{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:49:34Z","timestamp":1761518974317},"reference-count":46,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.spinee.2010.07.390","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T08:25:38Z","timestamp":1285230338000},"page":"999-1006","source":"Crossref","is-referenced-by-count":4,"title":["Excrescence of neurotransmitter glutamate from disc material has nociceptive qualities: evidence from a rat model"],"prefix":"10.1016","volume":"10","author":[{"given":"Doreen P.","family":"Osgood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth V.","family":"Kenney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Frederick","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2010.07.390_bib1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0736-0266(01)00016-X","article-title":"In vivo microdialysis and immunohistochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMDAR1 receptors, but no signs of inflammation, in Jumper\u2019s knee","volume":"19","author":"Alfredson","year":"2001","journal-title":"J Orthop Res"},{"key":"10.1016\/j.spinee.2010.07.390_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/jnnp.11.1.13","article-title":"Observations on the cause and mechanism of symptom-production in sciatica and low-back pain","volume":"11","author":"Falconer","year":"1948","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.spinee.2010.07.390_bib3","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/00007632-199804150-00005","article-title":"The involvement of matrix metalloproteinases and inflammation in lumbar disc herniation","volume":"23","author":"Matsui","year":"1998","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.07.390_bib4","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1097\/ALN.0b013e3181a05aa0","article-title":"Randomized, double-blind, placebo-controlled, dose-response, and preclinical safety study of transforaminal epidural etanercept for the treatment of sciatica","volume":"110","author":"Cohen","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1016\/j.spinee.2010.07.390_bib5","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1097\/01.brs.0000245873.23876.1e","article-title":"The treatment of disc-herniation-induced sciatica with infliximab: one-year follow-up results of FIRST II, a randomized controlled trial","volume":"31","author":"Korhonen","year":"2006","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.07.390_bib6","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/00007632-200004150-00006","article-title":"Herniated lumbar disc material as a source of free glutamate available to affect pain signals through the dorsal root ganglion","volume":"25","author":"Harrington","year":"2000","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.07.390_bib7","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/01.brs.0000155422.64216.e4","article-title":"Physiological and behavioral evidence for focal nociception induced by epidural glutamate infusion in rats","volume":"30","author":"Harrington","year":"2005","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.07.390_bib8","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/art.1780360906","article-title":"The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis","volume":"36","author":"Lohmander","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.spinee.2010.07.390_bib9","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/BF01923583","article-title":"Molecular cloning and analysis of the protein modules of aggrecans","volume":"49","author":"Upholt","year":"1993","journal-title":"Experientia"},{"key":"10.1016\/j.spinee.2010.07.390_bib10","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/cne.21285","article-title":"Colocalization of metabotropic glutamate receptors in rat dorsal root ganglion cells","volume":"501","author":"Carlton","year":"2007","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.spinee.2010.07.390_bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0014-2999(97)00072-1","article-title":"Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats","volume":"324","author":"Lawand","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.spinee.2010.07.390_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2002-3-5-research0025","article-title":"Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes","volume":"3","author":"Copley","year":"2002","journal-title":"Genome Biol"},{"key":"10.1016\/j.spinee.2010.07.390_bib13","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.semcdb.2006.10.008","article-title":"Glutamate receptors and pain","volume":"17","author":"Bleakman","year":"2006","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.spinee.2010.07.390_bib14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0896-6273(88)90162-6","article-title":"Glutamate neurotoxicity and diseases of the nervous system","volume":"1","author":"Choi","year":"1988","journal-title":"Neuron"},{"key":"10.1016\/j.spinee.2010.07.390_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0169-328X(93)90183-P","article-title":"Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception","volume":"18","author":"Furuyama","year":"1993","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.spinee.2010.07.390_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0165-0173(02)00203-5","article-title":"Role of kainate receptors in nociception","volume":"40","author":"Ruscheweyh","year":"2002","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.spinee.2010.07.390_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.brainresrev.2008.12.007","article-title":"Metabotropic receptors for glutamate and GABA in pain","volume":"60","author":"Goudet","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.spinee.2010.07.390_bib18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pbb.2004.07.003","article-title":"NMDA-R1 antisense oligodeoxynucleotides modify formalin-induced nociception and spinal c-Fos expression in rat spinal cord","volume":"79","author":"Lee","year":"2004","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.spinee.2010.07.390_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0940-9602(02)80039-5","article-title":"Up-regulation of substance P and NMDA receptor mRNA in dorsal horn and preganglionic sympathetic neurons during adjuvant-induced noxious stimulation in rats","volume":"184","author":"Ohtori","year":"2002","journal-title":"Ann Anat"},{"key":"10.1016\/j.spinee.2010.07.390_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.brainres.2004.03.010","article-title":"Sustained potentiation by substance P of NMDA-activated current in rat primary sensory neurons","volume":"1010","author":"Wu","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.spinee.2010.07.390_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pain.2005.02.006","article-title":"Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord","volume":"115","author":"Liaw","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.spinee.2010.07.390_bib22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/cne.10101","article-title":"Glutamate transporters alterations in the reorganizing dentate gyrus are associated with progressive seizure activity in chronic epileptic rats","volume":"442","author":"Gorter","year":"2002","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.spinee.2010.07.390_bib23","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neuropharm.2007.10.003","article-title":"Dendritic and mitochondrial changes during glutamate excitotoxicity","volume":"52","author":"Greenwood","year":"2007","journal-title":"Neuropharamacology"},{"key":"10.1016\/j.spinee.2010.07.390_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0304-3959(03)00332-4","article-title":"Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation","volume":"106","author":"Tambeli","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.spinee.2010.07.390_bib25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1124\/jpet.106.105601","article-title":"Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 (GluR5) ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats","volume":"319","author":"Jones","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.spinee.2010.07.390_bib26","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1097\/00000542-199811000-00005","article-title":"AMPA\/kainite antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans","volume":"89","author":"Sang","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1016\/j.spinee.2010.07.390_bib27","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/AJP.0b013e31802e3377","article-title":"Preincisional subcutaneous infiltration of ketamine suppresses postoperative pain after circumcision surgery","volume":"23","author":"Tan","year":"2007","journal-title":"Clin J Pain"},{"key":"10.1016\/j.spinee.2010.07.390_bib28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neulet.2007.01.063","article-title":"The peripheral role of group 1 metabotropic glutamate receptors on nociceptive behaviors in rats with knee joint inflammation","volume":"416","author":"Lee","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.spinee.2010.07.390_bib29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1124\/jpet.300.1.149","article-title":"Group I metabotropic glutamate receptor antagonists block secondary thermal hyperalgesia in rats with knee joint inflammation","volume":"300","author":"Zhang","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.spinee.2010.07.390_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejphar.2004.07.110","article-title":"NMDA receptors and associated signaling pathways: a role in knee joint blood flow regulation","volume":"499","author":"Lawand","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.spinee.2010.07.390_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neulet.2003.08.009","article-title":"The glutamatergic N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors in the joint contribute to the induction, but not maintenance, of arthritic pain in rats","volume":"351","author":"Zhang","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.spinee.2010.07.390_bib32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0003-9861(92)90144-L","article-title":"Mechanism of catabolism of aggrecan by articular cartilage","volume":"294","author":"Ilic","year":"1992","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.spinee.2010.07.390_bib33","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s12035-009-8086-8","article-title":"Ionotropic glutamate receptors in spinal nociceptive processing","volume":"40","author":"Larsson","year":"2009","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.spinee.2010.07.390_bib34","first-page":"79","article-title":"Distribution of anionic sites on the perineurium","volume":"181","author":"Bush","year":"1992","journal-title":"J\u00a0Anat"},{"key":"10.1016\/j.spinee.2010.07.390_bib35","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1097\/00007632-200108010-00003","article-title":"Effects of anulus fibrosus and experimentally degenerated nucleus pulposus on nerve root conduction velocity: relevance of previous experimental investigations using normal nucleus pulposus","volume":"26","author":"Iwabuchi","year":"2001","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.07.390_bib36","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1213\/01.ane.0000281435.58012.e3","article-title":"Epidural tezampanel, an AMPA\/kainate receptor antagonist, produces postoperative analgesia in rats","volume":"105","author":"Jin","year":"2007","journal-title":"Anesth Analg"},{"key":"10.1016\/j.spinee.2010.07.390_bib37","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jpain.2006.03.010","article-title":"The effect of the AMPA\/kainate receptor antagonist LY293558 in a rat model of postoperative pain","volume":"7","author":"Lee","year":"2006","journal-title":"J Pain"},{"key":"10.1016\/j.spinee.2010.07.390_bib38","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1055\/s-2007-996518","article-title":"Pharmacokinetics of buprenorphine in subcutaneous administration","volume":"30","author":"Gralow","year":"1995","journal-title":"Anasthesiol Intensivmed Notfallmed Schmerzther"},{"key":"10.1016\/j.spinee.2010.07.390_bib39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0306-4522(96)00196-0","article-title":"Upregulation of spinal glutamate receptors in chronic pain","volume":"74","author":"Harris","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.spinee.2010.07.390_bib40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.molbrainres.2005.02.003","article-title":"Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus","volume":"136","author":"Tomiyama","year":"2005","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.spinee.2010.07.390_bib41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jbspin.2005.03.003","article-title":"Pathophysiology of disk-related sciatica. I.\u2014Evidence supporting a chemical component","volume":"l73","author":"Mulleman","year":"2006","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.spinee.2010.07.390_bib42","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/BRS.0b013e318162340a","article-title":"Effect of etanercept, a tumor necrosis factor alpha inhibitor, on neuropathic pain in the rat chronic constriction injury model","volume":"33","author":"Zanella","year":"2008","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.07.390_bib43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2210-1-7","article-title":"Effect of a short term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia","volume":"1","author":"Mayer","year":"2001","journal-title":"BMC Pharmacol"},{"issue":"Suppl 24","key":"10.1016\/j.spinee.2010.07.390_bib44","doi-asserted-by":"crossref","first-page":"45S","DOI":"10.1097\/00007632-199612151-00005","article-title":"Focus issue on lumbar disc herniation: macro- and microdiscectomy","volume":"21","author":"McCulloch","year":"1996","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.07.390_bib45","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/BSD.0b013e318093e5dc","article-title":"Success of lumbar microdiscectomy in patients with modic changes and low-back pain: a prospective pilot study","volume":"21","author":"Chin","year":"2008","journal-title":"J Spinal Disord Tech"},{"key":"10.1016\/j.spinee.2010.07.390_bib46","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1055\/s-0028-1082313","article-title":"Postoperative management of incidental durotomy in minimally invasive lumbar spinal surgery","volume":"51","author":"Than","year":"2008","journal-title":"Minim Invasive Neurosurg"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943010009435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943010009435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T22:57:21Z","timestamp":1544223441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943010009435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S1529943010009435"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2010.07.390","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}