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid","volume":"5","author":"Schwob","year":"1980","journal-title":"Neuroscience"},{"key":"10.1016\/j.spen.2005.03.002_bib56","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0166-4328(83)90136-5","article-title":"Limbic seizures produced by pilocarpine in rats","volume":"9","author":"Turski","year":"1983","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib57","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0361-9230(83)90037-0","article-title":"\u201cEpileptic\u201d brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies","volume":"10","author":"Sloviter","year":"1983","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.spen.2005.03.002_bib58","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1523\/JNEUROSCI.14-05-03106.1994","article-title":"Neuronal loss induced in limbic pathways by kindling","volume":"14","author":"Cavazos","year":"1994","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib59","doi-asserted-by":"crossref","first-page":"10432","DOI":"10.1073\/pnas.94.19.10432","article-title":"Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures","volume":"94","author":"Bengzon","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.spen.2005.03.002_bib60","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1126\/science.2449733","article-title":"Synaptic reorganization in the hippocampus induced by abnormal functional activity","volume":"239","author":"Sutula","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.spen.2005.03.002_bib61","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1523\/JNEUROSCI.17-10-03727.1997","article-title":"Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus","volume":"17","author":"Parent","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib62","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/1098-1063(2000)10:5<617::AID-HIPO13>3.0.CO;2-R","article-title":"Spine loss and other dendritic abnormalities in epilepsy","volume":"10","author":"Swann","year":"2000","journal-title":"Hippocampus"},{"key":"10.1016\/j.spen.2005.03.002_bib63","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0306-4522(84)90289-6","article-title":"Maturation of kainic acid seizure-brain damage syndrome in the rat. II","volume":"13","author":"Nitecka","year":"1984","journal-title":"Histopathological sequelae Neuroscience"},{"key":"10.1016\/j.spen.2005.03.002_bib64","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0165-3806(91)90158-F","article-title":"Resistance of the immature hippocampus to seizure-induced synaptic reorganization","volume":"60","author":"Sperber","year":"1991","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib65","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0165-3806(95)00110-Y","article-title":"Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals","volume":"89","author":"Carmant","year":"1995","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib66","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0006-8993(10)80015-0","article-title":"Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats","volume":"583","author":"Hirsch","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib67","doi-asserted-by":"crossref","first-page":"8382","DOI":"10.1523\/JNEUROSCI.18-20-08382.1998","article-title":"Patterns of status epileptic-induced neuronal injury during development and long-term consequences","volume":"18","author":"Sankar","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib68","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0165-3806(02)00358-9","article-title":"Downregulation of kainate receptors in the hippocampus following repeated seizures in immature rats","volume":"136","author":"Tandon","year":"2002","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib69","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-3806(96)00165-4","article-title":"GABA metabolism during status epilepticus in the developing rat brain","volume":"98","author":"Sankar","year":"1997","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib70","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuroscience.2004.01.040","article-title":"Effects of status epilepticus on hippocampal GABAA receptors are age-dependent","volume":"125","author":"Zhang","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.spen.2005.03.002_bib71","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1159\/000111257","article-title":"Developmental regulation of glutamate and GABA(A) receptor gene expression in rat hippocampus following kainate-induced status epilepticus","volume":"19","author":"Friedman","year":"1997","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib72","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/ana.10543","article-title":"Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death","volume":"53","author":"Sullivan","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib73","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0306-4522(02)00979-X","article-title":"Age dependence of seizure-induced oxidative stress","volume":"118","author":"Patel","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.spen.2005.03.002_bib74","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.nbd.2003.08.001","article-title":"Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development","volume":"14","author":"Rizzi","year":"2003","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.spen.2005.03.002_bib75","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1159\/000066743","article-title":"Age-dependent differences in flurothyl-induced c-fos and c-jun mRNA expression in the mouse brain","volume":"24","author":"Storey","year":"2002","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib76","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0306-4522(98)00609-5","article-title":"Neuroprotective effects of brain-derived neurotrophic factor in seizures during development","volume":"91","author":"Tandon","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.spen.2005.03.002_bib77","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0920-1211(94)90062-0","article-title":"Long-term behavioral deficits following pilocarpine seizures in immature rats","volume":"19","author":"Liu","year":"1994","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.spen.2005.03.002_bib78","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0920-1211(96)00047-2","article-title":"Developmental aspects of the pilocarpine model of epilepsy","volume":"26","author":"Priel","year":"1996","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.spen.2005.03.002_bib79","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/1531-8249(200010)48:4<580::AID-ANA4>3.0.CO;2-B","article-title":"Epileptogenesis after status epilepticus reflects age- and model-dependent plasticity","volume":"48","author":"Sankar","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib80","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1528-1157.1993.tb02582.x","article-title":"Age-dependent cognitive and behavioral deficits after kainic acid seizures","volume":"34","author":"Stafstrom","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib81","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0165-3806(92)90184-X","article-title":"Kainic acid seizures in the developing brain","volume":"65","author":"Stafstrom","year":"1992","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib82","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1212\/WNL.53.5.915","article-title":"Early-life seizures in rats increase susceptibility to seizure-induced brain injury in adulthood","volume":"53","author":"Koh","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.spen.2005.03.002_bib83","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ana.410440602","article-title":"Consequences of neonatal seizures in the rat","volume":"44","author":"Holmes","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib84","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0165-3806(99)00135-2","article-title":"Long-term effects of neonatal seizures","volume":"118","author":"Huang","year":"1999","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib85","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1471-4159.2003.02124.x","article-title":"Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility","volume":"88","author":"Zhang","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.spen.2005.03.002_bib86","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1523\/JNEUROSCI.22-11-04591.2002","article-title":"Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner","volume":"22","author":"Brewster","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib87","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/ana.410260303","article-title":"Mossy fiber reorganization in the epileptic human temporal lobe","volume":"26","author":"Sutula","year":"1989","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib88","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0165-3806(97)00211-3","article-title":"Synaptic reorganization following kainic acid-induced seizures during development","volume":"107","author":"Yang","year":"1998","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib89","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0306-4522(99)00064-0","article-title":"Consequences of recurrent seizures during early brain development","volume":"92","author":"Liu","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.spen.2005.03.002_bib90","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/hipo.10089","article-title":"Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures","volume":"13","author":"Bender","year":"2003","journal-title":"Hippocampus"},{"key":"10.1016\/j.spen.2005.03.002_bib91","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0165-3806(01)00177-8","article-title":"Recurrent neonatal seizures","volume":"129","author":"de Rogalski Landrot","year":"2001","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib92","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0006-8993(98)00030-4","article-title":"Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat","volume":"790","author":"Gray","year":"1998","journal-title":"Brain Res"},{"issue":"suppl 6","key":"10.1016\/j.spen.2005.03.002_bib93","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1111\/j.1528-1157.2000.tb01557.x","article-title":"Granule cell neurogenesis after status epileptics in the immature rat brain","volume":"41","author":"Sankar","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib94","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0013-9580.2004.23903.x","article-title":"Fate of newborn dentate granule cells after early life status epilepticus","volume":"45","author":"Porter","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib95","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1523\/JNEUROSCI.21-06-02094.2001","article-title":"Reduced neurogenesis after neonatal seizures","volume":"21","author":"McCabe","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib96","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.1523\/JNEUROSCI.20-16-06144.2000","article-title":"Granule-like neurons at the hilar\/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells","volume":"20","author":"Scharfman","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib97","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/brain\/awf130","article-title":"The neuronal channelopathies","volume":"125","author":"Kullmann","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.spen.2005.03.002_bib98","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1474-4422(02)00071-6","article-title":"Neurological disorders caused by inherited ion-channel mutations","volume":"1","author":"Kullmann","year":"2002","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib99","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0733-8619(03)00012-4","article-title":"Channelopathies in pediatric neurology","volume":"21","author":"Pandey","year":"2003","journal-title":"Neurol Clin"},{"key":"10.1016\/j.spen.2005.03.002_bib100","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/ng1393","article-title":"Mutations in EFHC1 cause juvenile myoclonic epilepsy","volume":"36","author":"Suzuki","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib101","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/ng832","article-title":"Mutations in LGI1 causes autosomal-dominant partial epilepsy with auditory features","volume":"30","author":"Kalachikov","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib102","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0387-7604(03)00149-9","article-title":"Genes and mutations in human idiopathic epilepsy","volume":"26","author":"Steinlein","year":"2004","journal-title":"Brain Dev"},{"key":"10.1016\/j.spen.2005.03.002_bib103","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1126\/science.279.5349.403","article-title":"A potassium channel mutation in neonatal human epilepsy","volume":"279","author":"Biervert","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.spen.2005.03.002_bib104","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng0198-25","article-title":"A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns","volume":"18","author":"Singh","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib105","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/ng0198-53","article-title":"A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family","volume":"18","author":"Charlier","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib106","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1126\/science.282.5395.1890","article-title":"KCNQ2 and KCNQ3 potassium channel subunits","volume":"282","author":"Wang","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.spen.2005.03.002_bib107","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/1531-8249(199909)46:3<305::AID-ANA5>3.0.CO;2-5","article-title":"A reduced K+ current due to a novel mutation in KCNQ2 causes neonatal convulsion","volume":"46","author":"Lerche","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib108","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/25367","article-title":"Moderate loss of function of cyclic-AMP-modulated KCNQ2\/KCNQ3 K+ channels causes epilepsy","volume":"396","author":"Schroeder","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.spen.2005.03.002_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/JNEUROSCI.22-02-j0003.2002","article-title":"Benign familial neonatal convulsions caused by altered gating of KCNQ2\/KCNQ3 potassium channels","volume":"22","author":"Castaldo","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib110","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0920-1211(02)00249-8","article-title":"Age-dependent modulation of hippocampal excitability by KCNQ-channels","volume":"53","author":"Okada","year":"2003","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.spen.2005.03.002_bib111","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1523\/JNEUROSCI.21-15-05535.2001","article-title":"Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine","volume":"21","author":"Tatulian","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib112","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/brain\/120.3.479","article-title":"Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes","volume":"120","author":"Scheffer","year":"1997","journal-title":"Brain"},{"key":"10.1016\/j.spen.2005.03.002_bib113","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/1531-8249(199901)45:1<75::AID-ART13>3.0.CO;2-W","article-title":"Generalized epilepsy with febrile seizures plus","volume":"45","author":"Singh","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib114","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1046\/j.1528-1157.2001.042007837.x","article-title":"Severe myoclonic epilepsy of infancy","volume":"42","author":"Singh","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib115","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/448","article-title":"Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B","volume":"19","author":"Wallace","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib116","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1086\/319516","article-title":"Neuronal sodium-channel alpha1-subunit mutations in generalized epilepsy with febrile seizures plus","volume":"68","author":"Wallace","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib117","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/74159","article-title":"Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2","volume":"24","author":"Escayg","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib118","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1086\/319524","article-title":"A novel SCN1A mutation associated with generalized epilepsy with febrile seizures plus and prevalence of variants in patients with epilepsy","volume":"68","author":"Escayg","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib119","doi-asserted-by":"crossref","first-page":"6384","DOI":"10.1073\/pnas.111065098","article-title":"A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction","volume":"98","author":"Sugawara","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.spen.2005.03.002_bib120","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0896-6273(02)00714-6","article-title":"Molecular basis of an inherited epilepsy","volume":"34","author":"Lossin","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.spen.2005.03.002_bib121","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1469-7793.2000.00533.x","article-title":"A sodium channel mutation causing epilepsy in man exhibits subtle defects in fast inactivation and activation in vitro","volume":"529","author":"Alekov","year":"2000","journal-title":"J Physiol"},{"key":"10.1016\/j.spen.2005.03.002_bib122","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1523\/JNEUROSCI.21-19-07481.2001","article-title":"Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2","volume":"21","author":"Spampanato","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib123","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0306-4522(02)00698-X","article-title":"Generalized epilepsy with febrile seizures plus type 2 mutation W1204R alters voltage-dependent gating of Na(v)1.1 sodium channels","volume":"116","author":"Spampanato","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.spen.2005.03.002_bib124","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0920-1211(02)00259-0","article-title":"Functional characterization of the D188V mutation in neuronal voltage-gated sodium channel causing generalized epilepsy with febrile seizures plus (GEFS)","volume":"53","author":"Cossette","year":"2003","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.spen.2005.03.002_bib125","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1046\/j.0953-816x.2001.01590.x","article-title":"Enhanced inactivation and acceleration of activation of the sodium channel associated with epilepsy in man","volume":"13","author":"Alekov","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib126","doi-asserted-by":"crossref","first-page":"11289","DOI":"10.1523\/JNEUROSCI.23-36-11289.2003","article-title":"Epilepsy-associated dysfunction in the voltage-gated neuronal sodium channel SCN1A","volume":"23","author":"Lossin","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib127","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ng0501-46","article-title":"First genetic evidence of GABA(A) receptor dysfunction in epilepsy","volume":"28","author":"Baulac","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib128","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1086\/338710","article-title":"Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus","volume":"70","author":"Harkin","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib129","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/ng885","article-title":"Mutation of GABARA1 in an autosomal dominant form of juvenile myoclonic epilepsy","volume":"31","author":"Cossette","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib130","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng0501-49","article-title":"Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures","volume":"28","author":"Wallace","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib131","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.neuropharm.2003.11.015","article-title":"A mutation in the GABAA receptor \u03b11 subunit linked to human epilepsy affects channel gating properties","volume":"46","author":"Fisher","year":"2004","journal-title":"Neuropharm"},{"key":"10.1016\/j.spen.2005.03.002_bib132","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ana.10607","article-title":"Association between genetic variation of CACNA1H and childhood absence epilepsy","volume":"54","author":"Chen","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib133","doi-asserted-by":"crossref","first-page":"9681","DOI":"10.1074\/jbc.C400006200","article-title":"Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy","volume":"279","author":"Khosravani","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.spen.2005.03.002_bib134","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/ng1121","article-title":"Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies","volume":"33","author":"Haug","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib135","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1212\/WNL.57.12.2168","article-title":"Classification system for malformations of cortical development","volume":"57","author":"Barkovich","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.spen.2005.03.002_bib136","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1212\/WNL.53.4.715","article-title":"Clinical and imaging features of cortical malformations in childhood","volume":"53","author":"Leventer","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.spen.2005.03.002_bib137","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1001\/archneur.59.3.361","article-title":"Disorders of cortical development and epilepsy","volume":"59","author":"Porter","year":"2002","journal-title":"Arch Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib138","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-4757-6376-8_12","article-title":"Cortical dysplasia and epilepsy","volume":"548","author":"Schwartzkroin","year":"2004","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.spen.2005.03.002_bib139","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1474-4422(03)00620-3","article-title":"Malformations of cortical development","volume":"3","author":"Sisodiya","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib140","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1136\/jnnp.34.4.369","article-title":"Focal dysplasia of the cerebral cortex in epilepsy","volume":"34","author":"Taylor","year":"1971","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.spen.2005.03.002_bib141","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1212\/WNL.50.1.27","article-title":"Cortical dysplasia","volume":"50","author":"Spreafico","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.spen.2005.03.002_bib142","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1212\/WNL.56.7.906","article-title":"Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia","volume":"56","author":"Crino","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.spen.2005.03.002_bib143","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1046\/j.1528-1157.2003.54802.x","article-title":"Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in taylor-type focal cortical dysplasia","volume":"44","author":"Aronica","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib144","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/1531-8249(199912)46:6<816::AID-ANA3>3.0.CO;2-O","article-title":"Epileptiform discharges in the human dysplastic neocortex","volume":"46","author":"Avoli","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib145","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1093\/brain\/awh181","article-title":"GABAA receptor-dependent synchronization leads to ictogenesis in the human dysplastic cortex","volume":"127","author":"D\u2019Antuono","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.spen.2005.03.002_bib146","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/1531-8249(200101)49:1<67::AID-ANA10>3.0.CO;2-L","article-title":"Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers","volume":"49","author":"White","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib147","doi-asserted-by":"crossref","first-page":"8762","DOI":"10.1073\/pnas.151033798","article-title":"A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice","volume":"98","author":"Kobayashi","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.spen.2005.03.002_bib148","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ana.10283","article-title":"Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures","volume":"52","author":"Uhlmann","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib149","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/ana.10648","article-title":"Impaired astrocyte glutamate transport in a mouse epilepsy model of tuberous sclerosis complex","volume":"54","author":"Wong","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib150","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0896-6273(00)80651-0","article-title":"Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia","volume":"21","author":"Fox","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.spen.2005.03.002_bib151","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/364717a0","article-title":"Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats","volume":"364","author":"Reiner","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.spen.2005.03.002_bib152","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0092-8674(00)80898-3","article-title":"A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome","volume":"92","author":"des Portes","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.spen.2005.03.002_bib153","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0092-8674(00)80899-5","article-title":"Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein","volume":"92","author":"Gleeson","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.spen.2005.03.002_bib154","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0896-6273(00)80778-3","article-title":"Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons","volume":"23","author":"Gleeson","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.spen.2005.03.002_bib155","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1432-1327.1999.00711.x","article-title":"LIS1 is a microtubule-associated phosphoprotein","volume":"265","author":"Sapir","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.spen.2005.03.002_bib156","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/1221","article-title":"Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality","volume":"19","author":"Hirotsune","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib157","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1523\/JNEUROSCI.20-07-02439.2000","article-title":"Hippocampal abnormalities and enhanced excitability in a murine model of human lissencephaly","volume":"20","author":"Fleck","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib158","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.1523\/JNEUROSCI.17-16-06236.1997","article-title":"A genetic animal model of human neocortical heterotopia associated with seizures","volume":"17","author":"Lee","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib159","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/(SICI)1096-9861(19980525)395:1<29::AID-CNE3>3.0.CO;2-J","article-title":"Subcortical connections of normotopic and heterotopic neurons in sensory and motor cortices of the tish mutant rat","volume":"395","author":"Schottler","year":"1998","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib160","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1528-1157.2000.tb00201.x","article-title":"Distribution and initiation of seizure activity in a rat brain with subcortical band heterotopia","volume":"41","author":"Chen","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib161","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/00005072-195610000-00006","article-title":"Malformation of the adult brain (albino rat) resulting from prenatal irradiation","volume":"15","author":"Riggs","year":"1956","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.spen.2005.03.002_bib162","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1046\/j.1528-1157.2001.38300.x","article-title":"Electroencephalographic characterization of an adult rat model of radiation-induced cortical dysplasia","volume":"42","author":"Kondo","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.spen.2005.03.002_bib163","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0920-1211(99)00104-7","article-title":"Flurothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatment","volume":"39","author":"Baraban","year":"2000","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.spen.2005.03.002_bib164","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0920-1211(99)00035-2","article-title":"Reduced density of parvalbumin- and calbindin D28k-immunoreactive neurons in experimental cortical dysplasia","volume":"37","author":"Robper","year":"1999","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.spen.2005.03.002_bib165","doi-asserted-by":"crossref","first-page":"8925","DOI":"10.1523\/JNEUROSCI.20-23-08925.2000","article-title":"Reduced inhibition in an animal model of cortical dysplasia","volume":"20","author":"Zhu","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib166","doi-asserted-by":"crossref","first-page":"7596","DOI":"10.1523\/JNEUROSCI.22-17-07596.2002","article-title":"Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy","volume":"22","author":"Calcagnotto","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib167","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0006-8993(97)01273-0","article-title":"Glutamate receptors in dysplasic cortex","volume":"782","author":"Rafiki","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.spen.2005.03.002_bib168","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.1523\/JNEUROSCI.21-17-06626.2001","article-title":"Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy","volume":"21","author":"Castro","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib169","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1152\/jn.00500.2002","article-title":"NPY sensitivity and postsynaptic properties of heterotopic neurons in the MAM model of malformation-associated epilepsy","volume":"88","author":"Pentney","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.spen.2005.03.002_bib170","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1086\/425985","article-title":"Mutations in the AHI1 Gene, encoding Jouberin, cause Joubert syndrome with cortical polymicrogyria","volume":"75","author":"Dixon-Salazar","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.spen.2005.03.002_bib171","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/cercor\/6.3.514","article-title":"Hyperexcitability in a model of cortical maldevelopment","volume":"6","author":"Jacobs","year":"1996","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.spen.2005.03.002_bib172","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1152\/jn.1999.81.1.159","article-title":"Focal epileptogenesis in a rat model of polymicrogyria","volume":"81","author":"Jacobs","year":"1999","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.spen.2005.03.002_bib173","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1152\/jn.1998.80.1.92","article-title":"Characterization of neuronal migration disorders in neocortical structures. II. Intracellular in vitro recordings","volume":"80","author":"Luhmann","year":"1998","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.spen.2005.03.002_bib174","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1046\/j.1460-9568.1998.00322.x","article-title":"Characterization of neuronal migration disorders in neocortical structures","volume":"10","author":"Zilles","year":"1998","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.spen.2005.03.002_bib175","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/jn.2000.83.1.315","article-title":"Alterations in NMDA receptors in a rat model of cortical dysplasia","volume":"83","author":"Defazio","year":"2000","journal-title":"J Neurophysiol"}],"container-title":["Seminars in Pediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071909105000392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071909105000392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T19:18:29Z","timestamp":1683141509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071909105000392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":175,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S1071909105000392"],"URL":"https:\/\/doi.org\/10.1016\/j.spen.2005.03.002","relation":{},"ISSN":["1071-9091"],"issn-type":[{"value":"1071-9091","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}