{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:05:35Z","timestamp":1781521535196,"version":"3.54.1"},"reference-count":66,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.spinee.2005.02.007","type":"journal-article","created":{"date-parts":[[2005,11,11]],"date-time":"2005-11-11T12:14:49Z","timestamp":1131711289000},"page":"S224-S230","source":"Crossref","is-referenced-by-count":55,"special_numbering":"S","title":["Carrier materials for spinal fusion"],"prefix":"10.1016","volume":"5","author":[{"given":"Brian","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis G.","family":"Jenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2005.02.007_bib1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0030-5898(05)70120-6","article-title":"Bone grafting for spinal fusion","volume":"30","author":"Sandhu","year":"1999","journal-title":"Ortho Clin North Am"},{"key":"10.1016\/j.spinee.2005.02.007_bib2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/01.BRS.0000048644.91330.14","article-title":"Simple carrier matrix modifications can enhance delivery of recombinant human bone morphogenetic protein-2 for posterolateral spine fusion","volume":"28","author":"Akamaru","year":"2003","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib3","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1097\/00007632-200212010-00005","article-title":"Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies","volume":"27","author":"Boden","year":"2002","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib4","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1097\/00007632-200104150-00003","article-title":"Evaluation of carriers of bone morphogenetic protein for spinal fusion","volume":"26","author":"Boden","year":"2001","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib5","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.addr.2003.08.010","article-title":"Collagen sponges for bone regeneration with rhBMP-2","volume":"55","author":"Geiger","year":"2003","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.spinee.2005.02.007_bib6","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1097\/00007632-199911010-00003","article-title":"Recombinant human bone morphogenetic protein-2 overcomes the inhibitory effect of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), on posterolateral lumbar intertransverse process spine fusion","volume":"24","author":"Martin","year":"1999","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00007632-200202150-00006","article-title":"Delivery of recombinant human bone morphogenetic protein-2 using a compression-resistant matrix in posterolateral spine fusion in the rabbit and in the non-human primate","volume":"27","author":"Suh","year":"2002","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib8","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1097\/00007632-199906150-00002","article-title":"Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2\/hydroxyapatite-tricalcium phosphate after laminectomy in the nonhuman primate","volume":"24","author":"Boden","year":"1999","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib9","doi-asserted-by":"crossref","first-page":"s141","DOI":"10.1007\/s005860100287","article-title":"Potential of an ultraporous beta-tricalcium phosphate synthetic cancellous bone void filler and bone marrow aspirate composite graft","volume":"10","author":"Erbe","year":"2001","journal-title":"Eur Spine J"},{"key":"10.1016\/j.spinee.2005.02.007_bib10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/01.BRS.0000090823.12652.F9","article-title":"Evidence of osteoinduction by Grafton demineralized bone matrix in nonhuman primate spinal fusion","volume":"29","author":"Louis-Ugbo","year":"2004","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1529-9430(01)00155-3","article-title":"Anterior lumbar interbody fusion with titanium mesh cages, coralline hydroxyapatite, and demineralized bone matrix as part of a circumferential fusion","volume":"2","author":"Thalgott","year":"2001","journal-title":"Spine J"},{"key":"10.1016\/j.spinee.2005.02.007_bib12","doi-asserted-by":"crossref","first-page":"s16","DOI":"10.1097\/00007632-200208151-00005","article-title":"Bone morphogenetic protein delivery systems","volume":"27","author":"Seeherman","year":"2002","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib13","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00002517-199712000-00002","article-title":"Augmentation of autograft using rhBMP-2 and different carrier media in the canine spinal fusion model","volume":"10","author":"Fischgrund","year":"1997","journal-title":"J Spinal Disord"},{"key":"10.1016\/j.spinee.2005.02.007_bib14","first-page":"s92","article-title":"Biodegradable poly-d,l-lactic acid-polyethylene glycol block copolymers as a BMP delivery system for inducing bone","volume":"83A","author":"Saito","year":"2001","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.spinee.2005.02.007_bib15","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1177\/036354659302100202","article-title":"A review of allograft processing and sterilization techniques and their role in transmission of human immunodeficiency virus","volume":"21","author":"Asselmeier","year":"1993","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.spinee.2005.02.007_bib16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00003086-200002000-00005","article-title":"The use of allograft bone in lumbar spine surgery","volume":"371","author":"Ehrler","year":"2000","journal-title":"Clin Orthop Rel Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib17","first-page":"210","article-title":"Demineralized bone matrix supplied by bone bank for a carrier of recombinant human bone morphogenetic protein (rhBMP-2): a substitute for autogeneic bone grafts","volume":"22","author":"Niederwnager","year":"1996","journal-title":"J Oral Implantol"},{"key":"10.1016\/j.spinee.2005.02.007_bib18","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/00007632-199904010-00005","article-title":"New formulations of demineralized bone matrix as a more effective graft alternative in experimental posterolateral lumbar spine arthrodesis","volume":"24","author":"Martin","year":"1999","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib19","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone: formation by autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.spinee.2005.02.007_bib20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/00003086-198809000-00044","article-title":"Ectopic bone induction on and in porous hydroxyapatite combined with collagen and bone morphogenetic protein","volume":"234","author":"Takaoka","year":"1988","journal-title":"Clin Orthop Rel Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00003086-199205000-00041","article-title":"Evaluation of polylactic acid homopolymers as carriers for bone morphogenetic protein","volume":"278","author":"Miyamoto","year":"1999","journal-title":"Clin Orthop Rel Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib22","doi-asserted-by":"crossref","first-page":"s50","DOI":"10.1097\/00007632-200208151-00012","article-title":"Purified bovine BMP extract and collagen for spine arthrodesis: preclinical safety and efficacy","volume":"27","author":"Damien","year":"2002","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0167-7799(01)01665-1","article-title":"Delivering on the promise of bone morphogenetic proteins","volume":"19","author":"Li","year":"2001","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.spinee.2005.02.007_bib24","doi-asserted-by":"crossref","first-page":"s95","DOI":"10.1097\/00003086-199910001-00010","article-title":"Carrier systems for bone morphogenic proteins","volume":"367","author":"Winn","year":"1999","journal-title":"Clin Orthop Rel Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-5173(99)00174-X","article-title":"Characterization of absorbable collagen sponges as rhBMP-2 carriers","volume":"187","author":"Friess","year":"1999","journal-title":"Int J Pharm"},{"key":"10.1016\/j.spinee.2005.02.007_bib26","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/S0142-9612(00)00322-7","article-title":"Evaluation of ceramics composed of different hydroxyapatite to tricalcium phosphate ratios as carriers for rhBMP-2","volume":"22","author":"Alam","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.spinee.2005.02.007_bib27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00007632-199904010-00004","article-title":"The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote spinal fusion in a human primate anterior interbody fusion model","volume":"24","author":"Hecht","year":"1999","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib28","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00024720-200304000-00001","article-title":"Is INFUSE bone graft superior to autograft bone? An integrated analysis of clinical trials using the LT-CAGE lumbar tapered fusion device","volume":"16","author":"Burkus","year":"2003","journal-title":"J Spinal Disord Tech"},{"key":"10.1016\/j.spinee.2005.02.007_bib29","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1097\/01.BRS.0000132512.53305.A1","article-title":"Comparison of posterolateral lumbar fusion rates of Grafton putty and OP-1 putty in an athymic rat model","volume":"29","author":"Bomback","year":"2004","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib30","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00007632-200101150-00004","article-title":"Evaluation of OP-1 as a graft substitute for intertransverse process lumbar fusion","volume":"26","author":"Grauer","year":"2001","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00586-003-0561-8","article-title":"A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions","volume":"12","author":"Vaccaro","year":"2003","journal-title":"Eur Spine J"},{"key":"10.1016\/j.spinee.2005.02.007_bib32","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1097\/00007632-200212010-00009","article-title":"Successful transpedicular lumbar interbody fusion by means of a composite of osteogenic protein-1 (rhBMP-7) and hydroxyapatite carrier: a comparison with autograft and hydroxyapatite in the sheep spine","volume":"27","author":"Blattert","year":"2002","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/1097-4636(200104)55:1<89::AID-JBM120>3.0.CO;2-X","article-title":"Effect of osteogenic protein 1 \/ collagen composite combined with impacted allograft around hydroxyapatite-coated titanium alloy implants is moderate","volume":"55","author":"Lind","year":"2001","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib34","unstructured":"Wheeler D. The use of non-collagen based carrier for OP-1. Paper presented at: 5th International Conference on Bone Morphogenetic Proteins; Nagoya, Japan; September 12, 2004."},{"key":"10.1016\/j.spinee.2005.02.007_bib35","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1034\/j.1600-0501.2003.00817.x","article-title":"Bone augmentation using rhGDF-5-collagen composite","volume":"14","author":"Kuniyasu","year":"2003","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00003086-200202000-00009","article-title":"Properties of osteoconductive biomaterials: calcium phosphates","volume":"395","author":"Legeros","year":"2002","journal-title":"Clin Orthop Rel Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1227\/01.NEU.0000097516.00961.EB","article-title":"Endoscopic instrumented posterolateral lumbar fusion with healos and recombinant human growth \/ differentiation factor \u2013 5","volume":"54","author":"Jahng","year":"2004","journal-title":"Neurosurg"},{"key":"10.1016\/j.spinee.2005.02.007_bib38","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/(SICI)1097-4636(199802)39:2<190::AID-JBM4>3.0.CO;2-K","article-title":"BMP-induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: topology of osteogenesis","volume":"39","author":"Kuboki","year":"1998","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib39","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0030-5898(05)70114-0","article-title":"Calcium sulfate\u2013 and calcium phosphate\u2013based bone substitutes","volume":"30","author":"Tay","year":"1999","journal-title":"Ortho Clin North Am"},{"key":"10.1016\/j.spinee.2005.02.007_bib40","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/00001665-199505000-00011","article-title":"Efficacy of hydroxyapatite ceramic as a carrier for recombinant human bone morphogenetic protein","volume":"6","author":"Ono","year":"1995","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.spinee.2005.02.007_bib41","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1023\/A:1008939524807","article-title":"Biomechanical evaluation of cell-loaded and cell-free hydroxyapatite implants for the reconstruction of segmental bone defects","volume":"10","author":"Chistolini","year":"1999","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.spinee.2005.02.007_bib42","doi-asserted-by":"crossref","first-page":"s571","DOI":"10.3928\/0147-7447-20020502-05","article-title":"The role of the osteoconductive scaffold in synthetic bone graft","volume":"25","author":"Vaccaro","year":"2002","journal-title":"Orthopedics"},{"key":"10.1016\/j.spinee.2005.02.007_bib43","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/0885328203017004001","article-title":"Ceramic drug delivery: a perspective","volume":"17","author":"Paul","year":"2003","journal-title":"J Biomat Appl"},{"key":"10.1016\/j.spinee.2005.02.007_bib44","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/01.BRS.0000101446.26071.EB","article-title":"Ne-Osteo bone growth factor for posterolateral lumbar spine fusion: results from a nonhuman primate study and a prospective human clinical pilot study","volume":"29","author":"Boden","year":"2004","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib45","doi-asserted-by":"crossref","first-page":"s396","DOI":"10.1097\/00003086-199910001-00038","article-title":"Alpha-BSM: a biomimetic bone substitute and drug delivery vehicle","volume":"367","author":"Lee","year":"1999","journal-title":"Clin Orthop Rel Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib46","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0736-0266(03)00082-2","article-title":"rhBMP-2 Injected in a calcium phosphate paste (Alpha-BSM) accelerates healing in the rabbit ulnar osteotomy model","volume":"21","author":"Li","year":"2003","journal-title":"J Ortho Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib47","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/1097-4636(20010305)54:3<445::AID-JBM190>3.0.CO;2-9","article-title":"The biocompatibility and osteoconductive activity of a novel hydroxyapatite \/ collagen composite biomaterial, and its function as a carrier of rhBMP-2","volume":"54","author":"Itoh","year":"2001","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib48","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0736-0266(02)00011-6","article-title":"Retention of 125I-labeled recombinant human bone morphogenetic protein-2 by biphasic calcium phosphate or a composite sponge in a rabbit posterolateral spine arthrodesis model","volume":"20","author":"Louis-Ugbo","year":"2002","journal-title":"J Ortho Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib49","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00776-003-0749-0","article-title":"Experimental study of carriers of bone morphogenetic protein used for spinal fusion","volume":"9","author":"Minamide","year":"2004","journal-title":"J Ortho Sci"},{"key":"10.1016\/j.spinee.2005.02.007_bib50","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2106\/00004623-199704000-00004","article-title":"Treatment of acute fractures with a collagen-calcium phosphate graft material: a randomized clinical trial","volume":"79A","author":"Chapman","year":"1997","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.spinee.2005.02.007_bib51","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/00003086-199607000-00039","article-title":"Evaluation of collagen ceramic composite graft materials in a spinal fusion model","volume":"328","author":"Muschler","year":"1996","journal-title":"Clin Orthop Rel Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib52","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/jor.1100100411","article-title":"Fibrillar collagen\u2013biphasic calcium phosphate composite as a bone graft substitute for spinal fusion","volume":"10","author":"Zerwekh","year":"1992","journal-title":"J Ortho Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib53","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.biomaterials.2003.08.030","article-title":"Long-term stability of bone tissues induced by an osteoinductive biomaterial, recombinant human bone morphogenetic protein-2 and a biodegradable carrier","volume":"25","author":"Kokubo","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.spinee.2005.02.007_bib54","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/00003086-200202000-00006","article-title":"Nonallograft osteoconductive bone graft substitutes","volume":"395","author":"Bucholz","year":"2002","journal-title":"Clin Orthop Rel Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib55","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0266-4356(96)90098-4","article-title":"Long-term evaluation of recombinant human bone morphogenetic protein-2 induced bone formation with a biologic and synthetic delivery system","volume":"34","author":"Alpaslan","year":"1996","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.spinee.2005.02.007_bib56","doi-asserted-by":"crossref","first-page":"s318","DOI":"10.1080\/03008200390181843","article-title":"Laser-perforated membranous biomaterials induced pore size-dependent bone induction when used as a new BMP carrier","volume":"44","author":"Kuboki","year":"2003","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib57","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0142-9612(96)85763-2","article-title":"Poly (alpha-hydroxy acids): carriers for bone morphogenetic proteins","volume":"17","author":"Hollinger","year":"1996","journal-title":"Biomaterials"},{"key":"10.1016\/j.spinee.2005.02.007_bib58","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/bit.1086","article-title":"Engineering temperature-sensitive poly (N-isopropylacrylamide) polymers as carriers of therapeutic proteins","volume":"73","author":"Uladag","year":"2001","journal-title":"Biotech Bioeng"},{"key":"10.1016\/j.spinee.2005.02.007_bib59","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S1529-9430(02)00412-6","article-title":"The use of bioabsorbable implants in the spine","volume":"3","author":"Vaccaro","year":"2003","journal-title":"Spine J"},{"key":"10.1016\/j.spinee.2005.02.007_bib60","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1097\/00007632-199910010-00002","article-title":"Lumbar spinal fusion using recombinant human bone morphogenetic protein in the canine: a comparison of three dosgaes and two carriers","volume":"24","author":"David","year":"1999","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2005.02.007_bib61","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00003086-199309000-00050","article-title":"Polylactic acid\u2013polyethylene glycol block copolymer. A new biodegradable synthetic carrier for bone morphogenetic protein","volume":"294","author":"Miyamoto","year":"1994","journal-title":"Clin Orthop Rel Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib62","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1016\/S0142-9612(03)00040-1","article-title":"New synthetic biodegradable polymers as BMP carriers for bone tissue engineering","volume":"24","author":"Saito","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.spinee.2005.02.007_bib63","doi-asserted-by":"crossref","first-page":"E17","DOI":"10.1208\/pt020317","article-title":"Porous bone morphogenetic protein-2 microspheres: polymer binding and in vitro release","volume":"2","author":"Schrier","year":"2001","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.spinee.2005.02.007_bib64","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/(SICI)1097-4636(19981215)42:4<491::AID-JBM3>3.0.CO;2-F","article-title":"Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds","volume":"42","author":"Whang","year":"1998","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.spinee.2005.02.007_bib65","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S8756-3282(03)00028-0","article-title":"Local bone formation by injection of recombinant human bone morphogenic protein-2 contained in polymer carriers","volume":"32","author":"Saito","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.spinee.2005.02.007_bib66","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/jbm.10169","article-title":"Experimental studies on bone induction using low-molecular weight poly (dl-Lactide-co-glycolide) as a carrier for recombinant human bone morphogenetic protein-2","volume":"61","author":"Bessho","year":"2002","journal-title":"J Biomed Mater Res"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943005000860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943005000860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T10:39:13Z","timestamp":1683283153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943005000860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S1529943005000860"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2005.02.007","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}