{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:53:43Z","timestamp":1775883223340,"version":"3.50.1"},"reference-count":158,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Pediatric Neurology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.spen.2019.08.008","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T02:04:08Z","timestamp":1565316248000},"page":"100772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Neuroprotection Strategies in Preterm Encephalopathy"],"prefix":"10.1016","volume":"32","author":[{"given":"Pratik","family":"Parikh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra E.","family":"Juul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.spen.2019.08.008_bib0001","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0140-6736(14)61698-6","article-title":"Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: An updated systematic analysis","volume":"385","author":"Liu","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.spen.2019.08.008_bib0002","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","article-title":"Global, regional, and nationalcauses of child mortality: An updated systematic analysis for 2010 with time trends since 2000","volume":"379","author":"Liu","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.spen.2019.08.008_bib0003","first-page":"1","article-title":"Births in the United States, 2016","author":"Martin","year":"2017","journal-title":"NCHS Data Brief"},{"key":"10.1016\/j.spen.2019.08.008_bib0004","series-title":"Preterm Birth: Causes, Consequences, and Prevention","article-title":"Preterm Birth: Causes, Consequences, and Prevention","year":"2007"},{"key":"10.1016\/j.spen.2019.08.008_bib0005","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1542\/peds.2010-1150","article-title":"Early-childhood neurodevelopmental outcomes are not improving for infants born at <25 weeks' gestational age","volume":"127","author":"Hintz","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0006","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1056\/NEJMoa1605566","article-title":"Survival and neurodevelopmental outcomes among periviable infants","volume":"376","author":"Younge","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.spen.2019.08.008_bib0007","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.pediatrneurol.2015.04.006","article-title":"Brain injury in the preterm infant: New Horizons for pathogenesis and prevention","volume":"53","author":"Back","year":"2015","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.spen.2019.08.008_bib0008","doi-asserted-by":"crossref","first-page":"e265","DOI":"10.1371\/journal.pmed.0030265","article-title":"Abnormal cortical development after premature birth shown by altered allometric scaling of brain growth","volume":"3","author":"Kapellou","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.spen.2019.08.008_bib0009","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/ana.22627","article-title":"Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants","volume":"71","author":"Buser","year":"2012","journal-title":"Ann Neurol."},{"key":"10.1016\/j.spen.2019.08.008_bib0010","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00401-017-1718-6","article-title":"White matter injury in the preterm infant: Pathology and mechanisms","volume":"134","author":"Back","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.spen.2019.08.008_bib0011","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/ana.22489","article-title":"Systemic inflammation disrupts the developmental program of white matter","volume":"70","author":"Favrais","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2019.08.008_bib0012","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.mcn.2009.07.010","article-title":"Wnt signaling is sufficient to perturb oligodendrocyte maturation","volume":"42","author":"Feigenson","year":"2009","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.spen.2019.08.008_bib0013","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nn.2333","article-title":"HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction","volume":"12","author":"Ye","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.spen.2019.08.008_bib0014","doi-asserted-by":"crossref","first-page":"15066","DOI":"10.1523\/JNEUROSCI.1320-12.2012","article-title":"Pleiotrophin suppression of receptor protein tyrosine phosphatase-beta\/zeta maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells","volume":"32","author":"McClain","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2019.08.008_bib0015","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.1651-2227.2010.01811.x","article-title":"The development of the subplate and thalamocortical connections in the human foetal brain","volume":"99","author":"Kostovic","year":"2010","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.spen.2019.08.008_bib0016","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.neuron.2006.07.008","article-title":"Subplate neurons regulate maturation of cortical inhibition and outcome of ocular dominance plasticity","volume":"51","author":"Kanold","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.spen.2019.08.008_bib0017","first-page":"112","article-title":"Subplate neurons\u2013missing link in brain injury of the premature infant?","volume":"97","author":"Volpe","year":"1996","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0018","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/pr.2015.106","article-title":"Impaired cognitive performance in premature newborns with two or more surgeries prior to term-equivalent age","volume":"78","author":"Gano","year":"2015","journal-title":"Pediatr Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0019","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/STROKEAHA.111.632265","article-title":"Differential susceptibility to axonopathy in necrotic and non-necrotic perinatal white matter injury","volume":"43","author":"Riddle","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.spen.2019.08.008_bib0020","first-page":"87","article-title":"Early immunohistochemical detection of axonal damage and glial activation in extremely immature brains with periventricular leukomalacia","volume":"20","author":"Hirayama","year":"2001","journal-title":"Clin Neuropathol"},{"key":"10.1016\/j.spen.2019.08.008_bib0021","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/ana.22501","article-title":"Histopathological correlates of magnetic resonance imaging-defined chronic perinatal white matter injury","volume":"70","author":"Riddle","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2019.08.008_bib0022","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S1474-4422(08)70294-1","article-title":"Brain injury in premature infants: A complex amalgam of destructive and developmental disturbances","volume":"8","author":"Volpe","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.spen.2019.08.008_bib0023","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jpeds.2016.06.051","article-title":"Intubation attempts increase the risk for severe intraventricular hemorrhage in preterm infants\u2014A retrospective cohort study","volume":"177","author":"Sauer","year":"2016","journal-title":"J Pediatr"},{"key":"10.1016\/j.spen.2019.08.008_bib0024","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/ana.24313","article-title":"Regional impairmentsof cortical folding in premature infants","volume":"77","author":"Engelhardt","year":"2015","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2019.08.008_bib0025","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1203\/PDR.0b013e3181a1fb3d","article-title":"Cerebellar development in the preterm neonate: Effect of supratentorial brain injury","volume":"66","author":"Tam","year":"2009","journal-title":"Pediatr Res"},{"issue":"suppl 1","key":"10.1016\/j.spen.2019.08.008_bib0026","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/14767058.2012.664343","article-title":"Brain tissue volumes in preterm infants: prematurity, perinatal risk factors and neurodevelopmental outcome: A systematic review","volume":"25","author":"Keunen","year":"2012","journal-title":"J Maternal-Fetal Neonatal Med"},{"key":"10.1016\/j.spen.2019.08.008_bib0027","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1148\/radiol.12110367","article-title":"Deep gray matter maturation in very preterm neonates: Regional variations and pathology-related age-dependent changes in magnetization transfer ratio","volume":"263","author":"Nossin-Manor","year":"2012","journal-title":"Radiology"},{"key":"10.1016\/j.spen.2019.08.008_bib0028","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1126\/scitranslmed.3004666","article-title":"Slower postnatal growth is associated with delayed cerebral cortical maturation in preterm newborns","volume":"5","author":"Vinall","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.spen.2019.08.008_bib0029","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1542\/peds.2006-2508","article-title":"Quantification of deep gray matter in preterm infants at term-equivalent age using manual volumetry of 3-tesla magnetic resonance images","volume":"119","author":"Srinivasan","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0030","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1126\/scitranslmed.3004669","article-title":"Prenatal cerebral ischemia disrupts MRI-defined cortical microstructure through disturbances in neuronal arborization","volume":"5","author":"Dean","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.spen.2019.08.008_bib0031","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1523\/JNEUROSCI.4445-12.2013","article-title":"Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birth","volume":"33","author":"Malik","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2019.08.008_bib0032","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1177\/0883073809338067","article-title":"Cerebellum of the premature infant: Rapidly developing, vulnerable, clinically important","volume":"24","author":"Volpe","year":"2009","journal-title":"J Child Neurol"},{"key":"10.1016\/j.spen.2019.08.008_bib0033","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1542\/peds.2004-2282","article-title":"Impaired trophic interactions between the cerebellum and the cerebrum among preterm infants","volume":"116","author":"Limperopoulos","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0034","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1148\/radiol.2521081525","article-title":"Cerebellar injury in preterm infants: Incidence and findings on US and MR images","volume":"252","author":"Steggerda","year":"2009","journal-title":"Radiology"},{"key":"10.1016\/j.spen.2019.08.008_bib0035","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/s12311-013-0487-6","article-title":"Small cerebellar hemorrhage in preterm infants: Perinatal and postnatal factors and outcome","volume":"12","author":"Steggerda","year":"2013","journal-title":"Cerebellum"},{"key":"10.1016\/j.spen.2019.08.008_bib0036","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/cercor\/bhs354","article-title":"Injury to the premature cerebellum: Outcome is related to remote cortical development","volume":"24","author":"Limperopoulos","year":"2014","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.spen.2019.08.008_bib0037","doi-asserted-by":"crossref","DOI":"10.1203\/PDR.0b013e3181e1d032","article-title":"Cerebellar injury in the premature infant is associated with impaired growth of specific cerebral regions","author":"Limperopoulos","year":"2010","journal-title":"Pediatr Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0038","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1203\/01.pdr.0000220324.27597.f0","article-title":"Reduction in cerebellar volumes in preterm infants: Relationship to white matter injury and neurodevelopment at two years of age","volume":"60","author":"Shah","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0039","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1542\/peds.2007-1041","article-title":"Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors?","volume":"120","author":"Limperopoulos","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0040","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/brain\/124.1.60","article-title":"Cognitive and motor function and the size of the cerebellum in adolescents born very pre-term","volume":"124","author":"Allin","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.spen.2019.08.008_bib0041","doi-asserted-by":"crossref","DOI":"10.3390\/nu9030197","article-title":"Omega-3 fattyacid intake of pregnant women and women of childbearing age in the United States: Potential for deficiency?","volume":"9","author":"Nordgren","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.spen.2019.08.008_bib0042","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.plefa.2015.05.003","article-title":"What is the relationship between gestational age and docosahexaenoic acid (DHA) and arachidonic acid (ARA) levels?","volume":"100","author":"Baack","year":"2015","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.spen.2019.08.008_bib0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plefa.2015.04.003","article-title":"A dose response randomised controlled trial of docosahexaenoic acid (DHA) in preterm infants","volume":"99","author":"Collins","year":"2015","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.spen.2019.08.008_bib0044","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/pr.2016.11","article-title":"Early postnatal docosahexaenoic acid levels and improved preterm brain development","volume":"79","author":"Tam","year":"2016","journal-title":"Pediatr Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0045","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1001\/jama.2008.945","article-title":"Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid: A randomized controlled trial","volume":"301","author":"Makrides","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.spen.2019.08.008_bib0046","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1542\/peds.2007-1511","article-title":"Improved cognitive development among preterm infants attributable to early supplementation of human milk with docosahexaenoic acid and arachidonic acid","volume":"121","author":"Henriksen","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0047","article-title":"Long chain polyunsaturated fatty acid supplementation in infants born at term","volume":"3","author":"Jasani","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.spen.2019.08.008_bib0048","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2147\/IJWH.S36610","article-title":"Nutrition in pregnancy: The argument for including a source of choline","volume":"5","author":"Zeisel","year":"2013","journal-title":"Int J Womens Health"},{"issue":"suppl 5","key":"10.1016\/j.spen.2019.08.008_bib0049","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/j.jpeds.2006.06.065","article-title":"The fetal origins of memory: The role of dietary choline in optimal brain development","volume":"149","author":"Zeisel","year":"2006","journal-title":"J Pediatr"},{"key":"10.1016\/j.spen.2019.08.008_bib0050","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1076\/apab.110.5.393.11832","article-title":"Free and phospholipid-bound choline concentrations in serum during pregnancy, after delivery and in newborns","volume":"110","author":"Ozarda Ilcol","year":"2002","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.spen.2019.08.008_bib0051","doi-asserted-by":"crossref","first-page":"e43448","DOI":"10.1371\/journal.pone.0043448","article-title":"Early second trimester maternal plasma choline and betaine are related to measures of early cognitive development in term infants","volume":"7","author":"Wu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.spen.2019.08.008_bib0052","article-title":"Nutritional intervention and neurodevelopmental outcome in newborn infants at risk of neurodevelopmental impairment: The Dolphin neonatal double-blind randomized controlled trial","author":"Andrew","year":"2018","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.spen.2019.08.008_bib0053","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1542\/peds.50.4.515","article-title":"A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants","volume":"50","author":"Liggins","year":"1972","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0054","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1001\/jama.1995.03520290065031","article-title":"Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH consensus development panel on the effect of corticosteroids for fetal maturation on perinatal outcomes","volume":"273","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.spen.2019.08.008_bib0055","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004454.pub2","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","author":"Roberts","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.spen.2019.08.008_bib0056","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/bmj.38576.494363.E0","article-title":"Antenatal exposure to betamethasone: Psychological functioning and health related quality of life 31 years after inclusion in randomised controlled trial","volume":"331","author":"Dalziel","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.spen.2019.08.008_bib0057","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1097\/AOG.0000000000000748","article-title":"Neurodevelopmental outcome after a single course of antenatal steroids in children born preterm: A systematic review and meta-analysis","volume":"125","author":"Sotiriadis","year":"2015","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.spen.2019.08.008_bib0058","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","volume":"3","author":"Roberts","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.spen.2019.08.008_bib0059","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(14)61651-2","article-title":"A population-based, multifaceted strategy to implement antenatal corticosteroid treatment versus standard care for the reduction of neonatal mortality due to preterm birth in low-income and middle-income countries: The ACT cluster-randomised trial","volume":"385","author":"Althabe","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.spen.2019.08.008_bib0060","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1542\/peds.95.2.263","article-title":"Can magnesium sulfate reduce the risk of cerebral palsy in very low birthweight infants?","volume":"95","author":"Nelson","year":"1995","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0061","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1097\/AOG.0b013e3181a60495","article-title":"Antenatal magnesium sulfate and neurologic outcome in preterm infants: A systematic review","volume":"113","author":"Doyle","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.spen.2019.08.008_bib0062","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/MOP.0b013e3283504da1","article-title":"Antenatal magnesium sulfate and neuroprotection","volume":"24","author":"Doyle","year":"2012","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.spen.2019.08.008_bib0063","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1067\/mob.2000.109491","article-title":"Magnesium prevents seizure-induced reduction in excitatory amino acid receptor (kainate and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) binding in pregnant rat brain","volume":"183","author":"Hallak","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.spen.2019.08.008_bib0064","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/pr.2015.96","article-title":"Effects of antenatal magnesium sulfate treatment for neonatal neuro-protection on cerebral oxygen kinetics","volume":"78","author":"Stark","year":"2015","journal-title":"Pediatr Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0065","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1001\/jama.2014.11189","article-title":"School-age outcomes of very preterm infants after antenatal treatment with magnesium sulfate vs placebo","volume":"312","author":"Doyle","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.spen.2019.08.008_bib0066","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/AOG.0b013e3181d4ffa5","article-title":"Committee opinion no. 455: Magnesium sulfate before anticipated preterm birth for neuroprotection","volume":"115","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.spen.2019.08.008_bib0067","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1097\/AOG.0000000000001860","article-title":"Committee opinion no. 684: delayed umbilical cord clamping after birth","volume":"129","year":"2017","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.spen.2019.08.008_bib0068","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1701-2163(16)35268-9","article-title":"Early versus delayed cord clamping in term and preterm births: A review","volume":"34","author":"Garofalo","year":"2012","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.spen.2019.08.008_bib0069","doi-asserted-by":"crossref","DOI":"10.1111\/jog.12657","article-title":"Umbilical cord milking reduces need for red cell transfusions and improves neonatal adaptation in preterm infants: Meta-analysis","author":"Dang","year":"2015","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0070","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000441891","article-title":"Neurodevelopmental outcomes at 2 and 3.5 years for very preterm babies enrolled in a randomized trial of milking the umbilical cord versus delayed cord clamping","volume":"109","author":"Rabe","year":"2016","journal-title":"Neonatology"},{"key":"10.1016\/j.spen.2019.08.008_bib0071","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1542\/peds.2005-2382","article-title":"Beneficial effects of breast milk in the neonatal intensive care unit on the developmental outcome of extremely low birth weight infants at 18 months of age","volume":"118","author":"Vohr","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0072","doi-asserted-by":"crossref","first-page":"e953","DOI":"10.1542\/peds.2006-3227","article-title":"Persistent beneficial effects of breast milk ingested in the neonatal intensive care unit on outcomes of extremely low birth weight infants at 30 months of age","volume":"120","author":"Vohr","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0073","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1651-2227.2010.02064.x","article-title":"Predictors of the risk of cognitive deficiency in very preterm infants: The EPIPAGE prospective cohort","volume":"100","author":"Beaino","year":"2011","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.spen.2019.08.008_bib0074","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jpeds.2016.06.045","article-title":"Breast milk feeding, brain development, and neurocognitive outcomes: A 7-year longitudinal study in infants born at less than 30 weeks' gestation","volume":"177","author":"Belfort","year":"2016","journal-title":"J Pediatr"},{"key":"10.1016\/j.spen.2019.08.008_bib0075","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/ana.21008","article-title":"Protective effects of caffeine on chronic hypoxia-induced perinatal white matter injury","volume":"60","author":"Back","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spen.2019.08.008_bib0076","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1203\/PDR.0b013e31820efbcf","article-title":"Adverse and protective influences of adenosine on the newborn and embryo: Implications for preterm white matter injury and embryo protection","volume":"69","author":"Rivkees","year":"2011","journal-title":"Pediatr Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0077","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1097\/00001756-200207020-00026","article-title":"A1 adenosine receptor activation induces ventriculomegaly and white matter loss","volume":"13","author":"Turner","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.spen.2019.08.008_bib0078","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/157015905774322543","article-title":"The potential of caffeine for functional modification from cortical synapses to neuron networks in the brain","volume":"3","author":"Yoshimura","year":"2005","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.spen.2019.08.008_bib0079","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/0883073814538500","article-title":"Effects of caffeine treatment for apnea of prematurity on cortical speech-sound differentiation in preterm infants","volume":"30","author":"Maitre","year":"2015","journal-title":"J Child Neurol"},{"key":"10.1016\/j.spen.2019.08.008_bib0080","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jpeds.2009.10.033","article-title":"Caffeine increases cerebral cortical activity in preterm infants","volume":"156","author":"Supcun","year":"2010","journal-title":"J Pediatr"},{"key":"10.1016\/j.spen.2019.08.008_bib0081","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1056\/NEJMoa073679","article-title":"Long-term effects of caffeine therapy for apnea of prematurity","volume":"357","author":"Schmidt","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.spen.2019.08.008_bib0082","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1001\/jama.2011.2024","article-title":"Survival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurity","volume":"307","author":"Schmidt","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.spen.2019.08.008_bib0083","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/pr.2015.72","article-title":"A pilot randomized trial of high-dose caffeine therapy in preterm infants","volume":"78","author":"McPherson","year":"2015","journal-title":"Pediatr Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0084","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1001\/jama.1994.03520110033025","article-title":"Individualized developmental care for the very low-birth-weight preterm infant","volume":"272","author":"Als","year":"1994","journal-title":"JAMA"},{"key":"10.1016\/j.spen.2019.08.008_bib0085","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1053\/j.nainr.2012.12.002","article-title":"The neonatal integrative developmental care model: Seven neuroprotective core measures for family-centered developmental care","volume":"13","author":"Altimier","year":"2013","journal-title":"NewbornInfant Nurs Rev"},{"key":"10.1016\/j.spen.2019.08.008_bib0086","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1542\/peds.113.4.846","article-title":"Early experience alters brain function and structure","volume":"113","author":"Als","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0087","doi-asserted-by":"crossref","first-page":"e1414","DOI":"10.1542\/peds.2005-2580","article-title":"Reducing premature infants' length of stay and improving parents' mental health outcomes with the creating opportunities for parent empowerment (COPE) neonatal intensive care unit program: A randomized, controlled trial","volume":"118","author":"Melnyk","year":"2006","journal-title":"Pediatrics"},{"issue":"suppl 2","key":"10.1016\/j.spen.2019.08.008_bib0088","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1038\/sj.jp.7211840","article-title":"Impact of a family-centered care initiative on NICU care, staff and families","volume":"27","author":"Cooper","year":"2007","journal-title":"J Perinatol"},{"key":"10.1016\/j.spen.2019.08.008_bib0089","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/imhj.21444","article-title":"Effects of kangaroo mother care on maternal mood and interaction patterns between parents and their preterm, low birth weight infants: A systematic review","volume":"35","author":"Athanasopoulou","year":"2014","journal-title":"Infant Ment Health J."},{"key":"10.1016\/j.spen.2019.08.008_bib0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2431-8-13","article-title":"Kangaroo mother care diminishes pain from heel lance in very preterm neonates: A crossover trial","volume":"8","author":"Johnston","year":"2008","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.spen.2019.08.008_bib0091","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/apa.12618","article-title":"Effect of kangaroo mother care on growth and development of low birthweight babies up to 12 months of age: A controlled clinical trial","volume":"103","author":"Bera","year":"2014","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.spen.2019.08.008_bib0092","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4103\/0970-0218.143030","article-title":"Effect of kangaroo mother care on vital physiological parameters of the low birth weight newborn","volume":"39","author":"Bera","year":"2014","journal-title":"Indian J Commun Med"},{"key":"10.1016\/j.spen.2019.08.008_bib0093","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002771.pub3","article-title":"Kangaroo mother care to reduce morbidity and mortality in low birthweight infants","author":"Conde-Agudelo","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.spen.2019.08.008_bib0094","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-2238","article-title":"Kangaroo mother care and neonatal outcomes: A meta-analysis","volume":"137","author":"Boundy","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.earlhumdev.2016.02.004","article-title":"Kangaroo-mother care method and neurobehavior of preterm infants","volume":"95","author":"Silva","year":"2016","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.spen.2019.08.008_bib0096","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biopsych.2013.08.012","article-title":"Maternal-preterm skin-to-skin contact enhances child physiologic organization and cognitive control across the first 10 years of life","volume":"75","author":"Feldman","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.spen.2019.08.008_bib0097","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1242\/dev.129.2.505","article-title":"Erythropoietin receptor signalling is required for normal brain development","volume":"129","author":"Yu","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.spen.2019.08.008_bib0098","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.critrevonc.2007.03.001","article-title":"Role of erythropoietin in the brain","volume":"64","author":"Noguchi","year":"2007","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.spen.2019.08.008_bib0099","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/pr.2013.155","article-title":"Erythropoietin signaling promotes oligodendrocyte development following prenatal systemic hypoxic-ischemic brain injury","volume":"74","author":"Jantzie","year":"2013","journal-title":"Pediatr Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0100","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/cercor\/bhu066","article-title":"Postnatal erythropoietinmitigates impaired cerebral cortical development following subplate loss from prenatal hypoxia-ischemia","volume":"25","author":"Jantzie","year":"2015","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.spen.2019.08.008_bib0101","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/35088074","article-title":"Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades","volume":"412","author":"Digicaylioglu","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.spen.2019.08.008_bib0102","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nbd.2016.04.006","article-title":"Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke","volume":"93","author":"Larpthaveesarp","year":"2016","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.spen.2019.08.008_bib0103","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1542\/peds.2007-2711","article-title":"A phase I\/II trial of high-dose erythropoietin in extremely low birth weight infants: Pharmacokinetics and safety","volume":"122","author":"Juul","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0104","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1542\/peds.2007-2591","article-title":"An approach to using recombinant erythropoietin for neuroprotection in very preterm infants","volume":"122","author":"Fauchere","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0105","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/jp.2012.78","article-title":"Outcomes of extremely low birth weight infants given early high-dose erythropoietin","volume":"33","author":"McAdams","year":"2013","journal-title":"J Perinatol"},{"key":"10.1016\/j.spen.2019.08.008_bib0106","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1542\/peds.2013-4307","article-title":"Cognitive outcomes of preterm infants randomized to darbepoetin, erythropoietin, or placebo","volume":"133","author":"Ohls","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0107","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-4317","article-title":"Prophylactic early erythropoietin for neuroprotection in preterm infants: A meta-analysis","volume":"139","author":"Fischer","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.spen.2019.08.008_bib0108","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40748-015-0028-z","article-title":"Neuroprotective potential of erythropoietin in neonates; design of a randomized trial","volume":"1","author":"Juul","year":"2015","journal-title":"Matern Health Neonatol Perinatol"},{"key":"10.1016\/j.spen.2019.08.008_bib0109","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3727\/000000006783982034","article-title":"Behavioral and histological characterization of intrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ischemic injury","volume":"15","author":"Yasuhara","year":"2006","journal-title":"Cell Transplant"},{"key":"10.1016\/j.spen.2019.08.008_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2009.03.003","article-title":"Regeneration of the ischemic brain by engineered stem cells: Fuelling endogenous repair processes","volume":"61","author":"van Velthoven","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.spen.2019.08.008_bib0111","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1203\/PDR.0b013e3181bf594b","article-title":"Mesenchymal stem-cell transplantation for hypoxic-ischemic brain injury in neonatal rat model","volume":"67","author":"Lee","year":"2010","journal-title":"Pediatr Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0112","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.1523\/JNEUROSCI.1835-10.2010","article-title":"Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function","volume":"30","author":"van Velthoven","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.spen.2019.08.008_bib0113","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.bbi.2011.03.021","article-title":"Mesenchymal stem cell transplantation changes the gene expression profile of the neonatal ischemic brain","volume":"25","author":"van Velthoven","year":"2011","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.spen.2019.08.008_bib0114","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1161\/STROKEAHA.112.679092","article-title":"Mesenchymal stem cells prevent hydrocephalus after severe intraventricular hemorrhage","volume":"44","author":"Ahn","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.spen.2019.08.008_bib0115","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/jcb.20886","article-title":"Mesenchymal stem cells as trophic mediators","volume":"98","author":"Caplan","year":"2006","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.spen.2019.08.008_bib0116","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1634\/stemcells.2005-0614","article-title":"Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells","volume":"24","author":"Rivera","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.spen.2019.08.008_bib0117","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbi.2009.10.017","article-title":"Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration","volume":"24","author":"van Velthoven","year":"2010","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.spen.2019.08.008_bib0118","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/stem.1304","article-title":"Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: A double-blind, randomized, placebo-controlled trial","volume":"31","author":"Min","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.spen.2019.08.008_bib0119","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jpeds.2013.11.036","article-title":"Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy","volume":"164","author":"Cotten","year":"2014","journal-title":"J Pediatr"},{"key":"10.1016\/j.spen.2019.08.008_bib0120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jpeds.2017.02.061","article-title":"Two-year follow-up outcomes of premature infants enrolled in the phase i trial of mesenchymal stem cells transplantation for bronchopulmonary dysplasia","volume":"185","author":"Ahn","year":"2017","journal-title":"J Pediatr"},{"key":"10.1016\/j.spen.2019.08.008_bib0121","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/BF02253360","article-title":"Actions of melatonin in the reduction of oxidative stress. A review","volume":"7","author":"Reiter","year":"2000","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.spen.2019.08.008_bib0122","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1096\/fj.10-154450","article-title":"Melatonin signaling and cell protection function","volume":"24","author":"Luchetti","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.spen.2019.08.008_bib0123","doi-asserted-by":"crossref","first-page":"9379","DOI":"10.3390\/ijms14059379","article-title":"Neuroprotective effect of melatonin: A novel therapy against perinatal hypoxia-ischemia","volume":"14","author":"Alonso-Alconada","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.spen.2019.08.008_bib0124","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/dmcn.12415","article-title":"Is melatonin ready to be used in preterm infants as a neuroprotectant?","volume":"56","author":"Biran","year":"2014","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.spen.2019.08.008_bib0125","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000085993","article-title":"Melatonin provides neuroprotection in the late-gestation fetal sheep brain in response to umbilical cord occlusion","volume":"27","author":"Miller","year":"2005","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.spen.2019.08.008_bib0126","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1203\/01.pdr.0000252546.20451.1a","article-title":"Melatonin reduces inflammation and cell death in white matter in the mid-gestation fetal sheep following umbilical cord occlusion","volume":"61","author":"Welin","year":"2007","journal-title":"Pediatr Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0127","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.3109\/14767058.2011.636094","article-title":"Prophylactic administration of melatonin to the mother throughout pregnancy can protect against oxidative cerebral damage in neonatal rats","volume":"25","author":"Watanabe","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.spen.2019.08.008_bib0128","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1600-079X.2004.00167.x","article-title":"Maternally administered melatonin protects against ischemia and reperfusion-induced oxidativemitochondrial damage in premature fetal rat brain","volume":"37","author":"Watanabe","year":"2004","journal-title":"J Pineal Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0129","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/bcp.12092","article-title":"Pharmacokinetics of melatonin in preterm infants","volume":"76","author":"Merchant","year":"2013","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.spen.2019.08.008_bib0130","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-079X.1998.tb00550.x","article-title":"Maternal-fetal transfer of melatonin in pregnant women near term","volume":"25","author":"Okatani","year":"1998","journal-title":"J Pineal Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0131","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1600-079X.1988.tb00787.x","article-title":"Plasma, cerebrospinal fluid, and brain distribution of 14C-melatonin in rat: A biochemical and autoradiographic study","volume":"5","author":"Vitte","year":"1988","journal-title":"J Pineal Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0132","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbi.2016.11.011","article-title":"Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury","volume":"60","author":"Drommelschmidt","year":"2017","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.spen.2019.08.008_bib0133","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1634\/stemcells.2008-0329","article-title":"Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro","volume":"26","author":"Rose","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.spen.2019.08.008_bib0134","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/stem.459","article-title":"Concise review: Hitting the right spot with mesenchymal stromal cells","volume":"28","author":"Tolar","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.spen.2019.08.008_bib0135","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.bbamem.2016.02.011","article-title":"Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases","volume":"1858","author":"Janas","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.spen.2019.08.008_bib0136","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.4161\/cbt.6.12.5161","article-title":"New enlightenment of French Paradox: Resveratrol's potential for cancer chemoprevention and anti-cancer therapy","volume":"6","author":"Liu","year":"2007","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.spen.2019.08.008_bib0137","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuroscience.2013.03.015","article-title":"Resveratrol protects spinal cord dorsal column from hypoxic injury by activating Nrf-2","volume":"241","author":"Kesherwani","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.spen.2019.08.008_bib0138","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ejphar.2011.05.015","article-title":"Ischemic insult induced apoptotic changes in PC12 cells: Protection by trans resveratrol","volume":"666","author":"Agrawal","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.spen.2019.08.008_bib0139","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2006.06.096","article-title":"Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus","volume":"1111","author":"Gao","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0140","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000105477","article-title":"Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury","volume":"29","author":"West","year":"2007","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.spen.2019.08.008_bib0141","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3345\/kjp.2008.51.10.1102","article-title":"Neuroprotective effects of resveratrol via anti-apoptosis on hypoxic-ischemic brain injury in neonatal rats","volume":"51","author":"Shin","year":"2008","journal-title":"Korean J Pediatr"},{"key":"10.1016\/j.spen.2019.08.008_bib0142","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.brainres.2011.09.044","article-title":"Resveratrol ameliorates hypoxia\/ischemia-induced behavioral deficits and brain injury in the neonatal rat brain","volume":"1425","author":"Karalis","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0143","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1203\/01.PDR.0000157722.07810.15","article-title":"Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury","volume":"57","author":"Loren","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0144","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.placenta.2012.01.012","article-title":"Maternal resveratrol treatment during pregnancy improves adverse fetal outcomes in a rat model of severe hypoxia","volume":"33","author":"Bourque","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.spen.2019.08.008_bib0145","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-0-387-46401-5_10","article-title":"Molecular targets of curcumin","volume":"595","author":"Lin","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.spen.2019.08.008_bib0146","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1742-2094-11-59","article-title":"Curcumin attenuates acute inflammatory injury by inhibiting the TLR4\/MyD88\/NF-\u03baB signaling pathway in experimental traumatic brain injury","volume":"11","author":"Zhu","year":"2014","journal-title":"J Neuroinflamm"},{"key":"10.1016\/j.spen.2019.08.008_bib0147","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.brainres.2009.05.009","article-title":"Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia","volume":"1282","author":"Yang","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0148","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1002\/anie.201107724","article-title":"Curcumin-from molecule to biological function","volume":"51","author":"Esatbeyoglu","year":"2012","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.spen.2019.08.008_bib0149","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2174\/187152006776930918","article-title":"Biological effects of curcumin and its role in cancer chemoprevention and therapy","volume":"6","author":"Singh","year":"2006","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.spen.2019.08.008_bib0150","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bbr.2008.06.012","article-title":"Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat","volume":"193","author":"Dohare","year":"2008","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0151","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s11064-009-0065-y","article-title":"Curcumin improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats","volume":"35","author":"Zhao","year":"2009","journal-title":"Neurochem Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0152","first-page":"1","article-title":"Curcumin protects neuron against cerebral ischemia-induced inflammation through improving PPAR-gamma function","volume":"2013","author":"Liu","year":"2013","journal-title":"Evid Based Complement Altern Med"},{"key":"10.1016\/j.spen.2019.08.008_bib0153","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3109\/10799893.2015.1006331","article-title":"Protection of curcumin against amyloid-beta-induced cell damage and death involves the prevention from NMDA receptor-mediated intracellular Ca2+elevation","volume":"35","author":"Huang","year":"2015","journal-title":"J Recept Signal Transduct Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0154","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1021\/nn405077y","article-title":"Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in alzheimer's disease modelviacanonical Wnt-beta-catenin pathway","volume":"8","author":"Tiwari","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.spen.2019.08.008_bib0155","doi-asserted-by":"crossref","DOI":"10.1007\/s12274-018-2104-y","article-title":"Curcumin-loaded polymeric nanoparticles for neuroprotection in neonatal rats with hypoxic-ischemic encephalopathy","author":"Joseph","year":"2018","journal-title":"Nano Res"},{"key":"10.1016\/j.spen.2019.08.008_bib0156","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejpb.2013.02.005","article-title":"Curcumin loaded solid lipid nanoparticles: An efficient formulation approach for cerebral ischemic reperfusion injury in rats","volume":"85","author":"Kakkar","year":"2013","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.spen.2019.08.008_bib0157","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jconrel.2015.07.009","article-title":"Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury","volume":"214","author":"Nance","year":"2015","journal-title":"J Control Release"},{"key":"10.1016\/j.spen.2019.08.008_bib0158","article-title":"Long-term healthcare outcomes of preterm birth: An executive summary of a conference sponsored by the national institutes of health","author":"Raju","year":"2016","journal-title":"J Pediatr"}],"container-title":["Seminars in Pediatric Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071909119300798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071909119300798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T06:36:32Z","timestamp":1761028592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071909119300798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":158,"alternative-id":["S1071909119300798"],"URL":"https:\/\/doi.org\/10.1016\/j.spen.2019.08.008","relation":{},"ISSN":["1071-9091"],"issn-type":[{"value":"1071-9091","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotection Strategies in Preterm Encephalopathy","name":"articletitle","label":"Article Title"},{"value":"Seminars in Pediatric Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.spen.2019.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100772"}}